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{
Learning by doing
Engineering + biology = ?
Now what?
}
# endy@stanford.edu
# Yale NUS STEM Innovation
# 27 April 2017
# fair use, public domain, have fun
Growing is Forever, a film by Jesse Rosten
#include <biology.h>
watermelon eggplant carrot
banana corn broccoli
#include <domestication.h>
#include <breeding.h>
#include <landuse.h>
#include <rDNA.h>
http://www.whatisbiotechnology.org/science/rdna
Engineering even a single
gene can be incredibly
important & valuable.
http://www.apsnet.org/edcenter/intropp/lessons/viruses/Pages/PapayaRingspotvirus.aspx
Dennis
Gonsalves
Graphic c/o "Synthetic Aesthetics,” MIT Press (2014)
http://www.nature.com/nbt/journal/v34/n3/abs/nbt.3491.html
#include <bioeconomy.h>
Third sentence:
“In the use of the term
bioengineering in this
book we exclude
genetic engineering;
that is, the systematic
design of phenotypes
by manipulation of
genotypes.”
http://www.depts.washington.edu/hhmibio/MIT05.pdf
http://www.depts.washington.edu/hhmibio/MIT05.pdf
http://www.depts.washington.edu/hhmibio/MIT05.pdf
Cure diseases.
Understand & “debug” natural
biological systems.
Teach me to…
Save environments.
Design & build organisms.
Make doing the above easier.
Could we make biology
easy to engineer?
Atomic-scale thermal noise
Self-mixing molecular
systems
Reproducing “machines”
High heterogeneity
Living ramifications
Free .PDF of full briefing via DOI 1721.1/38455
Graphic from "Synthetic Aesthetics" MIT Press (2014)
TAATACGACTCACTATAGGGAGA
DNA synthesis = 4 key keyboard for genetic stuff
Raw chemicals,
not derived
from existing
DNA
Play however you
like to get the
DNA you want,
from scratch.
Systems = One or more devices encoding
a human defined function(s). Note that my
system your device, and so on.
Devices = One or more parts encoding a
human defined function(s).
Parts = Basic biological functions encoded
via molecules.
DNA = Material encoding moleculesCTATAGGGAGA
8-bit counter
Abstraction barrier! Do not cross!
Abstraction barrier! Do not cross!
Abstraction barrier! Do not cross!
https://en.wikipedia.org/wiki/Pedagogy_of_the_Oppressed
“(Friere) argues for pedagogy
to treat the learner as a co-
creator of knowledge.”
MIT 2003
St-Pierre & Endy
PNAS USA 2008
http://youtu.be/sLkZ9FPHJGM
George Boole, c.1854
George Boole, c.1854
MIT 2004
SBC 2004
iGEM 2005
iGEM 2006
Tianjin 2006
iGEM 2007
iGEM 2008
http://diyhpl.us/wiki/dna/projects/
iGEM 2009
Cambridge iGEM 2009
iGEM 2010
38
iGEM.org ~2015
http://partsregistry.org/wiki/index.php?title=Part:BBa_K590087
http://synbiobeta.com/news/igem-startup-pvp-biologics-closes-35-million-agreement-pharmaceutical-company-takeda/
https://www.youtube.com/watch?v=JI5exP6iHWw
Overcoming Teaching Disorders
& Delusional Deliverables
What is more valuable,
the puzzle or the answer?
kiva.org
What capacities should be available to all citizens?
Jefferson to
Adams re:
“natural
aristocracy”
October 1813
How many people should be
able to read and write?
http://themindunleashed.com/2015/06/see-the-worlds-most-spoken-languages-in-one-eye-opening-infographic.html
http://githut.info/
https://www.infoq.com/news/2014/01/IDC-software-developers
How many people should be able to
read and write computer programs?
igem.org
How many people should be able to
read and write DNA?
What should be the price of using a language?
http://www.cnn.com/2013/11/18/tech/innovation/gettysburg-address-preservation/
www.sb7.info

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Learning bioengineering by doing