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Lab Animals in Research
• AALAC
 – http://www.aaalac.org/


• IACUC
 – http://www.iacuc.org/
Lab Animal &
Small Mammal
 Husbandry
Rabbits
   veterinarypartner.com
   www.rabbit.org
CHAPTER   9
Rabbits
Oryctolagus cuniculus
•   Rabbit - not rodent but lagomorph
•   Size range 3 lbs to 20 lbs
•   About 45 different breeds
•   Uses: Meat, fur, research & pets
History of Rabbits
• Fossils date back 30 to 37 million years
• Domestic breeds developed from European
  wild rabbit
  – First reports during 1100 BC
  – Domesticated by French monks in
    Middle Ages
• Became pests in latter 19th century
  – European wilds now flourish
  – Cottontail common in North America
  – http://www.rabbitfreeaustralia.org.au/rabbit_problem.html
    An initial introduction of 24 wild European rabbits in 1859 produced
    an astounding 10 billion rabbits by the 1920’s.
Uses for Rabbits
•   Meat
•   Research
•   Fur/wool (rex, angora)
•   4H / FFA Project animals
•   Pets
Five Rabbit Weight
           Categories
•   Dwarf or miniature
•   Small
•   Medium
•   Large
•   Giant

http://www.arba.net/breeds.htm
Dwarf or Miniature
           Rabbits
•   Britannia Petite
•   Netherland Dwarf
•   Himalayan
•   Dwarf Hotot
•   Polish
•   Jersey Wooly
•   Holland Lop
•   American Fuzzy Lop
•   Mini Rex
Small Rabbits
•   Dutch
•   Tan
•   Florida White
•   Silver
•   Havana
•   Mini Lop (mini refers to ear length, not body size)
Medium Rabbits
•   English Spot          •   Silver Martin
•   Standard Chinchilla   •   Belgian Hare
•   English Angora        •   Rhinelander
•   Satin Angora          •   Harlequin
•   French Angora         •   Sable
•   Lilac                 •   Shorthaired Rex
Large Rabbits
                      • Champagne
                        d’Argent
                      • American
                      • American Chinchilla
•   Beveren
                      • English Lop
•   Californian
                      • New Zealand
•   Hotot
                      • Silver Fox
•   Palomino
•   Satin
•   Cinnamon
•   Creme d’Argent
Giant Rabbits
•   Giant Angora
•   French Lop
•   Checkered Giant
•   Giant Chinchilla
•   Flemish Giant
Breeding

• Male – buck; Female – doe; young – kit
   Process of giving birth – kindling
• Life span: 5 to 8+ years
• Sexual maturity: 4-10 months
• Induced ovulators (like cats)
• Sexual dimorphism
Breeding &
                            Gestation

• ALWAYS take the female to the male’s cage
  for breeding (does cage protective)
• Gestation 29-35 days (4-10 typical litter size)
• Nesting box necessary
• Extremely rich milk, fed 1-2x/day (if not wrinkled,
  if warm & if bunched together it’s being fed)
• Do not disturb doe and kits first 10-14 days
• Weaned at 4-6 weeks
Anatomy
• Continuously
  growing teeth. Two
  pairs of incisors.
• Cecum, like horses:
  hind gut fermenters            • Nictitating membrane
• Cecotrope (a type of             (Third eyelid)
  dropping that is eaten by
  the rabbit directly from the   • Highly vascular ears
  anus and then digested to
  give aa’s, FAs, vitamins
  from low energy foods)         • Fragile spine
Rabbit Housing & Equipment
• Rabbit houses called “hutches”
  – Determined by breed, bigger is better
  – Partial solid floors prevent irritation (pododermatitis
    2nd to poor sanitation / 100% wire flooring)
  – SECURE LID, DOORS
  – Absorbent materials best for litter: pelleted
    paper, pelleted grass (NOT corn cob, walnut shell,
    clay litter)
• Other equipment
  – For feeding: Galvanized-metal self-feeders
  – For water: Ceramic bowls or vacuum-type bottles
http://www.radil.missouri.edu/info/dora/RABBPAGE/mi
s.htm
Rabbit Feeding
• FREE CHOICE grass, oat or timothy hay
• Alfalfa is too high in Ca++ & calories
• Vegetables: 3+ different types daily of dark green / dark
  yellow veggies – kale, dandelion greens, broccoli leaves,
  collard greens, green/yellow peppers
• Commercial pelleted rabbit food – free choice to young,
  measured and limited amount to adults (no >20% of diet)
• Fruit as a treat (no > 1-2 tbsp per 5#/day)
• Particularly when warm: clean, fresh water
  should be abundantly available
Rabbit Maintenance
• Regular (daily ideal) cleaning, sanitation of
  housing / environment
• Nail trimming
• Some require incisor trimming
  (malocclusion)
• Brushing (1-2x/week; daily if long hair)
• May need flea/insect prevention (cat meds /
  doses often used)
Bunny Behavior
• Generally docile disposition
• Noises: occasional panic scream, warning
  growl
• May spray urine if upset (males > females)
• Can be housebroken, harness trained
• Chewers! (make sure hutch is sturdy)
• Not heat tolerant
• Coprophagic
Handling of Rabbits
• Rabbit’s size drives handling method
  – Never pick a rabbit up by the ears
• Approach cage slowly, speaking to rabbit
• Rub rabbit before attempting lifting
  – Place one hand under belly, one behind
  – For large rabbits, use arm for cradling
  – Tuck head under elbow of supporting arm
• Put rabbit down slowly, hind end first
  – Allow rabbit to see where it is going
Restraint
• Never pick up by the ears
• DO scruff behind ears
• Always support the hindquarters!!!
  – Can fracture spine if rear legs kick too hard
    or in awkward position – Delicate!
• Restraint by hypnosis (cradle on its back,
  scruff in hand, rear end supported w/ back
  resting against handler)
• Return to cage hind end first
Injection Sites in Rabbits
• Injection Sites
  – IM: quadriceps
  – SQ, IP also may be used
• Venipuncture sites
  – Marginal ear vein
  – Cephalic vein
  – Lateral saphenous vein
  – Jugular vein
• May require anesthesia for catheter
  placement – delicate veins (delicate skin, too)
                                             26
Rabbit Anesthesia
• Withhold food?
  – When fasting is not recommended in rabbits, it has to with exhausting glycogen
    stores which can lead to hypoglycemia which may cause post-operative ileus.
    When fasting is recommended, it is to decrease stomach volume compressing
    the diaphragm and respiratory space. The inability to vomit is also sometimes
    cited a reason to not require fasting in rabbits.
  – rabbits are unlikely to vomit/regurgitate in the perianesthetic period. I
    usually take the animals off water 1-2 hrs before just in case they will passively
    reflux under anesthesia. Prolonged fasting in rabbits is likely to lead to
    ileus, a common problem in rabbits.

• Must be free from respiratory disease
• Injectable agents
  – Ketamine + Midazolam/Diazepam + Xylazine + Butorphanol (healthy)
  – Midazolam/Diazepam + Butorphanol + Glycopyrrolate (ill/debilitated)
  – Ketamine + Acepromazine, Ketamine + Xylazine
Common Lagomorph
Diseases / Conditions
Common Rabbit Ailments
• Gastrointestinal (anorexia > 24-28h  hepatic lipidosis,
  diarrhea or ileus, no stool)
   – Trichobezoars
   – Bacterial (Tyzzer’s: Clostridium piliformis; other Cl. Sp.),
     coccidia,
   – Dental Malocclusion, tooth root abscess

• Respiratory (Dyspnea, Pneumonia)
   – Heat stress / stroke
   – Bacterial (Pasturella, Pseudomonas, Klebsiella, Bordatella,
     Staphylococcus…) rhinitis, pneumonia, pyothorax
   – Neoplasia (metastasis of uterine adenocarcinoma)
Trichobezoars
           (Hairballs)
• Rabbits are clean and groom frequently
• Diagnosis: Not eaten in 24 hrs, and x-
  rays show food in the stomach
• Treatment: Drugs early on to change
  gut motility, or surgery (50% mortality
  rate)
• Prevention: High fiber diet; hair ball
  medication; frequent brushing
Common Rabbit Ailments
• Neurologic
   – Otitis interna, torticollis (Pasturella, Staphylococcus)
   – Trauma
   – Fungal
   – Toxin (lead)

• Integument
   – Infection, wounds 2nd to poor housing/sanitation
   – Parasites – pruritis – fleas

• Urogenital
   – Uroliths, sludge
   – Dystocia, Mastitis
Pasturella
               (Snuffles)
• Clinical Signs:
  – Discharge from eyes and/or nose
  – Squinting or redness of eyes
  – Otitis  torticollis
  – Abscesses
• Tx: Abx (injection, oral, IN, ocular)
• Many rabbits are chronically infected
Skin Diseases
• Bacterial Infections: Treat with Antibiotics

• Ringworm: Treat with topical medication,
  oral medication or medicated shampoos

• Fleas: Can use products safe on cats
Parasites
• Mange (walking dandruff) – seen as hair loss
  and dandruff Diagnosis by skin scraping
  Treatment- medicated shampoo
• Ear mites: Dark crusty material in ears,
  scratching and shaking head – injectable or
  topical medication
• Coccidia: Fecal testing to find - medication
Cystic Calculi
        (Bladder Stones)
• Clinical Signs:
  Frequent urination, straining to urinate
  Blood in the urine.
• Treatment: Surgical Removal
• Prevention: Increase activity level and
  provide more space, Decrease/remove
  pellets and add fiber, leafy greens to
  diet, plenty of water
Uterine Adenocarcinoma
     and/or pyometra
• Intact (not spayed) female rabbits
• Clinical signs:
   Older female, listless, not eating
• Treatment – exploratory surgery
• Prevention – spay early; If breeding the
  doe, spay when breeding life is done.
Disease Prevention
• Quarantine new rabbits for 30 days
• Reduce stress
• Avoid overcrowding
• Avoid dietary changes, provide
  appropriate & quality diet
• Keep litter clean
Guinea Pigs
  (cavy)
CHAPTER   14
Guinea Pigs
Cavia porcellus
• Guinea Pig Rodent - More closely
  related to porcupines and chinchillas
• Average weight 750 grams
• Eleven breeds for show
History of Guinea Pigs
• Exact history of domestic cavy unknown
  – May come from C. aperea, C. tschudii, or C. fulgida
  – Does not come from Guinea
• Bred for meat production in South America for at
  least 3,000 years
• Brought to Europe in 16th century
• Since mid-1800s, used for pathology, nutrition,
  genetics, and toxicology research, as well as
  serum development
Uses for Guinea Pigs
•   Meat (S. America)
•   Research
•   4H / FFA Project animals
•   Pets
Common Guinea Pig
         Varieties
•   Abyssinian
•   American
•   Peruvian
•   Satin
•   Silkie
•   Teddy
•   White Crested
Abyssinian Guinea Pig
• Rough, wiry hair coat
  – Hair made of rosettes (swirls or cowlicks)
  – More rosettes are desirable
• Found in all colors and color
  combinations
American Guinea Pig
• Most common variety
• Short, very glossy, fine hair
  – Short hair eases care
• Found in widely varied colors and color
  combinations
Peruvian
  Guinea Pig
• Longhaired variety
  – Hair length, evenness, and balance are
    deciding features
  – Hair requires much upkeep (can be 20”
    long)
• Lacks a tail
• Found in many of the colors and color
  combinations as American variety
Satin Guinea Pig
• Fur is distinguishing feature
  – Fine, dense, and soft
  – Luxurious and shiny
• Found in colors and color combinations
  of other varieties
Silky
Guinea Pig
• Longhaired variety
  – Unlike Peruvian, no long frontal sweep
    over head
  – Mane sweeps back from head, between
    ears, over the back, and down the sides
• Sometimes called the Sheltie
• Found in colors and color combinations
  of other varieties
Teddy Guinea Pig
• Short, kinky hair
  – Short, resilient strands
  – Lies thick and close to the body
  – Whiskers also kinked
• Found in colors and color combinations
  of other varieties
White Crested

• Shorthaired variety
  – Resembles American shorthair except
    for crest
  – Crest is white rosette that radiates evenly from
    center of forehead
• Found mainly in self, solid, and
  agouti colors
Characteristics of
           Guinea Pigs
• Physical makeup
   –   Adult length of 8 to 10”, weight of 1 to 2 pounds
   –   Short, stocky build with short legs
   –   Short, blunt, rounded nose
   –   Short ears with little fur
   –   Agouti, self, solid, and marked colors
• Skills
   – Very sensitive hearing
   – Highly developed sense of smell
   – Excellent peripheral vision
• Behaviors
   – Live in colonies or clans
   – One dominant male and 5 to 10 females
Anatomy
• No tail          • Open rooted teeth
• One pair of      • Born with teeth
  mammary glands   • Born with eyes open
• Herbivore        • Heavy body weight
                     for size
                   • Susceptible to
                     Bordatella
Guinea Pig Reproduction
• Average life span 5 years (4-8y)
• Males are boars
• Females are sows
• Polyestrous with spontaneous (induced)
  ovulation
• 1-6 young/litter
Guinea Pig Reproduction
• Sexual maturity
   – Females at 2 months (4-6w)
   – Males at 3 months (9-10w)
• First breeding before female is 6 months / before
  reaching 500 grams body weight (6m old is when
  pelvic symphysis fuses)

   – Pair breeding (monogamous)
   – Colony breeding (polygamous / harem: 1 boar/4-10 sows)
• Gestation period from 56 to 74 days
• Up to 5 litters yearly (2 to 4 average)
• Young fully developed at birth (precocious)
   – Weigh 1½ to 4½ ounces
   – Have open eyes and full fur
   – Running and eating solid food in 24 hours
Desired Qualities of
                Guinea Pig Housing
•   At least 12” x 12” x 12” per adult (double size if breeders)
•   Plastic bottom that is 3 or 4” deep
•   Sides of vertical wire bars or glass
•   Hiding box / area for sleeping
•   Abundant bedding – shavings, shredded paper
    – CLEAN FREQUENTLY
• Heavy glass or earthenware food bowls
• Vacuum-type water bottle
• When housed outside
   – Portable house or run-in (3 square feet/pig)
   – Temperatures above 50°F (55-70 ideal, >80-85 BAD)
Basics of Guinea Pig Feeding
• Sensitive GI system – no rapid diet changes!
• Vegetarian diet – mix of veggies, hay, guinea pig pellets
   – Must consume vitamin C (~0.5mg/kg/day)
   – Vit C deficiencies often from use of old food
• Foods tailored to age/state
   – Young or pregnant pigs: alfalfa pellets and dry alfalfa hay
   – Adults: Clover and grass hay pellets and low-protein dry
     clover and grass hays
• Other food sources
   – Dandelion greens, Romaine or green leaf lettuce (no
     iceberg), kale, carrots, apples, pears, turnips, beets,
     cucumbers
• Constant source of fresh water – clean daily
Basic Care of Guinea Pigs
• Regular grooming
  – Shorthaired: Daily brushing
  – Longhaired: Combing and brushing, clipping
• Occasional bathing
  – Use mild shampoo
  – Avoid chills
• Regular nail clipping
Handling Methods for
       Guinea Pigs
• Acclimation process
  – In new home, allow long exploration time
  – Offer treats (fresh greens, carrots, apples)
  – Pet and lift to overcome shyness
• Lifting technique
  – Grasp firmly around front shoulders with
    one hand, support rear with other
  – Cradle in palm and forearm close to body
Guinea Pig Ailments
•   Respiratory diseases (bacterial, viral pneumonia)
•   Diarrhea (bacterial, diet related enteritis)
•   Dystocia, Toxemia (pregnant females)
•   Integument:
    – Pododermatitis
    – Mites and biting lice
    – Neck swellings (e.g. cervical abscess)
• Overgrown or maloccluded teeth
• Genital-area obstructions – clean area to prevent
Scurvy
• Vitamin C deficiency
  Clinical Signs: anorexia/poor appetite,
  swollen, painful joints and ribs, reluctance to
  move, poor bone and teeth development,
  and spontaneous bleeding especially from
  the gums, into joints, and in muscle.
  Treatment: Supplement with Vitamin C
  injections; Add Vitamin C to water; feed
  fresher food and fresh vegetables
Dystocia & Toxemia
• Must be bred before 6 months of age
• Toxemia seen in obese guinea pigs
  during late pregnancy. Prevention
  includes reducing stress during
  pregnancy and correct diet.
Hyperthermia

• Temperatures over 85 degrees, Humidity
  over 70%, inadequate shade and ventilation,
  overcrowding
  Signs: panting, slobbering, weakness,
  lethargy, convulsions
  Treatment: cool water spray or bath, alcohol
  on foot pads, change environment to prevent
  future episodes

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Lec 19 20 Lab Animal Rabbits And Guinea Pigs

  • 1. Lab Animals in Research • AALAC – http://www.aaalac.org/ • IACUC – http://www.iacuc.org/
  • 2. Lab Animal & Small Mammal Husbandry
  • 3.
  • 4. Rabbits veterinarypartner.com www.rabbit.org
  • 5. CHAPTER 9 Rabbits
  • 6. Oryctolagus cuniculus • Rabbit - not rodent but lagomorph • Size range 3 lbs to 20 lbs • About 45 different breeds • Uses: Meat, fur, research & pets
  • 7. History of Rabbits • Fossils date back 30 to 37 million years • Domestic breeds developed from European wild rabbit – First reports during 1100 BC – Domesticated by French monks in Middle Ages • Became pests in latter 19th century – European wilds now flourish – Cottontail common in North America – http://www.rabbitfreeaustralia.org.au/rabbit_problem.html An initial introduction of 24 wild European rabbits in 1859 produced an astounding 10 billion rabbits by the 1920’s.
  • 8. Uses for Rabbits • Meat • Research • Fur/wool (rex, angora) • 4H / FFA Project animals • Pets
  • 9. Five Rabbit Weight Categories • Dwarf or miniature • Small • Medium • Large • Giant http://www.arba.net/breeds.htm
  • 10. Dwarf or Miniature Rabbits • Britannia Petite • Netherland Dwarf • Himalayan • Dwarf Hotot • Polish • Jersey Wooly • Holland Lop • American Fuzzy Lop • Mini Rex
  • 11. Small Rabbits • Dutch • Tan • Florida White • Silver • Havana • Mini Lop (mini refers to ear length, not body size)
  • 12. Medium Rabbits • English Spot • Silver Martin • Standard Chinchilla • Belgian Hare • English Angora • Rhinelander • Satin Angora • Harlequin • French Angora • Sable • Lilac • Shorthaired Rex
  • 13. Large Rabbits • Champagne d’Argent • American • American Chinchilla • Beveren • English Lop • Californian • New Zealand • Hotot • Silver Fox • Palomino • Satin • Cinnamon • Creme d’Argent
  • 14. Giant Rabbits • Giant Angora • French Lop • Checkered Giant • Giant Chinchilla • Flemish Giant
  • 15. Breeding • Male – buck; Female – doe; young – kit Process of giving birth – kindling • Life span: 5 to 8+ years • Sexual maturity: 4-10 months • Induced ovulators (like cats) • Sexual dimorphism
  • 16. Breeding & Gestation • ALWAYS take the female to the male’s cage for breeding (does cage protective) • Gestation 29-35 days (4-10 typical litter size) • Nesting box necessary • Extremely rich milk, fed 1-2x/day (if not wrinkled, if warm & if bunched together it’s being fed) • Do not disturb doe and kits first 10-14 days • Weaned at 4-6 weeks
  • 17. Anatomy • Continuously growing teeth. Two pairs of incisors. • Cecum, like horses: hind gut fermenters • Nictitating membrane • Cecotrope (a type of (Third eyelid) dropping that is eaten by the rabbit directly from the • Highly vascular ears anus and then digested to give aa’s, FAs, vitamins from low energy foods) • Fragile spine
  • 18. Rabbit Housing & Equipment • Rabbit houses called “hutches” – Determined by breed, bigger is better – Partial solid floors prevent irritation (pododermatitis 2nd to poor sanitation / 100% wire flooring) – SECURE LID, DOORS – Absorbent materials best for litter: pelleted paper, pelleted grass (NOT corn cob, walnut shell, clay litter) • Other equipment – For feeding: Galvanized-metal self-feeders – For water: Ceramic bowls or vacuum-type bottles
  • 20. Rabbit Feeding • FREE CHOICE grass, oat or timothy hay • Alfalfa is too high in Ca++ & calories • Vegetables: 3+ different types daily of dark green / dark yellow veggies – kale, dandelion greens, broccoli leaves, collard greens, green/yellow peppers • Commercial pelleted rabbit food – free choice to young, measured and limited amount to adults (no >20% of diet) • Fruit as a treat (no > 1-2 tbsp per 5#/day) • Particularly when warm: clean, fresh water should be abundantly available
  • 21. Rabbit Maintenance • Regular (daily ideal) cleaning, sanitation of housing / environment • Nail trimming • Some require incisor trimming (malocclusion) • Brushing (1-2x/week; daily if long hair) • May need flea/insect prevention (cat meds / doses often used)
  • 22. Bunny Behavior • Generally docile disposition • Noises: occasional panic scream, warning growl • May spray urine if upset (males > females) • Can be housebroken, harness trained • Chewers! (make sure hutch is sturdy) • Not heat tolerant • Coprophagic
  • 23. Handling of Rabbits • Rabbit’s size drives handling method – Never pick a rabbit up by the ears • Approach cage slowly, speaking to rabbit • Rub rabbit before attempting lifting – Place one hand under belly, one behind – For large rabbits, use arm for cradling – Tuck head under elbow of supporting arm • Put rabbit down slowly, hind end first – Allow rabbit to see where it is going
  • 24. Restraint • Never pick up by the ears • DO scruff behind ears • Always support the hindquarters!!! – Can fracture spine if rear legs kick too hard or in awkward position – Delicate! • Restraint by hypnosis (cradle on its back, scruff in hand, rear end supported w/ back resting against handler) • Return to cage hind end first
  • 25.
  • 26. Injection Sites in Rabbits • Injection Sites – IM: quadriceps – SQ, IP also may be used • Venipuncture sites – Marginal ear vein – Cephalic vein – Lateral saphenous vein – Jugular vein • May require anesthesia for catheter placement – delicate veins (delicate skin, too) 26
  • 27. Rabbit Anesthesia • Withhold food? – When fasting is not recommended in rabbits, it has to with exhausting glycogen stores which can lead to hypoglycemia which may cause post-operative ileus. When fasting is recommended, it is to decrease stomach volume compressing the diaphragm and respiratory space. The inability to vomit is also sometimes cited a reason to not require fasting in rabbits. – rabbits are unlikely to vomit/regurgitate in the perianesthetic period. I usually take the animals off water 1-2 hrs before just in case they will passively reflux under anesthesia. Prolonged fasting in rabbits is likely to lead to ileus, a common problem in rabbits. • Must be free from respiratory disease • Injectable agents – Ketamine + Midazolam/Diazepam + Xylazine + Butorphanol (healthy) – Midazolam/Diazepam + Butorphanol + Glycopyrrolate (ill/debilitated) – Ketamine + Acepromazine, Ketamine + Xylazine
  • 29. Common Rabbit Ailments • Gastrointestinal (anorexia > 24-28h  hepatic lipidosis, diarrhea or ileus, no stool) – Trichobezoars – Bacterial (Tyzzer’s: Clostridium piliformis; other Cl. Sp.), coccidia, – Dental Malocclusion, tooth root abscess • Respiratory (Dyspnea, Pneumonia) – Heat stress / stroke – Bacterial (Pasturella, Pseudomonas, Klebsiella, Bordatella, Staphylococcus…) rhinitis, pneumonia, pyothorax – Neoplasia (metastasis of uterine adenocarcinoma)
  • 30. Trichobezoars (Hairballs) • Rabbits are clean and groom frequently • Diagnosis: Not eaten in 24 hrs, and x- rays show food in the stomach • Treatment: Drugs early on to change gut motility, or surgery (50% mortality rate) • Prevention: High fiber diet; hair ball medication; frequent brushing
  • 31.
  • 32. Common Rabbit Ailments • Neurologic – Otitis interna, torticollis (Pasturella, Staphylococcus) – Trauma – Fungal – Toxin (lead) • Integument – Infection, wounds 2nd to poor housing/sanitation – Parasites – pruritis – fleas • Urogenital – Uroliths, sludge – Dystocia, Mastitis
  • 33.
  • 34. Pasturella (Snuffles) • Clinical Signs: – Discharge from eyes and/or nose – Squinting or redness of eyes – Otitis  torticollis – Abscesses • Tx: Abx (injection, oral, IN, ocular) • Many rabbits are chronically infected
  • 35. Skin Diseases • Bacterial Infections: Treat with Antibiotics • Ringworm: Treat with topical medication, oral medication or medicated shampoos • Fleas: Can use products safe on cats
  • 36. Parasites • Mange (walking dandruff) – seen as hair loss and dandruff Diagnosis by skin scraping Treatment- medicated shampoo • Ear mites: Dark crusty material in ears, scratching and shaking head – injectable or topical medication • Coccidia: Fecal testing to find - medication
  • 37. Cystic Calculi (Bladder Stones) • Clinical Signs: Frequent urination, straining to urinate Blood in the urine. • Treatment: Surgical Removal • Prevention: Increase activity level and provide more space, Decrease/remove pellets and add fiber, leafy greens to diet, plenty of water
  • 38. Uterine Adenocarcinoma and/or pyometra • Intact (not spayed) female rabbits • Clinical signs: Older female, listless, not eating • Treatment – exploratory surgery • Prevention – spay early; If breeding the doe, spay when breeding life is done.
  • 39. Disease Prevention • Quarantine new rabbits for 30 days • Reduce stress • Avoid overcrowding • Avoid dietary changes, provide appropriate & quality diet • Keep litter clean
  • 40. Guinea Pigs (cavy)
  • 41. CHAPTER 14 Guinea Pigs
  • 42. Cavia porcellus • Guinea Pig Rodent - More closely related to porcupines and chinchillas • Average weight 750 grams • Eleven breeds for show
  • 43. History of Guinea Pigs • Exact history of domestic cavy unknown – May come from C. aperea, C. tschudii, or C. fulgida – Does not come from Guinea • Bred for meat production in South America for at least 3,000 years • Brought to Europe in 16th century • Since mid-1800s, used for pathology, nutrition, genetics, and toxicology research, as well as serum development
  • 44. Uses for Guinea Pigs • Meat (S. America) • Research • 4H / FFA Project animals • Pets
  • 45. Common Guinea Pig Varieties • Abyssinian • American • Peruvian • Satin • Silkie • Teddy • White Crested
  • 46. Abyssinian Guinea Pig • Rough, wiry hair coat – Hair made of rosettes (swirls or cowlicks) – More rosettes are desirable • Found in all colors and color combinations
  • 47. American Guinea Pig • Most common variety • Short, very glossy, fine hair – Short hair eases care • Found in widely varied colors and color combinations
  • 48. Peruvian Guinea Pig • Longhaired variety – Hair length, evenness, and balance are deciding features – Hair requires much upkeep (can be 20” long) • Lacks a tail • Found in many of the colors and color combinations as American variety
  • 49. Satin Guinea Pig • Fur is distinguishing feature – Fine, dense, and soft – Luxurious and shiny • Found in colors and color combinations of other varieties
  • 50. Silky Guinea Pig • Longhaired variety – Unlike Peruvian, no long frontal sweep over head – Mane sweeps back from head, between ears, over the back, and down the sides • Sometimes called the Sheltie • Found in colors and color combinations of other varieties
  • 51. Teddy Guinea Pig • Short, kinky hair – Short, resilient strands – Lies thick and close to the body – Whiskers also kinked • Found in colors and color combinations of other varieties
  • 52. White Crested • Shorthaired variety – Resembles American shorthair except for crest – Crest is white rosette that radiates evenly from center of forehead • Found mainly in self, solid, and agouti colors
  • 53. Characteristics of Guinea Pigs • Physical makeup – Adult length of 8 to 10”, weight of 1 to 2 pounds – Short, stocky build with short legs – Short, blunt, rounded nose – Short ears with little fur – Agouti, self, solid, and marked colors • Skills – Very sensitive hearing – Highly developed sense of smell – Excellent peripheral vision • Behaviors – Live in colonies or clans – One dominant male and 5 to 10 females
  • 54. Anatomy • No tail • Open rooted teeth • One pair of • Born with teeth mammary glands • Born with eyes open • Herbivore • Heavy body weight for size • Susceptible to Bordatella
  • 55. Guinea Pig Reproduction • Average life span 5 years (4-8y) • Males are boars • Females are sows • Polyestrous with spontaneous (induced) ovulation • 1-6 young/litter
  • 56. Guinea Pig Reproduction • Sexual maturity – Females at 2 months (4-6w) – Males at 3 months (9-10w) • First breeding before female is 6 months / before reaching 500 grams body weight (6m old is when pelvic symphysis fuses) – Pair breeding (monogamous) – Colony breeding (polygamous / harem: 1 boar/4-10 sows) • Gestation period from 56 to 74 days • Up to 5 litters yearly (2 to 4 average) • Young fully developed at birth (precocious) – Weigh 1½ to 4½ ounces – Have open eyes and full fur – Running and eating solid food in 24 hours
  • 57. Desired Qualities of Guinea Pig Housing • At least 12” x 12” x 12” per adult (double size if breeders) • Plastic bottom that is 3 or 4” deep • Sides of vertical wire bars or glass • Hiding box / area for sleeping • Abundant bedding – shavings, shredded paper – CLEAN FREQUENTLY • Heavy glass or earthenware food bowls • Vacuum-type water bottle • When housed outside – Portable house or run-in (3 square feet/pig) – Temperatures above 50°F (55-70 ideal, >80-85 BAD)
  • 58. Basics of Guinea Pig Feeding • Sensitive GI system – no rapid diet changes! • Vegetarian diet – mix of veggies, hay, guinea pig pellets – Must consume vitamin C (~0.5mg/kg/day) – Vit C deficiencies often from use of old food • Foods tailored to age/state – Young or pregnant pigs: alfalfa pellets and dry alfalfa hay – Adults: Clover and grass hay pellets and low-protein dry clover and grass hays • Other food sources – Dandelion greens, Romaine or green leaf lettuce (no iceberg), kale, carrots, apples, pears, turnips, beets, cucumbers • Constant source of fresh water – clean daily
  • 59. Basic Care of Guinea Pigs • Regular grooming – Shorthaired: Daily brushing – Longhaired: Combing and brushing, clipping • Occasional bathing – Use mild shampoo – Avoid chills • Regular nail clipping
  • 60. Handling Methods for Guinea Pigs • Acclimation process – In new home, allow long exploration time – Offer treats (fresh greens, carrots, apples) – Pet and lift to overcome shyness • Lifting technique – Grasp firmly around front shoulders with one hand, support rear with other – Cradle in palm and forearm close to body
  • 61. Guinea Pig Ailments • Respiratory diseases (bacterial, viral pneumonia) • Diarrhea (bacterial, diet related enteritis) • Dystocia, Toxemia (pregnant females) • Integument: – Pododermatitis – Mites and biting lice – Neck swellings (e.g. cervical abscess) • Overgrown or maloccluded teeth • Genital-area obstructions – clean area to prevent
  • 62. Scurvy • Vitamin C deficiency Clinical Signs: anorexia/poor appetite, swollen, painful joints and ribs, reluctance to move, poor bone and teeth development, and spontaneous bleeding especially from the gums, into joints, and in muscle. Treatment: Supplement with Vitamin C injections; Add Vitamin C to water; feed fresher food and fresh vegetables
  • 63. Dystocia & Toxemia • Must be bred before 6 months of age • Toxemia seen in obese guinea pigs during late pregnancy. Prevention includes reducing stress during pregnancy and correct diet.
  • 64. Hyperthermia • Temperatures over 85 degrees, Humidity over 70%, inadequate shade and ventilation, overcrowding Signs: panting, slobbering, weakness, lethargy, convulsions Treatment: cool water spray or bath, alcohol on foot pads, change environment to prevent future episodes

Editor's Notes

  1. Lateral saphenous vein can also be used for indwelling catheters.
  2. Induce hypnosis in rabbit by placing it in dorsal recumbency and gently stroking its ventrum.
  3. Texel gp