This document discusses the importance of recognizing a "lactate gap" - a discrepancy between lactate levels measured by different analyzers - in diagnosing ethylene glycol poisoning. It describes two cases where patients presented with acidosis but very high lactate levels only on the Radiometer point-of-care analyzer, revealing ethylene glycol toxicity. The author emphasizes that a lactate gap can provide an early diagnosis and avoid delays in critical treatment for ethylene glycol poisoning. He concludes by stressing the importance of using multiple analyzers and considering all diagnostic clues when evaluating unclear causes of acidosis.