2. Pick an organ, any organ . . .
Autoimmunity can affect ANY organ/organ system
in the human body
Autoimmune Uveitis Multiple Sclerosis
Psoriasis
Sjogren’s Syndrome
Pemphigus
Systemic Lupus Erythematosus
Rheumatic Fever
Diabetes
Autoimmune Hepatitis
Addison’s Disease
Autoimmune Oophoritis Ulcerative Colitis
Rheumatoid Arthritis
Autoimmune hemolytic Anemia
5. Historical Perspective
The Virgin with Canon van
The Painter’s Family
Der Paele, 1436
Jacob Jordaens (1593-1678)
Jan van Eyck (1385-1440)
Evidence of:
Evidence of:
Rheumatoid Arthritis
Temporal (Giant Cell)
Arteritis
8. Multiple Cell Types and Cytokine Signaling Pathways Involved
in Chronic Inflammatory Arthritis
Modified from Choy, E. H.S. et al. N Engl J Med 2001;344:907-916
Key cytokines in Chronic
Naï ve T cell
Inflammatory Arthritis:
TNF-α
IL-1
IFN-γ
IL-6
OPGL (RANK-ligand)
IL-17
15. Selamat menikmati workshop
Update on autoimmune diseases
Advances on the treatment for RA
Autoimmune diseases in opthalmology
The role of cyclosporine in psoriasis
Clinical experience in Cyclosporine + Mtx in the Th/ of RA
The role of cyclosporine in uveitis treatment
Notas del editor
Autoimmune diseases (AIDs) may be classified as organ-specific or systemic (non-organ-specific). There is a spectrum of AIDs including some that exhibit intermediate features.