Contains illust

1. Agonist
Drugs used in Inflammation Antagonist
Enzyme
Adelimumab lipocortin-1 PLA2
Infliximab
IL-2 Aspirin
arachidonic acid
TNF-a, IL-1, ... Celecoxib
LOX
Ibuprofen COX
IL-1R Paracetamol Zileuton
antagonist
5 12 15
PGD-F TXA PGI 5-HPETE 12-HETE lipoxins
Cromoloyn sodium/
Sodium cromoglycate
Rapamycin
Anakinra
Sirolimus LTA-E
IL-1 R mTOR growth, proliferation
Zafirlukast
LT R Cyclosporin,
Tacrolimus
Ca2+ calcineurin
Alem-
tuzumab
CD52
Hsp90
Corticosteroids GCR-a
Y
Omali-
zumab IgE
MHCII
Theophylline
phosphodiesterase
b2-adreno R Gs cAmp
Salbutamol
Gq Ca2+ contraction DNA precursors
mACh R Methotrexate, Azathiprine,
Ipratropium Mycophenolate Sodium

2. Antibiotics
membrane
b-lactams ionophores
glycopeptides
wall
fluoroquinolones
rifampicin
ribosome DNA related
tetracyclins enzymes
aminoglycosides
macrolides
fusidic acid
chloramphenicol
daunomycin
bleomycin
aziridines:
mitomycin C DNA
sulfa drugs/
sulfonamides DNA precursors
trimethoprim

3. antibiotics that inhibit cell wall synthesis
b-lactams: penicillins, carbapenems, cephalosporins, monobactams
glycopeptides: vancomycin
• Fosfomycin - inhibits pyruvyl transferase
• D-cycloserine - inhibits L-Ala racemase, DADA synthase and ligase
• Bacitracin - inhibits bactoprenol
• Penicillin, Amp, Amox, Meth - inhibits peptidoglycan transpeptidase
• Vancomycin - complexes D-Ala peptide side-chains
• Clavulanate - inhibits b-lactamase
• Augmentin - mix of amoxicillin and clavulanate
• Isoniazid - inhibits mycolic acid synthesis
antibiotics that inhibit protein synthesis
tetracyclines: tetracycline, spectinomycin
aminoglycosides: streptomycin, gentamycin
macrolides: erythromycin
amphenicols: chloramphenicol
• tetracycline, tetracycline - binds 30S, blocks rotation of tRNA in A-site
• spectinomycin, tetracycline - binds 30S and inhibits EF-G during translocation
• streptomycin, aminoglycoside - binds 30S near A-site, decreases fidelity
• gentamycin, aminoglycoside - binds 30S near A-site, decreases fideliy
• erythromycin, macrolide - binds 50S exit tunnel
• chloramphenicol, amphenicol - binds 50S blocks translocation
• fusidic acid - inhibits EF-G

4. antibiotics that inhibit DNA replication and transcription
Binding to DNA-related enzymes
Fluoroquinolones: Ciprofloxacin
Rifampicin
• ciprofloxacin - fluoroquinolone, bactTPII inhibitor, broad spectrum
• rifampicin - DNA-dep RNA polymerase, blocks RNA exit tunnel, mycobacteria
Binding to DNA itself:
Anthracycline: Daunomycin
Chelators: Bleomycin
Aziridines: Mitomycin C
• daunomycin - anthracycline, chelates and blocks hTPII
• bleomycin - glycopeptide, chelates to cause ds and ss breaks, toxic
• mitomycin C - aziridine, alkylates at G-c, used in chemotherapy
antibiotics that inhibit precursor formation
Sulfa-drugs
Trimethoprim
• sulfamethoxazole - inhibits dihydropteroate synthase
• trimethoprim - inhibits dihydrofolate reductase
• co-trimoxazole
antibiotics that inhibit membrane formation (in bacteria)
ionophores
• valinomycin - ring-shaped K+ uniporter
• gramicidin A - polypeptide dimer
• polymixin - micelles

5. Anti-protozoal drugs
membrane
amphotericin B
miconazole
heme
degradation
chloroquine
ribosome
tetracycline
ATP synthesis
arsenicals: melarsen
suramin
sulfadoxin DNA precursors
pyrimethamine
fansidar