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Autonomic Nervous System Agents Ma. Tosca Cybil A. Torres, RN, MAN
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nervous system
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Body Tissue/Organ Sympathetic Response Parasympathetic Response Eye Dilates pupils Constricts pupils Lungs Dilates bronchioles Constricts bronchioles and increase secretions Heart Increases heart rate Decreases heart rate Blood vessels Constricts Dilates GI Relaxes smooth muscles of GIT Increases peristalsis Bladder Relaxes bladder muscle Constricts bladder Uterus  Relaxes uterine muscles Salivary gland Increases salivation
Autonomic Nervous System: Sympathetic and Parasympathetic Sympathetic Stimulants Sympathomimetics (  adrenergics, adrenomimetics, or adrenergic agonists ) Parasympathetic Stimulants Direct-Acting Parasympathomimetics (cholinergics or cholinergic agonists) Action:  Increase BP Increase PR Relax bronchioles Dilates pupils Relax uterine muscles Increase blood sugar Action:  Decrease blood pressure Decrease pulse rate Constrict bronchioles Constrict pupils Increase urinary contraction  Increase peristalsis Indirect-Acting Cholinesterase inhibitors (anticholinesterase)  Action:  Increase muscle tone  Sympathetic Depressants Sympatholytics( adrenergic blockers, adrenolytics, or adrenergic antagonists ) Parasympathetic Depressants Parasympatholytics (anticholinergics, cholinergics antagonists, or antispasmodics) Action:  Decrease PR Decrease BP Constrict Bronchioles Action:  Increase PR Decrease mucous secretions  Decrease GI motility Increase urinary retention Dilate pupils
Cholinergic Agents  and Cholinergic Blocking Agents
Cholinergic Agents
Cholinergic Agents ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Receptors ,[object Object],[object Object],[object Object],[object Object]
Nicotinic Receptors ,[object Object],[object Object],[object Object]
Nicotinic  receptor sites
Muscle contraction
Muscarinic Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Mechanism of Action ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Indirect-Acting Cholinergic Agents (Cholinesterase Inhibitors) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of Cholinergic Agents ,[object Object],[object Object]
Drug Effects of Cholinergic Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of Cholinergic Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of Cholinergic Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of Cholinergic Agents ,[object Object],[object Object]
Cholinergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object]
Cholinergic Agents: Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Interactions ,[object Object],[object Object]
Cholinergic Agents:   Nursing Implications ,[object Object],[object Object],[object Object]
Cholinergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object]
Cholinergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object]
Cholinergic Agents:  Nursing Implications ,[object Object],[object Object]
Cholinergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents
Cholinergic Blocking Agents ,[object Object]
Cholinergic Blocking Agents: Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Chemical Class ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of  Cholinergic Blocking Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of  Cholinergic Blocking Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of  Cholinergic Blocking Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Therapeutic Uses  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents:  Side Effects ,[object Object],[object Object],[object Object]
Cholinergic Blocking Agents:  Side Effects ,[object Object],[object Object],[object Object]
Cholinergic Blocking Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents:  Interactions ,[object Object],[object Object]
Cholinergic Blocking Agents: Nursing Implications ,[object Object],[object Object],[object Object]
Cholinergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Nursing Implications ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Nursing Implications ,[object Object],[object Object],[object Object]
Cholinergic Blocking Agents: Nursing Implications ,[object Object]
Cholinergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object]
Cholinergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 &  
Adrenergics
[object Object],[object Object],[object Object],[object Object]
Effects of Adrenergics at Receptors Receptor Physiologic Responces Alpha 1 Increases force of heart contraction; vasoconstriction increases BP; mydriasis; salicary glands decrease secretions; bladder and prostate capsule increases contraction and ejaculation  Alpha 2 Inhibits the release of norepinephrine; dilates blood vessels; produces hypotension; decreases GI motility and tone  Beta 1 Increases heart rate and contraction; increases renin secretion----increase BP Beta 2 Dilates bronchioles; promotomes GI and uterine relaxation; promotes increase in blood sugar through glycogenolysis in the liver; increases blood flow in the skeletal muscles
[object Object],[object Object],[object Object],[object Object]
Indications for use ,[object Object],[object Object],[object Object]
Indications of adrenergics cont. ,[object Object],[object Object],[object Object],[object Object]
Contraindications to use of adrenergics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Individual adrenergic drugs ,[object Object],[object Object]
epinephrine ,[object Object],[object Object],[object Object]
epinephrine ,[object Object],[object Object],[object Object]
epinephrine ,[object Object],[object Object],[object Object],[object Object]
epinephrine ,[object Object],[object Object],[object Object],[object Object]
Other adrenergics ,[object Object]
Pseudophed ,[object Object]
isuprel (Isoproterenol) ,[object Object],[object Object],[object Object],[object Object]
Neosynephrine (Phenylephrine) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Toxicity of adrenergics in critically ill patients ,[object Object],[object Object],[object Object],[object Object],[object Object]
Toxicity ,[object Object]
Nursing considerations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Blockers
Anti-adrenergics ,[object Object],[object Object]
Antiadrenergics—mechanisms of action and effects ,[object Object],[object Object]
Alpha-Adrenergic  Agonists and blocking agents ,[object Object],[object Object],[object Object]
Alpha 1 adrenergic blocking agents ,[object Object],[object Object]
Alpha 1 adrenergic blocking agents ,[object Object],[object Object],[object Object]
Alpha 1 antagonists ,[object Object],[object Object]
Alpha 1 antagonists cont. ,[object Object],[object Object]
Alpha 2 agonists ,[object Object],[object Object],[object Object]
Beta adrenergic blocking medications ,[object Object]
Effects of beta blocking drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Effects of beta blocking drugs ,[object Object],[object Object],[object Object],[object Object]
Effects of beta blocking agents ,[object Object],[object Object],[object Object]
Indications for use ,[object Object],[object Object],[object Object]
Regitine (phentolamine) ,[object Object]
Indications for use ,[object Object],[object Object],[object Object]
Beta blocking medications ,[object Object],[object Object]
Beta blockers ,[object Object],[object Object],[object Object]
Beta blockers ,[object Object],[object Object]
Beta blockers ,[object Object],[object Object],[object Object],[object Object]
Beta Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object]
Receptor selectivity ,[object Object],[object Object],[object Object]
Non-Receptor selectivity ,[object Object],[object Object]
Combination selectivity ,[object Object],[object Object],[object Object],[object Object]
Intrinsic  sympathomimetic  activity ,[object Object],[object Object],[object Object],[object Object]
Specific conditions-alpha agonists and antagonists ,[object Object],[object Object],[object Object]
Specific condtions-beta blockers ,[object Object],[object Object],[object Object]
Special conditions—beta blockers ,[object Object]
Ethnic considerations ,[object Object],[object Object]
Nursing responsibilities ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Autonomic Nervous System Agents

  • 1. Autonomic Nervous System Agents Ma. Tosca Cybil A. Torres, RN, MAN
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  • 7. Body Tissue/Organ Sympathetic Response Parasympathetic Response Eye Dilates pupils Constricts pupils Lungs Dilates bronchioles Constricts bronchioles and increase secretions Heart Increases heart rate Decreases heart rate Blood vessels Constricts Dilates GI Relaxes smooth muscles of GIT Increases peristalsis Bladder Relaxes bladder muscle Constricts bladder Uterus Relaxes uterine muscles Salivary gland Increases salivation
  • 8. Autonomic Nervous System: Sympathetic and Parasympathetic Sympathetic Stimulants Sympathomimetics ( adrenergics, adrenomimetics, or adrenergic agonists ) Parasympathetic Stimulants Direct-Acting Parasympathomimetics (cholinergics or cholinergic agonists) Action: Increase BP Increase PR Relax bronchioles Dilates pupils Relax uterine muscles Increase blood sugar Action: Decrease blood pressure Decrease pulse rate Constrict bronchioles Constrict pupils Increase urinary contraction Increase peristalsis Indirect-Acting Cholinesterase inhibitors (anticholinesterase) Action: Increase muscle tone Sympathetic Depressants Sympatholytics( adrenergic blockers, adrenolytics, or adrenergic antagonists ) Parasympathetic Depressants Parasympatholytics (anticholinergics, cholinergics antagonists, or antispasmodics) Action: Decrease PR Decrease BP Constrict Bronchioles Action: Increase PR Decrease mucous secretions Decrease GI motility Increase urinary retention Dilate pupils
  • 9. Cholinergic Agents and Cholinergic Blocking Agents
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  • 68.
  • 69. Effects of Adrenergics at Receptors Receptor Physiologic Responces Alpha 1 Increases force of heart contraction; vasoconstriction increases BP; mydriasis; salicary glands decrease secretions; bladder and prostate capsule increases contraction and ejaculation Alpha 2 Inhibits the release of norepinephrine; dilates blood vessels; produces hypotension; decreases GI motility and tone Beta 1 Increases heart rate and contraction; increases renin secretion----increase BP Beta 2 Dilates bronchioles; promotomes GI and uterine relaxation; promotes increase in blood sugar through glycogenolysis in the liver; increases blood flow in the skeletal muscles
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