The document describes SucceedTM, a nutritional supplement containing N-oleoyl-phosphatidyl-ethanolamine (NOPE) and epigallocatechin gallate (EGCG) from green tea extract. Animal and human studies found that SucceedTM enhanced weight loss and appetite control. It improved metabolic parameters and helped subjects adhere to low-calorie diets better than a placebo. The proprietary formulation is said to increase the bioavailability and effectiveness of NOPE and EGCG for weight management.
9. N-Acyl-Phosphatidyl-Ethanolamine (NAPE) Intestinal Levels Pmol / mmol P G. Peterson et al. Biochimica Biophysica Acta (2006) 1761:143 Measurements of individual N-Acyl species of NAPE in liquid extracts of tissue samples were carried out by GC-MS in the presence of deutero internal standards, after determination of lipid phosphorus (P) in each sample. Values are means ± SEM ( n =6). *P<0.05 when applying one way ANOVA followed by Tukey’s Post Hoc test. **P<0.01 when applying one way ANOVA followed by Tukey’s Post Hoc test. 1.4 + 0.09 1.3 + 0.09 1.5 + 0.21* 1.1 + 0.07 C20:4 NArPE 39 + 2.4 56 + 5.2 14 + 1.1** 43 + 6.7 C18:2 4.5 + 0.40 4.3 + 0.28 4.1 + 0.36 3.7 + 0.12 C18:1 n-7 8.2 + 0.45 11 + 11 3.4 + 0.19** 8.6 + 1.4 C18:1 n-9 NOPE 7.8 + 0.36 8.1 + 0.23 7.9 + 0.60 8.0 + 0.3 C18:0 20 + 0.97 20 + 0.70 15 + 1.1* 19 + 0.7 C16:0 Starved 24h and re-fed 4h Starved 24h and re-fed 1h Starved 24h Free- feeding ACYL GROUP N-Acyl composition of NAPE in rat intestine after starvation and re-feeding:
10.
11.
12.
13. Succeed™ Mechanism Of Action EGCG NOE EFFECTS Enhanced release of endothelium NO. Reduction of LDL oxidation. Improved vessel integrity. Improved insulin sensitivity. GPR119 activation. Improved glucose handling. Liver UCP2-UCP3 activation. Adipocyte PPAR receptor activation. Increased lipidic catabolism. Boosts thermogenesis. Intestinal PPAR receptor activation. Increased sense of satiety. Mechanism Mechanism
14.
15.
16.
17. Results OP diet + Succeed TM Reduction of weight gain and total body fat. OP-diet+Succeed™ OP-diet S-diet 21.6 + 0.8 25.3 + 0.7 18.1 + 0.6 % Body fat 17.3 + 0.5 17.1 + 0.4 19.2 + 0.4 % Body proteins 57.1 + 0.6 53.4 + 0.5 58.6 + 0.6 % H 2 O 344.3 + 8.4 367.0 + 8.3 311.6 + 7.6 Final weight at 14 weeks 236.8 + 7.6 258.9 + 7.5 217.6 + 6.8 Weight at 10 weeks 106.06 + 0.9 106.65 + 1.1 106.1 + 1.0 Starting weight at 6 weeks GROUP 3 GROUP 2 GROUP 1
18. Results OP diet + Succeed TM Improvement of glucose, triglycerides and cholesterol plasma levels. OP-diet+Succeed™ OP-diet S-diet 1.04 + ±0.06 1.06 + 0.08 1.01 + 0.07 Cholesterol HDL 1.77 + 0.13 2.17 + 0.16 1.64 + 0.14 Total cholesterol 1.24 + ±0.12 1.78 + ±0.21 b 1.06 + 0.11 Triglycerides 9.65 + 0.59 10.59 + 0.55 9.89 + 0.48 Glucose GROUP 3 GROUP 2 GROUP 1
20. Succeed™ Human Clinical Study “ Administration of a dietary supplement (N-oleoyl-phosphatidyl-ethanolamine and epigallocatechin-3-gallate formula) enhanced compliance with diet in healthy overweight subjects: a randomized controlled trial” M. Rondanelli et al. British Journal of Nutrition 2009; 101 :457-464
21. Study Design 138 Subjects (F=106 / M=32) GROUP 1 NOPE-EGCG complex N 71 (F=53 / M=18) GROUP 1 PLACEBO N 67 (F=53 / M=14) COMPLETED N 67 (F=50 / M=17) DROPPED OUT N 4 (F=3 / M=1) COMPLETED N 49 (F=39 / M=10) DROPPED OUT N 18 (F=14 / M=4)
![Succeed™ ,[object Object],[object Object],N-oleoyl-phosphatidyl-ethanolamine epigallocatechin gallate from standardized green tea extract. and EGCG NOPE](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)