The document discusses health risks at the human-animal-ecosystem interface and proposes practical steps forward. It notes that 2012 presents opportunities to advance the "One Health" approach due to growing interest in pandemic preparedness, disaster risk reduction, and managing risks across economic, environmental and social systems. It recommends 10 practical steps, including starting with community experiences, bringing livestock into policies on poverty and food security, focusing on resilience to health risks at interfaces, and establishing an operational framework to guide investments in a sustainable multi-stakeholder process.