This document discusses the biopharmaceuticals market and challenges with current production methods. It introduces MediaOmics' Cell Functional Enviromics technology which can design tailored culture media to increase biopharmaceutical production capacity by 50% and reduce costs by 50%. MediaOmics is seeking a 2 million euro investment which is expected to be paid back within 5 years, with a net present value of 1.6 million euros. The company founders and their qualifications and experience in relevant fields are also summarized.
2. Biopharmaceuticals Market
Treating complex
diseases
80 Bln $ market
Cell culture Cell culture
Media Process
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3. Market Problem
Biomedicines are extremely difficult to manufacture
× High production costs = 68 M US$/100 kg biomedicine
× Systemic production capacity shortage
Capacity installed Demand Demand for 5 new blockbusters
4,0 87% 91% 100%
Capacity occupancy (%)
80%
Volume (million L)
80%
3,0 62%
52% 60%
2,0 61% 61% 62%
51% 50% 55% 40%
46%
1,0 20%
0,0 0%
Sources:
2007 2008 2009 2010 2011 2012 2013
Heinzle, E., A.P. Biwer, and C.L. Cooney. Development of Sustainable Bioprocesses: Modeling and Assessment (2007). Wiley.
Challenges and Solutions for Biopharmaceutical Manufacturing. BioProcess Technology Consultants, Inc. http://www.bptc.com
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4. Current methodology for culture media design
However...
Life could never have evolved by chance!
Francis Cricket, Nobel Prize winner
...Why should culture media?
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5. Our Uniqueness
Cell Functional Tailored Culture Media:
Enviromics Technology Right ingredients
Right amounts
Higher performance
Less time
Portuguese PATENT;
International patent
application scheduled.
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6. Our Solution
Pilot scale
50 L
2 productivity
50% fixed capital costs
100% production capacity
■ InvitrogenTM ■ MediaOmics®
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7. Our Partners
Culture media
CMO
Process
development CMO
Clone developer
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8. Investment and Return
MediaOmics® needs a €2 million investment.
The expected payback is in 5 years.
Net present value of €1.6 million.
Free Cash Flow Cumulative Cash Flow Sales
6,0
5,0
5,0
4,1
Cash Flow (million EUR)
4,0 3,7
3,0
1,9
2,0
1,0
1,0
0,0
0,0
2012 2013 2014 2015 2016 2017
-1,0
-2,0
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9. MediaOmics® Promoters
Rui Oliveira Nuno Carinhas
Rui Oliveira holds a chemical engineering degree and a Nuno holds a Biology degree and is sch
Biochemical
engineering Ph.D. since 1998. He is the head of the SystemsBiotechnology this year. His work focuses o
Biology and
Ph.D. Biochem. at FCT-UNL since 2001. He has been thePh.D.scientist of biotechnology, the core of M
Engineering Lab Eng. approaches to
lead Biotechnol.
Assistantresearch projects with Biopharma companies in the US andjournals. He entrepreneurial and biote
several
Professor at heEurope. He
has taken
Post-Doc researcher at
is author of more than 50 research papers in high impact scientific
universities, including UNL and MIT. Alon
Universidadeof two de Lisboa. patents and 3 national Universidade Nova departicularly in the Bio
is inventor Nova international patents. He hasfinance, Lisboa.
enthusiast of
Inventor of the technology. of CFE-Media technology and of Pichia-FEMTM.
coordinated the development
®
Filipe Ataíde Filipe holds a M.Sc. degree in Chemical
António Dinis FCT-UNL since 2007. He is currently dev
António holds a Biotechnology degree and a MBA. Since 2007 He works as an
nanobiotechnology. He has experience in
Account Manager at Hovione promoting products and nanoparticles with functional coatings to
services to
Biotechnol. Degree M.Sc. Chem. Biochem. Eng.
pharmaceutical companies. Previously he worked for seven years at DSM,gases to liquids. This technol
transfer from
PhD international Universidade
Student at
MBA he held several managerial positions and was involvedmedia ingredients and could be a valua
where
Business Catalyst António is also an experienced business Nova de Lisboa. operations management o
strategic projects. catalyst and has
enthusiast of
helped a number of scientists to bring their technologies closer to market.
entrepreneurial activities.
Ana Ferreira
João Dias Ana Raquel holds a Chemical Engineering
João Dias holds a Chemical Engineering degree and a Chemical and
Biochemical Engineering Ph.D. from FCT-UNL. He is currently a She started her PhD thesis in March 2008
Post-doctoral
She has more than 5 years’ experience in
researcher at the same institution. He has over 7 years’ experience in
Ph.D. Chem. Biochem. Eng. bioinformatics. He has participated Eng.experience in Pichia pastoris
computational systems biology and Chem. has Degree
She in 2008-
Post-Docaresearcher at with Merck&Co - FASTPICHIA - for the optimization different scales, including sh
2009 in research project PhD Student at Universidade
production at
pilot scale reactors. She has been dee
of Pichia pastoris cultivations. João has also been deeply involved in the
Universidade of CFE-Media® technology and of Pichia-FEMTM and he is Lisboa.and she is one of the invento
development
Nova de Lisboa. Nova de
Pichia-FEMof
one
TM
Inventor of the technology.® technology.
the inventors of MediaOmics Inventor of the Technology
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