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Viviane performs a non-compartmental analysis. She reports the results of her analysis in the following graph: Plasma concentrations on a logarithmic scale Why the terminal slope (ke) cannot be determined? It is known that usually the terminal slope is obtained graphically from the single dose PK profile; and that it takes 3 half-life times and 3-4 points to adequately characterize it..

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Viviane performs a non-compartmental analysis. She reports the results of her analysis in the following graph: Plasma concentrations on a logarithmic scale Why the terminal slope (ke) cannot be determined? It is known that usually the terminal slope is obtained graphically from the single dose PK profile; and that it takes 3 half-life times and 3-4 points to adequately characterize it.

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