A 62-year-old female presented with progressive left upper extremity numbness and a history of liver transplant. Differential diagnoses included malignant melanoma, foreign body reaction, glial neoplasm, and phaeohyphomycosis. Cerebral phaeohyphomycosis due to the fungus Cladophialophora bantiana was suspected given the presence of darkly pigmented, thick-walled muriform cells called sclerotic bodies on frozen section. Phaeohyphomycosis has a high mortality rate of 70% for C. bantiana infections and morbidity.
