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Biocatalysis - Jonathan Dordick
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Biocatalysis - Jonathan Dordick
1.
Biocatalysis for Our
Sustainable Future whattheythink.com
2.
Chemical Processing: Fueling
the 20th Century Straathof et al. Curr. Opin. Biotech. 13, 548-556, 2002
3.
Biocatalysis: Fueling the
21st “Sustainable” Century Chemicals Fuels Drugs
4.
From Nature (1.3
billion tons)…
5.
…to Products Through
Biorefining
6.
Challenges to Overcome
Ionic Liquids scidac.org Cellulase
7.
Biocatalysis for Healthcare
OH O O OH OH OCH3 O OH O NH2 O OH
8.
9.
Drug Discovery at
a Crossroads $2 billion/approval? Source: Burrill & Co.
10.
Biology’s Complexity
11.
Biocatalysis- driven Drug
Discovery Human Toxicity =
12.
Developing Better Biocatalytic
Materials
13.
From Enzymology to
Enzyme-Based Materials Nanoscale Materials Designed Gels Enzymes Biocatalytic Plastics Biocatalytic Coatings Up in Space
14.
Exploiting Nature’s Composite
Materials Biomimetic, Biocatalytic Coating CYP3A4 100 nM Ketoconazole 250 nM Sulfaphenazole CYP2C9 10 nM Quinidine 100 nM Ketoconazole Biocatalytic 250 nM Sulfaphenazole Plastics 10 nM Quinidine CYP2D6 100 nM Ketoconazole 250 nM Sulfaphenazole 10 nM Quinidine ) ) )