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Attracting EC
Funding
The Human Variome Project
5th Biennial Meeting
19th-23rd May, 2014
Paris
Diana Salmen
Innovative and Personalised Medicine Unit
Health Research Directorate
DG Research & Innovation
Research and
Innovation
HORIZON 2020
• The EU’s 2014-20 programme
for research & innovation
(around € 80 billion)
• A core part of Europe 2020, Innovation
Union & European Research Area
• Three priorities: Excellent science,
Industrial leadership, Societal challenges
Research and
Innovation
Building on the FP7
experience…
Research and
Innovation
FP7 'Health' – the largest
multi-national fund…
• …for collaborative
research
• …to fund excellence
• …to bring together
scientists
• …to tackle global
challenges
Research and
Innovation
Key figures
6 b€ invested to date
1,000 projects
11,000 teams
3,500 organisations
130 countries
First outcomes
(on 329 closed projects = 1/3 of funded projects)
200 patent applications
9,000 publications
3,3 average SJR* publication
30 spin-offs created
* SCImago Journal Ranking
Research and
Innovation
International K.O.
Mouse Consortium
International
Cancer Genomics
Consortium
International cooperation: Working on the
big challenges
International Human
Microbiome Consortium
Global Research Collaboration
for Infectious Disease
Preparedness
International Rare
Diseases Research
Consortium
International Initiative
for Traumatic Brain
Injury Research
©rtguest/Fotolia.com
Global Alliance for
Chronic Diseases
International Human
Epigenome Consortium
Research and
Innovation
International K.O.
Mouse Consortium
International
Cancer Genomics
Consortium
International cooperation: Working on the
big challenges
International Human
Microbiome Consortium
Global Research Collaboration
for Infectious Disease
Preparedness
International Rare
Diseases Research
Consortium
International Initiative
for Traumatic Brain
Injury Research
©rtguest/Fotolia.com
Global Alliance for
Chronic Diseases
International Human
Epigenome Consortium
Research and
Innovation
www.irdirc.org
200 therapies
and
means to
diagnose most
rare disease by
2020
Research and
Innovation
Basic principles
• Teams up public and private organisations investing in
rare diseases research
• Research funders with relevant programmes >$10
million US over a 5-year period can join & work
together
• Each organisation funds research its own way
• Funded projects adhere to a common framework
• Agree to share data / standards
Alignment – Flexibility - Commitment
Research and
Innovation
Executive Committee
Chair: Paul Lasko
Diagnostics
Chair: Kym Boycott
Interdisciplinary
Chair: Hanns Lochmueller
Therapies
Chair: Yann Le Cam
Scientific Committees
Working Groups
EU-funded SUPPORT-IRDiRC provides organisational
support for Executive and Scientific Committees and Working Groups
Coordinator: Prof. Ségolène Aymé, INSERM
IRDiRC Governance Structure
Research and
Innovation
IRDiRC timelineExploratory
Workshop
Reykjavik
Launch
Washington
Scientific
Committees
Working
Groups
IRDiRC
2013
Conference
3000
diagnostics
50 new applications
for market
authorisation
Support-
IRDiRC
Scientific
Secretariat
6000
diagnostics
200 new applications
for market
authorisation
2010 2011 2012 2013 2015 2020
Research and
Innovation
Europe
E-RARE 2 Consortium (EU)
European Commission
EURORDIS (EU)
Academy of Finland
French Muscular Dystrophy Association
French National Research Agency
French Foundation for Rare Diseases
Children's New Hospitals Management
Group (GE)
German Federal Ministry of Education
and research
Italian Higher Institute of Health
Research
Italian Telethon Foundation
Lysogene (FR)
Netherlands Organisation for Health
Research and Development
Prosensa (NL)
Spanish Carlos III Health Institute
UK National Institute for
Health Research
Committed members
© rtguest/Fotolia.com
Australia
National Health
and Medical
Research Council
Asia
BGI (CN)
Chinese Rare
Disease
Consortium
Korea National
Institute of Health
North America
Canadian Institutes for Health
Research
Genome Canada
FDA Orphan Products Grants Program
Genetic Alliance (US)
Genzyme (US)
Isis Pharmaceuticals (US)
Mendelian Disorders Genome Centres
(US NIH)
National Centre for Translational
Sciences (US NIH)
National Cancer Institute (US NIH)
National Institute of Neurological
Disorders and Stroke (US NIH)
National Institute of Arthritis and
Musculoskeletal and Skin Diseases (US
NIH)
National Institute of Child Health and
Human Development (US NIH)
National Eye Institute (US NIH)
NKT Therapeutics (US)
NORD (US)
Office of Rare Diseases (US NIH)
PTC Therapeutics (US)
Sanford Research (US)
Shire (US)
Research and
Innovation
International K.O.
Mouse Consortium
International
Cancer Genomics
Consortium
International cooperation: Working on the
big challenges
International Human
Microbiome Consortium
Global Research Collaboration
for Infectious Disease
Preparedness
International Rare
Diseases Research
Consortium
International Initiative
for Traumatic Brain
Injury Research
©rtguest/Fotolia.com
Global Alliance for
Chronic Diseases
International Human
Epigenome Consortium
Research and
Innovation
The International Human Epigenome Consortium (IHEC) is a global consortium
with the primary goal of providing free access to high-resolution reference
human epigenome maps for normal and disease cell types to the research
community.
EU
Germany
USA
JapanKorea
Canada
http://ihec-epigenomes.org/
Research and
Innovation
At a Glance
Generate reference maps of human epigenomes for key cellular states
relevant to health and disease.
 Ambitious goal to complete 1000 epigenomes
Rapid Data Release, Data Coordination, Archiving
Environment Disease Aging
Translation into Improved Human Health
Mechanism Prevention Diagnosis Therapy
Research and
Innovation
IHEC Data
Research and
Innovation
Horizon 2020
What's new?
Research and
Innovation
• Challenge driven
• Broad topics
• Less prescriptive topics
• Two-year work programme
• Stronger focus on the end users
Research and
Innovation
• Simplified eligibility criteria
• Simpler rules for grants
• Transparent funding rates
• New SME instrument
• Successful project running quicker
Research and
Innovation
• Horizon 2020 is open
• Automatic funding
• Member States
• Associated countries
• Countries in Annex of the WP
• Exceptions
Research and
Innovation
Horizon 2020
'Health, demographic
change and wellbeing'
Research and
Innovation
• Ageing population
• Increased disease burden
• Unsustainable and unequal
healthcare systems
• Healthcare sector under
pressure to reform
Research and
Innovation
• Translating science to benefit citizens
• Improve health outcomes
• Support a competitive healthcare sector
• Test and demonstrate new healthcare
models, approaches and tools
• Promote healthy and active ageing
The Work Programme 2014 - 2015
Call for 'co-ordination activities'
16 topics (11 in 2014, 5 in 2015)
Call 'personalising health and care'
34 topics (15 in 2014, 17 in 2015, 2 open in both years)
+ 8 other actions
not subject to calls for proposals
Research &
Innovation
EU funding for health research and innovation 2014-2015
Research &
Innovation
Understanding
health, ageing &
disease
Improving health
information, data
exploitation and
providing an evidence
base for health policies
and regulation
Integrated,
sustainable,
citizen-centered
care
Innovative
treatments and
technologies
Improving
diagnosis
Implementing personalized medicine in healthcare settings
Effective health
promotion, disease
prevention,
preparedness and
screening
Advancing active
and healthy aging
Research &
Innovation
Research &
Innovation
Research and
Innovation
http://ec.europa.eu/research/participants/portal
Participant Portal– your one-stop shop
Research and
Innovation
Thank you
Diana.Salmen@ec.europa.eu
http://ec.europa.eu/research/health
http://ec.europa.eu/programmes/horizon2020

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Attracting EC Funding - Diana Salmen

  • 1. Attracting EC Funding The Human Variome Project 5th Biennial Meeting 19th-23rd May, 2014 Paris Diana Salmen Innovative and Personalised Medicine Unit Health Research Directorate DG Research & Innovation
  • 2. Research and Innovation HORIZON 2020 • The EU’s 2014-20 programme for research & innovation (around € 80 billion) • A core part of Europe 2020, Innovation Union & European Research Area • Three priorities: Excellent science, Industrial leadership, Societal challenges
  • 3. Research and Innovation Building on the FP7 experience…
  • 4. Research and Innovation FP7 'Health' – the largest multi-national fund… • …for collaborative research • …to fund excellence • …to bring together scientists • …to tackle global challenges
  • 5. Research and Innovation Key figures 6 b€ invested to date 1,000 projects 11,000 teams 3,500 organisations 130 countries First outcomes (on 329 closed projects = 1/3 of funded projects) 200 patent applications 9,000 publications 3,3 average SJR* publication 30 spin-offs created * SCImago Journal Ranking
  • 6. Research and Innovation International K.O. Mouse Consortium International Cancer Genomics Consortium International cooperation: Working on the big challenges International Human Microbiome Consortium Global Research Collaboration for Infectious Disease Preparedness International Rare Diseases Research Consortium International Initiative for Traumatic Brain Injury Research ©rtguest/Fotolia.com Global Alliance for Chronic Diseases International Human Epigenome Consortium
  • 7. Research and Innovation International K.O. Mouse Consortium International Cancer Genomics Consortium International cooperation: Working on the big challenges International Human Microbiome Consortium Global Research Collaboration for Infectious Disease Preparedness International Rare Diseases Research Consortium International Initiative for Traumatic Brain Injury Research ©rtguest/Fotolia.com Global Alliance for Chronic Diseases International Human Epigenome Consortium
  • 9. Research and Innovation Basic principles • Teams up public and private organisations investing in rare diseases research • Research funders with relevant programmes >$10 million US over a 5-year period can join & work together • Each organisation funds research its own way • Funded projects adhere to a common framework • Agree to share data / standards Alignment – Flexibility - Commitment
  • 10. Research and Innovation Executive Committee Chair: Paul Lasko Diagnostics Chair: Kym Boycott Interdisciplinary Chair: Hanns Lochmueller Therapies Chair: Yann Le Cam Scientific Committees Working Groups EU-funded SUPPORT-IRDiRC provides organisational support for Executive and Scientific Committees and Working Groups Coordinator: Prof. Ségolène Aymé, INSERM IRDiRC Governance Structure
  • 11. Research and Innovation IRDiRC timelineExploratory Workshop Reykjavik Launch Washington Scientific Committees Working Groups IRDiRC 2013 Conference 3000 diagnostics 50 new applications for market authorisation Support- IRDiRC Scientific Secretariat 6000 diagnostics 200 new applications for market authorisation 2010 2011 2012 2013 2015 2020
  • 12. Research and Innovation Europe E-RARE 2 Consortium (EU) European Commission EURORDIS (EU) Academy of Finland French Muscular Dystrophy Association French National Research Agency French Foundation for Rare Diseases Children's New Hospitals Management Group (GE) German Federal Ministry of Education and research Italian Higher Institute of Health Research Italian Telethon Foundation Lysogene (FR) Netherlands Organisation for Health Research and Development Prosensa (NL) Spanish Carlos III Health Institute UK National Institute for Health Research Committed members © rtguest/Fotolia.com Australia National Health and Medical Research Council Asia BGI (CN) Chinese Rare Disease Consortium Korea National Institute of Health North America Canadian Institutes for Health Research Genome Canada FDA Orphan Products Grants Program Genetic Alliance (US) Genzyme (US) Isis Pharmaceuticals (US) Mendelian Disorders Genome Centres (US NIH) National Centre for Translational Sciences (US NIH) National Cancer Institute (US NIH) National Institute of Neurological Disorders and Stroke (US NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (US NIH) National Institute of Child Health and Human Development (US NIH) National Eye Institute (US NIH) NKT Therapeutics (US) NORD (US) Office of Rare Diseases (US NIH) PTC Therapeutics (US) Sanford Research (US) Shire (US)
  • 13. Research and Innovation International K.O. Mouse Consortium International Cancer Genomics Consortium International cooperation: Working on the big challenges International Human Microbiome Consortium Global Research Collaboration for Infectious Disease Preparedness International Rare Diseases Research Consortium International Initiative for Traumatic Brain Injury Research ©rtguest/Fotolia.com Global Alliance for Chronic Diseases International Human Epigenome Consortium
  • 14. Research and Innovation The International Human Epigenome Consortium (IHEC) is a global consortium with the primary goal of providing free access to high-resolution reference human epigenome maps for normal and disease cell types to the research community. EU Germany USA JapanKorea Canada http://ihec-epigenomes.org/
  • 15. Research and Innovation At a Glance Generate reference maps of human epigenomes for key cellular states relevant to health and disease.  Ambitious goal to complete 1000 epigenomes Rapid Data Release, Data Coordination, Archiving Environment Disease Aging Translation into Improved Human Health Mechanism Prevention Diagnosis Therapy
  • 18. Research and Innovation • Challenge driven • Broad topics • Less prescriptive topics • Two-year work programme • Stronger focus on the end users
  • 19. Research and Innovation • Simplified eligibility criteria • Simpler rules for grants • Transparent funding rates • New SME instrument • Successful project running quicker
  • 20. Research and Innovation • Horizon 2020 is open • Automatic funding • Member States • Associated countries • Countries in Annex of the WP • Exceptions
  • 21. Research and Innovation Horizon 2020 'Health, demographic change and wellbeing'
  • 22. Research and Innovation • Ageing population • Increased disease burden • Unsustainable and unequal healthcare systems • Healthcare sector under pressure to reform
  • 23. Research and Innovation • Translating science to benefit citizens • Improve health outcomes • Support a competitive healthcare sector • Test and demonstrate new healthcare models, approaches and tools • Promote healthy and active ageing
  • 24. The Work Programme 2014 - 2015 Call for 'co-ordination activities' 16 topics (11 in 2014, 5 in 2015) Call 'personalising health and care' 34 topics (15 in 2014, 17 in 2015, 2 open in both years) + 8 other actions not subject to calls for proposals
  • 25. Research & Innovation EU funding for health research and innovation 2014-2015
  • 26. Research & Innovation Understanding health, ageing & disease Improving health information, data exploitation and providing an evidence base for health policies and regulation Integrated, sustainable, citizen-centered care Innovative treatments and technologies Improving diagnosis Implementing personalized medicine in healthcare settings Effective health promotion, disease prevention, preparedness and screening Advancing active and healthy aging