Il17 &stat 3 in psoriasis pathogenesis

Signal Transducer &Activator of Transcription( STAT)-3 & T Helper (Th) 17 Cell in Psoriasis Immunopathogenesis ,[object Object],[object Object]

Signal transducers and activators of transcription ) Stat) Family ,[object Object],[object Object],[object Object]

STAT3 Activation ,[object Object],[object Object],[object Object]

Mechanism of Stat3 signaling ,[object Object]

Psoriasis ,[object Object],[object Object]

Psoriasis Clinical Presentation

Psoriasis as an immune disorder

T helper 1 versus 2 in psoriasis ,[object Object],[object Object],[object Object],[object Object]

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T helper cell precursors being skewed towards Th1, Th2, Th17 and T regulatory cell (Treg) phenotypes on the basis of the cytokine environment .

PSORIASIS IS A Th17 DISEASE :A Hypothesis ,[object Object],[object Object],[object Object]

PSORIASIS IS A Th17 DISEASE ,[object Object],[object Object],[object Object],[object Object]

Microbial Antigens & Th 17 Response ,[object Object]

ACTIVATION of T h 17 &STAT3 ,[object Object],[object Object],[object Object]

STAT3 REGULATION of CYTOKINE-MEDIATED GENERATION of TH 17 ,[object Object],[object Object],[object Object],[object Object]

Proinflammatory Effects of IL17

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis ,[object Object],[object Object],[object Object],[object Object],[object Object]

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A positive feedback mechanism for Th1/Th17 inflammation . ,[object Object],[object Object],[object Object]

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Do Other Therapies Work Within This Framework? ,[object Object],[object Object]

Studies on Stat 3 in Psoriasis

Therapeutic Targets ( Fitch et al , Current Rheumatology Reports 2007, 9: 461–467 ) Fitch et al.

Message Home ,[object Object],[object Object]

Il17 &stat 3 in psoriasis pathogenesis

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Il17 &stat 3 in psoriasis pathogenesis