1. INNOVATIONS IN
PHARMACEUTICAL
INDUSTRY

2. INNOVATION
o Defined as the idea which must be replicable at an economic cost and must
satisfy specific need.
o Involves applications of information, imagination and initiative in deriving
greater or different values from resources.
o It includes all processes by which new idea generated and converted into useful
products.

3. 3D PRINTING
What is 3D Printing of Drugs?
Three-dimensional (3D) printing of drugs uses computer-aided designs to
manufacture individualized pharmaceutical drug products.
The USFDA approved an epilepsy medicine called spritam introduced by Aprecia
pharmaceutical company.
TECHNOLOGY:-
o Inkjet based fabrication
o Direct-write
o ZipDose®
o Thermal Inkjet printing
o Stereolithography (SLA)
o Fused deposit modeling (FDM).

4. ZIPDOSE TECHNIQUE:-

5. What is the Purpose of 3D Printing of Pharmaceuticals?
o To develop medications with controlled release of drugs & fixed-dose
combinations.
o 3D bio-printed human models, tissues or organs are being used in oncology therapy
to develop newer anti-cancer drugs. Use of these models would help formulate
anti-cancer drugs quickly.
Advantages:-
o Small batches can be manufactured
o Hospitals could manufacture small batches on-demand, eliminating the need to
maintain an extensive inventory of generic formulations
o There is no need to provide extended shelf life for a product

6. mHealth Sensors
o mHealth sensors are used in the practice of medicine supported by mobile
devices.
o Can be monitored with the health and physiological data without visiting
doctor.
o Patient-compliance is more.
o World’s first Virtual Care Center– Mercy Virtual Center

7. Types
• Wearable
Sensors
• Wireless
sensor
networks
• eHealth
• wBAN
Uses
• Pulse rate
check
• Detection
of diseases
• Monitoring
• Fitness
check
Advantages
• Connect
with
patients
• Complete
records
• Immediate
updates

8. Organ-on-chip Technology
o Emulate developed organ-on-chip technology, which has created a new living
system that emulates a human biology.
o It has been done to understand the diseases, medicines, and food affect the
human health.
o The main motive to develop this technology is to provide more predictive and
useful measures of safety and efficacy of new drug or drug combination and
also to reduce use of animals and humans in testing.
o Company has developed working models on liver, lung, intestine and brain.

9. o Translucent polymer chip models, about the size of a AA battery, could provide
drug candidate safety data with greater speed and accuracy.
o On 11 April 2017 FDA Signs Collaborative Agreement with Emulate, to Use
Organs-on-Chips Technology as a Toxicology Testing Platform for
Understanding How Products Affect Human Health and Safety.
o In human chip, we simply recreate the environment required for the particular
organ.

10. Design of different organ chips

11. MALACIDINS
o New class of antibiotic discovered in Rockefeller University, New York
o Used DNA information that encodes production of antibiotic in daptomycin
o Active against multidrug – resistant pathogens, Staphylococcus aureus (MRSA) skin
infections

12. Culture Independent Strategy:
Figure: Using a culture – independent strategy for the discovery of malacidins from the global microbiome

13. TruMedicine
Drug and pill packet tracking app
o Pattern Image Recognition
Tru Medicines uses advanced Image Edge Neural Network processing to
identify Billions of registered pill images. Method protected by U.S. and
International Patents.
o FDA Guidance
2011 Oct FDA guidance recommends the use
of colored excipients for identification and
prevention of counterfeiting.
o High Speed Cameras
To verify quality of pills and capsules in 2,500 production lines. 360
degree photos 2,000/min., 100%inspection, images uploaded to cloud
databases

14. o Opioid Treatment Tracking
Compliance with drug treatment programs can monitor hundreds of
patients at a fraction of the cost of traditional 30 day in-service treatment
programs. Stops Relapse
o Deep pill open Source API
TruMedicines open source API interface allows 3rd party developers to
integrate image recognition into hardware; Pill Packaging, Smart Pill
dispensers, etc.

15. Track billons of
pills or pill packets
instantly using GPS
It helps
to recalls
product
within
24 hr
Combine
power of
machine
learning image
recognition

16. References
o https://www.omicsonline.org/open-access/3d-printing-technology-in-
o http://www.rroij.com
o https://mhealthintelligence.com
o Straus, S.K. & Hancock, R.E. Mode of action of the new antibiotic for Gram
positive pathogens daptomycin. Biochim. Biophys. Acta 1758, 1215-1223
(2006).
o https://www.nature.com/articles/s41564-018-0110-1