Additive manufacturing (AM) offers a few major benefits to biomedical applications. To improve the knowledge on AM possibilities, Sirris is organizing two different masterclasses. The first will address the technology, materials used and applications, with experts in the matter explaining all relevant aspects.

1. Masterclass:
Biomedical applications of
Additive Manufacturing
Part 01: General considerations and clinical case studies

2.  Masterclass part 01:
• Entirely dedicated to current and mature industrial
applications
• Theory – basic principles, technologies, applications and
software
• Case studies and general future applications of AM
 Masterclass part 02:
• Futuristic applications: bio-printing & organ-printing
• More theoretical
• Current applications, future perspectives and case studies
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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3.  11h45: Reception & lunch
 12h40: Welcome session – introduction
• Carsten Engel, SIRRIS
 13h10: Taking into consideration the technical aspects
• Julien Magnien, SIRRIS
 13h50: Taking into consideration the medical aspects
• Bernardo Innocenti, ULB
 14H30: From medical images to design of a custom medical
device
• Herlien Declerck, Materialise
 15h15: Coffee Break (and snow fight)
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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4.  15h25: Case study 01 - Practical clinical case study using MIMICS software
from Materialise
• Bram Lenaerts, Mobelife
 16h00: Case study 02 - Clinical support requirement for Additive
Manufacturing to be successful: Lessons learned from the Walter Reed
Army Medical Center
• Stephen Rouse, AM consultant
 16h35: Case study 03 - Veterinary case studies – successful AM
manufactured bone replacements
• Vojislav Petrovic, AIMME
 17H10: New features and functions in implants through an innovative
design approach and Additive Manufacturing (Laser Beam Melting)
• Thomas Töppel, Fraunhofer IWU
 17h45: 2nd Coffee Break
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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5.  17h50: Future perspectives and business opportunities of
Additive Manufacturing. Market overview, latest trends in
technologies, applications and materials
• Thierry Dormal, SIRRIS
 18h20: Networking
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6. Masterclass:
Biomedical applications of
Additive Manufacturing
Welcome session and general introduction

7. Aerospace Automotive Construction products
Contracting & Maintenance Electrical engineering
Industrial automation Mechatronical engineering
Information and communication technologies (ICT)
Metals & materials Metal processing Mounting & cranes
Plastics & composites Security & defence
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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8. Ghent Leuven
Materials Engineering Mechatronics
Technology Coaching
Brussels
Software Engineering & ICT Hasselt
Technology Coaching Materials Engineering
Production Technology
Liège
Charleroi Additive Manufacturing
Additive Manufacturing Materials Engineering
Bio- Manufacturing Platform Nanomaterials
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9. Case study: Femoral & Total hip implants
• Today : Mass fabrication of standard femoral implants (& others)
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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10. Yes, it will work. But ….
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11. Next generation pre-operative manufactured implants:
• Custom implant manufacture :
• CT-Scan
• CAD File of the patient is produced
• Engineer + Surgeon 3D implant approved
• FEM analysis (when needed)
• Custom manufacturing (low cost)
• Surgery
• Follow up
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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12. Medical Additive Manufacturing Software:
• Materialise: Mimics
• Materialise: 3matic
• Marcam: Autofab
• Able Software Corp: 3D Doctor
• Medicim: Maxilim
• ProEngineer
• New: Lenexa: Analyze
• New: Brisbane: Anatomics
• (…)
[Mimics & 3-matic - Materialise]
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13. Trends in biocompatible materials used in Rapid Prototyping /
Manufacturing:
Metals: Polymers:
• Titanium (Ti6Al4V) • PTFE (Polytetrafluoroethylene)
• Ti-alloys • PMMA (Polymethyl methaacrylate)
• Stainless steel • PE (Polyethylene)
• Shape memory alloys (Ni-Ti) – in research
• PEEK
• Noble materials (Gold) • PEKK
• … • … others, too but not implantable
Ceramics:
• Hydroxyapatite (HAP)
• Zirconium Others:
• Tricalcium phosphate (TCP) • Hydrogels + Human cells
• Alumina
• …
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14. Leading applications:
• Pre-surgical planning: [Arcam & Objet technology]
• Custom implant manufacture
[Z. Corp Medical Modeling Solutions]
• Physician to physician communication
• Powerful patient presentation tool
• Medical student/resident education
[Sirris ADD]
• 3D Surface Scanning/Custom Prosthesis Design
[Z. Corp Medical Modeling Solutions]
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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15. Leading applications: “No matter how good our 3-D graphics are, there is
nothing like a model in your hands . . .”
• Pre-surgical planning:
• Implant pre-contouring
• Screw trajectory
• Screw selection/location
• Instrument selection
• Technique rehearsal
[Objet] [Objet]
[Objet Connex Eden 500] [Objet]
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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16. Leading applications:
• Pre-surgical planning advantages:
• Significantly reduces O.R. time
• Lowers cost
• Reduces O.R. team fatigue
• Enhances patient outcomes
• Reduces “re-do” procedures
• Minimizes size of incisions [Z. Corp Medical Modeling Solutions]
• Speeds recovery time
• Improves anatomical alignment
• Enables multiple procedure rehearsals
[Case study: The Alfred Hospital, Melbourne, Australia]
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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17. Leading applications:
• Physician to physician communication
• Powerful patient presentation tool
• Medical student/resident education
• Custom Prosthesis Design
• Complex parts manufacturing [Sirris ADD] [Sirris ADD]
[Sirris ADD] [Sirris ADD] [Sirris ADD] [Sirris ADD]
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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18. [Sirris ADD] [Sirris ADD]
0,5mm
[Sirris ADD] [Sirris ADD] [Sirris ADD]
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19. [Walter Reed Army Medical Center, Washington DC, USA ]
[Dr J. Poukens - UHasselt]
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20. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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21. [UHasselt, Layerwise, Xilloc, Sirris, CamBioceramics, Orbis Medisch Centrum, Xios, KUL]
Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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22. Ti6Al4V: E(GPa) = 110 !
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23. Case study: Femoral & Total hip implants
• Tomorrow: Custom-fit femoral implants & adapted Young’s modulus
• Patient custom-fit implants
• Better distribution of the stresses
• Reducing stress-shielding
• Reducing micro-motion between bone & sinkage
• Surface roughness for strong fixation
• Hydroxyapatite coating eased up
• Complex biodegradable scaffolds combining HAP & βTCP
+ +
[Sirris - ADD]
[Sirris - ADD]
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24. Finger implant (Dr. P. Ledoux, Prof. G. Guerlement UMONS)
[Université de Mons, Faculté Polytechnique]
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25. Masterclass: Biomedical applications of Additive Manufacturing Organized by SIRRIS the 12th of March 2013
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26. « Medical Additive Manufacturing & Rapid Prototyping »
« Sirris »
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27. Carsten ENGEL
Biomedical Engineer
Additive Manufacturing Department
Mail: carsten.engel@sirris.be
Mobile: +32 498 91 94 50
Skype: Carsten-Engel
SIRRIS
Rue Auguste Piccard, 20
B-6041 GOSSELIES BELGIUM
http://www.sirris.be
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