1. Clinicopathologic characteristics and survival outcomes of five subtypes of adenocarcinoma that has been associated with histological characteristics of EML4-ALK NSCLC Sai-Hong Ignatius Ou, MD PhD Associate Clinical Professor Chao Family Comprehensive Cancer Center Department of Medicine, Division of Hematology-Oncology University of California Irvine Medical Center, Orange, CA 92868

6. < 0.0001 152 (42.3) 35 (9.8) 51 (14.2) 39 (10.9) 82 (22.8) 16 (6.1) 13 (5.0) 54 (20.6) 129 (49.2) 50 (19.1) 319 (25.7) 95 (7.7) 170 (13.7) 375 (30.2) 282 (22.7) 184 (48.6) 47 (12.4) 43 (11.4) 26 (6.9) 79 (20.8) 3139 (43.8) 403 (5.6) 658 (9.2) 1171 (16.3) 1800 (25.1) 9174 (18.3) 2610 (5.2) 8315 (16.6) 18409 (36.8) 11581 (23.1) AJCC stage I II III IV Unknown < 0.0001 86 (24.0) 126 (35.1) 86 (24.0) 6 (1.7) 55 (15.3) 2 (0.8) 24 99.2) 131 (50.0) 3 (1.2) 102 (38.9) 204 (16.4) 411 (33.1) 189 (15.2) 16 (1.3) 421 (33.9) 61 (16.1) 208 (54.9) 89 (23.5) 4 (1.1) 17 (4.5) 2119 (29.6) 1840 (25.7) 614 (8.6) 55 (0.8) 2543 (35.5) 2635 (5.3) 11484 (22.9) 21743 (43.4) 794 (1.6) 13433 (26.8) Tumor differentiation Well Moderate Poor Undifferentiated Unknown 0.0001 255 (71.0) 20 (5.6) 37 (10.3) 47 (13.1) 0 (0.0) 190 (72.5) 19 (7.3) 31 (11.8) 21 (8.0) 1 (0.4) 875 (70.5) 86 (6.9) 108 (8.7) 169 (13.6) 3 (0.2) 290 (76.5) 23 (6.1) 30 (7.9) 34 (9.0) 2 (0.5) 5226 (72.9) 481 (6.7) 646 (9.0) 800 (11.2) 18 (0.3) 37677 (75.2) 3695 (7.4) 4310 (8.6) 4215 (8.4) 192 (0.4) Ethnicity Caucasian African-American Hispanic Asian Other < 0.0001 149 (41.5) 210 (58.5) 146 (55.7) 116 (44.3) 592 (47.7) 649 (52.3) 166 (43.8) 213 (56.2) 2958 (41.3) 4213 (58.8) 26062 (52.0) 24027 (48.0) Gender Male Female < 0.0001 1 (0.3) 21 (5.9) 65 (18.1) 115 (32.0) 101 (28.1) 56 (15.6) 13 (5.0) 24 (9.2) 64 (24.4) 80 (30.5) 65 (24.8) 16 (6.1) 20 (1.6) 86 (6.9) 253 (20.4) 386 (31.1) 386 (31.1) 110 (8.9) 3 (0.8) 24 (6.3) 61 (16.1) 142 (37.5) 111 (29.3) 38 (10.0) 66 (0.9) 327 (4.6) 1095 (15.3) 2197 (30.6) 2569 (35.8) 917 (12.8) 666 (1.3) 3516 (7.0) 9852 (19.7) 16198 (32.3) 14822 (29.6) 5035 (10.1) Age category 0-39 40-49 50-59 60-69 70-79 80+ < 0.0001 21 (1-62) 5.5 (1-58) 17 (1-115) 31 (3-98) 28 (1-151) 9 (1-109) Median f/u time (95%CI) < 0.0001 68 (48-85) 64 (40-80) 67 (46-82) 66 (47-83) 69 (49-83) 67 (46-83) Median age (95% CI) 359 262 1241 379 7171 50089 N p Mixed adenoCA SRC Papillary carcinoma Acinar carcinoma BAC AdenoCA

7. Smoking status according to adenoCA subtype

8. Kaplan-Meier survival curves by adenoCA subtypes

9. Cox analysis < 0.0001 < 0.0001 < 0.0001 (1.792-1.966) (2.220-2.392) (3.460-3.720) 1.000 1.877 2.305 3.588 AJCC stage* I II III IV < 0.0001 < 0.0001 < 0.0001 (1.126-1.221) (1.318-1.426) (1.226-1.437) 1.000 1.173 1.370 1.327 Tumor differentiation* Well Moderate Poor Undifferentiated 0.4782 < 0.0001 0.4714 (0.978-1.048) (0.784-0.838) (0.957-1.021) 1.000 1.013 0.810 0.988 Ethnicity Caucasian African American Asian Hispanic < 0.0001 (0.813-0.843) 1.000 0.828 Gender Male Female < 0.0001 (1.011-1.013) 1.012 Age 0.0006 0.0182 < 0.0001 0.0019 0.0029 (0.653-0.889) (0.688-0.966) (0.812-0.866) (0.848-0.963) (1.069-1.382) 1.000 0.762 0.815 0.838 0.903 1.215 Histology Adenocarcinoma Acinar carcinoma Mixed adenocarcinoma BAC Papillary carcinoma Signet-ring cell carcinoma p 95% Confidence Interval Hazard Ratio