Presented by Dr Steven Tucker, Founder, Tucker Medical at ISS Seminar: How Analytics is Transforming Healthcare on 31 Oct 2014.

1. TRANSFORMING HEALTHCARE
THE
QUANTIFICATION OF
EVERYTHING
STEVEN TUCKER, MD, FACP, FAMS
Global Health Advisor, SingTel
Founder, Tucker Medical

2. WARNING !
We tend to overestimate
the effect of a technology
in the short run and
underestimate the effect
in the long run.
Roy Amara
Co-founder, Institute for the Future

3. 1
EXPONENTIALS

4. 1974 1984 1994 2004 2014 EXPONENTIALS
4E+09
3E+09
2E+09
1E+09
4E+03

5. 4E+09
3E+09
2E+09
1E+09
4E+03
COMPUTING
POWER
1974 1984 1994 2004 2014 2024

6. 4E+09
3E+09
2E+09
1E+09
4E+03
MOORE’S
LAW
1974 1984 1994 2004 2014 2024

7. Computers
4E+09
3E+09
2E+09
1E+09
4E+03
MOORE’S
LAW
1974 1984 1994 2004 2014 2024

8. Computers
4E+09
3E+09
Sensors
2E+09
1E+09
4E+03
MOORE’S
LAW
1974 1984 1994 2004 2014 2024

9. Computers
4E+09
3E+09
Sensors
2E+09
1E+09
4E+03
MOORE’S
LAW
Biology
1974 1984 1994 2004 2014 2024

10. Computers
4E+09
3E+09
Sensors
2E+09
1E+09
4E+03
MOORE’S
LAW
Biology
Pan-omics
1974 1984 1994 2004 2014 2024

11. 2
PROBLEMS

12. Healthcare is not
a science problem,
it’s an information
problem.
-Thomas Goetz

13. DIABETES
382 Million
Source: International Diabetes Federation

14. OBESITY
500 Million
Source: World Health Organisation

15. HEART DISEASE
17.3 Million
Source: World Health Organisation

16. CANCER
14.1 Million
Source: World Health Organisation

17. 3
SENSORS

18. If you cannot
measure it, you
cannot improve it.
-Lord Kelvin

19. SENSOR
EVOLUTION
Sensor 1.0
Sensor 2.0
Sensor 3.0
Ability to measure
+ record signal
Sensor web
integration; share
+ access data
Passive data
gathering +
aggregating +
meaningful insight

20. ACTIVITY

21. HEALTH

22. MEDICAL

23. THE TRICORDER

24. VITAL SIGNS

25. EMERGENCY

41. BIRTH CONTROL

42. WIRELESS
BIRTH CONTROL

43. 4
BIOLOGY

46. THERANOS

47. RETAIL LABS

48. HOME TRACKING

49. HOME DIAGNOSIS

50. HOME DIAGNOSIS

51. LAB ON A CHIP

52. CELL CAPTURE

53. LIQUID BIOPSY

55. GENOME MATH
23Pairs of
chromosomes

56. GENOME MATH
20k Genes

57. GENOME MATH
4Bases
A - T
G - C

58. GENOME MATH
3.2
Base pairs
per genome
billion

59. GENOME MATH
3.2billion 40xCoverage BP 128billion
data points

60. SEQUENCING $

61. GENOMICS 2001

62. GENOMICS 2007

63. GENOMICS 2013

64. GENOMICS 2014

65. GENOMICS 2014

66. GENOMICS 2016

67. GENOMICS 2018

69. NEXT GEN
SEQUENCING

70. NEXT
NEXT GEN
SEQUENCING ?

73. 5
PLATFORMS

75. $2.4
Billion

76. $26
Billion

77. SENSORS

78. SENSORS
Gyroscope Proximity

79. SENSORS
Gyroscope
Proximity
Gesture
Fingerprint

80. SENSORS
Gyroscope
Proximity
Gesture
Compass
Fingerprint
Hall cover

81. SENSORS
Gyroscope
Gesture
Heart rate
Proximity
Compass
Barometer
Fingerprint
Hall cover

82. SENSORS
Gyroscope
Gesture
Ambient light
Heart rate
Accelerometer
Proximity
Compass
Barometer
Fingerprint
Hall cover

86. 6
PAN-OMICS

91. Exposome
33
48
Cd
80
Hg
28
Ni
81
82
Ti
Pb
As

92. EPphigeennoommee

93. !
TRANSFORM

94. Digital Health as
Google Map
HEALTH AS A
GOOGLE MAP
SENSOR
ACTIVITY
DIET
GENOME
MICROBIOME
LAB
PHENOME
UNIQUE
PERSON

95. Digital Health as
Google Map
HEALTH AS A
GOOGLE MAP
SENSOR
ACTIVITY
DIET
GENOME
MICROBIOME
LAB
PHENOME
UNIQUE
PERSON

96. 6P4
MEDICINE

97. P4 MEDICINE
1. Predictive
2. Preventive
3. Personalized
4. Participatory

98. 100k WELLNESS
PROJECT
1. Predictive
2. Preventive
3. Personalized
4. Participatory

99. P4 MEDICINE
Predictive
You will track your health.
It’s your data.
Identify transition states.

100. P4 MEDICINE
Preventive
Wellness networks.
Illness networks.
A systems-based approach
to repair and maintenance.

101. P4 MEDICINE
Personalized
You are your own control.
Your health data cloud.
Molecular + Environmental.

102. P4 MEDICINE
Participatory
Transformative for health.
Societal change - enormous.
Patients will adapt.
Doctors may adapt?

103. THE PIVOT
Health Status 20% of patients =
80% of costs
Healthy
Low Risk At Risk High
Risk
Chronic
Disease
Early
Active
Disease
End of Life
Care
Chronic
Disease
Progression
VALUE COST

104. 6
LONGEVITY

106. Life Expectancy at birth
85
82
79
76
73
70
1990 2000 2008 1990 2000 2008 1990 2000 2008 1990 2000 2008
< 12 12 13-­‐15 > 16
Years of Educa>on

107. TECHNOLOGY

108. BIOLOGY

110. CALICO

111. 7
AND…

120. THANK YOU
For your 9me & a>en9on