A field experiment was conducted during 2004 and 2005 cropping seasons to determine effect of different weed control practices on proximate composition, nutrient concentration and nutrient uptake of maize (Zea maysL.) at the Teaching and Research Farm of Ambrose Alli University, Ekpoma, Nigeria. Seven treatments were used for the experiment, viz no weeding (control), Primextra (3.0kg a.i./ha), mulching (wood shavings), one- hoe weeding at 3 weeks after planting (WAP), two hoe- weedings at 3 and 7 WAP, cover cropping with melon minus hoe-weeding, cover-cropping with melon plus one hoe-weeding at 3WAP. The seven treatments were laid out in randomized complete block design with four replicates. Results showed that mulched plot with wood shavings had the lowest weed density and highest proximate composition, grain nutrient concentration, ear leaf concentration and nutrient uptake followed by Primextra treated plot .The study recommends that small holder farmers to adopt mulching technique with wood shaving to improve the nutritional quality of maize grain since it does not involve any technical rigor besides signifying a non-chemical weed control.