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Mad Cow Disease!
      Hari Kumar
  Medical Microbiology
           
Mad Cow Disease (MCD) -
             Introduction
• It’s formal name is Bovine Spongiform
  Encephalopathy, but we know it as Mad Cow
  Disease.
• It causes the breakage of spongy tissue in the
  brain and spinal cord of cows.
• By eating the brain or spinal cord of cows that
  are affected by this disease, we humans can
  get this disease.
MCD – In Humans
• When in humans instead of Mad Cow
  Disease, it is called Cruetzfeld - Jakob Disease.
• This disease had mostly attacked the United
  Kingdom, killing 166 people in that country.
  But it has also spread to places like the
  USA, Canada, and Ireland.
• 44 people not living in the UK have been killed
  worldwide.
Mad Cow
Diseased Brain




                 Regular
                 Brain
MCD – How it Happens?
• Prion (Proteinaceous Infectious Particles)
  proteins cause MCD as they turn the normal
  protein of a cow into a diseased protein.
• This causes the protein to deform the tissue
  into an infectious tissue.
• The result of this is holes in the brain, mental
  and physical deformities, and eventually
  death.
MCD – History
• The origins of this disease were first noted by
  Hippocrates in 500 BCE in cattle and then in
  humans.
• Also Publius Flavius Vegetius Renatus recorded
  signs of this disease in 400 CE.
• Then in the 1970’s the British government
  took note of this disease and published their
  findings.
MCD - Symptoms
• During the incubation period of this prion,
  there are no noticeable symptoms.
• Once the disease is present, the only way to
  detect it is to have your brain “scanned” and
  exam some of your brain tissue.
• The symptoms in cows may be loss in milk
  production, lethargy, and anorexia.
MCD – Prevention
• There is no real way at this point to cure the
  disease although they are taking measures to
  try to prevent it.
• In countries that have this disease
  present, they banned having cattle or bone
  meat fed to the cows. Also in the UK Slaughter
  houses, the body parts that are infected in
  cows must be disposed of properly.
MCD – Why does it matter?
• This disease, though it hasn’t killed as many
  humans as other diseases, has killed many
  cows and they are living organisms too!
• Over 200 people have been killed and you
  can’t just look over that!
• We have to be careful with our cows and look
  after them so they will stay safe and so will
  we!
Madcowdisease hk

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Madcowdisease hk

  • 1. Mad Cow Disease! Hari Kumar Medical Microbiology 
  • 2.
  • 3. Mad Cow Disease (MCD) - Introduction • It’s formal name is Bovine Spongiform Encephalopathy, but we know it as Mad Cow Disease. • It causes the breakage of spongy tissue in the brain and spinal cord of cows. • By eating the brain or spinal cord of cows that are affected by this disease, we humans can get this disease.
  • 4. MCD – In Humans • When in humans instead of Mad Cow Disease, it is called Cruetzfeld - Jakob Disease. • This disease had mostly attacked the United Kingdom, killing 166 people in that country. But it has also spread to places like the USA, Canada, and Ireland. • 44 people not living in the UK have been killed worldwide.
  • 5. Mad Cow Diseased Brain Regular Brain
  • 6. MCD – How it Happens? • Prion (Proteinaceous Infectious Particles) proteins cause MCD as they turn the normal protein of a cow into a diseased protein. • This causes the protein to deform the tissue into an infectious tissue. • The result of this is holes in the brain, mental and physical deformities, and eventually death.
  • 7. MCD – History • The origins of this disease were first noted by Hippocrates in 500 BCE in cattle and then in humans. • Also Publius Flavius Vegetius Renatus recorded signs of this disease in 400 CE. • Then in the 1970’s the British government took note of this disease and published their findings.
  • 8. MCD - Symptoms • During the incubation period of this prion, there are no noticeable symptoms. • Once the disease is present, the only way to detect it is to have your brain “scanned” and exam some of your brain tissue. • The symptoms in cows may be loss in milk production, lethargy, and anorexia.
  • 9. MCD – Prevention • There is no real way at this point to cure the disease although they are taking measures to try to prevent it. • In countries that have this disease present, they banned having cattle or bone meat fed to the cows. Also in the UK Slaughter houses, the body parts that are infected in cows must be disposed of properly.
  • 10. MCD – Why does it matter? • This disease, though it hasn’t killed as many humans as other diseases, has killed many cows and they are living organisms too! • Over 200 people have been killed and you can’t just look over that! • We have to be careful with our cows and look after them so they will stay safe and so will we!