This article is built on the content of two game changing books on operational excellence, 'The Path - Leveraging Operations in a Complex and Chaotic World' and 'Building Manufacturing Competitiveness'. While the first book presents a detailed action oriented and story driven case of how pharma companies are making operations central to their competitive strategy in today's business environment, the second one provides a technical explanation of the first. Following the release of the two books, there has been a demand from pharma plants to bring out successful case studies on how throughput of plants can be improved 'dramatically' and 'quickly' on an ongoing basis; this article is directed to meet this demand.