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Introduction to Obstetric
Anesthesia
Dr A Alberts
Department of
Anesthesiology and
Critical Care
2007
INTRODUCTION
During obstetric anesthesia the
anesthetist controls the following
Maternal
– Gas exchange, perfusion of vital organs and metabolism
– Pain perception and reflexes
– Skeletal muscle tone
– Consciousness or unconsciousness
Fetal
– Gas exchange, perfusion of vital organs, metabolism
Uterine
– Myometrial tone
AND IS RESPONSIBLE FOR …..
the maintenance of
Maternal
– Physiology
– Safety
– Comfort
Fetal
– Physiology
Surgical
– Surgical conditions
This is the aim of the obstetric anesthetist
ASA '96 162
Risks involved
Physician Insurers Association of America
(PIAA)
– Malpractice claims against anesthetists
– Most frequent conditions for which claims were made
–Pregnancy and birth
American Society of Anesthetists
(ASA)
– Obstetric vs. non-O malpractice claims
– C/S risk double that of any other procedure
Risks involved
Medical Insurance Cover
Obstetricians in Private Practice
R76 130 (2006)
(MPS)
ASA 2005, 402
“ It will be necessary to ascertain
anesthesia’s precise effect, both upon the
action of the uterus and on the assistant
abdominal muscles; its influence, if any,
upon the child; whether it has a tendency
to hemorrhage or other complications.”
Scottish obstetrician James Simpson after administering
ether to a woman to treat the pain of childbirth
1847
“If we could induce local anesthesia without
the absence of consciousness, which occurs
in general anesthesia, many would see it as
a still greater improvement.”
Sir James Young after the first maternal
death due to anesthesia in England
1848
WHAT’S DIFFERENT?
Why the increased risk?
TWO IN ONE
INTRA-OPERATIVE AWARENESS
PHYSIOLOGY / PHARMACOLOGY !
ECG CHANGES
ASSOCIATED PATHOLOGY
PRE-ECLAMPSIA – ECLAMPSIA
HELLP – SYNDROME
ANTEPARTUM HEMORRHAGE
RHEUMATIC HEART DISEASE
Q VADIS
What does the anesthetist need, firstly himself to survive,
and secondly have mother and child survive too
– NORMAL VS ALTERED PHYSIOLOGY
– NORMAL VS ALTERED PHARMACOLOGY
– VASCULAR ACCESS
– AIRWAY MANAGEMENT
– REGIONAL ANESTHESIA
– RESUSCITATION
• KNOWLEDGEKNOWLEDGE
•• SKILLSSKILLS
i.e. A COMPETENT CLINICIAN!
Altered Physiology
1. Hematological
2. Cardiovascular
3. Respiratory
4. Gastro-intestinal
5. Etc
1 Hematological
Obstetric blood loss
Normal PV delivery
– 600ml
Normal PV delivery of twins
– 1000ml
Caesarian section
– 1000ml
Substantial blood loss is to be
expected in the obstetric patient!
1 Hematological
↑ mineralocorticoid activity
– Na+ retention, ↑ body H2O content
↑ PV 50% and ↑ TBV 40%
– Hb ↓ 10-11 gm%
– S-ChE activity ↓ 20%
– S-Protein ↓ < 6 gm/dl
↑ Free fraction of protein-bound drugs
2 Cardiovascular
↓ SVR
– Estrogens, progesterones
– Initiated by prostacyclin
↑ HR 25%
↑ CO 50%
Aorta-caval compression, result ⇒
supine hypotensive syndrome
Lateral angiogram from two supine subjects
Non-pregnant Pregnant
SHS
Paleness
Hypotension
Sweating
Tachycardia
Reflex bradycardia
Nausea
Max effect
36-38 weeks
SHS
Paleness
Hypotension
Sweating
Tachycardia
Reflex bradycardia
Nausea
Max effect
36-38 weeks
SHS
- management -
POSITION
IV VOLUME
VASOPRESSORS
→ LATERAL
→ >1000 ML RL
→ EPHEDRINE
ALVEOLAR VENTILATION
⇑ 70% (term)
Tidal volume ↑ 40%
Respiratory rate ↑ 15%
STATIC LUNGVOLUMES
UPPER AIRWAY
3 Respiratory
Static lung volumesThe rate at which term
patients change from
pink to blue is
breathtakingly fast
4 Gastro-intestinal
Large uterus
– ↑ IAP
– ↑ IGP
↑ Gastrin secretion
– ↑ volume of gastric secretions
– ↓ pH of gastric secretions
↓ Gastric emptying
– ↓ secretion of motilin
– pain, anxiety and opioids
– ↑ secretion of progesterone (↓ smooth muscle tone)
LES
– ↓ tone
– altered angle
Recipe for disaster i.e.
ASPIRATION
Risk aspiration
Predicted mortality rates (%) after aspiration. Each shaded area
represents the mortality rate interval predicted for a specific
pH and volume of solution aspirated.
Prevention of aspiration
AVOID GENERAL
ANESTHESIA
NPO
PRO-KINETICS
ANTI-ACIDS
SELLICK MANEUVRE
→ SPINAL / EPIDURAL
→ FLUID
→ METOCLOPRAMIDE
→ NON PARTICULATE
Na CITRATE, PNEUCID
→ CRICOID PRESSURE
Prevention of aspiration
- Sellick maneuver or cricoid pressure -
All(!) patients from 12 weeks gestation.
Altered pharmacology
↓ MAC for inhalational agents
– From 8-12 weeks gestation
– Due to ↑ progesterone levels
↓ dose of LA
– Epidural venous engorgement
– ↑ sensitivity of nerves, ? progesterone
Regression lines for dose of epidural solution and age in
nonpregnant women at term. The gravida obviously requires
much less drug.
ASA 2005 402
WHAT’S ON OFFER?
a. STANDBY (“no interference”)
b. O2, N2O, OPIATES
c. GENERAL ANESTHETICS
– USA; babies of 23% of pregnant women delivered by C/S (2005)
d. REGIONAL ANESTHETICS
– EPIDURAL (CAUDAL)
– SPINAL
– COMBINED SPINAL-EPIDURAL
– CONTINUOUS SPINAL
– PATIENT CONTROLLED EPIDURAL ANALGESIA
c. General anesthetics
↓↓ incidence / popularity
Risks involved
– Failure to intubate
– Aspiration
Experience of childbirth
– Bonding
– Presence of father
Probably a difficult intubation!
Motto of many an
obstetric unit
“Where possible, avoid general
anesthesia”
d. REGIONAL ANESTHESIA
Potential advantages (c-section)
INABILITY TO INTUBATE
EARLY BONDING
POSTOP PAIN / MOBILIZATION
“ positive experience in childbirth “
Regional anesthesia
I. Which drugs to use?
II. Which nerves to block?
I. Amide Na+-channel blockers
Lignocaine
Bupivacaine Macaine
Ropivacaine Naropin
L-Bupivacaine Chirocaine
- with/without opiates/epinephrine -
II. Anatomy
Early labor
– T11 - T12
Progressing cervical dilatation
– T10 - L1
Second stage
– S2 – 4
– distention of vaginal vault and perineum
International Headache Society ASA '05 103
PDPH
Bilateral; frontal, occipital or both
– May involve neck and upper shoulders
Develops < 7days following LP
– Generally < 48hours
– > 3days in 25% of cases
Disappears < 14days following LP
Worsens < 15min assuming upright position
Improves < 30min assuming recumbent position
PDPH
Proposed mechanisms
Traction on pain sensitive intracranial structures
– 150ml CSF: 75ml spinally / 75ml supra –
– Volunteers: removal of 10% of CSF = headache
Cerebral venous dilatation
– “compensatory” intracranial hyperaemia
– More evidence than first mechanism
PDPH
Greatest influence on the incidence
1. Technique
a. Direction of bevel (Quincke type needle)
Parallel with longitudinal fibers of dura
2. Choice of needle
a. Size (smaller is safer)
Not larger than 26G
b. Design
Pencil-point tip, i.e. not to cut fibers
PDPH - management
Conservative measures
– Bed rest
– Analgesics
– Hydration (caffeine)
Epidural saline
Epidural blood patch (EBP)
SUMMARY
Role of anesthetist during C/S
Attending primarily to the mother,
and by doing so, assuring the best
possible outcome for the baby
- in a cramped space shared by at least seven demanding people -
SUMMARY
REALISE AND RECOGNISE ALTERED
– PHYSIOLOGY
– ANATOMY
– PHARMACOLOGY
COMMUNICATE WITH OBSTETRICIAN
CAN BE REWARDING!
THANK YOU!

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Obstetricanesthesia(1)

  • 1. Introduction to Obstetric Anesthesia Dr A Alberts Department of Anesthesiology and Critical Care 2007
  • 2. INTRODUCTION During obstetric anesthesia the anesthetist controls the following Maternal – Gas exchange, perfusion of vital organs and metabolism – Pain perception and reflexes – Skeletal muscle tone – Consciousness or unconsciousness Fetal – Gas exchange, perfusion of vital organs, metabolism Uterine – Myometrial tone AND IS RESPONSIBLE FOR …..
  • 3. the maintenance of Maternal – Physiology – Safety – Comfort Fetal – Physiology Surgical – Surgical conditions This is the aim of the obstetric anesthetist
  • 4. ASA '96 162 Risks involved Physician Insurers Association of America (PIAA) – Malpractice claims against anesthetists – Most frequent conditions for which claims were made –Pregnancy and birth American Society of Anesthetists (ASA) – Obstetric vs. non-O malpractice claims – C/S risk double that of any other procedure
  • 5. Risks involved Medical Insurance Cover Obstetricians in Private Practice R76 130 (2006) (MPS)
  • 6. ASA 2005, 402 “ It will be necessary to ascertain anesthesia’s precise effect, both upon the action of the uterus and on the assistant abdominal muscles; its influence, if any, upon the child; whether it has a tendency to hemorrhage or other complications.” Scottish obstetrician James Simpson after administering ether to a woman to treat the pain of childbirth 1847
  • 7. “If we could induce local anesthesia without the absence of consciousness, which occurs in general anesthesia, many would see it as a still greater improvement.” Sir James Young after the first maternal death due to anesthesia in England 1848
  • 8. WHAT’S DIFFERENT? Why the increased risk? TWO IN ONE INTRA-OPERATIVE AWARENESS PHYSIOLOGY / PHARMACOLOGY ! ECG CHANGES ASSOCIATED PATHOLOGY PRE-ECLAMPSIA – ECLAMPSIA HELLP – SYNDROME ANTEPARTUM HEMORRHAGE RHEUMATIC HEART DISEASE
  • 9. Q VADIS What does the anesthetist need, firstly himself to survive, and secondly have mother and child survive too – NORMAL VS ALTERED PHYSIOLOGY – NORMAL VS ALTERED PHARMACOLOGY – VASCULAR ACCESS – AIRWAY MANAGEMENT – REGIONAL ANESTHESIA – RESUSCITATION • KNOWLEDGEKNOWLEDGE •• SKILLSSKILLS i.e. A COMPETENT CLINICIAN!
  • 10. Altered Physiology 1. Hematological 2. Cardiovascular 3. Respiratory 4. Gastro-intestinal 5. Etc
  • 11. 1 Hematological Obstetric blood loss Normal PV delivery – 600ml Normal PV delivery of twins – 1000ml Caesarian section – 1000ml Substantial blood loss is to be expected in the obstetric patient!
  • 12. 1 Hematological ↑ mineralocorticoid activity – Na+ retention, ↑ body H2O content ↑ PV 50% and ↑ TBV 40% – Hb ↓ 10-11 gm% – S-ChE activity ↓ 20% – S-Protein ↓ < 6 gm/dl ↑ Free fraction of protein-bound drugs
  • 13. 2 Cardiovascular ↓ SVR – Estrogens, progesterones – Initiated by prostacyclin ↑ HR 25% ↑ CO 50% Aorta-caval compression, result ⇒ supine hypotensive syndrome
  • 14. Lateral angiogram from two supine subjects Non-pregnant Pregnant
  • 17. SHS - management - POSITION IV VOLUME VASOPRESSORS → LATERAL → >1000 ML RL → EPHEDRINE
  • 18. ALVEOLAR VENTILATION ⇑ 70% (term) Tidal volume ↑ 40% Respiratory rate ↑ 15% STATIC LUNGVOLUMES UPPER AIRWAY 3 Respiratory
  • 19. Static lung volumesThe rate at which term patients change from pink to blue is breathtakingly fast
  • 20. 4 Gastro-intestinal Large uterus – ↑ IAP – ↑ IGP ↑ Gastrin secretion – ↑ volume of gastric secretions – ↓ pH of gastric secretions ↓ Gastric emptying – ↓ secretion of motilin – pain, anxiety and opioids – ↑ secretion of progesterone (↓ smooth muscle tone) LES – ↓ tone – altered angle Recipe for disaster i.e. ASPIRATION
  • 22. Predicted mortality rates (%) after aspiration. Each shaded area represents the mortality rate interval predicted for a specific pH and volume of solution aspirated.
  • 23. Prevention of aspiration AVOID GENERAL ANESTHESIA NPO PRO-KINETICS ANTI-ACIDS SELLICK MANEUVRE → SPINAL / EPIDURAL → FLUID → METOCLOPRAMIDE → NON PARTICULATE Na CITRATE, PNEUCID → CRICOID PRESSURE
  • 24. Prevention of aspiration - Sellick maneuver or cricoid pressure - All(!) patients from 12 weeks gestation.
  • 25. Altered pharmacology ↓ MAC for inhalational agents – From 8-12 weeks gestation – Due to ↑ progesterone levels ↓ dose of LA – Epidural venous engorgement – ↑ sensitivity of nerves, ? progesterone
  • 26. Regression lines for dose of epidural solution and age in nonpregnant women at term. The gravida obviously requires much less drug.
  • 27. ASA 2005 402 WHAT’S ON OFFER? a. STANDBY (“no interference”) b. O2, N2O, OPIATES c. GENERAL ANESTHETICS – USA; babies of 23% of pregnant women delivered by C/S (2005) d. REGIONAL ANESTHETICS – EPIDURAL (CAUDAL) – SPINAL – COMBINED SPINAL-EPIDURAL – CONTINUOUS SPINAL – PATIENT CONTROLLED EPIDURAL ANALGESIA
  • 28. c. General anesthetics ↓↓ incidence / popularity Risks involved – Failure to intubate – Aspiration Experience of childbirth – Bonding – Presence of father
  • 29. Probably a difficult intubation!
  • 30. Motto of many an obstetric unit “Where possible, avoid general anesthesia”
  • 31. d. REGIONAL ANESTHESIA Potential advantages (c-section) INABILITY TO INTUBATE EARLY BONDING POSTOP PAIN / MOBILIZATION “ positive experience in childbirth “
  • 32. Regional anesthesia I. Which drugs to use? II. Which nerves to block?
  • 33. I. Amide Na+-channel blockers Lignocaine Bupivacaine Macaine Ropivacaine Naropin L-Bupivacaine Chirocaine - with/without opiates/epinephrine -
  • 34. II. Anatomy Early labor – T11 - T12 Progressing cervical dilatation – T10 - L1 Second stage – S2 – 4 – distention of vaginal vault and perineum
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  • 40. International Headache Society ASA '05 103 PDPH Bilateral; frontal, occipital or both – May involve neck and upper shoulders Develops < 7days following LP – Generally < 48hours – > 3days in 25% of cases Disappears < 14days following LP Worsens < 15min assuming upright position Improves < 30min assuming recumbent position
  • 41. PDPH Proposed mechanisms Traction on pain sensitive intracranial structures – 150ml CSF: 75ml spinally / 75ml supra – – Volunteers: removal of 10% of CSF = headache Cerebral venous dilatation – “compensatory” intracranial hyperaemia – More evidence than first mechanism
  • 42. PDPH Greatest influence on the incidence 1. Technique a. Direction of bevel (Quincke type needle) Parallel with longitudinal fibers of dura 2. Choice of needle a. Size (smaller is safer) Not larger than 26G b. Design Pencil-point tip, i.e. not to cut fibers
  • 43. PDPH - management Conservative measures – Bed rest – Analgesics – Hydration (caffeine) Epidural saline Epidural blood patch (EBP)
  • 44. SUMMARY Role of anesthetist during C/S Attending primarily to the mother, and by doing so, assuring the best possible outcome for the baby - in a cramped space shared by at least seven demanding people -
  • 45. SUMMARY REALISE AND RECOGNISE ALTERED – PHYSIOLOGY – ANATOMY – PHARMACOLOGY COMMUNICATE WITH OBSTETRICIAN CAN BE REWARDING!