Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability

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tskehwar

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Concept of Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability for IMRT Plans. T. S. KEHWAR , D.Sc., Ph.D. M. Saiful Huq, PhD and Dwight E. Heron, MD University of Pittsburgh Cancer Institute UPMC Cancer Centers, Pittsburgh

[object Object],[object Object],[object Object],OBJECTIVES

[object Object],[object Object],[object Object],BEEUD for Tumors Tumor with non-uniform dose distribution SANCHEZ-NIETO, B & NAHUM, AE. THE DELTA-TCP CONCEPT: A CLINICALLY USEFUL MEASURE OF TUMOR CONTROL PROBABILITY. Int. J. Radiation Oncology Biol. Phys., Vol. 44, No. 2, pp. 369–380, 1999

[object Object],[object Object],[object Object],[object Object],Tumor with uniform dose distribution

BEEUD for normal tissues ,[object Object],[object Object]

[object Object],[object Object],Tumor Normal tissue/organ D ref

[object Object],[object Object],[object Object],[object Object],[object Object],BEEUD for normal tissues

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Normal tissue with Uniform dose distribution

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RESULTS AND DISCUSSION

TCP for prostate for published values of  ,  /  and clonogenic cell density (ρ) for two IMRT plans. Brenner, D. J., Hall, E. J., 1999. Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 43(5), 1095 – 1101. King CR, Mayo CS. Is the prostate  ratio of 1.5 from Brenner & Hall a modeling artifact? Int J Radiat Oncol Biol Phys 2000; 47(2): 536 – 538. Wang JZ, Guerrero M, Li XA. How low is the / ratio for prostate cancer? Int J Radiat Oncol Biol Phys 2003;55:194–203

NTCP calculation ,[object Object],[object Object],[object Object],[object Object]

CONCLUSIONS ,[object Object],[object Object],[object Object]

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Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability

1. Concept of Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability for IMRT Plans. T. S. KEHWAR , D.Sc., Ph.D. M. Saiful Huq, PhD and Dwight E. Heron, MD University of Pittsburgh Cancer Institute UPMC Cancer Centers, Pittsburgh

10. TCP for prostate for published values of  ,  /  and clonogenic cell density (ρ) for two IMRT plans. Brenner, D. J., Hall, E. J., 1999. Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 43(5), 1095 – 1101. King CR, Mayo CS. Is the prostate  ratio of 1.5 from Brenner & Hall a modeling artifact? Int J Radiat Oncol Biol Phys 2000; 47(2): 536 – 538. Wang JZ, Guerrero M, Li XA. How low is the / ratio for prostate cancer? Int J Radiat Oncol Biol Phys 2003;55:194–203

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12. Clinical Plans

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14. Thanking you all

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Good afternoon In my talk I am presenting a new concent of BEEUD to calculate TCP and NTCP for non uniform dose distribution.

Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability

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Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability

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