1. Vth Semesester B. pharmacy
Pharmacognosy and Phytochemistry-II
Unit-I
Basic Metabolic Pathway(Part-3)
(Acetate Pathway)
Presented By :
Miss. Pooja D. Bhandare
(Assistant Professor)
Kandhar College of Pharmacy, Nanded
2. ACETATE PATHWAY
It is also one of the important pathway for the synthesis of different
types of secondary metabolites cells of plant.
Why it is know as acetate pathway?: As starting material utilizes in
this pathway is acetate.
This Acetate is utilize in the form of Acetyl Co-A. As t is the active
form of acetate.
3. Acetate occupy central position in relation to general
metabolism, From this only different metabolic pathway
originated for the biosynthesis of different secondary
metabolites.
Different straight chain compounds and aromatic compounds
get biosynthesized from this acetate by different metabolic
pathway.
4. Acetate pathway have two main route : that means there is
mainly 2 main pathway in which this acetate is utilized a
starting material.
1. Acetate Mevalonate pathway/ Isoprenoid pathway :
Formation of terpenes & steroids.
2. Acetate Melonante Pathway: Formation of Fatty acids
and Polyketides
6. ACETATE MEVOLNATE PATHWAY/ MEVALONIC ACID
PATHWAY/ISOPRENOIDS PATHWAY/ METHYLERYTHRITOL
PATHWAY
Contribute 1/3rd know secondary metabolite
One of the most important intermediate formed or utilized in this pathway is
Mevalonate that is mevalonic acid.
This mevalonate or mevalonic acid i.e intermediate which synthesize in this
pathway, this mevalonate only further used for the synthesis of terpenoids.
Terpenoids are derived from isoprene units which are joined in head-to-tail or
head-to head .
7.
8. The mevalonate pathway are used by nature to prepare Dimethylallyl Pyrophosphate(DMAPP)
and Isopentenyl Pyrophosphate(IPP).
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10.
11. ACETATE MELONANTE PATHWAY
Polyketide constituent a large class of natural products grouped together
on purely biosynthetic pathways.
Their diverse structures can be explained as being derived from poly-β-
keto chains formed by coupling of acetic acid (C2) units via condensation
reactions.
Included in such compounds are fatty acids, polyacetylenes,
prostaglandins, macrolide antibiotics and many aromatic compounds, e.g.,
anthraquinones and tetracyclines.