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Delirium & Dementia
IPP 3-2016
Delirium
Delirium
•A sudden onset (often within hours or a
few days) of disturbance in mental
abilities that results in a decreased
awareness of environment and confused
thinking
Symptoms
•Inability to stay focused
•Withdrawn from environment
•Poor memory, particularly of recent events
•Difficulty understanding speech
Symptoms
•Rambling or nonsense speech
•Difficulty reading or writing
•Restlessness, agitation, irritability/combative
behavior
•Disturbed sleep habits
Causes
•Dementia
•Older age
•Fever and acute infection
•Previous delirium episodes
Causes
•Poor nutrition, dehydration, chronic or terminal
illness
•Alcohol, drug abuse or withdrawal
•Pain medications (opioids)
•Sleep medications (hypnotics)
•Allergy medications (antihistamines)
Investigations
•Mental status assessment
•Physical and neurological exams
•Vision, balance, coordination and reflexes
•Brain-imaging tests (used when a diagnosis can't be
made with other available information)
Treatment
•Address any underlying causes or triggers
•Protect the airway, provide fluids and nutrition
•Assist with movement, treat pain, incontinence
•Keep oriented to the surroundings
•A calm, comfortable environment that includes
familiar objects from home
Treatment
•Pharmacologic treatment indicated for acute
agitation
•Neuroleptics/anxiolytics are often used
•Duration commonly ranges from days to weeks
Drugs Used-Generic Names
Neuroleptics-Major Tranquilizers
• Haloperidol
• Aripiprazole
• Asenapine
• Chlorpromazine
•Olanzapine
•Paliperidone
•Quetiapine
•Risperidone
Drugs Used-Generic names
Anxiolytics-Benzodiazepines
• Alprazolam
• Diazepam
• Brotizolam
•Clonazepam
•Clorazepate
•Zaleplon
Anti-psychotics-MOA
•Neuroleptics
•Block D2 receptors in brain dopamine pathways
•Atypical neuroleptics antagonize
5HT2A receptors
Adverse Effects
•Parkinson’s syndrome
•Akathisia
•Acute dystonic reactions
•Tardive dyskinesia
•Seizures
•Weight gain
•Infertility
•Loss of libido
•Impotence & infertility
in men
•Act on GABA receptors
•Binding results in opening chloride channels &
increased chloride conductance
•Influx of chloride ions causes a small hyper-
polarization therefore inhibiting the formation of
action potential
•Drowsiness and confusion: most common side
effects
•Ataxia at high doses
•Cognitive impairment, early morning
insomnia
Some Brand Names
Antipsychotics
•Largectil, Flunox, Pride, Clopenia,
clopixol, Clozepin, Olenaz, Ozapine,
Rizdon, Zaydon, Motival
Some Brand Names
Benzodiazepines
•Calm, Restoril, Siesta, Zolp, Somnia, Clonexa,
Alloram, Alp, Alpram, Enzo, Xanax, Zenith,
Lexotanil, Freedom, Relaxin, Diazepam, Diazen,
Valium, Ativan, Tranquil
Dementia
Dementia
•Not a specific disease
•Group of symptoms affecting thinking &
social abilities severe enough to interfere with
daily functioning.
•Alzheimer's disease is most common cause
Dementia
•Gradual memory loss
•Impaired judgment or language, and the inability
to perform some daily activities
•Changes in personality and social behavior
•Some causes are treatable and even reversible
Symptoms
• Difficulty communicating, performing complex tasks,
planning and organizing
• Difficulty with coordination and motor functions
• Problems with orientation, such as getting lost
• Personality changes, inappropriate behavior
• Paranoia, Agitation, Hallucinations
Risk factors
• Age. Increases (especially after 65, not a normal part of aging), can occur in
younger people.
• Family history.
• Down syndrome. By middle age, many with Down syndrome develop plaques
and tangles in brain that are associated with Alzheimer's
• Diabetes. increased risk
• High estrogen levels. years after menopause, greater risk
• Obesity. Being overweight or obese during the middle life may increase risk
Risk factors
• Alcohol use. heavy alcohol consumption may have a higher risk
• Atherosclerosis. buildup of fats other substances in artery walls can reduce the
blood flow to brain and lead to stroke. Reduced blood flow to brain can also
cause vascular dementia
• Blood pressure. high or low both may increase risk.
• Cholesterol. high levels of LDL cholesterol, may have an increased risk of
developing vascular dementia or Alzheimer's disease
• Depression. not yet well understood, late-life depression, especially in men,
may be an indication for the development of Alzheimer's-related dementia.
Dementia-causes-Reversible
• D= Drugs, Delirium
• E=Emotions (such as
depression) and Endocrine
Disorders
• M=Metabolic Disturbances
• E=Eye and Ear Impairments
• N=Nutritional Disorders
• T=Tumors, Toxicity, Trauma
to Head
• I=Infectious Disorders
• A=Alcohol, Arteriosclerosis
Dementia-causes
• Irreversible:
• Alzheimer
• Lewy Body Dementia
• Pick’s Disease (Fronto-temperal Dementia)
• Parkinson’s disease
• Huntington’s Disease
• Jacob-Cruzefeldt Disease
Normal vs AD Brain
Normal brain Alzheimer’s brain
Related Drugs
• Acetylcholine esterase inhibitor- Donezipil, Galantamine
• Benzodiazepines
• Antiepileptics- Sodium Valporate, Oxcarbezapine
• Parasympathomimetic- Rivastigmine
• Glutametargic receptor antagonist- Memantine
• SSRI- Sertraline
Donepezil
• Used to delay or slow the symptoms of AD in mild,
moderate and severe AD
• Loses its effect over time
• Does not prevent or cure AD
Citalopram
• Used to reduce depression and anxiety
• May take 4 to 6 weeks
• Sometimes used to help to sleep
Rivastigmine
• Used to delay or slow the symptoms of AD
• Loses its effect over time
Sodium Valproate
• Used to treat severe aggression
• Also used to treat depression and anxiety
Sertraline
• Used to reduce depression and anxiety
• May take 4 to 6 weeks
• Sometimes used to help people get to sleep
Oxcarbazepine
• Used to treat severe aggression
• Also used to treat depression and anxiety
Psychologist Role
Required for both patient & family
• Crisis intervention counseling
• Individual counseling
• Family therapy
• Group therapy
• Institutionalization
Difference b/w delirium &
dementia
Differences between delirium and dementia include:
• Delirium occurs within a short time, while dementia
usually begins with relatively minor symptoms that
gradually worsen over time.
• Inability to stay focused or maintain attention is
significantly impaired with delirium
• A person in the early stages of dementia remains generally
alert
•Delirium symptoms can fluctuate
significantly and often throughout the
day
•People with dementia, memory and
thinking skills stay at a fairly constant
level during the course of a day
Some Brand Names
•Donepizil-- Azenil, Donep, Donecept
•Galantamine- -Dementio, Reminyl
•Mamantine- -Afdol, Dementin, Mantex
•Rivastigmine- -Exelon, Memomax, Zivar
•Valproic acid- -Epival, Valprux
Yes We Are Done

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Delirium---Dementia-20032023-064817pm.pptx

  • 3. Delirium •A sudden onset (often within hours or a few days) of disturbance in mental abilities that results in a decreased awareness of environment and confused thinking
  • 4. Symptoms •Inability to stay focused •Withdrawn from environment •Poor memory, particularly of recent events •Difficulty understanding speech
  • 5. Symptoms •Rambling or nonsense speech •Difficulty reading or writing •Restlessness, agitation, irritability/combative behavior •Disturbed sleep habits
  • 6.
  • 7. Causes •Dementia •Older age •Fever and acute infection •Previous delirium episodes
  • 8. Causes •Poor nutrition, dehydration, chronic or terminal illness •Alcohol, drug abuse or withdrawal •Pain medications (opioids) •Sleep medications (hypnotics) •Allergy medications (antihistamines)
  • 9. Investigations •Mental status assessment •Physical and neurological exams •Vision, balance, coordination and reflexes •Brain-imaging tests (used when a diagnosis can't be made with other available information)
  • 10. Treatment •Address any underlying causes or triggers •Protect the airway, provide fluids and nutrition •Assist with movement, treat pain, incontinence •Keep oriented to the surroundings •A calm, comfortable environment that includes familiar objects from home
  • 11. Treatment •Pharmacologic treatment indicated for acute agitation •Neuroleptics/anxiolytics are often used •Duration commonly ranges from days to weeks
  • 12. Drugs Used-Generic Names Neuroleptics-Major Tranquilizers • Haloperidol • Aripiprazole • Asenapine • Chlorpromazine •Olanzapine •Paliperidone •Quetiapine •Risperidone
  • 13. Drugs Used-Generic names Anxiolytics-Benzodiazepines • Alprazolam • Diazepam • Brotizolam •Clonazepam •Clorazepate •Zaleplon
  • 14. Anti-psychotics-MOA •Neuroleptics •Block D2 receptors in brain dopamine pathways •Atypical neuroleptics antagonize 5HT2A receptors
  • 15. Adverse Effects •Parkinson’s syndrome •Akathisia •Acute dystonic reactions •Tardive dyskinesia •Seizures •Weight gain •Infertility •Loss of libido •Impotence & infertility in men
  • 16. •Act on GABA receptors •Binding results in opening chloride channels & increased chloride conductance •Influx of chloride ions causes a small hyper- polarization therefore inhibiting the formation of action potential
  • 17.
  • 18. •Drowsiness and confusion: most common side effects •Ataxia at high doses •Cognitive impairment, early morning insomnia
  • 19. Some Brand Names Antipsychotics •Largectil, Flunox, Pride, Clopenia, clopixol, Clozepin, Olenaz, Ozapine, Rizdon, Zaydon, Motival
  • 20. Some Brand Names Benzodiazepines •Calm, Restoril, Siesta, Zolp, Somnia, Clonexa, Alloram, Alp, Alpram, Enzo, Xanax, Zenith, Lexotanil, Freedom, Relaxin, Diazepam, Diazen, Valium, Ativan, Tranquil
  • 22. Dementia •Not a specific disease •Group of symptoms affecting thinking & social abilities severe enough to interfere with daily functioning. •Alzheimer's disease is most common cause
  • 23. Dementia •Gradual memory loss •Impaired judgment or language, and the inability to perform some daily activities •Changes in personality and social behavior •Some causes are treatable and even reversible
  • 24. Symptoms • Difficulty communicating, performing complex tasks, planning and organizing • Difficulty with coordination and motor functions • Problems with orientation, such as getting lost • Personality changes, inappropriate behavior • Paranoia, Agitation, Hallucinations
  • 25. Risk factors • Age. Increases (especially after 65, not a normal part of aging), can occur in younger people. • Family history. • Down syndrome. By middle age, many with Down syndrome develop plaques and tangles in brain that are associated with Alzheimer's • Diabetes. increased risk • High estrogen levels. years after menopause, greater risk • Obesity. Being overweight or obese during the middle life may increase risk
  • 26. Risk factors • Alcohol use. heavy alcohol consumption may have a higher risk • Atherosclerosis. buildup of fats other substances in artery walls can reduce the blood flow to brain and lead to stroke. Reduced blood flow to brain can also cause vascular dementia • Blood pressure. high or low both may increase risk. • Cholesterol. high levels of LDL cholesterol, may have an increased risk of developing vascular dementia or Alzheimer's disease • Depression. not yet well understood, late-life depression, especially in men, may be an indication for the development of Alzheimer's-related dementia.
  • 27. Dementia-causes-Reversible • D= Drugs, Delirium • E=Emotions (such as depression) and Endocrine Disorders • M=Metabolic Disturbances • E=Eye and Ear Impairments • N=Nutritional Disorders • T=Tumors, Toxicity, Trauma to Head • I=Infectious Disorders • A=Alcohol, Arteriosclerosis
  • 28. Dementia-causes • Irreversible: • Alzheimer • Lewy Body Dementia • Pick’s Disease (Fronto-temperal Dementia) • Parkinson’s disease • Huntington’s Disease • Jacob-Cruzefeldt Disease
  • 29. Normal vs AD Brain Normal brain Alzheimer’s brain
  • 30. Related Drugs • Acetylcholine esterase inhibitor- Donezipil, Galantamine • Benzodiazepines • Antiepileptics- Sodium Valporate, Oxcarbezapine • Parasympathomimetic- Rivastigmine • Glutametargic receptor antagonist- Memantine • SSRI- Sertraline
  • 31. Donepezil • Used to delay or slow the symptoms of AD in mild, moderate and severe AD • Loses its effect over time • Does not prevent or cure AD
  • 32. Citalopram • Used to reduce depression and anxiety • May take 4 to 6 weeks • Sometimes used to help to sleep
  • 33. Rivastigmine • Used to delay or slow the symptoms of AD • Loses its effect over time
  • 34. Sodium Valproate • Used to treat severe aggression • Also used to treat depression and anxiety
  • 35. Sertraline • Used to reduce depression and anxiety • May take 4 to 6 weeks • Sometimes used to help people get to sleep
  • 36. Oxcarbazepine • Used to treat severe aggression • Also used to treat depression and anxiety
  • 37. Psychologist Role Required for both patient & family • Crisis intervention counseling • Individual counseling • Family therapy • Group therapy • Institutionalization
  • 39. Differences between delirium and dementia include: • Delirium occurs within a short time, while dementia usually begins with relatively minor symptoms that gradually worsen over time. • Inability to stay focused or maintain attention is significantly impaired with delirium • A person in the early stages of dementia remains generally alert
  • 40. •Delirium symptoms can fluctuate significantly and often throughout the day •People with dementia, memory and thinking skills stay at a fairly constant level during the course of a day
  • 41. Some Brand Names •Donepizil-- Azenil, Donep, Donecept •Galantamine- -Dementio, Reminyl •Mamantine- -Afdol, Dementin, Mantex •Rivastigmine- -Exelon, Memomax, Zivar •Valproic acid- -Epival, Valprux
  • 42. Yes We Are Done