Submit Search
Upload
Cell signaling
•
Download as PPT, PDF
•
9 likes
•
2,022 views
A
Aytaj Balakishiyeva
Follow
Cell Signalling molecules and their pathways
Read less
Read more
Science
Report
Share
Report
Share
1 of 38
Download now
Recommended
Second Messenger: cAMP Pathway
Second Messenger: cAMP Pathway
Hotaru Imai
Cell Signaling | Steps Involved | Types | Receptors | Signal Transduction | ...
Cell Signaling | Steps Involved | Types | Receptors | Signal Transduction | ...
Chetan Prakash
Receptor tyrosine kinases.ppt
Receptor tyrosine kinases.ppt
Dr. Khuram Aziz
Signal transduction pathways
Signal transduction pathways
Aamirlone47
Cell communication
Cell communication
aqeel hadithe
Enzyme linked cell surface receptors
Enzyme linked cell surface receptors
FoziyaKhan
Regulation of cell cycle and cell division
Regulation of cell cycle and cell division
physiologistnaidu
Cell surface receptors and signalling molecules
Cell surface receptors and signalling molecules
Anuradha Chimata Venkatakrishnan
Recommended
Second Messenger: cAMP Pathway
Second Messenger: cAMP Pathway
Hotaru Imai
Cell Signaling | Steps Involved | Types | Receptors | Signal Transduction | ...
Cell Signaling | Steps Involved | Types | Receptors | Signal Transduction | ...
Chetan Prakash
Receptor tyrosine kinases.ppt
Receptor tyrosine kinases.ppt
Dr. Khuram Aziz
Signal transduction pathways
Signal transduction pathways
Aamirlone47
Cell communication
Cell communication
aqeel hadithe
Enzyme linked cell surface receptors
Enzyme linked cell surface receptors
FoziyaKhan
Regulation of cell cycle and cell division
Regulation of cell cycle and cell division
physiologistnaidu
Cell surface receptors and signalling molecules
Cell surface receptors and signalling molecules
Anuradha Chimata Venkatakrishnan
Signal transduction
Signal transduction
KAUSHAL SAHU
Cell signaLling
Cell signaLling
Sanju Kaladharan
Cell signalling -
Cell signalling -
aqeel hadithe
Cell Adhesion Molecules(cams) and its types, Cadherins and Integrins and inte...
Cell Adhesion Molecules(cams) and its types, Cadherins and Integrins and inte...
Tahir Ali,Punjab University Lahore
Signal transduction
Signal transduction
Kashyap Kumar
Types of Recombinase
Types of Recombinase
sajal shrivastav
Slideshare second messengers aj
Slideshare second messengers aj
Anu Priya
Second messengers
Second messengers
Athira RG
covalent and electrostatic catalysis
covalent and electrostatic catalysis
sountharya Sen s
Protein sorting and targeting
Protein sorting and targeting
KAUSHAL SAHU
RNA SPLICING
RNA SPLICING
manojjeya
Cyclic amp pathway
Cyclic amp pathway
ssuser3f154a
Cell signaling
Cell signaling
aqeel hadithe
Genetic code and its properties
Genetic code and its properties
Anup Bajracharya
Gene regulation
Gene regulation
Ashfaq Ahmad
Allosteric Inhibition
Allosteric Inhibition
Rachel Jacob
Receptor ppt by kashikant yadav
Receptor ppt by kashikant yadav
Kashikant Yadav
Cell cycle and cell death
Cell cycle and cell death
Vamsi kumar
Topoisomerase
Topoisomerase
aishwarya suresh
MAPK pathway,
MAPK pathway,
Dr. Sandeep Kumar Singh
Cell signaling
Cell signaling
vishwanth555
Cell signaling
Cell signaling
Aytaj Balakishiyeva
More Related Content
What's hot
Signal transduction
Signal transduction
KAUSHAL SAHU
Cell signaLling
Cell signaLling
Sanju Kaladharan
Cell signalling -
Cell signalling -
aqeel hadithe
Cell Adhesion Molecules(cams) and its types, Cadherins and Integrins and inte...
Cell Adhesion Molecules(cams) and its types, Cadherins and Integrins and inte...
Tahir Ali,Punjab University Lahore
Signal transduction
Signal transduction
Kashyap Kumar
Types of Recombinase
Types of Recombinase
sajal shrivastav
Slideshare second messengers aj
Slideshare second messengers aj
Anu Priya
Second messengers
Second messengers
Athira RG
covalent and electrostatic catalysis
covalent and electrostatic catalysis
sountharya Sen s
Protein sorting and targeting
Protein sorting and targeting
KAUSHAL SAHU
RNA SPLICING
RNA SPLICING
manojjeya
Cyclic amp pathway
Cyclic amp pathway
ssuser3f154a
Cell signaling
Cell signaling
aqeel hadithe
Genetic code and its properties
Genetic code and its properties
Anup Bajracharya
Gene regulation
Gene regulation
Ashfaq Ahmad
Allosteric Inhibition
Allosteric Inhibition
Rachel Jacob
Receptor ppt by kashikant yadav
Receptor ppt by kashikant yadav
Kashikant Yadav
Cell cycle and cell death
Cell cycle and cell death
Vamsi kumar
Topoisomerase
Topoisomerase
aishwarya suresh
MAPK pathway,
MAPK pathway,
Dr. Sandeep Kumar Singh
What's hot
(20)
Signal transduction
Signal transduction
Cell signaLling
Cell signaLling
Cell signalling -
Cell signalling -
Cell Adhesion Molecules(cams) and its types, Cadherins and Integrins and inte...
Cell Adhesion Molecules(cams) and its types, Cadherins and Integrins and inte...
Signal transduction
Signal transduction
Types of Recombinase
Types of Recombinase
Slideshare second messengers aj
Slideshare second messengers aj
Second messengers
Second messengers
covalent and electrostatic catalysis
covalent and electrostatic catalysis
Protein sorting and targeting
Protein sorting and targeting
RNA SPLICING
RNA SPLICING
Cyclic amp pathway
Cyclic amp pathway
Cell signaling
Cell signaling
Genetic code and its properties
Genetic code and its properties
Gene regulation
Gene regulation
Allosteric Inhibition
Allosteric Inhibition
Receptor ppt by kashikant yadav
Receptor ppt by kashikant yadav
Cell cycle and cell death
Cell cycle and cell death
Topoisomerase
Topoisomerase
MAPK pathway,
MAPK pathway,
Viewers also liked
Cell signaling
Cell signaling
vishwanth555
Cell signaling
Cell signaling
Aytaj Balakishiyeva
Cell signaling, regulating mechanism and structure
Cell signaling, regulating mechanism and structure
GunJee Gj
Cell signaling transduction mechanisms
Cell signaling transduction mechanisms
jlquinonesrivera
Cell signaling -_introduction[1]
Cell signaling -_introduction[1]
Dilip Pandya
Cell signaling
Cell signaling
Ashish Kelwa
Introduction of cell signaling
Introduction of cell signaling
Central University of Gujarat, Gandhinagar
Customer Review For EphA2 Polyclonal Antibody (STJ92940)
Customer Review For EphA2 Polyclonal Antibody (STJ92940)
St John's Laboratory Ltd
Mm unit 4point3
Mm unit 4point3
Rai University
Mm unit 3point1
Mm unit 3point1
Rai University
B.Sc. Microbiology/Biotech II Cell biology and Genetics Unit 3 cell transport
B.Sc. Microbiology/Biotech II Cell biology and Genetics Unit 3 cell transport
Rai University
Mm unit 3point2
Mm unit 3point2
Rai University
Cell to Cell Communication in Development
Cell to Cell Communication in Development
Samchuchoo
phosphatases and kinase in cell signalling
phosphatases and kinase in cell signalling
Peyman Ghoraishizadeh
Cell membrane model fall 2015
Cell membrane model fall 2015
Lorraine Stratton
Mm unit 4point1
Mm unit 4point1
Rai University
Recent role of calcium in cell signaling
Recent role of calcium in cell signaling
Dr Muhammad Mustansar
Cell Differentiation
Cell Differentiation
musselburghgrammar
Apoptosis
Apoptosis
joshnamalempati
Seminar- recent advances in apoptosis
Seminar- recent advances in apoptosis
Ekta Jajodia
Viewers also liked
(20)
Cell signaling
Cell signaling
Cell signaling
Cell signaling
Cell signaling, regulating mechanism and structure
Cell signaling, regulating mechanism and structure
Cell signaling transduction mechanisms
Cell signaling transduction mechanisms
Cell signaling -_introduction[1]
Cell signaling -_introduction[1]
Cell signaling
Cell signaling
Introduction of cell signaling
Introduction of cell signaling
Customer Review For EphA2 Polyclonal Antibody (STJ92940)
Customer Review For EphA2 Polyclonal Antibody (STJ92940)
Mm unit 4point3
Mm unit 4point3
Mm unit 3point1
Mm unit 3point1
B.Sc. Microbiology/Biotech II Cell biology and Genetics Unit 3 cell transport
B.Sc. Microbiology/Biotech II Cell biology and Genetics Unit 3 cell transport
Mm unit 3point2
Mm unit 3point2
Cell to Cell Communication in Development
Cell to Cell Communication in Development
phosphatases and kinase in cell signalling
phosphatases and kinase in cell signalling
Cell membrane model fall 2015
Cell membrane model fall 2015
Mm unit 4point1
Mm unit 4point1
Recent role of calcium in cell signaling
Recent role of calcium in cell signaling
Cell Differentiation
Cell Differentiation
Apoptosis
Apoptosis
Seminar- recent advances in apoptosis
Seminar- recent advances in apoptosis
Similar to Cell signaling
Signal transduction ....................
Signal transduction ....................
YashhGoel
Cell Signaling through GCPRs and intracellular receptors.pptx
Cell Signaling through GCPRs and intracellular receptors.pptx
Zeleke Endalew
Cell signaling
Cell signaling
JayaBellad
Signal Transduction.ppsx
Signal Transduction.ppsx
Abreham Degu
Protein phosphorylation, kinases and phosphatases
Protein phosphorylation, kinases and phosphatases
Jeju National University
Biomembrane Signaling Transduction
Biomembrane Signaling Transduction
Abdallah M. Youssof
11- cellcommunication text.ppt
11- cellcommunication text.ppt
MarkAlvinRestan1
overview signaltransductionpathways
overview signaltransductionpathways
ANU RAJ
Endocrine Signaling.ppt
Endocrine Signaling.ppt
Arijit Bhowmik
intracellular receptors ,signaling,transcription factors , nucleic acids
intracellular receptors ,signaling,transcription factors , nucleic acids
Dina Kishor
Hormone (1).pptx
Hormone (1).pptx
RezaAfrisham
Druge target
Druge target
aqeel hadithe
4.ion channels & secondary messengers
4.ion channels & secondary messengers
ANU KUNNATH
Signal Transducer mechanisms
Signal Transducer mechanisms
Koppala RVS Chaitanya
Endo 2 kevin
Endo 2 kevin
Kevin Balda
SIGNAL TRANSDUCTION (1).pptx
SIGNAL TRANSDUCTION (1).pptx
Priyanka Saroj
Lecture7_Signaling2xpg.pdf
Lecture7_Signaling2xpg.pdf
hdthao
4) Signaling, Ola Elgaddar
4) Signaling, Ola Elgaddar
Ola Elgaddar
Chap.11 cellcommunication
Chap.11 cellcommunication
sbarkanic
Signal Transduction Revised
Signal Transduction Revised
MD Specialclass
Similar to Cell signaling
(20)
Signal transduction ....................
Signal transduction ....................
Cell Signaling through GCPRs and intracellular receptors.pptx
Cell Signaling through GCPRs and intracellular receptors.pptx
Cell signaling
Cell signaling
Signal Transduction.ppsx
Signal Transduction.ppsx
Protein phosphorylation, kinases and phosphatases
Protein phosphorylation, kinases and phosphatases
Biomembrane Signaling Transduction
Biomembrane Signaling Transduction
11- cellcommunication text.ppt
11- cellcommunication text.ppt
overview signaltransductionpathways
overview signaltransductionpathways
Endocrine Signaling.ppt
Endocrine Signaling.ppt
intracellular receptors ,signaling,transcription factors , nucleic acids
intracellular receptors ,signaling,transcription factors , nucleic acids
Hormone (1).pptx
Hormone (1).pptx
Druge target
Druge target
4.ion channels & secondary messengers
4.ion channels & secondary messengers
Signal Transducer mechanisms
Signal Transducer mechanisms
Endo 2 kevin
Endo 2 kevin
SIGNAL TRANSDUCTION (1).pptx
SIGNAL TRANSDUCTION (1).pptx
Lecture7_Signaling2xpg.pdf
Lecture7_Signaling2xpg.pdf
4) Signaling, Ola Elgaddar
4) Signaling, Ola Elgaddar
Chap.11 cellcommunication
Chap.11 cellcommunication
Signal Transduction Revised
Signal Transduction Revised
Recently uploaded
Pests of Sunflower_Binomics_Identification_Dr.UPR
Pests of Sunflower_Binomics_Identification_Dr.UPR
PirithiRaju
well logging & petrophysical analysis.pptx
well logging & petrophysical analysis.pptx
zaydmeerab121
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
PirithiRaju
KDIGO-2023-CKD-Guideline-Public-Review-Draft_5-July-2023.pdf
KDIGO-2023-CKD-Guideline-Public-Review-Draft_5-July-2023.pdf
GABYFIORELAMALPARTID1
whole genome sequencing new and its types including shortgun and clone by clone
whole genome sequencing new and its types including shortgun and clone by clone
chaudhary charan shingh university
Science (Communication) and Wikipedia - Potentials and Pitfalls
Science (Communication) and Wikipedia - Potentials and Pitfalls
Dobusch Leonhard
GENERAL PHYSICS 2 REFRACTION OF LIGHT SENIOR HIGH SCHOOL GENPHYS2.pptx
GENERAL PHYSICS 2 REFRACTION OF LIGHT SENIOR HIGH SCHOOL GENPHYS2.pptx
RitchAndruAgustin
Environmental acoustics- noise criteria.pptx
Environmental acoustics- noise criteria.pptx
priyankatabhane
Observation of Gravitational Waves from the Coalescence of a 2.5–4.5 M⊙ Compa...
Observation of Gravitational Waves from the Coalescence of a 2.5–4.5 M⊙ Compa...
Sérgio Sacani
DECOMPOSITION PATHWAYS of TM-alkyl complexes.pdf
DECOMPOSITION PATHWAYS of TM-alkyl complexes.pdf
DivyaK787011
FBI Profiling - Forensic Psychology.pptx
FBI Profiling - Forensic Psychology.pptx
Payal Shrivastava
AZOTOBACTER AS BIOFERILIZER.PPTX
AZOTOBACTER AS BIOFERILIZER.PPTX
Govt. N.P.G College of Science Raipur (C.G)
final waves properties grade 7 - third quarter
final waves properties grade 7 - third quarter
HanHyoKim
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
priyankatabhane
complex analysis best book for solving questions.pdf
complex analysis best book for solving questions.pdf
SubhamKumar3239
How we decide powerpoint presentation.pptx
How we decide powerpoint presentation.pptx
JosielynTars
Combining Asynchronous Task Parallelism and Intel SGX for Secure Deep Learning
Combining Asynchronous Task Parallelism and Intel SGX for Secure Deep Learning
vschiavoni
PLASMODIUM. PPTX
PLASMODIUM. PPTX
Govt. N.P.G College of Science Raipur (C.G)
Forensic limnology of diatoms by Sanjai.pptx
Forensic limnology of diatoms by Sanjai.pptx
kumarsanjai28051
projectile motion, impulse and moment
projectile motion, impulse and moment
donamiaquintan2
Recently uploaded
(20)
Pests of Sunflower_Binomics_Identification_Dr.UPR
Pests of Sunflower_Binomics_Identification_Dr.UPR
well logging & petrophysical analysis.pptx
well logging & petrophysical analysis.pptx
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
KDIGO-2023-CKD-Guideline-Public-Review-Draft_5-July-2023.pdf
KDIGO-2023-CKD-Guideline-Public-Review-Draft_5-July-2023.pdf
whole genome sequencing new and its types including shortgun and clone by clone
whole genome sequencing new and its types including shortgun and clone by clone
Science (Communication) and Wikipedia - Potentials and Pitfalls
Science (Communication) and Wikipedia - Potentials and Pitfalls
GENERAL PHYSICS 2 REFRACTION OF LIGHT SENIOR HIGH SCHOOL GENPHYS2.pptx
GENERAL PHYSICS 2 REFRACTION OF LIGHT SENIOR HIGH SCHOOL GENPHYS2.pptx
Environmental acoustics- noise criteria.pptx
Environmental acoustics- noise criteria.pptx
Observation of Gravitational Waves from the Coalescence of a 2.5–4.5 M⊙ Compa...
Observation of Gravitational Waves from the Coalescence of a 2.5–4.5 M⊙ Compa...
DECOMPOSITION PATHWAYS of TM-alkyl complexes.pdf
DECOMPOSITION PATHWAYS of TM-alkyl complexes.pdf
FBI Profiling - Forensic Psychology.pptx
FBI Profiling - Forensic Psychology.pptx
AZOTOBACTER AS BIOFERILIZER.PPTX
AZOTOBACTER AS BIOFERILIZER.PPTX
final waves properties grade 7 - third quarter
final waves properties grade 7 - third quarter
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
complex analysis best book for solving questions.pdf
complex analysis best book for solving questions.pdf
How we decide powerpoint presentation.pptx
How we decide powerpoint presentation.pptx
Combining Asynchronous Task Parallelism and Intel SGX for Secure Deep Learning
Combining Asynchronous Task Parallelism and Intel SGX for Secure Deep Learning
PLASMODIUM. PPTX
PLASMODIUM. PPTX
Forensic limnology of diatoms by Sanjai.pptx
Forensic limnology of diatoms by Sanjai.pptx
projectile motion, impulse and moment
projectile motion, impulse and moment
Cell signaling
1.
Copyright © 2005
Pearson •http://aimediaserver.com/studiodaily/videoplayer/?src=harvard/harvard.swf&width=640&height=520
2.
Copyright © 2005
Pearson Cell Signaling • General Principles of Cell Signaling – signaling cell => signaling molecule binds to receptor molecule on target cell Signaling Distances: => Four Types of Signaling F.16-3 • Endocrine • Paracrine • Neuronal • Contact Dependent • T16-1 • testosterone, • TGF-b, acetylcholine, • Delta
3.
Copyright © 2005
Pearson Cell Signaling • Receptor: – Each Target Cell Responds to Limited Set of Signals (origin of complexity) – Must have receptor molecule for the signaling molecule (thousands of receptors) – Different receptors for same signal on different cells F16-5 A & C or F16-5 B & C •
4.
Copyright © 2005
Pearson Cell Signaling • Intracellular Signaling Pathways: – Same receptor molecule can interact w/many intracellular relay systems so same signal & same receptor => different effects in different cells F16-5A & B – Same relay system many act on many different intracellular targets F16-7
5.
Copyright © 2005
Pearson Cell Signaling • Target Cell Action: Depends upon ---- F16-6 – Signals That are Present – Receptors That Target Cell Synthesizes – Intracellular Relay Systems = Signaling Cascades That Target Cell Synthesizes – Intracellular Targets That Target Cell Synthesizes F16-8 • Any target cell type at any one time has only a subset of all possible – Receptors, – Intracellular Relay Systems, – Intracellular Targets
6.
Copyright © 2005
Pearson 16_06_extracellular_sig.jpg
7.
Copyright © 2005
Pearson 16_08_cascades.jpg
8.
Copyright © 2005
Pearson Cell Signaling • Signaling Cascades: Critical Functions • pp. 539 & 540 • (be able to apply each function to components of the signaling cascades we study) • Transduce Signal • Relay signal from point of reception to point of response production • Amplify F16-29 • Distribute signal to >1 process simultaneously • Modulate signal to fit other internal & external conditions
9.
Copyright © 2005
Pearson 16_29_amplifies_light.jpg
10.
Copyright © 2005
Pearson Cell Signaling • Extracellular Signaling Molecules: • Two Types of Extracellular Signaling Molecules • Based on Ability to Cross Plasma Membrane F.16-9 • Cross Plasma Membrane (hydrophobic) – NO directly activate intracellular enzymes F16-10 • vascular endothelial cells release NO • activates guanyl cyclase in smooth muscle => relaxation => vasodilation • guanyl cyclase: GTP = cGMP • nitroglycerine, erection, Viagra (blocks cGMP reakdown) – Steroid Hormones F16-11 & 12 •
11.
Copyright © 2005
Pearson 16_09_molecules_bind.jpg
12.
Copyright © 2005
Pearson 16_10_Nitric_oxide.jpg
13.
Copyright © 2005
Pearson 16_11_phobic_hormone.jpg
14.
Copyright © 2005
Pearson 16_12_cortisol.jpg
15.
Copyright © 2005
Pearson Cell Signaling • Ligand for Cell Surface Receptor • (hydrophilic: don’t cross plasma membrane) F16-1 – Ion-Channel-Linked Receptors F16-14A • convert chemical to electrical signals – G-protein-linked Receptors F16-14B, & F16-17 • ligand binding => G-Protein activation by exchange bound GDP for GTP • Common structure = 7-pass membrane protein F16-16 – Enzyme-Linked Receptors F16-14C
16.
Copyright © 2005
Pearson 16_14_3_basic_classes.jpg
17.
Copyright © 2005
Pearson 16_13_receptor_protein.jpg
18.
Copyright © 2005
Pearson Cell Signaling • Intracellular Signaling Molecules – Many are Molecular Switches – switched on by signaling molecule, must also be turned off • Most common switching mechanisms T16-2 nicotine, morphine & heroin – phosphorylation F16-15A – signal activated kinase; – dephosphorylation – phosphatase – GTP binding proteins: F16-15B – GDP bound = inactive, – GTP bound = active
19.
Copyright © 2005
Pearson Cell Signaling G-Protein Linked Receptors • Largest family of cell-surface receptors – 100s of members • 7-pass Transmembrane Proteins F16-16 • Ligand binding Activates G-Protein subunits F16-17 Inactivated by hydrolysis of its own bound GTP F16-18 cholera toxin prevents this; G protein stays on => water & ion loss
20.
Copyright © 2005
Pearson 16_18_Gprot_subunit.jpg
21.
Copyright © 2005
Pearson Cell Signaling G-Protein Linked Receptors • Action mechanisms – Some regulate ion channels F16-19 • Some activate membrane-bound enzymes => increase “2nd messengers” F16-20 – 2nd messenger = cAMP F16-24 • adenyl cyclase => ATP to cAMP cAMP phosphodiesterase => cAMP to ATP cAMP dependent protein kinase activation by Camp cAMP => both rapid and slow responses F16-23 – 2nd messengers = IP3 & DAG phospholipase c => IP3 & DAG F16-25 IP3 => opens ER Ca+2 channels . >>>> cytoplasmic Ca+2. > free Ca+2 => many effects DAG (w free Ca+2) => activated PKC to inner face of membrane activated PKC => many effects – 2nd messenger = Ca+2 free Ca+2 => many effect via Ca+2 binding proteins e.g. calmodulin & calmodulin dependent protein kinases
22.
Copyright © 2005
Pearson Some regulate ion channels
23.
Copyright © 2005
Pearson Some activate membrane-bound enzymes => increase “2nd messengers”
24.
Copyright © 2005
Pearson 2nd messenger = cAMP
25.
Copyright © 2005
Pearson 2nd messenger = cAMP
26.
Copyright © 2005
Pearson 16_23_slowly_rapidly.jpg
27.
Copyright © 2005
Pearson 2nd messengers = IP3 & DAG
28.
Copyright © 2005
Pearson Cell Signaling Enzyme Linked Receptors • Transmembrane proteins • cytoplasmic domain is enzyme or interacts w enzyme • When ligand is soluble signaling protein, action usually gene regulation – slow • Receptor Tyrosine Kinases (= RTK) – Ligand binding => – dimerization of RTK subunits => – activate kinase activity => – binding of intracellular signaling proteins F16-30 – protein phosphatases remove P from RTK • Intracellular signaling proteins include – a phospholipase that, like PLC, activates IP3 pathway – a PI 3-kinase that PO4s membrane IPLs, then bind other signaling proteins – Ras: important in loss of control of cell division, & thus in cancer
29.
Copyright © 2005
Pearson Cell Signaling Enzyme Linked Receptors • All RTKs Activate Ras – Ras = One of lg family of monomeric GTP Binding Proteins F16-31 • NOT trimeric like G protein • resembles a subunit of trimeric G proteins • Activated by binding GTP • Inactivated by hydrolysis of its own bound GTP • Activated Ras activates MAP kinase phosphorylation cascade F16-32 • Effect of inactivating Ras => cell ignores signals to divide • Effects of permanent activation of Ras => cell acts as if constantly receiving mitogens • Mutant Ras in cancer cells (~30% of all human cancers have mutant) => constantly “on”
30.
Copyright © 2005
Pearson 16_31_active_Ras.jpg
31.
Copyright © 2005
Pearson 16_32_MAP-kinase.jpg
32.
Copyright © 2005
Pearson 16_34_Ras_transmits.jpg
33.
Copyright © 2005
Pearson Cell Signaling Enzyme Linked Receptors • Some activate fast track to the nucleus – Cytokines & a few hormones – JAK-STAT Pathway • Receptor kinase activation => activation & translocation to nucleus of latent gene regulatory proteins held at plasma membrane F16-36 – SMAD Pathway F16-37 • RTKs of the TGF-b superfamily – important in animal development – Auto phosphorylation => recruits & activates a SMAD, which releases, binds a different SMAD, move to nucleus & takes part in regulating gene activity
34.
Copyright © 2005
Pearson 16_36_Cytokine_recpt.jpg
35.
Copyright © 2005
Pearson 16_37_TGF_B_receptor.jpg
36.
Copyright © 2005
Pearson Cell Signaling• SIGNALING PATHWAYS CAN BE HIGHLY INTERCONNECTED F16-38 • (like nerve networks in brain or microprocessors in a computer) • “... a major challenge to figure out how cell communication pieces fit together to allow cells to integrate environmental signals and to respond appropriately”
37.
Copyright © 2005
Pearson 16_38_Signal_pathways.jpg
38.
Copyright © 2005
Pearson 16_39_integrate_signal.jpg
Editor's Notes
<number>
16_06_extracellular_sig.jpg
16_08_cascades.jpg
16_29_amplifies_light.jpg
16_09_molecules_bind.jpg
16_10_Nitric_oxide.jpg
16_11_phobic_hormone.jpg
16_12_cortisol.jpg
16_14_3_basic_classes.jpg
16_13_receptor_protein.jpg
16_18_Gprot_subunit.jpg
16_19_open_K_chan.jpg
16_20_second_messeng.jpg
16_21_Cyclic_AMP.jpg
16_24_cAMP_activate.jpg
16_23_slowly_rapidly.jpg
16_25_PhospholipaseC.jpg
16_31_active_Ras.jpg
16_32_MAP-kinase.jpg
16_34_Ras_transmits.jpg
16_36_Cytokine_recpt.jpg
16_37_TGF_B_receptor.jpg
16_38_Signal_pathways.jpg
16_39_integrate_signal.jpg
Download now