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www.insightssuccess.com
VOL-12 | ISSUE-12 | 2022
A Data Superhero Changing the Way the World Manages Data
Technophile
CTO’...
The Attributes
that Signify
Brilliance
Editor’s Desk
Abhishek Joshi
Abhishek Joshi
he modern industry is being unpredictable,
Tparticularly in the last few decades, as consumer
attitudes and technological ...
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Technophile CTOs of the Year 2022.pdf

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This edition features a handful of Technophile CTOs of the Year across several sectors that are at the forefront of leading us into a digital future

Read More: https://insightssuccess.com/technophile-ctos-of-the-year-2022-december2022/

This edition features a handful of Technophile CTOs of the Year across several sectors that are at the forefront of leading us into a digital future

Read More: https://insightssuccess.com/technophile-ctos-of-the-year-2022-december2022/

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Technophile CTOs of the Year 2022.pdf

  1. 1. www.insightssuccess.com VOL-12 | ISSUE-12 | 2022 A Data Superhero Changing the Way the World Manages Data Technophile CTO’s CTO’s of the Year of the Year Technophile 2022 2022 Guy Adams, Chief Technology Officer and co-founder DataOps.live Guy Adams
  2. 2. The Attributes that Signify Brilliance Editor’s Desk Abhishek Joshi Abhishek Joshi
  3. 3. he modern industry is being unpredictable, Tparticularly in the last few decades, as consumer attitudes and technological advancements have undergone significant changes. As a result, CTOs now need to be versatile masters of all trades. They must be aware of the majority of activities at their company. There always seems to be a core set of characteristics that they all share, despite the shifting expectations and various roles. Even though they assume a leadership position, a CTO must be an exceptional team player. They should be constantly seeking the input of everybody else involved. It’s also vital that they act as a mediator between the different parts of their team in order to solve issues and foster cooperation. In many ways, the CTO acts as the bonding force that holds a marketing team together. Their job is to keep everybody focused and remind them of the bigger picture. They accomplish this by getting all of the team members on the same page, united under a single cohesive vision. We live in an era defined by rapidly changing technology. Social media, in particular, is rarely static; it can change dramatically in a single day. Given that the majority of marketing now takes place on social media, CTOs must understand how to evolve with it. A successful CTO is always looking for innovative solutions. They recognise the importance of innovation and are willing to take risks to facilitate it. Furthermore, they understand when to let go of the past and what they've grown accustomed to in order for their team to move forward and explore innovative approaches. It takes a lot for a marketing campaign to stand out from the crowd. Being exciting, ground-breaking, and unique is the best way to cut through the oversaturated digital landscape. A good CTO is always aware of how the customer is feeling. They frequently monitor social media to gauge public sentiment. They also serve as customer advocates within their teams, considering how each decision may affect the consumer and arguing in their favour. Spotlighting such staunch aristocrats from the modern industry, Insights Success features some of the enthralling stories of the Technophile CTOs of the Year 2022. Flip through the pages and indulge in the aspects of coherency combined with a distinctive blend of modern advancements. Have a Delightful Read!
  4. 4. Cover Story 08 A Data Superhero Changing the Way the World Manages Data Guy Adams
  5. 5. Brigitte Falk A Doyen of Management in the IT Industry Leading by Example Benjamin Buchanan The Best IoT Professional 20 24 16 The impacts of the pandemic employees' lifestyle and healthcare. Rajan Beera An Enquiring Mind for Success Dushyant Varshney Novel Advancements in the Biopharmaceutical Industry 26 32
  6. 6. sales@insightssuccess.com December, 2022 Editor-in-Chief Senior Sales Manager Business Development Manager Marketing Manager Technical Head Technical Specialist Digital Marketing Manager Research Analyst Database Management Technology Consultant Marry D'Souza Managing Editor Executive Editor Assistant Editor Visualizer David King Art & Design Director Associate Designer Kshitij S Peter Collins John Matthew Sales Executives David, Martin Business Development Executives Steve, Joe Jacob Smile Prachi Mokashi Dominique T. SME-SMO Executive Sagar Lahigade Frank Adams Circulation Manager Robert Brown Stella Andrew David Stokes Copyright © 2022 Insights Success, All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights Success. Reprint rights remain solely with Insights Success. Follow us on : www.facebook.com/insightssuccess/ www.twitter.com/insightssuccess We are also available on : Abhishek Joshi Revati Badkas Jenny Fernandes Anish Miller Sandeep Tikode
  7. 7. Brief Company Name Adela Mehic-Dzanic is a female tech leader, speaker, and mentor. Featured Person Mavovo AG mavoco.com Adela Mehic-Dzanic Head of Connectivity Service Providers – CSP Alberto holds more than 15 years working with data and improving business profitability. GlucoVibes glucovibes.com Alberto Conde Mellado Founder and Chairman Benjamin tends to sell from a technical perspective, being the industry expert but placing emphasis on relationship building and follow-up. SBT Alliance sbt-alliance.com Benjamin Buchanan Chief Executive Officer Dushyant is an accomplished biotech executive with over 25 years of experience in leading entire product lifecycles of diverse modalities including mRNA, gene & cell-based therapeutics, biologics, vaccines and sterile injectables. Arcturus Therapeutics arcturusrx.com Dushyant Varshney Chief Technology Officer Guy is passionate about DataOps. He has spent 20+ years running software development organizations, and now his focus is bringing the principles and business value from DevOps and CI/CD to data. DataOps.live dataops.live Guy Adams Chief Technology Officer Rajan is an innovative leader with a proven track record in Research & Development. Pall Corporation pall.com Rajan Beera Chief Technology Officer Shimrit holds an MSc and PhD from the Hebrew University in Computer Science. The idea behind Secret Double Octopus was designed during Shimrit's post-doc research at Ben Gurion University. Secret Double Octopus doubleoctopus.com Shimrit Tzur-David CSO and Co-founder Technophile CTO’s CTO’s of the Year 2022 SBT Alliance partners with small, medium, and Fortune 500 customers to design, deploy, and support IoT-enabled solutions, systems, devices and technologies. SBT (Smarter Building Technologies) Alliance sbt-alliance.com Benjamin Buchanan CEO FORCAM supports companies with innovative digitalization solutions to successfully master the digital transformation towards the Smart Factory and to solve three key challenges of today and tomorrow. Forcam forcam.com Brigitte Falk CIO and COO
  8. 8. A Data Superhero Changing the Way the World Manages Data C O V E R S T O R Y I've spent 20+ years running software development organisations and now my focus is bringing the principles and business value from DevOps and CI/CD to data. Guy Adams
  9. 9. Guy Adams, Chief Technology Officer and co-founder DataOps.live
  10. 10. he data world has reached a crunch point. TContinuing the trend of the last decade, the requirements from business of their data (and by extension their data teams) are increasing exponentially. It's not just the complexity of the requirements but the pace of change that cause challenges – months and weeks are out and sometimes even days are too slow. Simultaneously, as business, consumers and regulators become more aware, a robust and fully implemented data governance strategy is a hard requirement to ensure that the data is consistent, does not get misused, and is trusted. To compound all of this, data engineers are between 45% and 75% less efficient than their software colleagues due to manual processes, lack of orchestration and lack of automated testing and deployments. Many of these problems have been seen before in the software domain starting 20+ years ago and then in the cloud infrastructure domain 10+ years ago. On a mission to address these issues Guy Adams, the Chief Technology Officer and co-founder has developed the world's leading DataOps platform, DataOps.live. Introduction Guy is a self-motivated leader with over two decades of experience, guiding teams through the Agile/DevOps/CICD journey. Contribution to the World of Data Life was all about DevOps and then CloudOps for Guy, initially bringing his expertise of Software DevOps into the cloud infrastructure world. When he came to the data world, it brought a feeling of déjà vu. The data world was incredibly advanced in some respects however, automation, orchestrations, testing, observability, development practices and deployment techniques were still in the dark ages! An early decision to work with the world's leading cloud data platform, Snowflake turned out to be pivotal – its unique combination of features unlocked key DataOps capabilities and Guy has become one of a very elite group of Snowflake Data Superheroes globally. A career path destined to challenge the status quo After graduating with a degree in electrical engineering from Imperial College, London (where he was awarded the Eric Laithwaite Prize for Innovation) and time spent with the Royal Air Force, Guy found his way into a junior network management consultant role at a small company - Parallel. He worked his way up to CTO, developing the industry's first web -based management platform and was part of the team that managed the acquisition of this company by iDirect, a leading satellite communications company. He remained at iDirect as VP of Engineering and over time added a variety of other responsibilities, including starting the first user experience department within the satellite industry. In the early days of his career, Guy struggled with being younger than most of his peers, but this taught him how to really fight for continual progress and against established dogma, even in the face of far more experienced people. Sometimes this meant driving small but continual improvements, but other times radical and fundamental rethinks were required. In 2018, Guy was ready for a move into a different industry and had fallen in love with the data world. He joined Datalytyx as CTO and was part of the team that lead the acquisition of this company by Mphasis. This set him on a path, with his co-founders Justin Mullen (CEO), Sam Hopper and Colin Bradford to challenge a whole industry of thirty years of legacy thinking. Today Guy is recognised as a global authority on the principles, practices, and technologies of DataOps. He was the original architect of the DataOps.live product and led the definition of the philosophy itself as www.truedataops.org. He presents at many conferences around the world each year and lectures as part of several DataOps provides end to end orchestration, environment management, CI/CD and automated testing wrapped in an elegant UI.
  11. 11. higher degree programmes. Most recently Guy co-authored the DataOps for Dummies book. Governance and Agility DataOps.live has a simple mission – to automate the build, test, deployment and observation of data applications and data products on the Snowflake Data Cloud. The company does this by taking all the best principles, processes, and technological solutions of twenty years of DevOps and ten years of CloudOps and using them as a baseline. DataOps.live has then identified the challenges unique to the data world and created new solutions on top of this foundation. This has led to numerous advantages for organisations from SMEs to the largest global enterprises. Changing the dynamics of data As businesses demand more agility, companies have reduced time to value for completely new initiatives from six months to six weeks. Releases that used to happen once every three months are now happening many, many times per day. This has partially been driven by a huge increase in developer/engineer efficiency. By designing and building a fundamentally new data developer experience, Guy and DataOps.live have, in many cases, doubled productivity. However, critically important for the Enterprise, this leap in agility and efficiency has not come at the cost of good governance. In fact, projects and data products managed using DataOps.live have far better governance with independent and concurrent development for any number of engineers, multi-stage peer reviews, automated testing, complete audit history for every type of change and of course the ability to roll back on the rare occasion that a production deployment doesn't go quite as planned. Transformation Brought by Technology Technology is a fundamental enabler for DataOps. Until two to three years ago, the underlying technology capabilities simply weren't there to allow DataOps to exist.
  12. 12. Innovations by Snowflake, such as Zero Copy Clone and Time Travel, have transformed what is possible. The team at DataOps.live is at the forefront of leveraging these to create #truedataops. The data and application space has been divided for the last 20+ years. Databases held data and applications extracted that data and did interesting things. That model has always created performance and security problems. Developers have to bring the data to the code and if the data is sensitive or large (and large here can be Petabytes or bigger) this is very challenging. The 'next big thing' is moving the code to the data. The ability to create applications using standard programming languages such as Java and Python and actually running these inside the Snowflake Cloud platform itself is game changing. Guy, his team and indeed their customers, are already starting to do this, but it means that a DataOps platform needs to support and manage not just the data but also all the requirements of the DevOps and CloudOps spaces. Guy and his rapidly expanding team are currently focused on making the amazing DataOps.live the de facto standard in the emerging DataOps industry. Beyond DataOps Outside of work, Guy is an avid builder of anything impractical and over engineered from tree houses and gazebos to soapbox cars and river rafts. He is also a skiing instructor (mostly to help keep up with his two young daughters who both race slalom), an aspiring wine bu ff (with a love for southern Italian Reds) and enjoys the challenge of competitive crosswording! Follow your Dream Asked about his experience, "Your career will never follow the path you think – looking back, my career has taken a left and right turns that I could never have predicted. If you work hard, you WILL get opportunities – the problem is that opportunities hardly ever have a big neon sign pointing to them saying -'I'm a great career opportunity.' More often than not, they look like risks, sidewise moves and sometimes even steps backward. Be open to possibilities and trust your gut and the advice of the people you have built faith in.” Be open to possibilities and trust your gut and the advice of the people you have built faith in. The problem is that opportunities hardly ever have a big neon sign pointing to them saying -'I'm a great career opportunity.' More often than not, they look like risks, sidewise moves and sometimes even steps backward.
  13. 13. The impacts of the in pandemic employees' lifestyle and healthcare. andemic and biology changed in just one year more Pthan technology in the last 10 years. All the technological tools were there but most of all big companies were not using them properly. And our lifestyle changed with it. Today, remote working or teleworking is very normal, as are conferences, phone calls and other activities that leave behind the face to face necessity and lots of traveling and commuting. This tendency has become the new reality and it could be a good step in the short term in terms of efficiency and productivity, but it has a critical impact on the lifestyle habits and employees' health. And the main reason is that we dramatically reduce our activity and we become more sedentary. This sedentary lifestyle affects health badly, and it opens the door to future metabolism disorders such as metabolic syndrome, obesity, insomnia or type 2 diabetes. We saw from Glucovibes users that the glucose levels of sedentary people is higher at all the time, both day and night. This means that the insulin levels are higher, too, and the lack of activity together with a high diet in carbohydrates and saturated fats is the perfect storm for metabolic disorders. Activity is the main regulator of our glucose levels, and it can not be replaced just by a specific diet or carbohydrates limitation. Our body and metabolism is created to have an active profile, our muscles need to be used to avoid their atrophy. Diet of course has a direct effect on glucose levels and metabolic health, and metabolic GPS like Glucovibes allows you to understand this effect together with activity and resting, the three main pillars of metabolic health. It is important to understand that any employee should introduce in his/her schedule some activity each 90 or 120 minutes, a little walk of 15 or 20 minutes have a positive effect on the metabolism, and if you take this short walk after your meals, our body receive the help of our muscles to regulate the intake of energy and glucose of each meal. At the same time, it is very important to balance the nutrients intake, in order to avoid a plain carbohydrate meal and most of all, a high added sugar meal, which is quite common in a lot of employees working remotely to maintain their attention. In fact, high carbohydrate intake meals generate reactive hypoglycemia which means a focus depreciation and new glucose desire or cravings pushing us to keep eating all the time. A simple way to regulate the metabolism could be a balance diet in Proteins, Carbohydrates and healthy Fats together with foods rich in fiber, together with some activity every day (a 30 minutes walking after meals is more effective that go to the gym twice a week), with 3 to 5 intakes per day, and 7 to 8 hours of good sleep with 10 to 14 of fasting period from dinner to breakfast. An early dinner helps, and some strength workout as first "to do" in the morning, even December 2022 | 16 | www.insightssuccess.com
  14. 14. Ph.D Alberto Conde Mellado Industrial Engineer Nutrition Sciences Founder Glucovibes December 2022 | 17 | www.insightssuccess.com
  15. 15. Impact on glucose levels of eating the same chocolate pu ffpastry during a walk or in the sofa (by Glucovibes) December 2022 | 18 | www.insightssuccess.com
  16. 16. for 10 to 15 minutes regulates our metabolism from the beginning of the day. Of course, avoiding processed foods and added sugar foods is a good choice. Remote working reduces activity and could have fatal consequences in any metabolism if we do not take action and balance our lifestyle. Early death and chronic metabolic disorders are growing each year and the pandemic will boost these numbers if we do not understand how to face it with better lifestyle habits. Fortunately, technology could help here, too, allowing us a guidance or metabolic GPS as Glucovibes does to understand the change and the impact of our lifestyle on our health. December 2022 | 19 | www.insightssuccess.com
  17. 17. Benjamin Buchanan The Best IoT Professional Over the years, many technological innovations quickly rose to prominence but ended up falling off just as fast. What happens to those systems beyond? Odds are those systems no longer work, leaving those businesses up a creek without a paddle! That’s why Benjamin Buchanan, Chief Executive Officer sets out to create something better, something smarter at SBT (Smarter Building Technologies) Alliance. An interview conducted between Benjamin Buchanan and Insights Success identifies his leadership development by fully embracing innovative thinking and building an all-star team to help drive the SBT mission forward. Below are the highlights of the interview: Kindly take us through your journey to becoming a proficient tech business leader. From my humble beginnings in this industry as a project designer, I saw the importance of working hard to bring the customer more than what they expected and making their project truly valuable. There are plenty of examples of projects built with cheap products, and I knew the customer had left so much on the table. So I made it my purpose to educate myself on all the technology available to marry them with the customer’s needs perfectly. This technology- first approach guided me from lighting into the world of wireless IoT systems and now is a cornerstone to SBT’s mission, bringing true value through technology to our customers and suppliers alike. What business roadblocks or challenges have you faced? And how did you overcome them? As with any business, leadership position, or professional role within an organization, roadblocks and challenges are abound – there’s simply no way around it. You’re going to hit roadblocks and confront challenges – be it cash flow, funding, sales, employee relations, productivity, etc. The question then becomes, will you persevere, or will you let them defeat you and knock you down? Perseverance and persistence is the path to success, in my opinion. It is only through perseverance and persistence that I’ve overcome business (and personal) roadblocks and challenges. How do you diversify your organization’s offerings to entice the target audience? SBT is committed to a business model that is product and technology agnostic. This approach allows our product and IoT solutions teams to engineer solutions for clients that answer specific data-related questions about their facilities while also solving critical business challenges. A one-size- fits-all approach simply doesn’t work in the sphere of IoT and technology-led solutions. It sounds nice, but proper IoT solutions are an amalgamation of many technologies, devices systems, and solutions that, when pulled together, create the enticing solution offering that meets our target audiences’ needs. That’s why we stand out with our clients; we don’t try to sell them something they don’t need. We partner with them to solve business and operational challenges and design a mix of solutions to achieve that goal. What culture change do you suggest for companies that want to embrace the full power of AI? The full power of AI, machine learning, and the Internet of Things (IoT), more broadly, honestly depends on each customer’s needs. In B2B – which is the sphere that SBT operates – it isn’t necessarily a question of culture change, rather a better understanding and realization of what’s possible when using the advanced technologies of IoT to solve business challenges. It is more about education and proof points. What are the vital traits that every business leader should possess? Leaders in any business setting should encompass some of the following traits/approaches, as I’ve identified in my own leadership development and shared by many of my leadership mentors within the business community. I chalk these traits into five vital characteristics of successful leaders: December 2022 | 20 | www.insightssuccess.com Technophile CTOs of the Year 2022
  18. 18. Benjamin Buchanan, Chief Executive Officer, SBT (Smarter Building Technologies) December 2022 | 21 | www.insightssuccess.com
  19. 19. that allows folks to contribute and help SBT deliver on our mission and reach our vision to transform how IoT products, services, and technologies are delivered to the market and optimized by customers. Where are you focusing your energy now, and where do you hope to make an impact next? Right now, we are in the whirlwind that comes with scaling a technology-focused company. I am keen to drive SBT forward to continue making the impact we are for our customers, industry partners, and the facility management space as a whole. My immediate energy is focused on continuing to build an all-star team of SBT team members who evoke our CIVIC values as a company and as individuals. These include: Ÿ Commitment Ÿ Integrity Ÿ Value Ÿ Innovation Ÿ Community “ SBT partners with small, medium, and Fortune 500s to create smart spaces that future- proof businesses. 1. Effective leaders need the ability to streamline and clarify the complex. 2. Passionate leaders must fully embrace new thinking – that’s what primes innovation. 3. Confident leaders must have both self-assurance and humility – they inspire, not belittle. 4. Compassionate leaders must set high standards but modesty to admit when wrong. 5. Responsible leaders need to be honest, truthful, and transparent – that’s what builds trust. How do you keep yourself up-to-date with the latest technology? As a technology-forward company, SBT and our team technicians and IoT thinkers keep me in the know, along with our industry partners with whom I continually meet. As I mentioned earlier, the SBT model focuses on product and technology agnosticism, so we’re continually meeting exciting new technology companies and learning how they approach IoT, AI, and machine learning. To me, there’s no better way to keep up to date than getting right in there and being hands-on with innovators as SBT does every day. What does it take to attract and retain tech talents? As I mentioned earlier in this conversation, it is my firm belief that if a leader takes to heart the five vital characteristics that I reviewed, they will set the stage and environment that will attract, retain, and encourage tech (and non-tech) talents. It’s about building an atmosphere December 2022 | 22 | www.insightssuccess.com
  20. 20. prominent personality in the international IT AIndustry, Brigitte Falk is setting a striking instance of impactful leadership. Brigitte brings 25 years of management experience in the IT industry to the table. Currently, she is serving as CIO and COO at a IIoT software company FORCAM, with a strong focus on the innovation environment, digitalization, and agile working methods. Brigitte started her professional career in 1996 at SAP as Product Manager Oil and Gas. During her tenure over, she worked in corporate development, innovation management and event management. In 2004, she took over the Business Operations department as Marketing Director. Having worked for several years there was a substantial learning experience accompanied by management & leadership techniques, innovation methodologies, product management know-how, intercultural and interdisciplinary teams. After graduating with Malik MZSG Executive Diploma, Brigitte Falk founded the Simplicity Company to support consulting firms, analysts and investment banks with strategic consulting worldwide. In 2014, she took over global responsibility for Marketing & Sales Applications at Celesio AG (today McKesson Europe). In 2017, she was appointed Division Lead Organization & Information of CRONIMET Holding GmbH. Brigitte's interdisciplinary studies of arts, humanities, and natural sciences, complemented by an open spirit, are the foundation of where she is today. She inculcates strategic thinking through work with venture capitalist in a startup environment, followed by taking on European ecommerce IT assignment in a challenging environment. Her achievements have been reflected over the last three years as “CIO of the year 2018” (CIO Magazine Germany), “CIO of the year 2019” (Bonhill – Women in IT Awards Europe), and “CIO of the Decade 2020 Germany” (Confare & EY). Customer Centric Approach FORCAM FORCE™ is the first turnkey and manufacturer- independent IT platform for the industrial Internet of Things (IIoT). The company's claim that it delivers results in productivity remains a solid foundation since its establishment in 2001. Almost two decades ago, FORCAM celebrated its debut and first deployment at Mercedes-Benz. The iconic automobile company has since celebrated many accolades, including the “Factory of the Year” award in 2007, 2008, and 2012. The most recent award in 2020 is the Manufacturing Leadership Partner Award by the National Association of Manufacturers. Since then, the company has evolved into a comprehensive IIoT solution partner with a high-performance manufacturing 4.0 platform and a vital ecosystem. Today, its turnkey and freely extensible cloud platform is used by large and medium-sized companies including Lockheed Martin Audi, BMW, BorgWarner, Daimler, KUKA, Pratt & Whitney, Schaeffler, Swarovski and many more. December 2022 | 24 | www.insightssuccess.com Technophile CTOs of the Year 2022
  21. 21. Today, more than 100,000 machines are monitored with FORCAM technology worldwide. Having Brigitte at the helm, the company is about to launch two new IIoT product lines by introducing “Customer centricity” as guiding principle. They are based on Ÿ market gap: connecting supposedly “non-connectable” older brownfield machines to the internet (FORCAM FORCE EDGE) and leverage their data potential and Ÿ the need for fast, easy and low-cost connection of production lines of SMEs or smaller subsidiaries to the internet (FORCAM FORCE SaaS) A Culture Change to be Adopted According to Brigitte, to embrace full power of AI, companies must show openness towards disruptive business models and the respective digital transformation across all parts of the business. They should unlock the hidden potential of their current staff, encourage them to take on bigger tasks beyond their usual level of comfort, agile principles (inspect and adapt), and take related responsibility. Brigi e Falk COO and CIO FORCAM December 2022 | 26 | www.insightssuccess.com
  22. 22. Besides, it is also important to attract and retain tech talents. She mentions that for companies, it takes a bold vision, creation of jobs for people from tech background based on their ambitions and strengths, and encompassing empowerment to attract and retain tech talents. Thought Leadership in the IIoT Domain Currently, Brigitte is focusing her energy to market the FORCAM solution portfolio geared towards real-time data- driven decision making on the shopfloor, grid connectivity and machine data lake offerings as foundation. Now, all her efforts are in the direction to drive vision and thought leadership in the IIoT domain. Besides, Brigitte keeps herself updated with the latest technological trends by reading, meeting, talking with an outmost heterogeneous, interdisciplinary audience and network from all over the world. She also keeps openness for inspirations from unusual sources beyond the mainstream. A Take on Sound Leadership When asked about essential traits every business leader should possess, Brigitte is of the opinion that every leader should focus on empowerment. They should always put strategic thinking and innovation into practice for every decision they take and communicate a related vision with everyone. A sound leader is one who leads by example, builds on trust, integrity & transparency, and actively listens. December 2022 | 27 | www.insightssuccess.com
  23. 23. Dushyant VarshneyNovel Advancements in the Biopharmaceu cal Industry Dr. Dushyant Varshney, Ph.D., Chief Technology Officer Arcturus Therapeu cs December 2022 | 28 | www.insightssuccess.com
  24. 24. he pace of technological development today is fast Tmoving and can impact all areas within an organization. Leaders need to be able to appropriately leverage these advancements within their own organizations in order to mitigate being outpaced by their peers as well as to meet or exceed stakeholder's expectations. Staying ahead of disruptive technology trends, while maintaining nimbleness to meet needs, has become a key component for success in such a rapidly evolving industry. Dr. Dushyant Varshney, Chief Technology Officer (CTO) at Arcturus Therapeutics, is one such leader who directs the entire product life cycle of diverse biotech modalities. With over 25 years of experience in global bio-pharma organizations, Dr. Dushyant's broad expertise includes mRNA therapeutics, gene & cell-based therapy, biologics, and vaccines. He has been a significant contributor in over 30 product launches, over 75 Investigational New Drugs (INDs) and Biological Licensing Agreements (BLAs), and Prior Approval Supplement (PAS) submissions, and has helped generate over $20 Billion in revenues at companies including Gilead, Pfizer, Novartis, and Sanofi. Insights Success had the opportunity to interview Dr. Varshney, in which he shared valuable facts about his successful innovations in the field of Biotechnology for the advancement of medicine. Below are the excerpts from the interview: Briefly describe your professional journey up until now. From grapevine to mRNA, my journey has been quite interesting and global. After learning my biopharma- technology basics in Nasik (also known as, wine capital city, popular for the best grapes in India) and pharmaceutical chemistry in Mumbai (Institute of Chemical Technology), I became a proud Hawkeye at the University of Iowa earning a Ph.D. in Chemistry with a focus on supramolecular self-assembly chemistry and biocatalysis. Over the last 25 years, I had the fortune to lead global teams at the Top 20 global Biopharma Companies, including Gilead-Kite, Pfizer, Novartis, and Sanofi. Earlier in my career in the US, my focus was on learning the entire Chemistry, Manufacturing and Controls (CMC) discipline. My introduction was at Eli Lilly, Indianapolis (during the time the Colts won the Super Bowl in 2006) and later at Sanofi, based out of New Jersey, as Senior Research Investigator. Diving into late-stage development and commercialization, I joined Novartis Vaccines and Diagnostics in North Carolina, contributing to quality, technology transfer, and sterile operations of novel cell-based Pandemic and Seasonal Influenza Vaccines. With the opportunity to make a bigger impact in sterile injectables by leading manufacturing assessment and strategy joined Pfizer (New Jersey) and legacy Hospira (Chicago, Illinois area). I oversaw global site teams, including India Manufacturing and Science & Technology. Driven by personal reasons towards fighting cancer, and to learn and make an impact in the field of immuno-oncology, gene and cell therapy, I joined Kite Pharma – Gilead in Santa Monica, California and built the first truly Global Manufacturing, Science &Technology organization for Clinical and Commercial Celltherapy and viral vector products. At Arcturus, I joined as the Chief Technology Officer (CTO), to lead and build the CMC, Technical Operations, Supply, and Quality capabilities for clinical and commercial development and take it to the next level - mRNA COVID vaccines and innovative technology platform pipeline for treating rare diseases such as ornithine transcarbamylase (OTC) deficiency and cystic fibrosis. At Arcturus, we have built our platform technologies for developing and delivering innovative next generation of mRNA for the treatment of rare diseases and self-amplifying mRNA for preventing COVID19 and influenza. Technophile CTOs of the Year 2022 December 2022 | 29 | www.insightssuccess.com
  25. 25. What challenges did you face along the way? The biggest challenge has been to rapidly learn-build- contribute while embracing highly novel and diverse modalities of biologics, vaccines, cell, gene-edited (e.g., CRISPR), and nucleic acid-based modalities that have been discovered in the last two decades for treatment, prevention, and personalized medicines (autologous CAR-Ts). Certainly, I faced challenges and enormous opportunities to lead and motivate teams of different culture-communication styles based out of the US, EU, Asia-Pacific, and recently out of Vietnam & Japan collaboration, yet with a common goal to make a difference in patients' and their families' lives. What significant impact have you brought to the Biotechnology industry? I am fortunate for opportunities to build and lead great teams globally that delivered great results. I feel proud that by investing time in people first and a whole-person paradigm leadership, learned from my biggest teacher Stephen Covey, enabled me to launch more than 30+ biopharma & biotechnology-based products worldwide. My efforts have helped reach patients by supplying more than 10 billion doses of quality therapeutics, vaccines, and thousands of personalized autologous CAR-T medicines ® ® like Yescarta and Tecartus for cancer patients. Honored to be part of the technology transfer, manufacturing, and ® launch team of novel vaccines like Flucelvax (the first US cell-based influenza vaccine, Trivalent & Quadrivalent) and Pre-Pandemic Vaccine stockpiles (bird & swine-flu, H5N1, H3N2, H7N9). How does Arcturus Therapeutics promote workforce flexibility, and what is your role in it? At Arcturus Therapeutics, although we are based out of sunny, San Diego. Still, we have a global footprint encompassing the US, EU, and the Asia Pacific with our manufacturing, supply chain, and clinical operation workforce and partners. We promote a flexible workforce based out of global locations and work from home based on the business capability support structure. I lead and collaborate with our HR team to enable smart and flexible work environments to support global manufacturing, quality control, and supply. What is your take on technology's importance, and how are you leveraging it? Success in the past decade of cell & gene therapeutic technology and recent mRNA-based COVID vaccine technology to fight the coronavirus pandemic rapidly is a true endorsement of technology's importance to save millions of lives and economic breakdown globally. I have been passionate and fortunate to leverage such novel biotechnology platforms that have the potential to treat or prevent current and future diseases. In particular, merging the power of the latest Digitization, Artificial Intelligence, and Automation has allowed me to imagine, build and implement platform technologies for manufacturing and supplying medicines otherwise unavailable. At Arcturus, we have built our platform technologies for developing and delivering innovative next generation of ® TM mRNA and self-amplifying mRNA (LUNAR & STARR ) for preventing COVID, influenza, and treatments for rare diseases like Ornithine Transcarbamylase (OTC) Deficiency and Cystic Fibrosis, and with the potential to deliver therapeutic RNA to diverse cell types including lung and liver. What will be the next significant change in the Biotechnology industry, and how are you preparing for it? I think the biggest challenge and opportunity in the future will be to custom design technologies and platforms to deliver diverse, innovative engineered modalities precisely and effectively inside the cell or nucleus to treat the underlying cause of rare diseases and prevent widespread diseases. The next significant change in the biotechnology industry will be to meet such lofty goals, both“in vivo and in vitro.” By leveraging our current and future toolbox of the CRISPR, Base, Prime, etc., edited-based technologies, molecular engineering, and diverse drug delivery approaches beyond our current lipid nanoparticulate and viral vector technologies, a key focus will be to scale up and validate such genetic medicine platforms in the clinic and commercially. What are your goals in the upcoming future? My upcoming aspirations and goals are to lead and build highly collaborative innovation-driven business models. Design and grow the next generation of genetic modality December 2022 | 30 | www.insightssuccess.com
  26. 26. platform technologies by applying the most advanced drug delivery, AI, and digital solutions. Provide rapid and comprehensive approaches to validate platforms in the clinics for commercialization and supply of quality-safe-effective medicines globally. What advice would you like to give the next generation of aspiring business leaders? My advice to the next generation of business leaders is to "Invest in people first" to make the best business ideas- technology-medicine dreams a reality. First, build great teams with innovation and patients in mind, and then develop meaningful therapeutic platform technologies and business models. Validate enough the proof-of-concept in pre- clinical/clinical, leverage fast-fail/success investigational approaches, and assure short & long-term safety and quality of novel biotech modality-based medicines. December 2022 | 31 | www.insightssuccess.com
  27. 27. Rajan Beera Chief Technology Officer Pall Corpora on December 2022 | 32 | www.insightssuccess.com
  28. 28. Rajan Rajan BEERA An Enquiring Mind for Success ow does it work?’ – a seemingly innocent question Hof a child becomes the precursor of a lifelong curiosity. It takes them into deep dives into esoteric subjects finding answers that leave an unanticipated impact on the world. Rajan Beera, the CTO of Pall Corporation, has always been driven by a powerful curiosity to understand. It led him to opt for engineering as his major in college. His avid interest in the materials that various electronics are constructed from brought about the development of a patented method to make synthetic diamonds for electronics applications. Rajan is an innovative leader with a proven track record in Research & Development. He has demonstrated successful ideation of new concepts in product & process technology development and has successfully scaled up technologies for high-volume manufacturing. He has achieved breakthrough improvements using Six Sigma methodology, structured problem-solving skills, and Danaher Business System (DBS) tools. With his work, Rajan demonstrates expertise in technology strategy, portfolio management, project management, and building global cross-functional high-performance teams. Pall Corporation is a global leader in filtration, separation, and purification. It uses innovative solutions to ensure the purity of products, efficiency, and safety in processes and maximizes production outputs. Pall operates across a broad spectrum of industries, including microelectronics, oil and gas, chemicals, power, automotive, and general industrial. Rajan Beera, in an exclusive interview with Insights Success, describes a career driven by curiosity, passion, and innovation. Below are the highlights: Briefly describe your professional journey up until now. Curiosity to understand ‘how things work’ has always been my passion. That propelled my professional journey, from studying Electronics Engineering during undergrad to continuing to a graduate program at Birla Institute of Technology, India, where I conducted research in optoelectronic detectors for far-infrared applications. The materials used to construct sophisticated electronic devices always intrigued me, which led me to develop a patented method of making synthetic diamonds for electronics applications during my Ph.D. program. The exposure I had in a state-of-the-art semiconductor fabrication facility, High-Density Electronics Center Innovation defines our future. One doesn’t have to be a t echnologist or an R&D scientist to innovate. In my experience, the key to success is staying curious, not hesitating to challenge the status quo, and a willingness to learn at any age or stage in your career. ‘ Technophile CTOs of the Year 2022 December 2022 | 33 | www.insightssuccess.com
  29. 29. (HiDEC), at the University of Arkansas helped me start my professional career at National Semiconductor Corporation, one of the leading semiconductor chip makers in the 90s, which I followed to Texas Instruments through acquisition. At National, I began as a process engineer and advanced in my career to leadership positions in technology. In 2013, I finally left TI to begin the next adventure of my career at Pall Corporation, where I became the Chief Technology Officer in 2021. What challenges did you face along the way? It wasn’t easy to conduct research in advanced semiconductors in those pre-internet days in India when communications were all through “snail mail.” One of the greatest challenges I faced in my career was to connect with a research program that was aligned with my passions in the United States so that I could conduct hands-on semiconductor fabrication research. Not only was it the farthest distance I had ever traveled in my life, to an entirely foreign country, but it was also a great financial burden as well. I was incredibly fortunate that my professor, Dr. William Brown, offered me a full-ride scholarship to conduct research on my favorite topic. That generosity enabled me to complete my Ph.D. and begin the career I have now, for which I am forever grateful. Another challenging decision I had to make was to move from the company I had built my career for 17 years to something new at Pall! But when I started working at Pall, I immediately knew I had made the right choice. I have been fortunate to work at a company started by Dr. David Pall 75 years ago, now part of the Danaher family, associated with an amazing team of highly talented scientists conducting cutting-edge research. What significant impact have you brought to the Materials & Technology industry? My passion to be curious, to learn, and explore had never left me in all the years of my career. Understanding customers’ problems or challenges and the openness to think outside of the box to find a solution by bringing December 2022 | 34 | www.insightssuccess.com
  30. 30. together competent teams and enabling them to be their best has always proved a worthy endeavor for me. As a leader, I take pleasure in empowering teams. Being a coach and mentor have been my favorite parts of my job at any company I worked for. Tell us about Pall Corporation and its foundation pillar. At Pall, we support diverse industries – for example, in Microelectronics, our products enable the processing of the finest features on a silicon wafer to build the most advanced semiconductor chips (computer chips) by removing nanometer-size contamination in process chemicals. Our Food & Beverage business supports the production of dairy products, ensures the integrity and flavor intensity in a bottle of wine, and helps our customers improve product quality, maximize yield, reduce operating costs and safeguard health. Pall technology supports the aerospace industry by protecting every critical piece of fluid equipment on an aircraft that requires fluid filtration and separation and proudly stands as the world's largest aerospace and defense filtration company. We serve the oil & gas, chemical, and power generation industries through our FTAP business which enables energy transition from fossil fuels to renewable energy sources while aiding the success of carbon capture technologies for a cleaner environment. The primary focus at Pall Corporation is to use the power of science to develop solutions that solve customers’ most challenging problems through innovation. What is your take on technology’s importance, and how are you leveraging it? We have a strong foundation on the core fundamentals of materials science, and we build on them for efficiency through the application of advanced technologies like Artificial Intelligence and Machine Learning. The human brain is unmatched in its innovative potential, but even it can be greatly enhanced by computational capabilities and predictive analytics. We do our part to apply smart tools both in R&D as well as in manufacturing, that brings us close to enabling Industry 4.0 objectives. What will be the next significant change in the technological industry, and how are you preparing for it? The future is full of challenges, and what excites me is the science and technology we develop every day to overcome them. As a global filtration and separation leader, we stay connected with technological advancements in product development through research and also from a manufacturing perspective. This generation is heavily reliant on connected solutions enabled by aspects like the Internet of Things (IoT). Ability to predict the performance of a product before it is fabricated through computational simulations using predictive analytics becomes very critical. At Danaher, we pride ourselves in continuous improvement through upskilling our internal talent and building a funnel with collaborations in academia and industry consortia. What are your goals in the upcoming future? We are steadfast with our primary focus of enabling our customers to develop the next generation technologies that produce advanced electronics, a cleaner environment, safe transportation, and healthy options for food & beverage. As a filtration and separation leader, we strive to push the boundaries of science to develop novel materials that are optimal for each of the applications where our products are used. We also assist our customers in predictive analytics through digital connectivity. What advice would you like to give the next generation of aspiring business leaders? As we say at Danaher, “Innovation defines our future.” One doesn’t have to be a technologist or an R&D scientist to innovate. In my experience, the key to success is staying curious, not hesitating to challenge the status quo, and having the willingness to learn at any age or stage in your career. I am passionate about innovation, and that passion has gotten me to where I am today. The other piece of advice I’d give is to always stay customer focused. December 2022 | 35 | www.insightssuccess.com

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