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Member:
1. Ahmad Rafiqan Bin Nayan
2. Muhammad Irfan Bin Alias
3. Mohammad Al-Karim Tayasneh
4. Mohd Izzad Samir Bin Iskandar
What is Heart-lung Bypass unit?
External systems that
provide circulation,
oxygenation, and
filtration of the
blood as a temporary
substitute for
circulatory and
pulmonary function.
 Often used for open-heart surgery, such as
coronary artery bypass grafting and cardiac
valve replacement.
 In some cases, used for extracorporeal
membrane oxygenation (ECMO) in patients
with respiratory distress syndrome or with
respiratory insufficiency due to pneumonia,
smoke inhalation, or other causes.
Block diagram of Heart-lung Bypass Unit
Process flow…
 During bypass, the patient is heparinized to
prevent blood from clotting within the heart-
lung bypass circuit. (After bypass,
anticoagulation must be reversed by protamine
sulfate)
 Heart is infused with a cardioplegic chemical
solution (e.g potassium chloride) to stop its
rhythmic contractions and reduce its metabolic
requirements so as to avoid ischemic damage
to the myocardium.
 The blood flows to the oxygenator/heat
exchanger for oxygenation, carbon dioxide
removal, temperature regulation, and any
necessary anesthetic exchanges.
 Blood that pools in the surgical site is suctioned
and collected in a cardiotomy reservoir, where
it is filtered, defoamed, and either pumped or
drained to the oxygenator.
 The oxygenated blood is then returned to the
patient, typically through the aorta, bypassing
the heart and lungs.
Extracorporeal
perfusion pumps
Oxygenator
Perfusion monitoring
and peripheral
equipment
Closed-circuit
systems
Roller pump Centrifugal pump
Roller pumps:
 The pumps are designed so that one of the
rollers is always in contact with the pump-head
tubing, compressing it and forcing the blood
forward.
 Pump-head occlusion is manually adjusted by
the operator. Some pumps can provide
pulsatile flow.
 Advantages :
1. Require low volume of blood for priming.
2. The association with minimal biocompatibility
problems (because the tubing is the only
surface that contacts the blood)
3. A low haemolysis rate (possibly due to the lack
of blood backflow or turbulence).
Blood
rupture
 Disadvantages:
1. Tubing will crack or release plastic fragments
that can become particulate emboli.
2. In the event of a tube blockage, there is a
possibility that the pump will continue to
operate and cause the tubing to rupture.
Centrifugal pump:
 Uses centrifugal force to move blood through
the system. Spinning cones or rotating fins
create a vortex and force blood centrifugally
through a port in the periphery of the pump
head.
 Flow output must be measured using a
noninvasive sensor or a disposable probe
inserted into the arterial line.
Advantage :
 Reducing the risk of generating particulate
matter in the blood.
 Provide protection against over pressurization
of the system in case of tubing occlusion.
 Air-lock system- preventing air from being
administered to the patient. If there is air, the
filter will remove the air as the pump will
continue function.
Disadvantage :
 Non-occlusive: not prevent blood backflow
from the patient if the pump stops, adding to
the risk of air entry into the circulation.
Generally:
 Both a backup arterial pump and a connection
to an emergency power system are necessary to
ensure reliable pump operation.
 A hand crank for manual pumping is
recommended as an additional backup as it can
provide the high rotational speeds required by
centrifugal pumps.
 Example :Membrane oxygenator. These devices
usually have an integral heat exchanger to
control the temperature of the blood.
 Oxygenator must be primed before use with
lactated Ringer’s solution of
5% dextrose, to remove air pockets and bubbles
from the bypass circuit.
 Consist of a gas-permeable membrane
separating a thin layer of blood from the
oxygenating gas.
 Three major types of membrane oxygenators are
PLATE, COIL, and HOLLOW FIBER.
 As a safety precaution, arterial blood is usually
pumped through an in-line arterial filter, which
helps trap particulate matter and gaseous emboli
before they reach the patient. If the filter becomes
clogged, the blood can be diverted through an
arterial-line shunt that has its own filter.
 After oxygenation and filtration, the blood is
pumped into the body through a cannula placed in
the ascending aort
or femoral artery at a rate of four to six liters
per minute (L/min), depending on the
patient’s physiologic requirements.
 To maintain the desired temperature in the
heat exchanger
 water mixer regulates delivery of warming and
cooling water
 mixer is typically part of the pump console and
includes a thermometer and a backup pressure-relief
valve
 A separate electric water heater/cooler can be used
instead of a mixer
 Thermistor probes are placed at various points
on the patient and in the extracorporeal circuit
 Blood gases can be monitored from drawn
samples, by an in-line differential oxygen
monitor
 Pressure monitors record left atrial, pulmonary
artery, and systemic arterial pressures
 Electronic safety devices have been
incorporated into heart-lung bypass units, with
varying degrees of acceptance
 Most manufacturers offer ultrasonic bubble
detectors, which use an ultrasonic transducer
and detector to shut down the pumps
automatically when gaseous emboli are
detected in the arterial line.
 Level detectors-which alarm when blood falls
below acceptable levels in the oxygenator,
cardiotomy reservoir, or other components.
 Some centrifugal pumps include a backflow
alarm to alert the clinician to retrograde blood
flow within the system.
 Minimally invasive closed-circuit systems (also
called mini-bypass systems) are designed to be
used intermittently during beating-heart
surgery.
 Incorporates the pump, filter, and oxygenator
in one housing and is stationed on the main
console.
 It small, use shorter tubing and can be placed
closer to the patient as result
patient’s blood spends less time outside the bo
dy
 less priming is required- this decreased
extracorporeal blood, coupled with less diluted
blood, results in less blood damage.
 EMBOLISM
 IMPROPER OR DEFECTIVE CONNECTION
IN TUBING
 FAILURE OF SYSTEM HARDWARE
 PROBLEM WITH CERTAIN ANCILLARY
PORTION OF EXTRACORPORCEAL
CIRCUITS
 INTERFERENCE BETWEEN HEART LUNG
MACHINE AND BISPECTRAL INDEX(BIS)
MONITOR
 ARTERIAL PUMP- ROLLER OR
CENTRIFUNGAL CONFIGURATION
 1 0R 2 SUCTION PUMP
 CARDIOPLEGIA PUMP
 BACKUP ARTERIAL PUMP-EMERGENCY
POWER SUPPLY
 MANUAL CRANK
 DISPOSABLE OXYGENATOR
 DEGREE OF MODULARITY OF EACH
SYSTEM
 PROCEDURE ROOM ELECTRICALY
CIRCUITRY AND CAPACITY BE ASSESSED
 GREEN SHIPPING AND PRODUCTION
METHOD
 ENERGY EFFICIENCY
 BIS(2-ethyhexly)phthalate (DEHP)- FREE
DISPOSABLE
DISPOSABLE
COMPONENT
HEPARIN-
COATED
EXTRACORPORE
AL
COMPUTERIZE
D PERFUSION
CONTROLLER
RATCHED STYLE
HANDPIECE AND
ADJUSTABLE
CARDIOPULMONA
RY BYPASSS
SYSTEM
Biomedical Benchmark
IPM Frequency
4 times per year
Heart lung by pass unit

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Heart lung by pass unit

  • 1. Member: 1. Ahmad Rafiqan Bin Nayan 2. Muhammad Irfan Bin Alias 3. Mohammad Al-Karim Tayasneh 4. Mohd Izzad Samir Bin Iskandar
  • 2.
  • 3. What is Heart-lung Bypass unit? External systems that provide circulation, oxygenation, and filtration of the blood as a temporary substitute for circulatory and pulmonary function.
  • 4.  Often used for open-heart surgery, such as coronary artery bypass grafting and cardiac valve replacement.  In some cases, used for extracorporeal membrane oxygenation (ECMO) in patients with respiratory distress syndrome or with respiratory insufficiency due to pneumonia, smoke inhalation, or other causes.
  • 5. Block diagram of Heart-lung Bypass Unit
  • 7.  During bypass, the patient is heparinized to prevent blood from clotting within the heart- lung bypass circuit. (After bypass, anticoagulation must be reversed by protamine sulfate)  Heart is infused with a cardioplegic chemical solution (e.g potassium chloride) to stop its rhythmic contractions and reduce its metabolic requirements so as to avoid ischemic damage to the myocardium.
  • 8.  The blood flows to the oxygenator/heat exchanger for oxygenation, carbon dioxide removal, temperature regulation, and any necessary anesthetic exchanges.  Blood that pools in the surgical site is suctioned and collected in a cardiotomy reservoir, where it is filtered, defoamed, and either pumped or drained to the oxygenator.  The oxygenated blood is then returned to the patient, typically through the aorta, bypassing the heart and lungs.
  • 9. Extracorporeal perfusion pumps Oxygenator Perfusion monitoring and peripheral equipment Closed-circuit systems
  • 11. Roller pumps:  The pumps are designed so that one of the rollers is always in contact with the pump-head tubing, compressing it and forcing the blood forward.  Pump-head occlusion is manually adjusted by the operator. Some pumps can provide pulsatile flow.
  • 12.  Advantages : 1. Require low volume of blood for priming. 2. The association with minimal biocompatibility problems (because the tubing is the only surface that contacts the blood) 3. A low haemolysis rate (possibly due to the lack of blood backflow or turbulence). Blood rupture
  • 13.  Disadvantages: 1. Tubing will crack or release plastic fragments that can become particulate emboli. 2. In the event of a tube blockage, there is a possibility that the pump will continue to operate and cause the tubing to rupture.
  • 14. Centrifugal pump:  Uses centrifugal force to move blood through the system. Spinning cones or rotating fins create a vortex and force blood centrifugally through a port in the periphery of the pump head.  Flow output must be measured using a noninvasive sensor or a disposable probe inserted into the arterial line.
  • 15. Advantage :  Reducing the risk of generating particulate matter in the blood.  Provide protection against over pressurization of the system in case of tubing occlusion.  Air-lock system- preventing air from being administered to the patient. If there is air, the filter will remove the air as the pump will continue function.
  • 16. Disadvantage :  Non-occlusive: not prevent blood backflow from the patient if the pump stops, adding to the risk of air entry into the circulation. Generally:  Both a backup arterial pump and a connection to an emergency power system are necessary to ensure reliable pump operation.  A hand crank for manual pumping is recommended as an additional backup as it can provide the high rotational speeds required by centrifugal pumps.
  • 17.
  • 18.  Example :Membrane oxygenator. These devices usually have an integral heat exchanger to control the temperature of the blood.  Oxygenator must be primed before use with lactated Ringer’s solution of 5% dextrose, to remove air pockets and bubbles from the bypass circuit.  Consist of a gas-permeable membrane separating a thin layer of blood from the oxygenating gas.
  • 19.  Three major types of membrane oxygenators are PLATE, COIL, and HOLLOW FIBER.  As a safety precaution, arterial blood is usually pumped through an in-line arterial filter, which helps trap particulate matter and gaseous emboli before they reach the patient. If the filter becomes clogged, the blood can be diverted through an arterial-line shunt that has its own filter.  After oxygenation and filtration, the blood is pumped into the body through a cannula placed in the ascending aort or femoral artery at a rate of four to six liters per minute (L/min), depending on the patient’s physiologic requirements.
  • 20.  To maintain the desired temperature in the heat exchanger  water mixer regulates delivery of warming and cooling water  mixer is typically part of the pump console and includes a thermometer and a backup pressure-relief valve  A separate electric water heater/cooler can be used instead of a mixer
  • 21.  Thermistor probes are placed at various points on the patient and in the extracorporeal circuit  Blood gases can be monitored from drawn samples, by an in-line differential oxygen monitor  Pressure monitors record left atrial, pulmonary artery, and systemic arterial pressures  Electronic safety devices have been incorporated into heart-lung bypass units, with varying degrees of acceptance
  • 22.  Most manufacturers offer ultrasonic bubble detectors, which use an ultrasonic transducer and detector to shut down the pumps automatically when gaseous emboli are detected in the arterial line.  Level detectors-which alarm when blood falls below acceptable levels in the oxygenator, cardiotomy reservoir, or other components.  Some centrifugal pumps include a backflow alarm to alert the clinician to retrograde blood flow within the system.
  • 23.  Minimally invasive closed-circuit systems (also called mini-bypass systems) are designed to be used intermittently during beating-heart surgery.  Incorporates the pump, filter, and oxygenator in one housing and is stationed on the main console.  It small, use shorter tubing and can be placed closer to the patient as result patient’s blood spends less time outside the bo dy
  • 24.  less priming is required- this decreased extracorporeal blood, coupled with less diluted blood, results in less blood damage.
  • 25.  EMBOLISM  IMPROPER OR DEFECTIVE CONNECTION IN TUBING  FAILURE OF SYSTEM HARDWARE  PROBLEM WITH CERTAIN ANCILLARY PORTION OF EXTRACORPORCEAL CIRCUITS  INTERFERENCE BETWEEN HEART LUNG MACHINE AND BISPECTRAL INDEX(BIS) MONITOR
  • 26.  ARTERIAL PUMP- ROLLER OR CENTRIFUNGAL CONFIGURATION  1 0R 2 SUCTION PUMP  CARDIOPLEGIA PUMP  BACKUP ARTERIAL PUMP-EMERGENCY POWER SUPPLY  MANUAL CRANK  DISPOSABLE OXYGENATOR
  • 27.  DEGREE OF MODULARITY OF EACH SYSTEM  PROCEDURE ROOM ELECTRICALY CIRCUITRY AND CAPACITY BE ASSESSED
  • 28.  GREEN SHIPPING AND PRODUCTION METHOD  ENERGY EFFICIENCY  BIS(2-ethyhexly)phthalate (DEHP)- FREE DISPOSABLE