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ISCTE-MIT Venture Competition
 Lisboa, 22 de Setembro de 2011
Biopharmaceuticals Market



                                                                         Treating complex
                                                                             diseases


                                                                         80 Bln $ market




     Cell culture                                         Cell culture
       Media                                               Process



2 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
Market Problem

             Biomedicines are extremely difficult to manufacture

  × High production costs = 68 M US$/100 kg biomedicine
  × Systemic production capacity shortage
                          Capacity installed        Demand              Demand for 5 new blockbusters
                        4,0                                                     87%     91%     100%




                                                                                                                Capacity occupancy (%)
                                                                         80%
   Volume (million L)




                                                                                                80%
                        3,0                                     62%
                                                 52%                                                      60%
                        2,0                                              61%     61%         62%
                                      51%        50%            55%                                       40%
                              46%
                        1,0                                                                               20%
                        0,0                                                                               0%
 Sources:
                              2007    2008       2009            2010     2011   2012         2013
 Heinzle, E., A.P. Biwer, and C.L. Cooney. Development of Sustainable Bioprocesses: Modeling and Assessment (2007). Wiley.
 Challenges and Solutions for Biopharmaceutical Manufacturing. BioProcess Technology Consultants, Inc. http://www.bptc.com

3 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
Current methodology for culture media design




  However...
            Life could never have evolved by chance!
                                                                     Francis Cricket, Nobel Prize winner



                                             ...Why should culture media?


4 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
Our Uniqueness

              Cell Functional                                        Tailored Culture Media:
          Enviromics Technology                                      Right ingredients
                                                                     Right amounts
                                                                     Higher performance
                                                                     Less time




      Portuguese PATENT;
      International patent
      application scheduled.



5 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
Our Solution



                   Pilot scale
                            50 L
                                                                     2 productivity


                                                                     50% fixed capital costs


                                                                     100% production capacity




         ■ InvitrogenTM ■ MediaOmics®

6 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
Our Partners



                                      Culture media
                                           CMO



     Process
development CMO




                                       Clone developer




7 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
Investment and Return

                                                  MediaOmics® needs a €2 million investment.
                                                  The expected payback is in 5 years.
                                                  Net present value of €1.6 million.
                                                 Free Cash Flow      Cumulative Cash Flow      Sales
                                           6,0
                                                                                                  5,0
                                           5,0
                                                                                        4,1
                Cash Flow (million EUR)




                                           4,0                                 3,7

                                           3,0
                                                                      1,9
                                           2,0
                                                            1,0
                                           1,0
                                                   0,0
                                           0,0
                                                   2012     2013      2014     2015     2016      2017
                                          -1,0
                                          -2,0

8 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
MediaOmics® Promoters

Rui Oliveira                                                         Nuno Carinhas
                        Rui Oliveira holds a chemical engineering degree and a Nuno holds a Biology degree and is sch
                                                                                            Biochemical
                        engineering Ph.D. since 1998. He is the head of the SystemsBiotechnology this year. His work focuses o
                                                                                            Biology and
                      Ph.D. Biochem. at FCT-UNL since 2001. He has been thePh.D.scientist of biotechnology, the core of M
                        Engineering Lab Eng.                                              approaches to
                                                                                      lead Biotechnol.
                      Assistantresearch projects with Biopharma companies in the US andjournals. He entrepreneurial and biote
                        several
                                  Professor at                                            heEurope. He
                                                                                              has taken
                                                                                     Post-Doc researcher at
                        is author of more than 50 research papers in high impact scientific
                                                                                          universities, including UNL and MIT. Alon
                      Universidadeof two de Lisboa. patents and 3 national Universidade Nova departicularly in the Bio
                        is inventor Nova international                               patents. He hasfinance, Lisboa.
                                                                                          enthusiast of
                      Inventor of the technology. of CFE-Media technology and of Pichia-FEMTM.
                        coordinated the development
                                                                   ®



                                                                     Filipe Ataíde          Filipe holds a M.Sc. degree in Chemical
António Dinis                                                                               FCT-UNL since 2007. He is currently dev
                        António holds a Biotechnology degree and a MBA. Since 2007 He works as an
                                                                                            nanobiotechnology. He has experience in
                        Account Manager at Hovione promoting products and nanoparticles with functional coatings to
                                                                                              services to
                      Biotechnol. Degree                                                M.Sc. Chem. Biochem. Eng.
                        pharmaceutical companies. Previously he worked for seven years at DSM,gases to liquids. This technol
                                                                                            transfer from
                                                                                        PhD international Universidade
                                                                                               Student at
                      MBA he held several managerial positions and was involvedmedia ingredients and could be a valua
                        where
                      Business Catalyst António is also an experienced business Nova de Lisboa. operations management o
                        strategic projects.                                              catalyst and has
                                                                                            enthusiast of
                        helped a number of scientists to bring their technologies closer to market.
                                                                                            entrepreneurial activities.

                                                                 Ana Ferreira
João Dias                                                                             Ana Raquel holds a Chemical Engineering
                        João Dias holds a Chemical Engineering degree and a Chemical and
                        Biochemical Engineering Ph.D. from FCT-UNL. He is currently a She started her PhD thesis in March 2008
                                                                                      Post-doctoral
                                                                                      She has more than 5 years’ experience in
                        researcher at the same institution. He has over 7 years’ experience in
                      Ph.D. Chem. Biochem. Eng. bioinformatics. He has participated Eng.experience in Pichia pastoris
                        computational systems biology and                        Chem. has Degree
                                                                                      She in 2008-
                      Post-Docaresearcher at with Merck&Co - FASTPICHIA - for the optimization different scales, including sh
                        2009 in research project                                 PhD Student at Universidade
                                                                                      production at
                                                                                      pilot scale reactors. She has been dee
                        of Pichia pastoris cultivations. João has also been deeply involved in the
                      Universidade of CFE-Media® technology and of Pichia-FEMTM and he is Lisboa.and she is one of the invento
                        development
                                      Nova de Lisboa.                            Nova de
                                                                                      Pichia-FEMof
                                                                                              one
                                                                                                  TM

                      Inventor of the technology.® technology.
                        the inventors of MediaOmics                              Inventor of the Technology


9 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
LIfe Sciences Finalist: Mediaomics

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LIfe Sciences Finalist: Mediaomics

  • 1. ISCTE-MIT Venture Competition Lisboa, 22 de Setembro de 2011
  • 2. Biopharmaceuticals Market Treating complex diseases 80 Bln $ market Cell culture Cell culture Media Process 2 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 3. Market Problem Biomedicines are extremely difficult to manufacture × High production costs = 68 M US$/100 kg biomedicine × Systemic production capacity shortage Capacity installed Demand Demand for 5 new blockbusters 4,0 87% 91% 100% Capacity occupancy (%) 80% Volume (million L) 80% 3,0 62% 52% 60% 2,0 61% 61% 62% 51% 50% 55% 40% 46% 1,0 20% 0,0 0% Sources: 2007 2008 2009 2010 2011 2012 2013 Heinzle, E., A.P. Biwer, and C.L. Cooney. Development of Sustainable Bioprocesses: Modeling and Assessment (2007). Wiley. Challenges and Solutions for Biopharmaceutical Manufacturing. BioProcess Technology Consultants, Inc. http://www.bptc.com 3 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 4. Current methodology for culture media design However... Life could never have evolved by chance! Francis Cricket, Nobel Prize winner ...Why should culture media? 4 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 5. Our Uniqueness Cell Functional Tailored Culture Media: Enviromics Technology Right ingredients Right amounts Higher performance Less time Portuguese PATENT; International patent application scheduled. 5 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 6. Our Solution Pilot scale 50 L 2 productivity 50% fixed capital costs 100% production capacity ■ InvitrogenTM ■ MediaOmics® 6 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 7. Our Partners Culture media CMO Process development CMO Clone developer 7 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 8. Investment and Return MediaOmics® needs a €2 million investment. The expected payback is in 5 years. Net present value of €1.6 million. Free Cash Flow Cumulative Cash Flow Sales 6,0 5,0 5,0 4,1 Cash Flow (million EUR) 4,0 3,7 3,0 1,9 2,0 1,0 1,0 0,0 0,0 2012 2013 2014 2015 2016 2017 -1,0 -2,0 8 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics
  • 9. MediaOmics® Promoters Rui Oliveira Nuno Carinhas Rui Oliveira holds a chemical engineering degree and a Nuno holds a Biology degree and is sch Biochemical engineering Ph.D. since 1998. He is the head of the SystemsBiotechnology this year. His work focuses o Biology and Ph.D. Biochem. at FCT-UNL since 2001. He has been thePh.D.scientist of biotechnology, the core of M Engineering Lab Eng. approaches to lead Biotechnol. Assistantresearch projects with Biopharma companies in the US andjournals. He entrepreneurial and biote several Professor at heEurope. He has taken Post-Doc researcher at is author of more than 50 research papers in high impact scientific universities, including UNL and MIT. Alon Universidadeof two de Lisboa. patents and 3 national Universidade Nova departicularly in the Bio is inventor Nova international patents. He hasfinance, Lisboa. enthusiast of Inventor of the technology. of CFE-Media technology and of Pichia-FEMTM. coordinated the development ® Filipe Ataíde Filipe holds a M.Sc. degree in Chemical António Dinis FCT-UNL since 2007. He is currently dev António holds a Biotechnology degree and a MBA. Since 2007 He works as an nanobiotechnology. He has experience in Account Manager at Hovione promoting products and nanoparticles with functional coatings to services to Biotechnol. Degree M.Sc. Chem. Biochem. Eng. pharmaceutical companies. Previously he worked for seven years at DSM,gases to liquids. This technol transfer from PhD international Universidade Student at MBA he held several managerial positions and was involvedmedia ingredients and could be a valua where Business Catalyst António is also an experienced business Nova de Lisboa. operations management o strategic projects. catalyst and has enthusiast of helped a number of scientists to bring their technologies closer to market. entrepreneurial activities. Ana Ferreira João Dias Ana Raquel holds a Chemical Engineering João Dias holds a Chemical Engineering degree and a Chemical and Biochemical Engineering Ph.D. from FCT-UNL. He is currently a She started her PhD thesis in March 2008 Post-doctoral She has more than 5 years’ experience in researcher at the same institution. He has over 7 years’ experience in Ph.D. Chem. Biochem. Eng. bioinformatics. He has participated Eng.experience in Pichia pastoris computational systems biology and Chem. has Degree She in 2008- Post-Docaresearcher at with Merck&Co - FASTPICHIA - for the optimization different scales, including sh 2009 in research project PhD Student at Universidade production at pilot scale reactors. She has been dee of Pichia pastoris cultivations. João has also been deeply involved in the Universidade of CFE-Media® technology and of Pichia-FEMTM and he is Lisboa.and she is one of the invento development Nova de Lisboa. Nova de Pichia-FEMof one TM Inventor of the technology.® technology. the inventors of MediaOmics Inventor of the Technology 9 | ISCTE-MIT Venture Competition | 22 September 2011 | MediaOmics