This document discusses drugs that affect the gastrointestinal system. It covers drugs that affect salivary secretion like gentian and nux vomica. It also discusses emetics that induce vomiting like ipecacuanha and apomorphine, as well as anti-emetics that prevent vomiting. Finally, it discusses drugs that affect appetite by stimulating or suppressing centers in the hypothalamus, including benzodiazepines, cyproheptadine, and glucocorticoids as appetite stimulants.
2. DRUGS AFFECTING
SALIVARY SECRETION
Saliva is watery & froathy substance
produced in mouth of human and animals.
Regulation of salivary secretion is via salivary
nuclei located in brain stem, which are
excited by taste and tactile stimuli from
tongue and other areas of mouth
• Saliva contains amylase which helps in
breakdown of starch to sugar, salivary lipase
helps in fat digestion.
4. INDIRECT ACTING SIALICS
These are mainly vegetable drugs.
They stimulate taste buds by mild irritant
action which inturn enhances salivary
secretion.
GENTIAN- Obtained from Gentiana Lutea.
Active principle present is Amarogentin
&Getiopicrin.
Works as stomachic for increasing appetite.
5. DOSE OF GENTIAN
POWDER
DOG-0.3-1.2g.
CATTLE-30-60g.
SHEEP AND PIGS-4-8g .
ROUTE OF ADMINISTRATION PER
ORAL.
6. NUX VOMICA
Obtained by strychnus nux vomica
Active principle strychnine and
Brucine.
It posses stomachic action
DOSECATTLE;4-8g TOTAL
HORSES;1.3-4g TOTAL
ROUTE OF ADMINISTRATION PER ORAL.
7. QUASSIA
Obtained from dried stem of Picraena
excelsa.
It has antihelminthic and fly repellent
property.
In small dose it act as appetite
stimulant but in large dose it induces
vomition due to irritation.
8. DIRECT ACTING SIALICS
Directly stimulates salivary gland.e.g
Cholinergic sialics like carbachol and
arecoline.
MOA Carbachol and arecoline
stimulate salivary gland directly via
muscuranic receptor and lead to
copious flow of saliva .
Ptyalism is seen in intoxication of
organophosphorous ,carbamates and
pyrethroid poisoning.
9. ANTISIALICS
Decrease the flow of saliva .
1. Used in oral surgery and pas
preanasthetics
2. Inhibition of saliva is seen as side
effect of several drugs
3. Theraupetically antimuscuranic drugs
like ( Atrophine,
hyoscine,glycopyronium) used as anti
sialics.
10. ATROPINE & HYOSCINE
Occurs naturally & used as
preanaesthetic ,primarilly to reduce
salivary & bronchial secretions.
These are non selective anti
muscuranic drugs.
Contraindicated in Horse as it causes
CNS excitation.
HYOSCINE has greater central
effects .
11. GLYCOPYRRONIUM
Its longer acting synthetic quaternary
compound( highly water soluble
cannot cross BBB ) to atrophine
sulphate.
Safe in horse
DOSE
HORSE-0.001-0.003mg/kg IV
DOG – 0.01-0.02mg/kg s/c, IM,IV
13. Gastrointestinal Tract
Continuous tube extending from the
mouth to the anus
Major function: convert complex
compounds into simpler compounds
that can be absorbed and used by
cells
◦ Also excretes waste products from the
body
14. GI Transit Time
Time it takes for material to pass from
one end of the GI tract to the other
end
Subdivided into gastric emptying and
small intestine and colon transit time
Speeding up transit time = less
absorption
Slowing transit time = more absorption
15. Stomach
Composed of layers of smooth muscle
lined with glands
Glands secrete
◦ Enzymes
◦ Hydrochloric acid
◦ Mucus
Food moves from the stomach to the
small intestine where most absorption
takes place
16. Factors Contributing to GERD
Pregnancy
Overeating
Eating on the run
Eating late at night
Drinking alcohol
Smoking cigarettes
Consuming various foods (high fat content,
caffeine, citrus, spices)
17. Therapy for GERD
Preventative behavior
Preventative dietary changes
Avoiding medications or other
substances that promote reflux
Using a combination of medications
18. Agents for GERD
Antacids
aluminum hydroxide (ALternaGel)
aluminum hydroxide-magnesium
carbonate (Gaviscon ES)
aluminum-hydroxide-magnesium
hydroxide-simethicone (Maalox Max)
magnesium hydroxide (Milk of
Magnesia)
Drug
List
19. Agents for GERD
H2 Antagonists
cimetidine (Tagamet, Tagamet HB)
famotidine (Pepcid, Pepcid AC)
nizatidine (Axid, Axid AR)
ranitidine (Zantac, Zantac 75)
Drug
List
20. Histamine2 Receptor
Antagonists
Block gastric acid and pepsin
secretion
Competitive inhibition on gastric
parietal cells
Bedtime dose is most important
All are available OTC in some
strengths
21. Therapeutic Uses of
ranitidine (Zantac, Zantac 75)
Active duodenal ulcers
Benign gastric ulcers
Long-term prevention of duodenal ulcers
Gastric hypersecretory states
GERD
Postoperative ulcers
Upper GI bleeding
Preventing stress ulcers
22. Proton Pump Inhibitors
Blocks acid secretion by inhibiting the
hydrogen-potassium ion pump in
parietal cells
23. omeprazole (Prilosec)
Indicated for short-term treatment
Take before meals
Also indicated for h. pylori
Diarrhea is primary side effect
24. lansoprazole (Prevacid)
Indicated for short-term therapy of
ulcers and esophagitis
Indicated for long-term treatment of
hypersecretory disorders and
Zollinger-Ellison syndrome
25. esomeprazole (Nexium)
Very similar to Prilosec, but is
metabolized slower which increases
the duration of action
Take on an empty stomach
26. pantoprazole (Protonix)
Less expensive than others in this
class
Drug of choice in many hospitals due
to IV dosage form availability
27. Agents for GERD
Combinations
calcium carbonate-famotidine-
magnesium hydroxide (Pepcid
Complete)
lansoprazole-naproxen (Prevacid
NapraPAC)
Drug List
28. Agents for GERD
Coating Agent:
sucralfate (Carafate)
Prostaglandin E Analog:
misoprostol (Cytotec)
Cholinergic Agent:
bethanechol (Urecholine)
Drug List
30. Ulcer
Local defect or excavation of the
surface of an organ or tissue
3 common types:
◦ Gastric
◦ Duodenal
◦ Stress
31. Gastric Ulcers
Local excavation in the gastric
mucosa
Have malignant potential
Occur more in men than women
Prevalent in smokers and populations
in the Western Hemisphere
H. pylori is a common contributing
factor
32. Duodenal Ulcers
Peptic lesion in the duodenum
Occur more in hypersecretors
More difficult to treat than gastric
ulcers due to the difficulty in getting
the medication to the duodenum
33. Pharmacologic Treatment of
H. pylori
H. pylori is the cause of most peptic
ulcers
H. pylori secretes enzymes that
neutralize stomach acid
Antibiotics are the mainstay of
therapy, mixed with an antacid or
proton pump inhibitor
34. Gastrointestinal Disease
Crohn’s disease: inflammatory bowel
disease
◦ Can affect any portion of tubular GI tract
◦ Cannot be cured with surgery
35. EMESIS
Emesis is complex process occurs due to
stimulation of vomition centre located in medula
oblangata .
Usually emesis occurs due to visual & olfactory
stimuli.
Apparent emetic impulse originating from
semicircular canal of vestibular apparatus are
transmitted by 8th cr nerve to vestibular nuclei via
cerebellum and induces vomition.
--Peripheral efferent pathway include stimulation
arising from various visceral organs and tissues.
Blood borne emetic substance include drugs,
hormones ,endotoxic substance induce vomition
via CTZ
36. EMETICS
Drugs which are used to evoke
vomiting.
Clinically emesis is induced to empty
anterior portion of GIT, Prior to
induction of general anaesthesia.
Mainly employed in dogs and cats.
38. LOCALLY ACTING
Vomition is induced by irritating the
epithelium of
oropharynx,oesophagus,stomach and
duodenum.
IPECACUANHA contains active
ingredient emetine and cephaline
thus irritating gastric mucosa
stimulating CTZ .
Pharmacological effect it takes 15-30
mis to induce emesis in dogs and cats
.
39. contd
SIDE EFFECTS cardiotoxicity.
NO SPECIFIC ANTIDOTE IS THERE
activated charcoal may be given.
DOSE
Dogs & Cats ; 1-2ml/kg PO. Total
dose more than 15 ml for dog.
40. LUKE WARM WATER
Administered by stomach tube for
inducing vomition.
Used in non corrosive poisoning .
SODIUM CHLORIDE
Induce vomition by irritating GI
mucosa
In DOG 30-60ml PO
41. Centrally acting anti emetics
APOMORPHINE –It acts on vomiting
centre and CTZ , its semi synthetic
derivative of morphine ,dopamine
agonist acts on D2 receptors present on
CTZ inturn induce vomition
CONTRAINDICATED in cats because of
CNS excitation
DOSE in DOG ; 0.04mg/kg IV
XYLAZINE alpha 2 adrenoreceptor
agonist its reliable emetic in CATS
DOSE IN CATS ;0.4-1mg/kg IM
42. ANTI EMETICS
Drugs which prevent vomition.
LOCALLY ACTING ANTI EMETICS
1. Demulcants and protectants e.g. kaolin,
pectin, bismuth salts
2. Gastric antacids and local anaesthetics
e.g. magnesium hydroxide, aluminium
hydroxide and benzocaine.
3. Anticholinergics e.g. glycopyronneum,
methscopalamine, propantheline.
4. Prokinetics e.g. domperidone and
cisapride
43. CENTRALLY ACTING ANTI
EMETICS – directly act on emetic
centre
1. H1 receptor antagonist used in case of motion
sickness e.g meclozine 2-6g/kg PO in dogs
,cyclizine,cinnerazine. these are administered
30-60 min before journey .
2. D2 receptor antagonist- phenothiazine
derivative, e.g. Chlorpromazine in dogs 0.25-0.5
mg/kg .Benzamides e.g. Metachlopromide D2
blocker acts on CTZ dose in dogs 0.1-0.3 mg/kg
po.
3. 5HT3 receptor antagonist acts centrally e.g.
Ondansetron dogs and cats 0.1-0.2mg/kg.
4. Muscuranic receptor antagonist e.g.hyoscine
dogs 0.03mg/kg.
44. MISCELLANEOUS DRUGS
1. GLUCOCORTICOIDS e.g.
Dexamethasone, Methyl
prednisolone.
2. BENZODIAZEPINES e.g. Diazepam,
lorazepam and midazolam.
3. CANNABINOIDS e.g. Dronabinone
and Nabilone.
45. DRUGS AFFECTING
APPETITE
Appetite is regulated by hunger & satiety
centre in hypothalamic nuclei & other
component of limbic system.
Neurotransmitter are alpha 2
adrenoreceptor,D1 dopamine
receptor,seretonine are involved in controll of
appetite.
Appetite stimulants are also called as
orexigenics/ Appetisers.
Inhibition of satiety centre increase in
appetite.
Stimulation of satiety centre –decrease in
appetite.
46. CLASSIFICATION OF
APPETISERS
1. BENZODIAZEPINES – inhibit satiety
centre via nor adrenaline/D1 receptor.
eg,Diazepam – 0.05-0.15g in Dog
PO,Oxazepam 0.3-0.4 mg PO in dogs.
2. CYPROHEPTADINE- is H1 blocker it
inhibits seratogenic receptors thus
inhibition of satiety centre. 5-20mg PO
in dogs.
3. GLUCOCORTICOIDS-steroids induced
euphoria results in increase feed intake.
E.g.0.25-0.5mg prednisolone in dogs
PO once a day.
47. contd
4) ANABOLIC STEROIDS-Synthetic
analogue of testosterone , they
promote appetite ,increase weight
gain.e.g.Stanozolol-0.25-3mg/kg PO
once daily.
5) PROGESTERONE –e,g Megesterol
acetate – 5mg/kg PO in dogs.
6) MISCELLANEOUS DRUGS –e,g,
Vitamin B preperations.
48. APPETITE SUPPRESENTS
These are the agents which suppress
the appetite by stimulation of satiety
centre.
These are used in management of
obesity due to excessive food intake.
These are not used in veterinary
medicine.
E,g, AMPHATAMINE used in case of
obesity.