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The role of S100 proteins in skin biology and physiology.ppt
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S100 proteins & skin
1.
S100 Proteins and
Their Role in Some Dermatological Diseases By M.Y.ABDEL-MAWLA,MD ZAGAZIG FACULTY OF MEDICINE,EGYPT
2.
S100 Proteins Structure
and Functions
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Structure of Proflaggrin
16.
17.
18.
Calcium and S100
proteins
19.
S100 Proteins
Functions
20.
21.
S100 Proteins in
Epidermis
22.
S100 proteins in
epidermis
23.
24.
25.
Protein targets of
S100 proteins
26.
S100 Proteins and
Their Role in Some Skin Diseases
27.
28.
29.
Schematic summary of
important innate immunity events in the pathophysiology of psoriasis
30.
31.
S100 Proteins and
Tumors
32.
33.
S100 proteins and
possible cancer diseases
34.
35.
S100 Protein immune
staging in melanocytic melanoma Biomarker Common nevi Spitz nevus Melanoma S100A Protein 56% weak dermal 100% strong, diffuse 33% weak dermal
36.
S100 Protein immune
staging in melanocytic nevi and their tumor mimics Marker Sensitivity/ specificity melanoma Carcinoma Sarcoma/soft tissue tumors Epithelioid cells Spindle cells S100 Proteins < 95%/ 75%-87% + + (98% Sensitivity) -(+Myoepithelial Carcinoma) +/-
37.
Staining with
S100 protein and other marker of neural hyperplasias and neoplasms Neural proliferation S100 Neurofilament Epithelial membrane antigen (EMA ) Other Traumatic neuroma + + + Neuron specific enolase positive Palisaded encapsulated neuroma + + + For capsule Schwannoma + - + for capsule only Vimentin positive Neurofibroma + Variable - Plexiform neurofibroma + + Neurothekeoma + - Variable Vimentin variable;usually EMA negative Cellular Neurothekeoma - - CD57 positive;Ki-Mip positive perineurioma - - + Vimentin positive;neuron-specific enolase negative Malignant peripheral nerve sheath tumor + + Variable Vimentin variable;cytokeratin negative ;neuron-specific enolase positive Primitive neuroectodermal tumor + If differentiated Neuron-specific enolase positive;CD99 positive Granular cell tumor + Neuron-specific enolase positive + = Positive: - = negative.
38.
How to detect
S100 Proteins?
39.
40.
Summary and Conclusion
41.
42.
Thank you
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