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Anti Tussives.pptx

  1. Archana B Chavhan M.Pharm (QA) KYDSCT’s College of Pharmacy, Sakegaon
  2. Mechanism of coughing Mucus coat cilia Mucus in goblet cell Basement membrane Blood vessels epithelium Mucus membrane Triggers of cough • Histamine release • Foreign body Vagus nerve Efferent nerve fibres Effector muscles • Laryngeal muscles • Bronchial smooth muscles Cough Reflex
  3. • Tussis or coughing is a complex physiological reflex that can be somewhat simplified by following mechanism Motor efferent to larynx and chest
  4. Respiratory infections Chronic obstructive pulmonary disease Asthma Lung cancer Gastro intestinal reflux Bronchitis
  5. The drug which are used to suppress cough or enhance removal of sputum. Anti Tussives Vasaka leaves Tolu balsam
  6. Synonyms:- Adhatada, adulsa Biological source:- It consists of dried as well as fresh leaves of the plant Adhatoda vasica Family: Acanthaceae Chemical Constituents: 1. Vasaka leaves contain quinazoline alkaloids such as vasicine, vasicinone and 6-hydroxy vasicine. 2. It also contain volatile oil, betain and vasakine and Adhatoda acid. vasicine.
  7. Therapeutic Uses: 1. The leaves of vasaka are used to treat cough, asthma, fever, tuberculosis, piles, jaundice, bleeding gum. 2. It is also used as an expectorant. 3. It has ability of bronchodilator. 4. The extract of leaves, bark and flower is used to treat bronchial, asthmatic and pulmonary affection. 5. It has anthelmintic property. 6. It has property of sedative, antispasmodic, anti- inflammatory, antidiabetic 7. It is used to treat leprosy, blood disorders, heart troubles, thirst, vomiting. 8. Its decoction has ability to treat cold and rheumatism
  8. Synonyms: Tolu Balsam; Thomas balsam; opobalsam; resin tolu; balsam of tolu Biological Source: Tolu Balsam is obtained by incision of stem of Myroxylon balsamum (L.) Harms., belonging to family Leguminosae. Morphological characters: Color: yellowish-brown or brown, odour :aromatic Taste: aromatic vanilla like It is insoluble in water and petroleum ether; soluble in alcohol, benzene, Chemical Constituents: 1. Tolu Balsam contains resin (80%) 2. Volatile oil (7.8%) – Benzyl benzoate; 3. Free organic acid – Cinnamic acid and Benzoic acid (8%) 4. It is also contains esters such as, benzyl cinnamate, vanillin, styrene, eugenol, ferulic acid.
  9. 1. To the alcoholic solution of tolu balsam, when a few drops of ferric chloride are added, green colour appears due to the presence of acidic group of benzoic acid and Cinnamic acid. 2. Mix 1 gm of balsam adds 5 ml of potassium permagnate and boil, odour of bitter almond (due to formation of benzaldehyde) is produced. Chemical test
  10. 1. Balsam of Tolu is used as an expectorant, stimulant, and antiseptic. 2. It is an ingredient of cough mixtures and compound benzoin tincture. 3. It is also used as a pleasant flavouring agent in medicinal syrups, confectionery, chewing gums, and perfumery.