During Expo Day selected Summit Partners and Sponsors showcased their latest initiatives and solutions. --Dr. Daniel Perez-Marcos, Senior Scientist at MindMaze, presented the MindMotion platform–a series of medical-grade virtual reality solutions for neurorehabilitation. --Alvaro Fernandez. SharpBrains‘ CEO & Editor-in-Chief discussed The State of Brain Health Innovation. --Mark Watson, Co-Director of the Watson Centre for Brain Health, explored latest research and programs for cognitive rehabilitation. Learn more at sharpbrains.com

1. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Expo Day: MindMaze, SharpBrains,
Watson Centre for Brain Health

2. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Sponsors
Expo Day!
8.15am. Charlie Hartwell at The Bridge Builders Collaborative
9am. Dr. Bob Bilder at UCLA
9.30am. Ron Riesenbach at the Canadian Centre for Aging and Brain
Health Innovation (CC-ABHI)
--10am. Break--
10.30am. Dr. Daniel Perez-Marcos at MindMaze
11am. Alvaro Fernandez at SharpBrains
11.30am. Mark Watson at the Watson Centre for Brain Health
--Noon. Lunch break--
1pm. Franck Tarpin-Bernard at Scientific Brain Training (SBT)
1.30pm. Jessica Poulin at the Arrowsmith Program
Expo Day Agenda

3. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Lausanne
Chemin de Roseneck 5
1006 Lausanne,
Switzerland
+41 (0)21 552 0801
Zurich
Technoparkstrasse 1,
Transfer Nord 2023 8005
Zürich,
Switzerland
+41 78 621 87 87
San Francisco
1161 Mission St.
Office 434
San Francisco, CA 94103
+1 (415) 781-5000
MindMotion™ Products:
a series of medical-grade virtual reality
solutions for neurorehabilitation
Daniel Perez-Marcos, Dr.-Ing.

4. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
To unlock human potential through neuro-
technology for learning and recovery
MindMaze’s Mission

5. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
16.9 million strokes per year
worldwide
~4.4M stroke survivors have
motor disabilities; incidence is
growing at 5%/year
~45% require chronic home
rehabilitation
10B$ Neurorehabilitation costs
in US & EU
Loss of Function after Stroke

6. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Rehabilitation Objectives
The ultimate goal of the
rehabilitation is to become
independent.
Rehabilitation should include
functional, activity and social
levels
-WHO

7. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Time is Brain
Time window of recovery
• Recovery of motor function
has been observed to be most
rapid during the first month
after stroke 1
• Ability to recover is highest
within first 15 days post stroke 2
However…
• Stroke onset to rehabilitation
admission interval is 17 days in
average 3
1 Lee et al. 2015
2 Salter, Rehabil Med 2006
3 Roth and Lovell, PM&R 2009
Modified from Ward et al., ACNR 2015;15(4):6-8

8. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Rehabilitation Dose & Intensity
• NICE guidelines call for 45
min of upper limb rehab per
day 1
• Only 9% of hospital units
meet guidelines target for
physiotherapy 2
• Patients spend 48.1% of the
day inactive 3
• Hospitalized patients spend
57% of their time alone in
their bedrooms 4
1 NICE Guidance – Stroke (QS2) 2010
2 UK Sentinel Stroke National Audit Programme, 2015
3 Bernhardt et al., Stroke 2004
4 West & Bernhardt, Stroke Res & Treatm 2012
Guidelines vs. “Real World” Training Time
Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland

9. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
MindMaze’s Continuum of Care
The MindMotion™ Series
Hospitals
Rehabilitation
Centers
(Inpatient)
Outpatient
Rehabilitation Home
ACUTE SUBACUTE CHRONIC

10. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Virtual Reality for Neurorehab
• Personalize medicine
• Motor and cognitive processes
• Ecological & intensive training
• Multisensory feedback
• Real-time rewards
• Enhance motivation

11. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland 11
MINDMOTION™ PRO
Hospital-based solution for early
upper limb rehabilitation
3D Motion
Tracking
Camera
Patient
Screen
for VR-based
exercises
Touch Screen
Rehabilitation
sessions assigned,
stored &
interrogated
Mobile
platform
Adapted to
bedside use

12. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Virtual Reality based Upper LimbNeurorehabilitation
Integrated therapy
Constraint-induced therapy
Mirror therapy
Action observation therapy
Motor imagery
Interactive &
immersive exercises
Increase motivation &
therapy dosage

13. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Rehabilitation is a Very Long Process
• Improvement in chronic
stroke through intensive
training is possible 1
• “Plateau” of recovery is
accentuated by
constraints or reduction in
rehabilitation services 2
1 Page et al., Arch Phys Med & Rehab 2004
2 Demain et al., Disability & Rehab 2006
Recovery continues for months & even
years after an initial, rapid recovery period
(Michaelsen at al., 2006; Wilson, 2010; Nudo,2003, 2013)

14. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
MindMaze’s Continuum of Care
The MindMotion™ Series
MindMotion™
PRO
MindMotion™ GO
ACUTE SUBACUTE CHRONIC
Hospitals
Rehabilitation
Centers
(Inpatient)
Outpatient
Rehabilitation Home

15. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
The Value of MindMotion™GO
 Helps increase training dose
 Enhances patient’s motivation
 Makes the therapy fun
 Tracks progress over time in
context of therapeutic goals
 Helps escape from the
disease
 Enhances re-learning process
 Provides stimulating
environment (problem solving)
 Allows treating more patients
 Increases therapy adherence

16. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
MindMotion™ GO: Virtual Reality Therapeutic games
HandUpper limb Trunk Lower limb

17. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
MindMaze’s Continuum of Care
The MindMotion™ Series
ACUTE SUBACUTE
Track patient journey - eCRF
Data collection from the MindMotion™platform
MindMotion™ PRO
MindMotion™
GO
CHRONIC
Hospitals
Rehabilitation
Centers
(Inpatient)
Outpatient
Rehabilitation Home
MindMotion™
HOME

18. Copyright 2016, All Rights Reserved – MindMaze SA
Lausanne, Switzerland
Lausanne
Chemin de Roseneck 5
1006 Lausanne,
Switzerland
+41 (0)21 552 0801
Zurich
Technoparkstrasse 1
Transfer Nord 2023 8005
Zürich,
Switzerland
+41 (0)78 621 87 87
San Francisco
535 Mission Street
14th Floor
San Francisco, CA 94105
U.S.A
+1 (415) 781-5000
info@mindmaze.com www.mindmaze.com
Thank You!

19. The State of
Brain Health Innovation
Alvaro Fernandez
SharpBrains’ CEO & Editor-in-Chief
December 8th, 2016

23. Next, Portuguese!

25. THE DEMAND

29. THE SUPPLY

36. THE SCIENCE

37. ① Lifelong neurogenesis
and neuroplasticity
② 2010 NIH evidence
review
③ Digital toolkit

39. Source: The SharpBrains Guide to Brain Fitness (second edition)

40. “Be the change
you want to see in the
world” “The best way to
predict the future is to
invent it”
@alvarof
alvaro@sharpbrains.com

41. SARPBRAINS VIRTUAL SUMMIT DECEMBER 8, 2016 41
Mark Watson,
Director,
Watson Centre For Brain Health

42. CURRENT
PARADIGM
IN TBI
RECOVERY
Majority of mild cases recover cognitive functions
(http://www.ninds.nih.gov/disorders/tbi/detail_tbi.htm)
Moderate cases do not and neither do more complicated mild cases
What do we do with cases that do not recover. Currently most seem to
employ compensatory programs to steer around under performing
networks
Challenge this and perhaps improve it through Capacity building:
Cognitive rehabilitation therapy (CRT) is a strategy aimed at helping
individuals regain their normal brain function through an individualized
training program. Using this strategy, people may also learn
compensatory strategies for coping with persistent deficiencies
involving memory, problem solving, and the thinking skills to get
things done. CRT programs tend to be highly individualized and their
success varies. A 2011 Institute of Medicine report concluded that
cognitive rehabilitation interventions need to be developed and
assessed more thoroughly.
(http://www.ninds.nih.gov/disorders/tbi/detail_tbi.htm)
Neuroplasticity = brain change
In learning disabilities the Arrowsmith Program has experienced great results
in increasing cognitive capacities for students with cognitive dysfunctions
WCBH 2016 42
WCBH BEGINS FALL OF 2013
WHILE AT U OF T’S NEURO REHAB
CONFERENCE

43. WCBH 2016 43

44. A PROBLEM
PEOPLE WITH TBI & ABI
POST ACUTE CARE PHASE
Current
Once past acute stage
What long term care is
provided? How much?
Why/why not?
What value could would be
associated if planning,
organizational and memory
function could be regained
following injury?
WCBH
Capacity building cognitive
rehabilitation
Desires to treat cognitive
symptoms
WCBH 2016 44

45. AN INTRODUCTION TO
THE WATSON CENTRE
FOR BRAIN HEALTH:
The Watson Centre for Brain Health’s mission is simple: to
improve the lives of people that have suffered a brain injury
and/or concussion by implementing programs aimed at
increasing capacities so that our clients will have the ability to
live more productive and independent lives.
WCBH 2016

46. OUR PROGRAM- (AP) 37
YRS. OF EXPERIENCE IN
LEARNING DISABILITIES
1. Individualized cognitive testing (AP)
2. Baseline testing results inform individualized program
design.
3. 4-5 days per week 3-3.5 hrs per day
4. Real time data analysis & goal setting (intrinsic)
5. Baseline and 9 month internal program testing to
determine progress
6. Qualitative self report
7. Real time Health Tracking using
WCBH 2016 46

47. LONG TERM REPORTED
COGNITIVE IMPACT OF BRAIN INJURY
HTTP://WWW.TRAUMATICBRAININJURY.NET/FAQS/
Problem solving
Attention and/or executive
funtioning
Learning, both using old
information and learning new
information
Memory loss

48. SELF-REPORTED
IMPOVEMENTS QUALITATIVE
FROM WCBH PARTICIPANTS
(AT 6 MONTH MARK)
Clearer
thinkin
g
Increase
d
memory
&
memory
for
details
Increased
executive
functionin
g/attentio
n
More
outgoing
and
talkative
Increased
understandi
ng in real
time
REPORTED FINDINGS WCBH, 2015
48

49. PRINCIPAL
INVESTIGATOR’S
STATEMENT
Dr. Nazrin Virji-Babul,UBC :
“The most important thing we have learned from the pilot
project using the Arrowsmith intervention/Watson Centre
Program is that the brain has an incredible capacity to
change. What we have seen – even with a small group of
participants – many of whom who had a chronic brain
injury – is that intervention/stimulation can make a
change in the brain and in cognitive/behavioural
function. We still have lots to learn about how to best
target intervention and many questions to answer about
the amount and type of intervention that can lead to most
optimal recovery.”
MORE RESEARCH NEEDS TO BE DONE.
WCBH 2016 49

50. WATSON CENTRE:
SHAPE OF THE DAY
Morning and Afternoon options
3.5 hour program
4 Arrowsmith Cognitive activities (35 minutes each)
1 Exercise period (35 minutes)
1 Nutrition Break (15 minutes)
1 Meditation period (10 minutes)
Assessment of fit:
Our program is for people with ABI 1-2 years
post injury
Participant must meet with our team to assess
their ability to engage in this program .
Program Costs:
• $14,225 for 6-month program (January 2017 to
June 2017)
• $9,800 for the first 3-month program and then
$7,900 for each subsequent 3-month program
(the full programming is assessment not
necessary after the initial program).
We do currently accept MEDICARD from ifinance
for program financing for clients in order to
increase accessibility

51. VISION FOR THE
FUTURE
A world where anyone can return some lost cognitive
function after an injury or illness…
Less stigma surrounding brain injuries
Better understanding of how brains can recover from
injuries and illnesses
More treatment options with increased accessibility to them
Learn more:
www.watsonbrainhealth.com
CONTACT:
MWATSON@WATSONBRAINHEALTH.COM

52. Q&A

53. Thank you to all Participants!

54. Sponsors
Thank you to all Speakers & Sponsors!

55. To learn more, visit sharpbrains.com