Se ha denunciado esta presentación.
Utilizamos tu perfil de LinkedIn y tus datos de actividad para personalizar los anuncios y mostrarte publicidad más relevante. Puedes cambiar tus preferencias de publicidad en cualquier momento.

Twenty-first Century disease threats, epidemiology and One Health

346 visualizaciones

Publicado el

Presentation by Fred Unger at the Veterinary Medicine International Conference (VMIC 2017), Surabaya, Indonesia, 12 July 2017.

Publicado en: Ciencias
  • It's been ten months without a yeast infection. More than that, for the past couple of months I only had one migraine attack, comparing to six a week as I used to. I also very often suffered from runny nose and acne on my forehead. Since I started your program, it's been like a miracle. My acne disappeared in less than 2 weeks, I lost 10 pounds, and the flu like symptoms I often use to suffer from are also a thing of the past. I feel so young and empowered and I would have never believed there was a natural solution for my problems, if I was told a year ago. I wish everybody knew about this method. There are so many hopeless women and men out there with candida yeast infections. I know I will never have to go through that again. ■■■ https://tinyurl.com/y4uu6uch
       Responder 
    ¿Estás seguro?    No
    Tu mensaje aparecerá aquí
  • For years, I was plagued by chronic yeast infections, including but not limited to: rashes, weight gain, insomnia, acne, constipation, chronic fatigue, depression, sensitivity to chemicals, you name it. After following your program, I had made a significant progress. My thrush, acne and rashes had vanished. My skin had almost completely cleared up. I hadn�t looked that good in 15 years. I felt rejuvenated, energized, happier and so much healthier... ▲▲▲ http://ishbv.com/index7/pdf
       Responder 
    ¿Estás seguro?    No
    Tu mensaje aparecerá aquí

Twenty-first Century disease threats, epidemiology and One Health

  1. 1. Twenty-first Century disease threats, epidemiology and One Health Fred Unger International Livestock Research Institute Veterinary Medicine International Conference (VMIC 2017) Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia 12 July 2017
  2. 2. Presentation outline • 21st century disease threats • History of Epidemiology • Basic concepts of Epidemiology • New concepts: Participatory Epidemiology • Related areas: One Health • Case studies
  3. 3. Human health in the 21st century • 7 billion people – 1 billion hungry; – 2 billion with hidden hunger; – 1.5 billion overweight or obese – increasing trend • 55 million die each year – 18 million from infection – 1.2 million from road traffic accidents – 20,000 from extreme weather events
  4. 4. Historical and current health constraints and causes in developed countries 1990 2013 Ischaemic heart disease Ischaemic heart disease Stroke Stroke Back and neck Back and neck Road injury Lung cancer Lung cancer Depression (MDD) Depression (MDD) COPD COPD Diabetes Self harm Sense Other musculoskeletal diseases Self harm Diabetes Falls Only minor changes over 23 years Risk factors for main diseases: Lifestyle and dietary issues
  5. 5. Historical and current health constraints and causes in developing countries 1990 2013 Lower respiratory infections Ischaemic heart disease Diarrhoeal diseases Lower respiratory infections Neonatal pre-term complications Stroke COPD Back and neck Malaria Diarrhoeal diseases Stroke Neonatal pre-term complications Protein energy malnutrition HIV Tuberculosis Road accidents Neonatal encephalopathy Malaria Ischemic heart disease Tuberculosis Some changes over 23 years others remain unchanged: Cardiovascular diseases have come up Infectious diseases still a major cause
  6. 6. Where do we get our diseases? • Most are earned – Degenerative diseases: heart failure, stroke, diabetes, cancer – Allergies, asthma, autoimmune diseases – Sexually transmitted infections such as HSV-2, gonorrhea • Many are “souvenirs” – Around 60% of human diseases shared with animals – 70% of emerging/re-emerging infectious disease are zoonotic • 30 to 50% among these are foodborne
  7. 7. 21st century disease threats
  8. 8. History of human diseases • Paleolithic baseline (up to about 10,000 years ago) – Mankind existed in small, isolated groups as hunter-gatherers where population size and density remained low • 1st epidemiological transition – mankind became less nomadic, and settled into larger population clusters – domestication of animals brought other disease (zoonoses): Anthrax, TB – 16th Century New world – small pox & old world – Syphilis • 2nd epidemiological transition (roughly 200 years ago) – Industrial revolution, railways & steam ships – new – chronic, non-infectious were added – 20th Century First World War – Spanish flu • 3rd epidemiological transition (began early 1980s …) (??) – newly emerging infectious diseases, re-emerging diseases carried over from the 2nd transition, antimicrobial resistant pathogens
  9. 9. Presentation outline • 21st century disease threats • History of epidemiology • Basic concepts of epidemiology • New concepts: Participatory epidemiology • Related areas: One Health & ecohealth • Case studies
  10. 10. History of epidemiology 400 BC Hippocrates Greek physician, known as the father of medicine Tried to explained disease occurrence from a rational standpoint. First person known to have examined the relationships between the occurrence of disease and environmental influences. He believed sickness of the human body to be caused by an imbalance of the four humors (air, fire, water and earth "atoms"). The cure = balance the 4 humors of the body.
  11. 11. History of epidemiology 1662 John Graunt, a London councilman Published a landmark analysis of mortality data in 1662. This publication was the first to quantify patterns of birth, death, and disease occurrence, noting disparities between males and females, high infant mortality, urban/rural differences, and seasonal variations 1800 William Farr built upon Graunt’s work by systematically collecting and analyzing Britain’s mortality statistics. Farr is considered the father of modern statistics and surveillance. He identified urbanisation and population density as public health issues.
  12. 12. History of epidemiology Jon Snow, mid-1800s “father of field epidemiology.” Twenty years before the development of the microscope, Snow conducted studies of cholera outbreaks both to discover the cause of disease and to prevent its recurrence. 1854, when an epidemic of cholera erupted in the Golden Square of London. He began his investigation by determining where in this area persons with cholera lived and worked. He marked each residence on a map of the area. He hypothesized correctly water as the source of infection for cholera.
  13. 13. History of epidemiology Developed a spot map showing pumps and households with cases of cholera. More case households clustered Around Pump A, than Pump B or C. Residents who lived in the area stated that they avoided Pump B & C because grossly contaminated or too inconveniently located. In a subsequent step he related water suppliers to specific pumps.
  14. 14. History of epidemiology Mid- and late 1800s, epidemiological methods began to be applied in the investigation of disease occurrence of infectious disease 1930s and 1940s, epidemiologists extended their methods to non-infectious diseases. Also behaviour, knowledge and attitudes (e.g. lung cancer and heart disease) 1960s and early 1970s health workers applied epidemiologic methods to eradicate naturally occurring smallpox 1990s/2000s, molecular/genetic epidemiology and participatory epidemiology were added
  15. 15. Presentation outline • 21st century disease threats • History of epidemiology • Definition and basic concepts of epidemiology • New concepts: Participatory epidemiology • Related areas: One Health • Case studies
  16. 16. Epidemiology - definition The word epidemiology comes from the Greek words: • epi, meaning on or upon • demos, meaning people, • and logos, meaning the study of. In other words, the word epidemiology has its roots in the study of what befalls a population. Epidemiology is the study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to the control of health problems Veterinary epidemiology deals with the investigation of animal diseases, productivity and animal welfare in populations.
  17. 17. Epidemiology – a few basic considerations Temporal patterns of disease broadly categorized into: • Sporadic, single cases or clusters of cases of disease • Epidemic, disease occurrence which is higher than expected • Endemic, usual frequency of disease or constant presence of disease • Pandemic widespread epidemics affecting a large proportion of the population and possibly many countries. Presented graphically as epidemiological curves • Vertical axis: new cases • Horizontal axis: time • Shape of curve used to conclude on cause or disease characteristics
  18. 18. Presentation outline • 21st century disease threats • History of epidemiology • Definition and basic concepts of epidemiology • New concepts: Participatory epidemiology • Related areas: One Health • Case studies
  19. 19. What is participatory epidemiology? • An relatively new approach to epidemiology develop in response to poor performing veterinary services, a common problem in developing countries • Participatory epidemiology (PE) is flexible, and adaptable to changing situations • PE is founded on equal partnership with mutual respect and trust to enable community empowerment • Method to improve understanding of animal diseases, and to design solutions to disease problems with livestock keepers
  20. 20. Rinderpest control & eradication (Somalia) and Participatory Diseases Surveillance and Response (Indonesia) Somalia • Used to achieve eradication of rinderpest in Somalia • Last foci detected and eradicated using PE Indonesia (later also Egypt) • Participatory Diseases Surveillance and Response (PDSR) • Initiated in 2005 • Thousands of PDSR officers have been trained
  21. 21. ILRI operational research 2008–12 • Evaluate the feasibility of a suite of control interventions for highly pathogenic avian influenza Dr. Henni, PDS trainer Bogor LDCC, conducing an interview in Bakasi District, 2006. • PE component: Participatory impact assessment of Interventions • Proportional pilling • Participatory mapping (mortality events, duck flocks, markets, etc.) • Seasonal calendars (link certain historical events with mortality e.g. last flood, Ramadan, village wedding)
  22. 22. PDS trainees, Bandung LDCC, conducting an interview during introductory training, 2006. http://www.fao.org/docrep/003/X8833E/X8833E00.HTM PE – a guide for trainers http://www.participatoryepidemiology.info/PE%20Guide%20electronic%20copy.pdf Conference: 2nd regional PENAPH conference, Khon Kaen, 10-12 January 2018 https://penaph.net/second-penaph-conference-participatory-approaches-in-animal-health- public-health-one-health-and-ecohealth/ Further readings Links: PENAPH.net PE website http://www.participatoryepidemiology.info Materials:
  23. 23. Presentation outline • 21st century disease threats • History of epidemiology • Basic concepts of epidemiology • New concepts: Participatory epidemiology • Related areas: One Health and ecohealth • Case studies
  24. 24. Ecohealth and One Health Driven in response to emerging disease threats along the 3rd epidemiological transition
  25. 25. Ecohealth – One Health Ecohealth Originated in biological Ecology/land conversation Complexity focus/systems Communicable/non-communicable diseases Pioneered from IDRC and outside traditional health (heavy metal toxicity in communities and related to mining) ‘Bottom Up’ Vets, medical doctors, epidemiologists, ecologists, social scientists, philosophers, indigenous perspectives etc. Eco health One Health Integrated approach One Health Schwabe’s One Medicine One world/One Medicine (Zinsstag) More quantitative focus (animal/human/wildlife) Communicable diseases, zoonoses Vets, medical doctors, some ecologists or epidemiologists Currently institutionalized (FAO, OIE, WHO) Modified after IAEA (2014)
  26. 26. Presentation outline • 21st century disease threats • History of epidemiology • Basic concepts of epidemiology • New concepts: Participatory epidemiology • Related areas: One Health and ecohealth • Case studies
  27. 27. Case study: Optimizing rabies control in Bali Combined epidemiological surveys with a transdisciplinary approach
  28. 28. Case study 1: Optimizing rabies control in Bali ILRI EcoZD 2010 to 2012 The problem • Rabies emerged since its introduction • Conventional control measures show limited success • Prominent role of dogs in Bali society – Initial mass culling faced strong obligations (local and international) – Obligations against general population control measures Classical vet approach Vaccination in dogs and sterilisation if applicable
  29. 29. Case study 1 Optimizing rabies control in Bali: An ecohealth approach Combination of epidemiology with a Eco Health perspective • Transdisciplinary research team • Behaviour and attitudes: – Socio-cultural relationship between dogs and the Balinese community using participatory epidemiological tools • Classical epidemiological approach: – Dog population and its dynamics – Dog ecology, estimate contact rates between dogs and with humans • Selected results: – Free-roaming (2–3) and juvenile dogs (10–70) have a higher risks to be unvaccinated – 79% of owners applied free-roaming dog practices – Discarding of unwanted female puppies remains an issue
  30. 30. Case study 2: Food safety along pork chains (since 2012) To assess impacts of pork-borne diseases on human health and the livestock and identify control points for risk management. Interdisciplinary team: Vets, public health specialists, economists, animal scientists Why it matters: Food safety ranked by Vietnamese equal or higher than eduction and health Why pork: Majority of consumed animal protein is pork Distributed mainly via informal value chains
  31. 31. Case study 2: Food safety along pork chains (since 2012) Epidemiological tools • Qualitative and quantitative risk assessment (Salmonella) Participatory epidemiology tools Proportional pilling, participatory mapping, observational checklists Value chain assessment along the entire pork chain • People’s living around slaughter houses (IDI) • Pork consumers (KII) • Community vets • Community health workers (KII • Slaughterhouse workers (FGD) • Pork sellers (FGD) • Local authorities, party committee (KII)
  32. 32. 32 Case study 2: Exiting results from participatory epidemiology study of pork sellers 1. Use of cloths to dry pork, clean equipment, hands or tables: some consumers related “wet” looking meat to low meat quality 2. Use of cupboards at market stools: same reason as under 1 3. Use of masks: in response to buyer/consumer perception that sellers may have a health problem. 4. Knowledge of zoonoses: poor misperception of foot- and-mouth disease and classical swine fever Results from participatory epidemiology helped to understand practices which were not in line with regulations Quantitative risk assessment: 1 to 1.5 over 10 consumers face a Salmonella-related infection annually
  33. 33. The problem • Parasitic zoonoses are often neglected disease but endemic in the Laos e.g. trichinellosis, cysticercosis and liver fluke • Some characteristics of animal production and food consumption habits in Laos likely promote zoonoses spread: – both human and animal populations live in in close proximity – abattoirs and wet markets operating with rudimentary hygiene – widespread consumption of raw meat/fish • Approach – Serological survey in pigs and humans – Participatory epidemiology Case study 3: Lao long-term study on parasitic foodborne zoonoses
  34. 34. Participatory rural appraisal Questionnaire Interview question Likert scale Very limited knowledge on cause and prevention Worms are common for villagers but not considered as health issue Very limited knowledge on cause and prevention Only 1.5%, link raw pork consumption to PFBD Perception that worms are not harmful for humans (85% agreement) Seroprevalence for Trichinella in pigs: 17% Main constraints ranked by farmers: Flood, water access, no market access, health Case study 3: Laos synthesis of selected results
  35. 35. Final reflections • New emerging and reemerging disease threats • Epidemiology of increasing importance – New approaches such as participatory epidemiology • One Heath and ecohealth evolved over the recent decade; supporting appoaches to epidemiology • Need to understand why people adopt certain practices • What are potential incentives for behaviour change • Regulations alone will not help
  36. 36. The presentation has a Creative Commons licence. You are free to re-use or distribute this work, provided credit is given to ILRI. better lives through livestock ilri.org Special thanks to: Delia Grace (ILRI), ComAccross (Lao) and EcoZD team (CIVAS)e On dogs, people, and a rabies epidemic: results from a sociocultural study in Bali, Indonesia Maria Digna Winda Widyastuti et al. 2016. Infectious Diseases of Poverty, 20154:30 Determinants of Vaccination Coverage and Consequences for Rabies Control in Bali, Indonesia Riana A Arief. 2017. Front Vet Sci. 2016; 3: 123.

×