Autoimmune disorders

AUTOIMMUNE DISEASES ,[object Object]

INTRODUCTION ,[object Object],[object Object]

PATHOPHYSIOLOGY ,[object Object],[object Object],[object Object]

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PREDISPOSING FACTORS ,[object Object],[object Object]

CLASSIFICATION OF AUTOIMMUNE DISEASES ,[object Object],Grave’s disease Hashimoto’s thyroiditis Addison’s disease Pernicious anemia Type1 DM Sympathetic ophthalmoplegia Goodpasteure’s syndrome Pemphigus vulgaris Bullous pemphigoides Idiopathic thrombocytopenic purpura Autoimmune hemolytic anemia Myasthenia gravis

contd... MULTI SYSTEM:immune response directed to widespread targeted antigens Rheumatoid arthritis Dermatomyositis Primary biliary cirrhosis Autoimmune hepatitis Sjogren’s syndrome systemic sclerosis, mixed connective tissue disease, SLE.

GEL & COOMB’S CLASSN. OF HYPERSENSITIVITY DISEASES ,[object Object],[object Object],[object Object]

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INVESTIGATIONS ,[object Object],[object Object],[object Object]

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[object Object],[object Object],[object Object],[object Object],[object Object],CREST variant of scleroderma (sensitivity 60%, specificity 98%) Also occasionally found in primary Raynaud's syndrome. Drug induced lupus. Polymyositis, dermatomyositis or polymyositis-scleroderma overlap (20-30%). Particularly associated with interstitial lung disease. Sjögren's syndrome SLE (20-60%). Mixed connective tissue disease SLE, usually in conjunction with anti-Sm antibodies.

[object Object],[object Object],[object Object],[object Object],SLE (35-60%): associated with photosensitivity, thrombocytopenia and subacute cutaneous lupus Maternal anti-Ro antibodies associated with neonatal lupus and congenital heart block Sjögren's syndrome (40-80%). Rapidly progressive diffuse scleroderma. Very specific for SLE (15-30%): associated with more benign prognosis. Diffuse scleroderma: associated with more severe organ involvement, including pulmonary fibrosis.

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TREATMENT ,[object Object],[object Object],[object Object]

Autoimmune disorders

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Autoimmune disorders