5. Innate Immune System
• Present from birth
• “Non-specific” - acts on many pathogens
and does not show specificity within a
pathogen type
• Does not become more efficient on
subsequent exposure to same pathogen
6. Laura Canesi, Gabriella Gallo, Miriam Gavioli, and Carla Pruzzo
Bacteria–hemocyte Interactions and Phagocytosis in Marine
Bivalves. 2002. Microscopy Research And Technique 57:469–476
32. Mining ESTs
from similar species
Gene Molecular Function Biological Process Cellular Component
rab1 GTPase activity vesicle-mediated golgi apparatus
transport
rab7 (WSSV receptor) GTPase activity, protein intracellular protein golgi apparatus,
binding transport lysosome
catalase catalase activity, response to oxidative peroxisome, plasma
antioxidant activity stress membrane
toll-interacting protein protein binding, signal inflammatory response cytoplasm
transducer activity
beta-glucan bacterial binding regulation of innate extracellular region
recognition protein immune response
manganese superoxide MnSD activity, response to oxidative mitochondrial matrix
dismutase antioxidant activity stress
plancitoxin deoxyribonuclease II DNA catabolic process, lysosome
activity DNA binding
Lindsay Braun and Cullen Taplin
38. Serine Protease Inhibitor
• Critical factor in disease pathogenesis
• Serine proteases produced by pathogen
• Facilitate penetration
• Stimulate degradation of host proteins involved
in immune defense
39. Expression
0.009
0.008
0.007
0.006
0.005
0.004
0.003
0.002
0.001
0
MA + MA - FL + FL - NJ + NJ -
Strain
Clams from different location of origin (MA, FL, NJ) all
grown in common field sites in MA. Plus (+) and minus
(-) symbols indicate two locations within a harbor.
