Alba Reyes Sagiv Skin and Hair Transplant Institute USA Toll Free Number: 1-(877)-627-8449 Santo Domingo: (809) 227-9500 Email: info@albareyes.com Website: http://www.albareyes.com

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2. About DermaGenoma
• DermaGenoma is a genetics dermatology company
• DermaGenoma develops therapeutic and diagnostic products
based on an individual’s genetic makeup
• World-renowned genetic scientists
• World-renowned hair dermatologists
• Products sold in over 30 countries on 6 continents
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3. Overview
• Current product lines:
– AcneDX - antibiotic therapy response for Acne Vulgaris
– HairDX - screen and therapy response for Androgenetic
Alopecia
– CelluliteDX - screen for moderate to severe cellulite (gynoid
lipodystrophy)
– HerpesDX - screen for frequent herpes outbreaks
– PsoriasisDX - screen for Psoriatic Arthritis
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4. What is the HairDX Genetic Test?
Genetic Test to determine Androgen Sensitivity
• Women with high androgen sensitivity are likely to respond to
anti-androgen therapy for the treatment of hair loss (AGA)
• Women with high androgen sensitivity are at an increased risk of
developing androgenetic alopecia (AGA)
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5. Science - Androgen Sensitivity
• Androgens are the male sex hormones testosterone and
dihydrotestosterone, which are found in smaller amounts in women
• Androgens bind to androgen receptors in cells
• Androgen receptor sensitivity is determined by the genetics of the
androgen receptor
• Androgen receptor sensitivity determines the affect of androgens on
hair loss and anti-androgen therapy
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6. Science - Genetics
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19 20 21 22 X Y
• Human cells contain 46 chromosomes (23 pairs)
• X and Y are sex chromosomes
• Women have two X chromosomes
• Men have one X and one Y chromosome
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7. Science - Genetics
• Chromosomes are made up of DNA
• There are four DNA bases C, A, G and T
• Sets of three DNA bases, called codons, can
encode amino acids, e.g., the CAG codon encodes
the amino acid glutamine
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8. Science - Androgen Receptor
• The androgen receptor (AR) gene is located on the X-chromosome
• Androgen sensitivity on the AR gene is determined by the number of
CAG repeats
• Women have two differentially activated X-chromosomes; hence, the
test determines the CAG repeat in the activated X-chromosome
• Patients with few CAG repeats have an increase in androgen receptor
activity and therefore high androgen sensitivity
• Patients with many CAG repeats have a decrease in androgen receptor
activity and therefore low androgen sensitivity
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9. HairDX Clinical Study
• Pioneering clinical study conducted by Dr. Sharon Keene
(2009-2010)
• Women received 1mg/day finasteride for 6 months
• Hair counts were used to measure finasteride response
• Responders had a CAG score <23.5 had approximately a +24%
change in hair counts (gain hair)
• Non-responders had a CAG score ≥23.5 had approximately a -4%
change in hair counts (lose hair)
• Replicated in an independent cohort
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10. HairDX Clinical Study
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11. The HairDX Female Androgen Sensitivity Test
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12. The HairDX Test Kit - Content
• 4 cheek (buccal) swabs
• Return envelope
• Instruction sheet
• Patient information sheet
• Service Agreement - General Terms and Conditions
• Informed consent form
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13. How is the Test Performed?
• The HairDX genetic test can be performed at home but we
recommend to perform the test at your clinic
• The test uses a cheek swabs that looks like a small toothbrush
• Four swabs are included in the test kit to assure a sufficient
amount of DNA is collected
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14. How is the Test Performed?
You MUST follow
the instruction sheet
included with the
HairDX Test Kit
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15. How is the Test Performed?
Make sure client
does NOT eat or drink
anything, 1 hour before
sample collection
• Carefully take out the sterile swab
NEVER touch the swab
tip with your fingers
• Swab the inside cheek for 30 seconds
• Use 2 swabs for each side
• Use all 4 swabs included with the kit
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16. How is the Test Performed?
NEVER touch the swab
tip with your fingers
• Put each used sterile swab back in
the container tube
• Place the container tubes in the
included envelope
• Seal the envelope
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17. The HairDX Test - Process
• Genetic analysis of patient samples typically takes 2 weeks
• The genetic analysis is performed at DermaGenoma labs, the
results are made available through a secure electronic or via fax
(U.S. domestic only)
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18. The HairDX Test - Timeline
+/- 3 Weeks
+/- 1 Month
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19. Safety and Confidentiality
• The sample collection procedure is safe
• The sample is shipped without any personal identification
• The DermaGenoma laboratory destroys all the samples after 30 days
• The DermaGenoma laboratory is CLIA and HIPAA compliant -
highest US laboratory and privacy standards
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20. Shipping to DermaGenoma (International)
• Storage prior to shipping to DermaGenoma should be at +4
degrees celsius
• Shipping to DermaGenoma should be by FedEx
• Shipping in standard package expedited delivery (no ice)
• Label on package to receive from DermaGenoma
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21. Shipping to DermaGenoma (Domestic)
• Immediately mail after the sample is collected in prepaid postage
bubble mailer provided in the test kit
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22. HairDX Sample Report - Positive
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23. HairDX Sample Report - Negative
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24. Contact Information and Q&A
United States Europe, Middle East, Africa
Phone: +1 (949) 428-2140 Phone: +32 47 725 8515
Fax: +1 (949) 428-2142 Fax: +32 1 153 3686
Email: info@dermagenoma.com Email: dirks@dermagenoma.com
Asia, Oceania
Phone: + 81 80 56 86 06 03
Fax: +1 (949) 428-2142
Email: junm@dermagenoma.com
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