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A major function of replicative DNA polymerases is to replicate DNA with the very high accuracy.

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REPLICATION FIDELITY
Presented by
Mr.Karthick J.
INTRODUCTION :
• Fidelity of DNA replication is depend on the
enzyme to catalyze many reaction before
relasing its substrate is called processivity.
• The key of processivity of DNA polymerase tjat
act at the replication fork in their association
with protein called sliding DNA clamps.
• The speed of DNA synthesis is largely due to
the progressive nature of DNA polymerase III
due to its binds with sliding DNA clamps and
stabilizes itself in elongation process.
• Thus the replication fidelity increases.
REPLICATION FIDELITY.pptx
• The another reason for fidelity is the proof
reading process of replication.
• In proof reading process, the incorrect base
pairs remove by the nucleus that originally
identified in the same polypeptide as the DNA
polymerase.
• In the polymerase 1 two nuclease , one is
exonuclease and one is endonuclease .
• Thus the fidelity is increased of the DNA
replication .
CONCLUSION :
• DNA replication itself can occasionally
damage, called mutation that introduces error,
hence the maintainance of the DNA
replication is needed for the next generation
purpose.
• DNA molecules are themselves irreplaceable,
it can cause cellular damage too.
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REPLICATION FIDELITY.pptx

  • 2. INTRODUCTION : • Fidelity of DNA replication is depend on the enzyme to catalyze many reaction before relasing its substrate is called processivity. • The key of processivity of DNA polymerase tjat act at the replication fork in their association with protein called sliding DNA clamps.
  • 3. • The speed of DNA synthesis is largely due to the progressive nature of DNA polymerase III due to its binds with sliding DNA clamps and stabilizes itself in elongation process. • Thus the replication fidelity increases.
  • 5. • The another reason for fidelity is the proof reading process of replication. • In proof reading process, the incorrect base pairs remove by the nucleus that originally identified in the same polypeptide as the DNA polymerase. • In the polymerase 1 two nuclease , one is exonuclease and one is endonuclease . • Thus the fidelity is increased of the DNA replication .
  • 6. CONCLUSION : • DNA replication itself can occasionally damage, called mutation that introduces error, hence the maintainance of the DNA replication is needed for the next generation purpose. • DNA molecules are themselves irreplaceable, it can cause cellular damage too.
  • 7. • Fidelity of DNA replication depends on the proof reading, repair system as well as in some enzymes function. • Such mechanism of DNA replication fidelity is also depends on the onway repair system like nick translation done by the phosphodiester bonds and with the help of ATPs.