The document discusses recent advances in understanding DNA regulation and replication. A key finding was the discovery of an enzyme thought to reside only in mitochondria, but is also found in the nucleus and may be involved in epigenetic regulation of DNA. Additionally, researchers created the first model of the eukaryotic DNA replication fork using yeast enzymes. This model allows study of the replication process and its regulation in fine detail. These discoveries provide insights into normal biological functions and disease states, aiding medical research and potential new treatments.

1.
Jessica Tatiana Reyes
Medicine Student
3rd Semester

4. The discovery of new mechanisms of
cellular function and it’s process is a
great aid to all researchers specially
community health as an great progress
in etiology understanding and
development of treatments of
different organic entities
The discovery of new mechanisms of
cellular function and it’s process is a
great aid to all researchers specially
community health as an great progress
in etiology understanding and
development of treatments of
different organic entities
The development of new tools in
medical genetics study are of great
importance for the understanding and
learning the different processes
involved, thus facilitating its study
and accessibility

5. SWEET GENES: new way found by which
metabolism is linked to the regulation of DNA
(July 3, 2014)
The DNA has a special
configuration, which allows not
only the maintenance and
stability but also conducive to
the different processes to be
performed for proper operation.
The DNA has a special
configuration, which allows not
only the maintenance and
stability but also conducive to
the different processes to be
performed for proper operation.

6. Among the fate of the DNA to its
operation is the relaxation of
chromatin which consists of genetic
material and proteins mainly histones,
this relaxation promotes replication
and development of the central
dogma of molecular biology
Among the fate of the DNA to its
operation is the relaxation of
chromatin which consists of genetic
material and proteins mainly histones,
this relaxation promotes replication
and development of the central
dogma of molecular biology
SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA

7. This process is made by a molecule
known acetyl-CoA. This relaxes the
DNA, allowing for DNA replication and
gene expression. This mechanism is
called "epigenetic regulation of DNA" is
very important for normal functions
This process is made by a molecule
known acetyl-CoA. This relaxes the
DNA, allowing for DNA replication and
gene expression. This mechanism is
called "epigenetic regulation of DNA" is
very important for normal functions
The way which the nucleus generates
acetyl-CoA for histone acetylation and
DNA relaxation had remained elusive,
until these days
The way which the nucleus generates
acetyl-CoA for histone acetylation and
DNA relaxation had remained elusive,
until these days
SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA

8. SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA
A research team discovered of an
enzyme which thought to reside
only with in mitochondria for energy
production by acetil CoA, called
Pyruvate Dehydrogenase Complex
(PDC), actually also has been find it
into the nucleus and maybe have
responsibility in epigenetic
regulation
A research team discovered of an
enzyme which thought to reside
only with in mitochondria for energy
production by acetil CoA, called
Pyruvate Dehydrogenase Complex
(PDC), actually also has been find it
into the nucleus and maybe have
responsibility in epigenetic
regulation

9. This work bring to us different implications for many
physiological and pathological conditions with this enzyme
discovered into the nucleus is comprehended the way what
is produced and can participate in the regulation of DNA
specifically epigenetic
STUDENT OBSERVATION
SWEET GENES: new way found by which
metabolism is linked to the regulation of
DNA

10. DNA 'replication fork' reconstituted for the
first time
(July 9, 2014)
The genetic material undergoes
different processes of great
importance to properly perform
its functions, including DNA
replication, the first step of the
central molecular biology dogma
The genetic material undergoes
different processes of great
importance to properly perform
its functions, including DNA
replication, the first step of the
central molecular biology dogma

11. DNA 'replication fork' reconstituted for the
first time
Replication fork is the region of
active DNA synthesis, is the
place where the parental
strands are separated and are
synthesized two new daughter
strands
Replication fork is the region of
active DNA synthesis, is the
place where the parental
strands are separated and are
synthesized two new daughter
strands

12. DNA 'replication fork' reconstituted for the
first time
To create his replication fork model,
researchers used enzymes from yeast.
Like human cells, yeast cells are
eukaryotic, meaning a membrane
encloses their nucleus
To create his replication fork model,
researchers used enzymes from yeast.
Like human cells, yeast cells are
eukaryotic, meaning a membrane
encloses their nucleus
Researchers at Rockefeller
University have built the first model
system about "replication fork" to
decipher what goes on here and
understanding the complete process
Researchers at Rockefeller
University have built the first model
system about "replication fork" to
decipher what goes on here and
understanding the complete process

13. They were able to purify and
reconstitute the central
components that propel the
eukaryotic replication fork
They were able to purify and
reconstitute the central
components that propel the
eukaryotic replication fork
That's why they said "for the first time
enables us to study the process and its
regulation by the cell in fine detail" and
it was presented as a research tool,
which could allow scientists to better
understand what occurs in DNA
replication and some disease states
That's why they said "for the first time
enables us to study the process and its
regulation by the cell in fine detail" and
it was presented as a research tool,
which could allow scientists to better
understand what occurs in DNA
replication and some disease states
DNA 'replication fork' reconstituted for the
first time

14. This model as a study tool allow researches and medical
people better understand the process of DNA replicaton and
what goes wrong in disease states
DNA 'replication fork' reconstituted for the
first time
STUDENT OBSERVATION

15.  Understand the different biological processes,
compounds and pathways involved followed by
the genetic material are of great impotence to
understand both normal and abnormal
procedures that are held for proper operation or
pathological states

16.  The discovery of the
enzyme PDC within the
nucleus and its possible
relationship to
epigenetic regulation is
a huge advance
understanding different
etiological processes or
to think of possible
medical interventions

17.  Creating a model that outlines the replication fork
eukaryotic cell with its components and processes
serves as a research tool to study in more detail
the mechanisms involved, normal versus abnormal
operating states and develop a possible medical
treatment

18.  The era of molecular biology and genetics with
broader developments, discoveries and study tools
have facilitated and improved medical work to
contribute their knowledge in the diagnostic aids
and treatments developed

19.  University of Alberta Faculty of Medicine & Dentistry. "Sweet
genes: New way found by which metabolism is linked to the
regulation of DNA." ScienceDaily.
www.sciencedaily.com/releases/2014/07/140703151821.htm
(accessed July 26, 2014).
 Rockefeller University. "DNA 'replication fork' reconstituted for
the first time." ScienceDaily.
www.sciencedaily.com/releases/2014/07/140709100106.htm
(accessed July 25, 2014)
 MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed.
Medellín: UPB. Fac. de Medicina, 2012.

20. TATACOA DESERT
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