Generic Diflucan (Forcan Tablets), a synthetic triazole antifungal agent is indicated for the treatment of Vaginal candidiasis, Oropharyngeal and esophageal candidiasis, Cryptococcal meningitis. Generic Diflucan is also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, disseminated candidiasis, and pneumonia.

1. Generic Diflucan Tablets
Generic Diflucan (Forcan Tablets), a synthetic
triazole antifungal agent is indicated for the
treatment of Vaginal candidiasis, Oropharyngeal
and esophageal candidiasis, Cryptococcal
meningitis. Generic Diflucan is also effective for the
treatment of Candida urinary tract infections,
peritonitis, and systemic Candida infections
including candidemia, disseminated candidiasis,
and pneumonia.
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2. Generic Diflucan Tablets
Chemical Structure
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3. Generic Diflucan Tablets
Indications
Generic Generic Diflucan (Forcan Tablets), is
used for the treatment of:
1. Genital candidiasis
Vaginal candidiasis (vaginal yeast infections due
to Candida)
Candida balanitis
2. Mucosal candidiasis:
Oropharyngeal and esophageal candidiasis
Brochopulmonary infections
Candiduria
Mucocutaneous candidiasis
chronic oral atrophic candidiasis (denture sore
mouth)
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4. Generic Diflucan Tablets
Indications
3. Tinea pedis, tinea corporis, tinea cruris, tinea
versicolor and dermal Candida infections. Forcan is
not indicated for nail infections and tinea capitis.
4. Systemic candidiasis
Candidaemia
Disseminated candidiasis
Peritonitis
Candidal infections of Endocardium, pulmonary and
urinary tracts
Candidal infections in patients with malignancy, in
intensive care units or those receiving cytotoxic or
immunosuppressive therapy may be treated
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5. Generic Diflucan Tablets
Indications
5. Cryptococcosis:
Cryptococcal meningi:s and infections of other sites
(e.g. pulmonary, cutaneous). Normal hosts and
patients with AIDS, organ transplants or other causes
of immunosuppression may be treated. Generic
Diflucan can be used as maintenance therapy to
prevent relapse of cryptococcal disease in patients
with AIDS.
6. Prophylaxis:
Generic Diflucan is also used to decrease the
incidence of candidiasis in patients undergoing bone
marrow transplantation who receive cytotoxic
chemotherapy and/or radiation therapy.
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6. Generic Diflucan Tablets
Active Ingredient
The active pharmaceutical
ingredient contained in
Generic Diflucan Tablets is
Fluconazole.
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7. Generic Diflucan Tablets
Recommended Adult Dosage
The recommended dosage for the treatment of
various indications is given below:
➔Single Dose:
➔Vaginal candidiasis: The recommended dosage
of Generic Diflucan for vaginal candidiasis is 150
mg as a single oral dose.
➔Multiple Dose: In general, a loading dose of twice
the daily dose is recommended on the first day of
therapy to result in plasma concentrations close to
steady-state by the second day of therapy.
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8. Generic Diflucan Tablets
Recommended Adult Dosage
➔Oropharyngeal candidiasis: The recommended
dosage of Generic Diflucan for oropharyngeal
candidiasis is 200 mg on the first day, followed by
100 mg once daily.
➔Esophageal candidiasis: The recommended
dosage of Generic Diflucan for esophageal
candidiasis is 200 mg on the first day, followed by
100 mg once daily. Doses up to 400 mg/day may
be used, depending on the patient's response to
therapy.
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9. Generic Diflucan Tablets
Recommended Adult Dosage
➔Systemic Candida Iinfections: In the case of
systemic Candida infections including
candidemia, disseminated candidiasis, and
pneumonia, optimal therapeutic dosage and
duration of therapy have not been established
and dosages of upto 400 mg daily have been
used.
➔Cryptococcal Meningitis: The recommended
dosage for treatment of acute cryptococcal
meningitis is 400 mg on the first day, followed
by 200 mg once daily.
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10. Generic Diflucan Tablets
Recommended Adult Dosage
➔Prophylaxis in patients undergoing
bone marrow transplantation: The
recommended Generic Diflucan daily
dosage for the prevention of candidiasis
in patients undergoing bone marrow
transplantation is 400 mg, once daily.
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11. Generic Diflucan Tablets
Contraindications
Generic Diflucan (Fluconazole Tablets) is
contraindicated in patients with the
following conditions:
➔Hypersensitivity to Fluconazole or any
inactive component of this medication.
➔ Caution should be used in prescribing
Forcan to patients with hypersensitivity to
other azoles.
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12. Generic Diflucan Tablets
Side Effects of Generic Diflucan Tablets
In Patients Receiving a Single Dose for
Vaginal Candidiasis:
The most common side effects reported in the
patients who received 150 mg single dose
fluconazole for vaginitis were headache (13%),
nausea (7%), and abdominal pain (6%). Other
side effects reported with an incidence equal to
or greater than 1% included diarrhea (3%),
dyspepsia (1%), dizziness (1%), and taste
perversion (1%). Most of the reported side
effects were mild to moderate in severity.
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13. Generic Diflucan Tablets
Side Effects of Generic Diflucan Tablets
In Patients Receiving Multiple Doses for
Other Infections:
The following treatment related clinical
side effects occurred at an incidence of
1% or greater in patients receiving
Generic Diflucan (Forcan Tablets) for 7 or
more days in clinical trials: nausea 3.7%,
headache 1.9%, skin rash 1.8%, vomiting
1.7%, abdominal pain 1.7%, and diarrhea
1.5%.
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14. Generic Diflucan Tablets
Warnings And Precautions
➔Simultaneous use of fluconazole and erythromycin
has the potential to increase the risk of cardiotoxicity
(prolonged QT interval, torsade de pointes) and
consequently sudden heart death.
➔Hepatic injury: Generic Diflucan should be
administered with caution to patients with liver
dysfunction.
➔Anaphylaxis: In rare cases, anaphylaxis has been
reported.
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15. Generic Diflucan Tablets
Warnings And Precautions
➔Dermatologic: Patients have rarely
developed exfoliative skin disorders during
treatment with Generic Diflucan. Patients who
develop rashes during treatment with Generic
Diflucan should be monitored closely and the
drug discontinued if lesions progress.
➔Use in Pregnancy: A rare pattern of distinct
congenital anomalies in infants exposed in
utero to high dose maternal fluconazole (400-
800 mg/day) during most or all of the first
trimester has been observed.
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16. Generic Diflucan Tablets
Warnings And Precautions
➔When driving vehicles or operating
machines, it should be taken into
account that occasionally dizziness or
seizures may occur.
➔Fluconazole should be administered
with caution to patients with renal
dysfunction.
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17. Generic Diflucan Tablets
Overdose Symptoms
There have been reports of overdose
with Fluconazole accompanied by
hallucination and paranoid behavior.
Very high doses of fluconazole, can
possibly cause decreased motility and
respiration, ptosis, lacrimation,
salivation, urinary incontinence, loss of
righting reflex, and cyanosis.
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18. Generic Diflucan Tablets
Overdose Treatment
In the event of overdose, symptomatic
treatment (with supportive measures
and gastric lavage if clinically indicated)
should be instituted. Fluconazole is
largely excreted in urine. A three-hour
hemodialysis session decreases
plasma levels by approximately 50%.
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19. Generic Diflucan Tablets
Forcan Tablets
Forcan Tablets from Cipla Ltd., India.
For more information click here
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