INTERMEDIARY
METABOLISM
PRESENTED BY
Mr.Karthick J.
The Biosynthesis of
Purines
de novo pathway for purine
biosynthesis

PURINES AND PYRIMIDINES
Purines &Pyrimidines are two classes of nucleotides in the cells
Primary function of nucleotide is to act as building blocks of DNA and RNA
Purines:Tw o types:Adenine & Guanine
Pyrimidines: Three types: Thymine, Cytosine & Uracil
Apart their role of "genetic information storage", nucleotides also serves
different functions in the cells such as:
Energy carrier (ATP and GTP)
Components of co-enzymes (NAD and FAD)
Signal transduction (CAMP and CGMP as 'second messengers)

PURINES AND PYRIMIDINES
Two pathways for the biosynthesis of Nucleotide:
Denovo synthesis: biochemical pathway where nucleotides are
Synthesized new from simple precursor molecules
Salvage pathway: used to recover bases and nucleosides formed during
the degradation of RNA and DNA