1. Dibyendu De, Ph.D.
Phone: 678-474-9358 (Home)
770-330-5849 (Cell)
E-mail: dibyendu122002@yahoo.com
List of Publication
Patent
1. De, D., Khanna, I. K., Pillarisetti, P. Novel Cyclopentapyrimidine Compounds. (Invention disclosure
filed with USPTO 2008; Provisional Patent Application filing is in progress).
2. Alexander, C. W., De, D., Khanna, I. K., Pillarisetti, P. Novel Pyrimidine Derivatives. (Invention
disclosure filed with USPTO 2008; Provisional Patent Application filing is in progress).
3. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Alexander, C., Jennepalli, S. Selective Benzylamine
Derivatives and their Utility as Cholesterol Ester-Transfer Protein Inhibitors. WO 2007/075194 A1.
4. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Alexander, C., Jennepalli, S., Maitra, S., Shanavas, A.
Selective Benzylamine Derivatives and their Utility as Cholesterol Ester-Transfer Protein Inhibitors. EP
2008/1981342 A1.
5. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Maitra, S., Alexander, C. W., Jennepalli, Dager, I.
Novel Benzylamine Derivatives and their utility as Cholesterol Ester-Transfer Protein Inhibitors. US
2007/0015758 A1.
6. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Maitra, S., Alexander, C. W., Jennepalli, Dager, I.
Novel Benzylamine Derivatives as CETP Inhibitors. WO 2006/073973 A2.
7. Player, M. R., Pottorf, R. S., Rentzeperis, D., De, D. Arylidenes for the Treatment of Estrogen Related
Receptor-Alpha Mediated Diseases. WO 2006/019741 A1.
8. Baruah, A., De, D., Khanna, I. K., Pillarisetti, P., Maitra, S., Alexander, C. W., Jennepalli, S.. Novel
Benzylamine Derivatives and their utility as Cholesterol Ester-Transfer Protein Inhibitors. US
2006/0178514 A1.
9. Player, M. R., Pottorf, R. S., Rentzeperis, D., De, D. Use of Estrogen Related Receptor-Modulating Aryl
Ethers. US 2006/0014812 A1.
10. Krogstad, D. J., De, D. Chloroquine Analogs, their Preparation, and Methods of Preventing and Treating
Plasmodial Diseases. WO 1996/40138.
11. De, D., Seth, M., Puri, S. K., Bhaduri, A. P. A process for the Preparation of 3-Arylmethyl-1-(3’-
dimethylaminopropyl)pyrrolidines. EP 1994/562185
Book Chapters
1. De, D., Khanna, I. Recent trends in HDL modulating therapies. Annual Reports in Medicinal Chemistry
2007, 42, 177-191.

2. Dibyendu De Page 2
2. Krogstad, D. J., De, D. Chloroquine: modes of action and resistance, and the activity of chloroquine
analogs. In: Malaria, edited by I. W. Sherman, American Society for Microbiology, Washington, D. C.,
1988, 331-339.
Publication
1. Ramanathan-Girish, S.; Catz, P.; Creek, M. R.; Wu, B.; Thomas, D.; Krogstad, D. J.; De, D.; Mirsalis, J.
C.; Green, C. E. Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats and Cynomolgus
Macaques. International Journal of Toxicology 2004, 23(3), 179-189.
2. Riccio, E. S.; Lee, P. S.; Winegar, R. A.; Krogstad, D. J.; De, D.; Mirsalis, J. C. Genetic toxicology
testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environmental and Molecular
Mutagenesis 2001, 38(1), 69-79.
3. De, D.; Krogstad, D. J. Pd(DIPHOS)2-Catalyzed Cross-Coupling Reactions of Organoborons with Free
or Polymer-Bound Aryl Halides. Organic Letters 2000, 2(7), 879-882.
4. De, D.; Krogstad, D. J.; Mague, J. T. Synthesis and crystal structure of N12
-(7-chloro-4-quinolinyl)-
N1
,N1
-diethyl-1,12-diaminododecane (AQ-40). Journal of Chemical Crystallography 1998, 28(12), 925-
929.
5. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Structure-Activity Relationships for
Antiplasmodial Activity among 7-Substituted 4-Aminoquinolines. Journal of Medicinal Chemistry
1998, 41(25), 4918-4926.
6. De, D.; Byers, L. D.; Krogstad, D. J. Antimalarials: synthesis of 4-aminoquinolines that circumvent
drug resistance in malaria parasites. Journal of Heterocyclic Chemistry 1997, 34(1), 315-320.
7. De, D.; Krogstad, F. M.; Cogswell, F. B.; Krogstad, D. J. Aminoquinolines that circumvent resistance in
Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 1996, 55(6), 579-
583.
8. Mague, J. T.; De, D.; Krogstad, D. J. An intermediate for chloroquine analogs: (E)-2-(4,7-dichloro-2-
quinolinyl)-3-(dimethylamino)-2-propenal. Acta Crystallographica, Section C: Crystal Structure
Communications 1995, C51(7), 1423-5.
9. De, D.; Mague, J. T.; Byers, L. D.; Krogstad, D. J. Synthesis of (E)-2-(4,7-dichloroquinolin-2-yl)-3-
dimethylamino-2-propen-1-al and its use as a synthetic intermediate. Tetrahedron Letters 1995, 36(2),
205-8.
10. De, D.; Bhaduri, A. P.; Milhous, W. K. A novel pyrrolidonoalkaneamine (WR268954) that modulates
chloroquine resistance of Plasmodium falciparum in vitro. American Journal of Tropical Medicine and
Hygiene 1993, 49(1), 113-120.
11. Batra, S.; De, D.; Seth, M.; Bhaduri, A. P. Novel Reformatsky reactions of 3-aryl-methylene-4,5-
dihydrofuran-2(3H)-ones and 4-arylmethyelene-3-methyl-isoxazole-5(4H)-ones. Journal of Chemical
Research 1993, 6, 1228-1238.
12. De, D.; Seth, M.; Bhaduri, A. P. Regioselective reactions of 1,2-dehydroprogesterone: syntheses of
pregnane derivatives as possible contragestational agents. Steroids 1991, 56(4), 189-94.

3. Dibyendu De Page 3
13. De, D.; Seth, M.; Bhaduri, A. P. Regioselective borohydride and Grignard reactions in (E)-3-
(arylmethylene)-2-oxotetrahydrofurans. Synthesis 1990, (10), 956-9.
14. De, D.; Seth, M.; Bhaduri, A. P. Novel synthesis of 6,7-dialkoxy-2,2-dialkyl-3-hydroxyethyl-1,2,3,4-
tetrahydroquinolines. Indian Journal of Chemistry 1990, 29B(1), 70-1.
15. De, D.; Seth, M.; Bhaduri, A. P. Syntheses of substituted aminoalkanes as possible resistance
modulators. Indian Journal of Chemistry 1990, 29B(3), 231-4.
16. De, D.; Seth, M.; Bhaduri, A. P. Synthetic applications of 6-hydroxy-1-arylhexane-1,3-diones. Indian
Journal of Chemistry 1989, 28B(6), 503-6.
17. De, D.; Seth, M.; Chandra, S.; Bhaduri, A. P. Reversal of chloroquine resistance: synthesis and
biological evaluation of substituted alkanolamines and diaminobutanes. Indian Journal of Chemistry
1989, 28B(2), 146-9.
National & International Conference Presentation
1. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Synthesis and antiplasmodial activities of 4-
amino-7-chloroquinoline with a terminal aliphatic N-heterocycle on the side chain. Book of Abstracts,
49th
ASTMH Annual Meeting, Houston, November 2000, 20.
2. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Modified aminoquinolines (AQs) with a terminal
piperidine on the diaminoalkane side chain. Book of Abstracts, 219th
ACS National Meeting, San
Francisco, CA, March 26-30, 2000, MEDI-001.
3. Grimm, D. A.; De, D.; Krogstad, D. J. MALDI-TOF-MS Technique to monitor polyethylene glycol
supported Suzuki coupling for carbon-carbon bond formation. Pittcon 2000, New Orleans, March 2000.
4. De, D.; Krogstad, D. J. Palladium-catalyzed coupling of aryl bromides with aryl boranes, alkenes, and
alkynes to produce byaryls, substituted alkenes, and alkynes. Book of Abstracts, 218th
ACS National
Meeting, New Orleans, Aug. 22-26 (1999), ORGN-595.
5. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Synthesis of long chain unsymmetrical N,N-
dialkyldiaminoalkanes leading to 4-aminoquinolines. Book of Abstracts, 215th
ACS National Meeting,
Dallas, March 29-April 2 (1998), ORGN-319.
6. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Structure and activity relationships of 4-
aminoquinolines against drug-resistant P. Falciparum. Book of Abstracts, 211th
ACS National Meeting,
San Francisco, CA, March 26-30, 2000, MEDI-001.
7. De, D.; Krogstad, F. M.; Cogswell, F. B.; Didier, P. J.; Byers, L. D.; Collins, W. E.; Krogstad, D. J.
Aminoquinolines that overcome drug resistance in plasmodium falciparum in vitro and in vivo. Book of
Abstracts, 211th
ACS National Meeting, New Orleans, LA, March 24-28 (1996), MEDI-018.
8. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Modification of the diaminoalkane side chain and
chloroquine resistance in p. falciparum. Book of Abstracts, 210th
ACS National Meeting, Chicago, IL,
August 20-24 (1995), (Pt. 2), MEDI-215.

4. Dibyendu De Page 4
9. Cogswell, F. B.; Preslan, J.; Spurlock, J. P.; Mack, P. A.; Krogstad, F. M.; De, D.; George, W. J.;
Krogstad, D. J. In vivo safety and antiplasmodial activity of chloroquine (CQ) analogs active against
CQ-resistant P. falciparum in vitro. 44th
ASTMH Annual Meeting, San Antonio, 1995.
10. De, D.; Krogstad, F. M.; Byers, L. D.; Krogstad, D. J. Synthesis of aminoquinoline analogs to define
structure-activity relationships, and identify molecules involved in antiplasmodial action and resistance.
Book of Abstracts, 208th
ACS National Meeting, Washington, DC, 1994, MEDI-045.
11. De, D.; Bhaduri, A. P.; Andersen, S. L.; Rossan, R. N.; Milhous, W. K. Circumvention of chloroquine
resistance by WR 268954, a newly synthesized reversal modulator. 41st
ASTMH Annual Meeting, Seatle,
1992, 198.
12. De, D.; Andersen, S. L.; Gerena, L.; Kyle, D. E.; Oduola, A. M. J.; Milhous, W. K. Antifungals
synergize antimalarials. XIIIth International Congress of Tropical Medicine & Malaria, Pattaya,
Thailand, 1992, Tu05-05.