Cleft lip and palate slideshare

CLEFT LIP AND
PALATE
Presented by:
Khushbu Agrawal
Dept of Orthodontics

CONTENTS
 Introduction
 Incidence
 Embryology
 Aetiology
 Predisposing factors
 Classification
 Diagnosis
 Problems associated with clefts
 Syndromes associated with clefts
2

3
 Management of Cleft lip and palate
• Timing of treatment sequence
• Presurgical Orthopedic treatment
• Nasoalveolar molding
• Alveolar Bone grafting
• Role of Orthodontist
• Orthognathic surgery
• Prosthetic rehabilitation
• Recent advances
• Other specialities
 Conclusion
 References

• Cleft lip and palate is the second most
common congenital anamoly after clubfoot
• Amoung the 15 types of orofacial clefting,
cleft lip and palate is the most common one.
4
INTRODUCTION

• Hippocrates (400 BC) and Galen (150 AD) mention cleft lip, but not
cleft palate in their writings
• Cleft palate – Fanco (1556)
• Repair of cleft lip – as early as 255-206 BC in China
• The first successful closure of a soft palate defect was reported in
1764 by LeMonnier, a French dentist.
5

Kingsley (1880)
- oral deformities as a branch of mechanical surgery
Calvin case (1921)
- a practical treatise on technique and principles of dental
orthopaedic and prosthetic correction of cleft palate
H.K.Cooper,Sr (1930’s)
- Introduced the integrated team concept and formed the Lanchester
cleft palate clinic
- True integration starts with a meeting of the minds of the individuals
who first examine the patient together and then agree on a program
together
6

INCIDENCE
• Worldwide one in 600 (1:600)
• cleft lip with or without the cleft palate 9.92/10,000
• cleft lip 3.28/10,000, and cleft lip and palate 6.64/10,000
• Birth prevalence of clefts between 27,000 and 33,000 clefts per year
A child is born with a cleft somewhere in the world every 2 minutes
according to a WHO study published in 2001
Reddy S et al. Incidence of cleft Lip and palate in the state of Andhra Pradesh, South India. Indian J Plast Surg. 2010 Jul-Dec; 43(2): 184–189.
8

• Caucasian population, the prevalence of CL was 25%, CLP 50%,
and CP 25%
• In India meta-analysis of 25 early studies from 1960 to 1979 showed
incidence of CLP 1.08 and CL 0.23 in 100 live births
• In India alone the number of infants born every year with CLP is
28,600
78 affected infants are born every day, or 3 infants with clefts born
every hour
9

• More common clefts are –
• Unilateral clefts
• Males female ratio is 2:1
• Left sided
• Males more affected by cleft lip
• Females more affected by cleft palate
10

EMBRYOLOGY
• Development of facial structures starts at the end of 4th week
• 5 facial prominences around stomatodeum
1. Unpaired frontonasal process
2. Paireed maxillary prominences
3. Paired mandibular prominences
12
Thronton JB, Nimer S and Howrd P. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168

• In following 2 weeks –
• The 2 medial nasal processes fuse in midline – upper lip
• Mandibular processes fuse in midline – lower lip
13

• The maxillary and lateral nasal process separated by nasolacrimal
groove/duct
• Frontonasal process – bridge of the nose
• Medial nasal process – tip of nose and philtrum of upper lip
• Lateral nasal process – ala of the nose
14

• Primary palate – maxillary and medial nasal process merge
• Formation of intermaxillary segment from merged medial nasal
prominences
15

16

• Secondary palate – formed from 2 outgrowths from maxillary
prominences – palatine shelves
• Fuse in midline at 7th week
• Incisive foramen – midline landmark between primary and secondary
palate
17

Formation of clefts
• Failure of fusion of maxillary and medial nasal processes – anterior
to incisive foramen
• Failure of fusion of palatine shelves – posterior to incisive foramen
• Cleft lip – failure of proliferation of mesodermal cells in midline
18

AETIOLOGY
Ancient Folk explanations
• Aztecs – eclipses occurred because a bite had been taken
out of the moon
• Prevented with an obsidian knife above the pregnant
abdomen
• Modern Mexico prevented with keys and safety pins
22

Early Chinese
• Eating rabbit “hare lip”
• Bad karma or wrong doings
Philippines
• Force to the fetal face
Familial or “In the blood”
23

Multi
factorial
Environ
mental
Genetic
24

1] Genetic
• Genetic disorders are classified into 4 groups
1. Chromosomal
2. Single gene
3. Multifactorial – oral clefts
4. Mitochondrial
25
John B. Thornton, Sue Nim Paul S. Howard. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168

2] Multifactorial because:
1) Chances increases if more than one family member if affected
2) More the severity, greater the chances of recurrence in sibling
3) Higher risk if affected individual is of less affected sex
4) Risk decreases in remotely related individuals
5) Consanguinity increases the rate because of sharing of genes
26
John B. Thornton, Sue Nim Paul S. Howard. The incidence, classification, etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168

2 unaffected parents with 1 child affected
 Risk for future children:
 4.4% for CL+/-palate
 2.5% for CP only
1 parent affected
 Risk for future children
1 parent affected with 1 child affected
 Risk for future children
27

3] Environmental factors
• Maternal smoking or tobacco exposure
• Viral infections
• Poor nutrition
• Certain Medicinal drugs
• Teratogens like:
 Rubella virus, Cortisone/ steroids, Mercaptopurine,
Methotrexate, Valium, Dilantin
28
Peter Mosby et al. Cleft Lip and Palate. Lancet 2009; 374: 1773–85

PREDISPOSING FACTORS
 High maternal age
 Diabetes
 Toxemia
 Reduced blood supply
 Folic acid deficiency
 Racial – mongoloids
 Radiations
29
Peter Mosby et al. Cleft Lip and Palate. Lancet 2009; 374: 1773–85

CLASSIFICATION
Bixler divided oral clefts into three groups
1. Syndromic / single-gene / chromosomal or environmental
 1% of CLP AND 8% of isolated cleft palate
2. Familial
 25% of CLP and 12% of isolated cleft palate
3. Isolated / non-familial
 75% of CLP and 80% of isolated cleft palate
31
Allori AC et al. Classification of Cleft Lip/Palate: Then and Now. Cleft Palate–Craniofacial Journal 2016;53(1)

Davis and Ritchie’s classification (1922)
Group I: Prealveolar process cleft (clefts affecting the lip)
1. Unilateral (right/left: complete/incomplete)
2. Bilateral (right: complete/incomplete; left: complete/incomplete)
3. Median (complete/incomplete)
Group II: Postalveolar process cleft (clefts affecting the palate)
1. Soft palate
2. Hard palate
32

Group III: Alveolar process cleft (any cleft involving the alveolar
process)
1. Unilateral (right/left: complete/incomplete)
2. Bilateral (right: complete/incomplete; left: complete/incomplete)
3. Median (complete/incomplete)
33

Victor Veau’s classification (1931)
A] Cleft lip
Class I : U/L notching of vermillion border, not extending into the lip.
Class II : cleft extending into the lip, but not including the floor of the nose.
Class III: extending into the floor of the nose.
Class IV: any b/l cleft of the lip, whether incomplete or complete.
34

35

B] Cleft palate
Class I : soft palate
Class II : soft/hard palate extending no further than incisive foramen.
Class III: complete unilateral cleft, extending from uvula to incisive
foramen, then deviating to one side
Class IV: two clefts extending forward from the incisive foramen into the
alveolus.
36

37

Fogh-Andersen’s classification (1942)
1. H arelip (single or double)
2. H arelip with cleft palate
3. Isolated cleft palate
4. R are atypical clefts, e.g., median cleft lip
38

Kernahan and Stark’s classification (1958)
1. Clefts of structures anterior to the incisive foramen
2. Clefts of structures posterior to the incisive foramen
3. Clefts affecting structures anterior and posterior to the incisive
foramen
39

American Cleft Palate–Craniofacial Association (ACPA)
classification (1962)
1. Clefts of the prepalate (cleft of lip and embryologic primary palate)
a. Cleft lip (cheiloschisis)
b. Cleft alveolus (alveoloschisis)
c. Cleft lip, alveolus, and primary palate (cheiloalveoloschisis)
2. Clefts of the palate (cleft of the embryologic secondary palate)
a. Cleft of the hard palate (uranoschisis)
b. Cleft of the soft palate (staphyloschisis or veloschisis)
c. Cleft of the hard and soft palate (uranostaphyloschisis)
40

3. Clefts of the prepalate and palate (alveolocheilopalatoschisis)
4. Facial clefts other than prepalatal and palatal
a. Cleft of the mandibular process
b. Naso-ocular clefts
c. Oro-ocular clefts
d. Oroaural clefts
41

Kernahan and Stark’s stripped Y classification (1971)
42

Spina’s classification (1973)
Group I: Preincisive foramen clefts
a. Unilateral
b. Bilateral
c. Medial
Group II: Transincisive foramen clefts
a. Unilateral
b. Bilateral
Group III: Post incisive foramen clefts
a. Total
b. Partial
Group IV: Rare facial clefts
43

Kernahan and Stark’s
stripped-Y:
Modification by Ehlsaky
(1973) and Millard
(1976)
44

Schuchardt and Pfeifer’s symbolic classification
left Right
Lip
Alveolus
Hard palate
Soft palate
Total cleft
Partial
45

LAHSHAL classification by Okriens (1987)
 Lahshal is a paraphrase of the anatomic areas affected by the
cleft.
L – lip
A – alveolus
H – hard palate
S – soft palate
H – hard palate
A – alveolus
L – lip
46

DIAGNOSIS
• Prenatal ultrasound – 2D or 3D
• Prenatal counselling
• 22% to 33% rates for detecting facial clefts
• 73% - fetal cleft lip
• 1.4% - isolated cleft palate
• Color Doppler ultrasonography can also be used
48
Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012

Ultrasound technique
- Non-invasive diagnostic tool
- Confirm fetal viability
- Determine gestational age
- Establish number of fetuses and their growth
- Check placental location
- Examine fetal anatomy for detecting malformations
49

Transabdominal US
- Not reliable till gestational age of 15 weeks
- Done at 20 or more weeks of gestation
Transvaginal USG
- Earlier visualization (12 weeks)
- Better image resolution
- Greater specificity and sensitivity
50

Babcock and McGahan (1997)
- Starts with coronal plane
- Assessment continues in axial view
- Bilateral clefts: sagittal view
- Isolated clefts: axial view
51

Advantages of prenatal cleft diagnosis
- Psychological preparation for parents to have realistic expectations
- Parent education for cleft management
- Preparation for neonatal care and feeding
- Opportunity to investigate other abnormalities
- Possibility of fetal surgery
52

Disadvantages of prenatal cleft diagnosis
- Emotional disturbance
- High maternal anxiety and dysfunction
- Termination of pregnancy
53

PROBLEMS ASSOCIATED
WITH CLEFT LIP & PALATE

55
Dental
Skeletal
Nasal
Feeding
Ear problems
Speech
Associated anomalies
*Jamal GA et al. Prevalence of Dental Anomalies in a Population of Cleft Lip and Palate Patients. Cleft Palate–Craniofacial Journal, 2010;47(4):413-20

DENTAL
 Tooth agenesis, hypodontia (most common)
 Supernumerary teeth (2nd most common)
 Enamel hypoplasia (CI)
 Crossbites
 Ectopic eruption, transposition
 Taurodontism, dilacerations
56
*Jamal GA et al. Prevalence of Dental Anomalies in a Population of Cleft Lip and Palate Patients. Cleft Palate–Craniofacial Journal, 2010;47(4):413-20

57
SKELETAL
 Maxillary deficiency
 Mandibular prognathism
 Class III malocclusion
 Concave profile
*Ana Paula Ramos Bernardes da Silva, Beatriz Costa, Cleide Felício de Carvalho Carrara, Dental Anomalies of Number in The Permanent Dentition of Patients
With Bilateral Cleft Lip: Radiographic Study, The Cleft Palate-Craniofacial Journal. 2008;45(5):473-476.

58
FEEDING PROBLEMS
 Oronasal fistulas
 Draining of oral fluids in nasal cavity and vice versa
 Bottle, cup and spoon, tube feeding
 Infant held at 30-450 angle to aid swallowing

SYNDROMES ASSOCIATED
WITH CLEFT LIP & PALATE

SYNDROMES
 Around 400 syndromes
 Chromosomal anomalies
• Trisomy 13 (Patau)
• Trisomy 18 (Edward)
• Trisomy 21 (Down’s)
• Velocardiofacial syndrome (22q11 deletion)
60
*Sommerland BC. Management of cleft lip and palate. Current Paediatrics 1994

 Inherited syndrome
• Sticklers (Autosomal dominant)
• Treacher Collins (AD)
• Van der Woude (AD)
 Non-inherited syndrome
• Pierre Robin Syndrome – triad of cleft
palate, glossoptosis, retrognathia
• Goldenhar syndrome
61

 Teratogenic
• Fetal alcohol syndrome
• Fetal phenytoin syndrome
• Fetal valproate syndrome
62

MANAGEMENT OF CLEFT LIP
& PALATE

64
MULTIDISCIPLINARY MANAGEMENT
CLEFT
TEAM
Dentist
Surgeon
Nursing
Genecists
Social
worker
Ophthalmol
ogist
Psychologi
st
Paediatrician
Speech
therapist
ENT/
audiologist

65
TIMING AND SEQUENCING OF CONSERVATIVE
SURGICAL-ORTHODONTIC TREATMENT (1980s)
*Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod 1996;2:169-184

66

Philadelphia Centre for research in Child growth-
Wilton Krogman (1947-71)
Divided the treatment into 8 phases:
• First stage – Prenatal phase
Complete history of gestation and maternal health, counseling of the parents
Genetisist and other Social workers
67

• Second stage – at birth
Pediatrician discusses the condition with the parents,
Surgeon advises about the operative plan,
Dental specialists appraises the arch relationships
• Third stage – birth to 1 year
Pediatrican - advises about the feeding
Surgeon - carries out the lip closure (rule of 10)
Dental specialist - secures the models and radiographs
Speech therapist - discusses about the insufficiency and incompetence of the
pharyngeal seal
68

• Fourth stage – 1-2yrs
Pediatrican - takes care of the health and nutrition.
Surgeon carries out the closure of the hard palate 1:2 soft palate 1:6
Speech therapist - monitors the vocabulary and option of a prosthetic
replacement
ENT - monitors the ear condition.
• Fifth stage – 2-6 years
Orthodontist – arch relations, crossbites, developing malocclusion
69

• Sixth stage – 6-12 years
Surgical corrections - secondary closure /repair of palate, lip and the nose
• Seventh stage – 12-18 years
Surgical follow up on the lip and nose correction, orthodontic treatment is
continued
• Eighth stage – 12 years onwards
Regular patient follow-up
70

1. No preoperative orthopedics.
2. Closure of Cleft lip in infancy – Millard procedure -3 months
3. Closure of the remaining isolated cleft – Von Langenbeck -18
months.
4. Secondary operations 18-30 yrs of age.
71
Cleft Lip and Palate Patients Management in OSLO-
Norway (1948)

1. Pre dental treatment-1-18 months of age.
2. Deciduous dentition 3-6 yrs of age-full eruption of primary dentition.
3. Early mixed dentition 7-9 yrs- after or during the eruption of
permanent maxillary incisors.
4. Late mixed and early permanent dentition 9 ½ yrs onwards
72
FISHMAN

1. Infancy – before the initial surgical repair of the lips.
2. During late primary and early mixed dentition.
3. Late mixed and early permanent dentition.
4. Late teens (after completion of facial growth in conjunction with
orthognathic surgery).
73
PROFITT

74
*Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.

Neonatal • Birth to 1 year
Deciduous
dentition
• 1 to 6 years
Mixed
deentition
• 6 to 12 years
Permanent
dentition
75
• 12 years
and adult

• Hoffman (1678) – extraoral devices to retract protruding premaxilla
• McNeil (1950s) – presurgical orthopaedic
• Hotz – premaxilla is normally placed, by age 10, face grows
downward and forward into balance with premaxilla
76
NASOALVEOLAR MOULDING

• Grayson (1993) – first technique to correct the alveolus, lip and
nose in cleft infants
• Matsuo (1988)
- Research for cartilage moulding
- high maternal level of estrogen at the time of birth correlates with an
increase in hyaluronic acid, which inhibits the linking of the cartilage
intercellular matrix
77

• Matsuo used a stent, silicone tubes to shape the nostrils
• Grayson (1999) adapted his nasal stent to extend from the anterior
flange of an intraoral molding plate.
• This new technique was named – “ Nasoalveolar molding”
78

Objectives:
• Reduce severity of initial cleft deformity
• Columella – Nonsurgical lengthening (in bilateral clefts) and uprighting (in
unilateral clefts)
• Reduction in the width of the alveolar cleft segments until passive contact
of the gingival tissues is achieved.
79

80
Procedure:
• A heavy-bodied impression material is used to take the initial
impression as soon after birth as possible.
• Grayson and Maull (1999) held infant in upside down position to
keep the tongue forward which permitted fluids to draw off the oral
cavity when impression tray is placed
• Yang (2003) took the impression using a pre-trimmed customized
pediatric tray with the baby being held in the erect position,
by one of the parents

• Prashanth (2013), Mishra (2010) obtained impression when the infant
was awake in a prone position on the dental chair, the child is held
on the lap of their parents with no anesthesia.
• Dubey (2011) made impression of the cleft region upper arch using
ice cream stick and impression compound.
81

• Plate – clear self-cure acrylic, trimmed with a denture soft material
• 2–3 mm in thickness
• The retention arm – 40 degrees to get appropriate activation and to
avoid dislodgement of the NAM plate from palate
82

• The nasal stent is added to the intraoral molding plate when the
cleft alveolar gap is reduced to 5mm or less
• Stent – 0.036-in gauge round stainless steel wire
• The intranasal portion is formed from hard acrylic, covered with a
thin layer of soft spongy acrylic denture liner
83

• Elastics used are 0.25 inch and it should be stretched about two
times the diameter for activation force of about 2 Oz
84

85

86
Complications and disadvantages:
• Irritation of the oral mucosal or gingival tissue
• Ulceration of intraoral tissues
• The intranasal lining of the nasal tip can become inflamed
• Skin irritation due to tape usage
• Parent compliance required
• Moulding plate may get dislodged and obstruct the airway

87
Benefits:
• Short-term: the tissues are well aligned prior to primary lip and nose
repair
• Long-term:
• change in nasal shape is stable
• Reduced number of surgical revisions
• Reduction of treatment cost
• Shetty V et al (2017) - improves arch symmetry and stability, and thus
may prevent arch collapse in the long term

CLEFT LIP REPAIR
88
• Goal: improve facial aesthetics by restoring nasal and lip contour
• Timing: 3 to 6 months
• Millards “RULE OF TEN”
[term coined by Wilhelmmesen and Musgrave in 1969]
• 10 weeks (age)
• 10 pounds (weight)
• 10 gm/dl (Hb)

89
Techniques:
1. Tennison – Randall (Z-Plasty)
2. Millards rotation advancement repair
3. Rose – Thompson straight line repair

PRESURGICAL ORTHOPEDIC TREATMENT
90
Presurgical orthopedic treatment (PSOT) ?????
 Many authors – many minds
 PSOT beneficial or not ??

 1920s -1930s – repair the defect by establishing an anatomical
continuity
 Priority of treatment
- Improve speech ability
- Dental function
- Facial aesthetics
 Importance of growth not recognized
91

 1950s – Two schools of thoughts
92
• McNeil and Burston
• Align palatal segments
• Delay palatal closure till 5-9 years
of age
Presurgical
Orthopedics
• Led by Pruzansky
• Did not favour PSOT
• Palatal closure at 2-4 years of age
Immediate
surgery

A Millard-Latham Procedure
93
 Latham manipulated the palatally pinned presurgical
orthopaedic appliance – mechanical expansion of the
lateral palatal segments is followed by the retraction of the
protruding premaxilla into position within the arch
 Floor of nose is surgically closed
 Gingivoperiosteoplasty – migration of alveolar bone cells –
close alveolar gap

94
 Modified appliance – a premaxillary stainless steel
pin 7/10 mm in diameter is inserted through the
posterior stem of the premaxilla.
 3 Oz force per side for premaxilla retraction
 Premaxilla retraction and expansion
 8-14 days – premaxilla is positioned within the
palatal segments

95
CHANGING SURGICAL CONCEPT FROM 1920S TO
1950S
• Graber (1950s) – surgery performed early, caused severe midfacial
deformity later
• Brophy, first proponent of surgical technique – steel-clamp and
silver-wire bony closure technique
• von Langenback soft tissue procedure alone to approximate lateral
halves of maxilla and reduce intermaxillary width

• Graber, Slaughter and Brodie (1950s-1960s) – negative reports on
surgical procedure done at an early age
• “No palatal surgery at an early age” (before 12 months)
• James Scott (1956) – Sutural growth theory
• McNeil and Burston – adopted his theory – functional paediatric
prosthesis – palatal closure between 5 to 9 years of age
96

• Melvin Moss (1968) – functional matric theory – septal cartilage
grows as a secondary response
• McNeil – Father of presurgical orthopaedics – supported Scott’s
theory
• Burston – premaxilla was normal and lateral palatal segments were
retruded in face
• Presurgical orthopaedics + primary bone grafting within first year of
life
• Prusanky – opposed the same
97

CLAIMED BENEFITS OF PSOT
• Control and modify postnatal development of maxilla
• Early alignment for better occlusion and function – swallowing and
speech
• Reduce middle ear infections
98

• Berkowitz (1978) – “State of art”
• Primary bone grafting – deleterious effects on midface
• No evidence that PSOT normalize feeding, tongue posture,
swallowing or growth
99

CONSERVATIVE TREATMENT – THE BEST APPROACH
• Same surgery performed can cause in different results at different
ages:
1. The cleft defect
2. The facial growth pattern
3. The surgical procedure
100

101
CLEFT PALATE SURGERY TIMING AND SPEECH
OUTCOME
1970s
• Mid to late 1970’s – 18 to 24 months surgical palate repair
• General trend of better speech results with earlier ages at surgery
• Jolleys (1954) – approximately 90% of children who underwent
surgery before the age of 2 years had good or excellent speech
• General age range for surgery – 6-9 months, before 8 months, 1
year range, between 2 to 3 years
*Peterson S. The Relationship Between Timing of Cleft Palate Surgery and Speech Outcome: What Have We Learned, and Where Do We Stand in the 1990s? Semin Orthod 1996;2:185-191

1980 – 1990s
• Kaplan (1981) – palatal closure between age of 3 to 6 months
• Dorf and Curtin (1982,1990) – importance for phonemic
development or articulation age
• Greater discrepancy in speech performance between the "12
months and younger group" and the children operated on over the
age of 12 months
• Ross (1987) – slightly better facial growth if surgery done in the first
year of life
102
*Peterson S. The Relationship Between Timing of Cleft Palate Surgery and Speech Outcome: What Have We Learned, and Where Do We Stand in the 1990s? Semin Orthod 1996;2:185-191

SURGERIES FOR CLEFT PALATE
1. Von Langenback
2. V-Y palatoplasty by Veau
3. Furlow’s technique
4. Wardill Kilner’s push back
103

104
BONE GRAFTING FOR ALVEOLAR CLEFT
DEFECTS
BONE
GRAFTING
Primary
bone
grafting
First 2 years of
life
Secondary
bone
grafting
Early – 2 to 5
years of life
Late – 11 to 14
years of life
*Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-196

OBJEVTIVES FOR SURGICAL GRAFTING:
• Stabilization of segments
• Improved oral hygiene
• Nasal secretions prevented from draining into the mouth
• Unites maxilla to better withstand occlusal forces
• Bony base for teeth eruption
• Improves nasal symmetry
• Provide feeling of normalcy and improve social acceptance
105

BONE GRAFTING AND ORTHODONTIC TOOTH MOVEMENT
• A general rule – “orthodontic tooth movement performed with
improved outcomes after the bone graft has been completed”
• Tooth movement initiated 1 to 3 months after grafting into the grafted
area
106

SURGICAL MANAGEMNT OF ALVEOLAR CLEFT
• Ideal timing:
- 9 to 11 years of age
- Before canine eruption, canine root is 1/3rd formed (Bergland et al)
• Best source of bone graft: (autologous cancellous bone)
- Anterior portion of iliac crest
- The rib, tibia
- The cranium
- The mandible
107

109
ROLE OF ORTHODONTIST
*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204.

A] NEONATAL MAXILLARY ORTHOPAEDICS
• McNeil (1950)s – Father of presurgical orthopaedics
• Rationale – realignment of collapsed segments
• Active or passive orthopaedic appliances
110

B] ORTHODONTIC-ORTHOPAEDIC TREATMENT IN DECIDUOUS
DENTITION
• Problems in deciduous dentition:
- Delay in eruption in vicinity of cleft
- Malformed or congenitally missing lateral incisor
- Anterior or posterior buccal crossbite
- Functional shift
111
*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204

• Turvey (1982) believe that orthodontic treatment in the deciduous
dentition, although possible, is contraindicated
• Rygh and Tindlund (1988) – Growth modification at this stage has
been proposed
• They recommend utilization of a quad-helix appliance soldered to
bands on the primary second molar teeth and canines to expand the
upper arch
• Alongwith protraction face mask to modify and redirect growth
112

C] ORTHODONTIC TREATMENT DURING THE MIXED DENTITION
• Bone grafting:
• 5 to 6 years of age
• After 8 to 9 years of age
• Radiographically, after root of unerupted canine is half or one-third developed.
113
*Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-204

• Orthodontics – 6 months before grafting
• Fixed appliance in upper arch
• Objectives at this stage:
- Expansion of maxilla,
- elimination of crossbites, derotations of malposed teeth,
- improve dental and aesthetic function
• Spontaneous canine eruption (27%), surgical uncovering (17%),
combined surgical and orthodontic traction (56%)
• Orthodontics resumed 3 months after graft placement
114

Expansion appliances for cleft palate patients:
1. Telescopic maxillary expander
2. Fan shaped maxillary expander
3. Butterfly maxillary expander
4. Spring jet for slow expansion
5. Banded / bonded rapid palatal expansion
6. Modified hyrax appliance
7. Quad helix
115

Protraction Facemask Therapy:
• Can be used before bone grafting in mild midfacial deficiency
• Increased growth at circumaxillary sutures
• Orthopaedic force – 350 to 500 gram/side
• 10-12 hours a day
• 12-15 months
116

D] ORTHODONTIC TREATMENT DURING THE PERMANENT
DENTITION
• Decision – orthodontics alone OR orthodontic combined with
orthognathic surgery
• Ross (1987) – 25% require surgery
• 3 consecutive cephalogram, 6 months apart showing no change in
length of mandible can be used
117

TREATMENT BY ORTHODONTICS ALONE
1. Tooth alignment
2. Establishment of a continuous maxillary arch with favourable archform
3. Correction of anterior and/or posterior crossbites
4. Stability of occlusion in the presence of dental compensations
5. Favourable dentofacial esthetics
118

TREATMENT BY ORTHODONTICS COMBINED WITH
ORTHOGNATHIC SURGERY
• Severe skeletal discrepancy, oronasal fistulas, speech deformity
• Maxillary surgery – multiple segment Le Fort I osteotomy with down-
grafting
• Presurgical orthodontic treatment – 12 months
• AP discrepancy – more than 8mm – bijaw surgery needs to be
planned
119

• Unilateral clefts – 2 piece Le Fort I osteotomy
120
*Posnick J. Orthognathic Surgery for the Cleft Lip and Palate Patient. Semin Orthod 1996;2:205-14

• Bilateral clefts – 3 piece Le Fort I osteotomy
121
*Posnick J. Orthognathic Surgery for the Cleft Lip and Palate Patient. Semin Orthod 1996;2:205-14

• Post-surgical orthodontic – 4 to 6 months
• Transverse maxillary stabilization by transpalatal arch or piggy-back
overlay arches
• Immediate retainers – Hawley’s type
• Cemented lingual arch in maxilla
• Vaccum formed retainers not indicated
122

• Ambrose Pare (1565) – prosthesis to obturate palate
• Obturators using sponges, wax, and silver to more modern
materials
• Latham appliance (1980) – unilateral or bilateral clefts
123
PROSTHETIC REHABILITATION FOR CLEFT PALATE
PATIENTS
*Gardener LK, Parr GR. Prosthetic Rehabilitation of the Cleft Palate Patient. Semin Orthod 1996;2:215-19

Restorative treatment options in permanent dentition
• Partial overdenture
• Removable partial dentures
• Fixed prosthetic rehabilitation
• Implant prosthodontics
• Restoration – laminates and veneers
124

 Velopharyngeal impairment – insufficient contact
between the velum and the posterior and lateral
pharyngeal walls
 Velopharyngeal insufficiency – deficiency
 Velopharyngeal incompetence – neuromuscular
125
VELOPHARYNGEAL IMPAIRMENT
*Dalston R. Velopharyngeal Impairment in the orthodontic patients. Semin Orthod 1996;2:220-7.

Treatment
1. Speech therapy
2. Non-surgical or speech aid prosthesis
• Obturators
• Transitional appliance in growing patients
3. Surgical
• Palatoplasty, Sphincter pharyngeoplasty
126

• Fetal surgery – done in intrauterine life (prior to 20 weeks)
• Non-life threatening defects like cleft lip, cleft palate, Pierre Robin
syndrome, Treacher-Collins syndrome, craniofacial microsomia
• Open fetal surgery
• Feto-endoscopic approach
127
RECENT ADVANCES
*Papadopulos NA. Foetal surgery and cleft lip and palate: current status and new perspectives. Br J Plast Surg. 2005 Jul;58(5):593-607

ADVANTAGES
1. Provide a scarless repair, “ripple effect” is eliminated
2. Correct the primary deformity,
3. Prevent secondary deformities, and
4. Give the parents a "normal“ - appearing child at birth
128
*Papadopulos NA. Foetal surgery and cleft lip and palate: current status and new perspectives. Br J Plast Surg. 2005 Jul;58(5):593-607

CONCLUSION
• Oral clefts are the second most common congenital anamoly, having
multifactorial origin
• A considerable knowledge about the etiology and embryology is
required for proper diagnosis and treatment planning of such patients
• Treatment begins soon after birth and continues till adulthood
requiring a team approach.
129

CONCLUSION
• Multiple problems and syndromes with clefts
• Multidisciplinary approach for management, patient-centered
• Variations in treatment sequence
• Role of orthodontists
130

REFERENCES
• Reddy S et al. Incidence of cleft Lip and palate in the state of Andhra
Pradesh, South India. Indian J Plast Surg. 2010 Jul-Dec; 43(2): 184–9.
• Allori AC et al. Cleft lip and palate classification: Then and Now. Cleft
Palate–Craniofacial Journal 2016;53(1)
• Graber Vanarsdall and Vig. Orthodontics: Current Principles and
Techniques. Elsevier 2012.
• John B. Thornton, Sue Nim Paul S. Howard. The incidence, classification,
etiology and embryology of oral clefts. Semin Orthod 1996;2:162-168
• Inderbir Singh. Human embryology. Macmillan India. Seventh edition 2001.
• Peter Mosby et al. Cleft Lip and Palate. Lancet 2009; 374: 1773–85
131

REFERENCES
1. Graber Vanarsdall and Vig. Orthodontics: Current Principles and Techniques. Elsevier 2012
2. Jamal GA et al. Prevalence of Dental Anomalies in a Population of Cleft Lip and Palate
Patients. Cleft Palate–Craniofacial Journal, 2010;47(4):413-20
3. Ana Paula Ramos Bernardes da Silva, Beatriz Costa, Cleide Felício de Carvalho Carrara,
Dental Anomalies of Number in The Permanent Dentition of Patients With Bilateral Cleft Lip:
Radiographic Study, The Cleft Palate-Craniofacial Journal. 2008;45(5):473-476.
4. Sommerland BC. Management of cleft lip and palate. Current Paediatrics 1994
5. Berkowitz S. A Comparison of Treatment Results in Complete Bilateral Cleft Lip and Palate
Using a Conservative Approach Versus Millard-Latham PSOT Procedure. Semin Orthod
1996;2:169-184
6. Peterson S. The Relationship Between Timing of Cleft Palate Surgery and Speech
Outcome: What Have We Learned, and Where Do We Stand in the 1990s? Semin Orthod
1996;2:185-191
132

7. Samuel Berkowitz. Celft Lip and Palate. 2006. 2nd edition Page number 451-8.
8. Waite P, Waite D. Bone Grafting for the Alveolar Cleft Defect. Semin Orthod 1996;2:192-
196
9. Vlachos C. Orthodontic Treatment for the Cleft Palate Patient. Semin Orthod 1996;2:197-
204
10. Posnick J. Orthognathic Surgery for the Cleft Lip and Palate Patient. Semin Orthod
1996;2:205-14
11. Gardener LK, Parr GR. Prosthetic Rehabilitation of the Cleft Palate Patient. Semin Orthod
1996;2:215-19
12. Dalston R. Velopharyngeal Impairment in the orthodontic patients. Semin Orthod
1996;2:220-7.
13. Papadopulos NA. Foetal surgery and cleft lip and palate: current status and new
perspectives. Br J Plast Surg. 2005 Jul;58(5):593-607
14. Chang J. Fetal plastic surgery: a review and preview. © Chang www.thefetus.net/
133

Cleft lip and palate slideshare

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Similar to Cleft lip and palate slideshare

Similar to Cleft lip and palate slideshare (20)

More from Dr. Khushbu Agrawal

More from Dr. Khushbu Agrawal (6)

Recently uploaded

Recently uploaded (20)

Cleft lip and palate slideshare