12. http://www.vetmed.ucdavis.edu/viruses/download.html
Coronavirus. Mouse hepatitis virus,
strain MHV-S/CDC. This virus, formerly
called "lethal intestinal virus of infant mice"
(LIVIM), is the etiologic agent of a lethal
enteritis, the most important disease of
infant laboratory mice [see Hierholzer JC,
Broderson JR, Murphy FA. New strain of
mouse hepatitis virus as the cause of lethal
enteritis in infant mice. Infect Immun. 1979
May;24(2):508-22.]. This is an ultra -- thin
section of the small intestine of an infant
mouse at two days post-infection when the
mouse was moribund. Virions have
accumulated upon the plasma membrane
of this intestinal epithelial cell as a result of
transport from sites of virion production in
the endoplasmic reticulum and exocytosis
via membrane fusion -- the virions then
stick to the outer surface of the cell.
Magnification approximately x40,000.
Micrograph from F. A. Murphy, School of
Veterinary Medicine, University of
California, Davis.
13. http://www.vetmed.ucdavis.edu/viruses/download.html
Human adenovirus 5. This
is an ultra-thin section of an
infected cell in a culture.
Adenoviruses replicate in the
nucleus of cells and as seen
here they may reach
extraordinary concentrations.
When isometric particles are
crowded together they form
six-fold, three-dimensional
arrays—when such arrays
are sectioned one sees
various planes of section
because the
pseudocrystalline array is not
perfect. Magnification:
approximately x80,000.
Micrograph from F. A.
Murphy, School of Veterinary
Medicine, University of
California, Davis.
18. Figure 1. Leading causes of death worldwide. Nearly 15 million (>25%) of the 57 million annual deaths
worldwide are caused by infectious disease
Fauci AS, Touchette NA, Folkers GK. Emerging infectious diseases: a 10-year perspective from the National Institute of Allergy and
Infectious Diseases. Emerg Infect Dis [serial on the Internet]. 2005 Apr [date cited]. Available
fromhttp://wwwnc.cdc.gov/eid/article/11/4/04-1167.htm
