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Presented By-
Md. Hafizur Rahman
General Manager
& Head of R&D
The IPI Ltd.
10/27/2022 1
10/27/2022 2
10/27/2022 3
10/27/2022 4
►Non-compartmental analysis (NCA) is a simple and quick method
for evaluating the exposure of a drug.
► It allows you to evaluate things like linearity and in vivo exposure.
► Noncompartmental analysis (NCA) provides the most elementary
pharmacokinetic information for a drug (i.e., peak concentration
and elimination half-life).
► NCAs are essential for characterizing new drug products and can
help guide development at each stage.
► It assumes that elimination follows first order
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NCAs often prove faster and more cost-efficient to conduct,
especially when compared to more complex compartmental
analyses (e.g., compartmental models that are applied to
population PK analyses and that rely upon sparse/few
sampling techniques)
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 The MRT is calculated by summing the total time in the body and
dividing by the number of molecules, which is turns out to be 85.6
minutes. Thus MRT represents the average time a molecule stays in
the body. Equations for the mean residence time (MRT) of drug in
the body and related functions are derived for drugs which are
intravenously administered into a one- or two-compartment system
with Michaelis-Menten elimination.
10/27/2022 12
MDT is the arithmetic mean value of any release profiles (Podczeck, 1993) and is
used to describe the drug release rate, to describe the hindering ability of the
used polymer (Asaduzzaman et al., 2011) , and to compare different release
profiles statistically (Podczeck, 1993). The mean disintegration time (MDGT; mean
time required for disintegration of tablets) and mean dissolution time
(MDST; mean time required for drug dissolution) of water-soluble drugs from solid
dosage forms were determined by moment analysis using microcalorimetric
curves.
10/27/2022 13
10/27/2022 14
Time, or better said Mean Arrival Time, corresponds to the
time on average that drug molecules spend prior
absorption, or in other words, the residence time of those
molecules 'outside' the absorption. 'site'.
For noninstantaneous input into a kinetic space, such as
oral absorption, the MRT estimated from extravascular
data includes a contribution of the mean transit time for
input, known as mean absorption time (MAT, or mean
arrival time, or mean input time).
10/27/2022 15
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 The AUMC (area under the first moment curve) is the area
under the concentration times versus time curve. The first
moment curve is prepared when concentration x time is
plotted versus time.
10/27/2022 17
 The first moment curve is prepared when concentration x
time is plotted versus time. AUMC can be mathematically
expressed as: (6.6) Knowledge about AUC and AUMC allows
further calculation and analysis of drug characteristics.
10/27/2022 18
 Physiologically based pharmacokinetic (PBPK) modeling is a
computational process that simulates the absorption,
distribution, metabolism, and excretion of a substance in the
body of an organism based on the interrelationships among
key physiological, biochemical, and physicochemical factors
using mathematical equations ...
 Pharmacokinetic (PK) models are mathematical tools that allow
simulating drug concentration levels in the blood prior to real
administration. These models can have countless applications
in new drug development and clinical activities.
10/27/2022 19
10/27/2022 20
 During the discovery phase, PK/PD models can be used to
identify and select the best drug candidates, which helps
characterize the mechanism of action and disease behavior of
a given drug, to predict clinical response in humans, and to
facilitate a better understanding about the potential clinical
relevance of ...
10/27/2022 21
10/27/2022 22

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Non compartmental analysis.pptx

  • 1. Presented By- Md. Hafizur Rahman General Manager & Head of R&D The IPI Ltd. 10/27/2022 1
  • 5. ►Non-compartmental analysis (NCA) is a simple and quick method for evaluating the exposure of a drug. ► It allows you to evaluate things like linearity and in vivo exposure. ► Noncompartmental analysis (NCA) provides the most elementary pharmacokinetic information for a drug (i.e., peak concentration and elimination half-life). ► NCAs are essential for characterizing new drug products and can help guide development at each stage. ► It assumes that elimination follows first order 10/27/2022 5
  • 8. NCAs often prove faster and more cost-efficient to conduct, especially when compared to more complex compartmental analyses (e.g., compartmental models that are applied to population PK analyses and that rely upon sparse/few sampling techniques) 10/27/2022 8
  • 12.  The MRT is calculated by summing the total time in the body and dividing by the number of molecules, which is turns out to be 85.6 minutes. Thus MRT represents the average time a molecule stays in the body. Equations for the mean residence time (MRT) of drug in the body and related functions are derived for drugs which are intravenously administered into a one- or two-compartment system with Michaelis-Menten elimination. 10/27/2022 12
  • 13. MDT is the arithmetic mean value of any release profiles (Podczeck, 1993) and is used to describe the drug release rate, to describe the hindering ability of the used polymer (Asaduzzaman et al., 2011) , and to compare different release profiles statistically (Podczeck, 1993). The mean disintegration time (MDGT; mean time required for disintegration of tablets) and mean dissolution time (MDST; mean time required for drug dissolution) of water-soluble drugs from solid dosage forms were determined by moment analysis using microcalorimetric curves. 10/27/2022 13
  • 15. Time, or better said Mean Arrival Time, corresponds to the time on average that drug molecules spend prior absorption, or in other words, the residence time of those molecules 'outside' the absorption. 'site'. For noninstantaneous input into a kinetic space, such as oral absorption, the MRT estimated from extravascular data includes a contribution of the mean transit time for input, known as mean absorption time (MAT, or mean arrival time, or mean input time). 10/27/2022 15
  • 17.  The AUMC (area under the first moment curve) is the area under the concentration times versus time curve. The first moment curve is prepared when concentration x time is plotted versus time. 10/27/2022 17
  • 18.  The first moment curve is prepared when concentration x time is plotted versus time. AUMC can be mathematically expressed as: (6.6) Knowledge about AUC and AUMC allows further calculation and analysis of drug characteristics. 10/27/2022 18
  • 19.  Physiologically based pharmacokinetic (PBPK) modeling is a computational process that simulates the absorption, distribution, metabolism, and excretion of a substance in the body of an organism based on the interrelationships among key physiological, biochemical, and physicochemical factors using mathematical equations ...  Pharmacokinetic (PK) models are mathematical tools that allow simulating drug concentration levels in the blood prior to real administration. These models can have countless applications in new drug development and clinical activities. 10/27/2022 19
  • 21.  During the discovery phase, PK/PD models can be used to identify and select the best drug candidates, which helps characterize the mechanism of action and disease behavior of a given drug, to predict clinical response in humans, and to facilitate a better understanding about the potential clinical relevance of ... 10/27/2022 21