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A Company of Destiny
MannatechMannatech
2 3Timeline
Glyconutritionals Through the Ages
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
340 B.C.
Alexander the Great
carries aloe vera plants
with him for soldiers
wounded in war.
1906
Erythropoietin (a glycoprotein
hormone that controls the
formation of red blood
cells) is discovered.
Since the beginning of recorded time, history has
validated the importance of the amazing aloe vera plant.
1983
Dr. Bill McAnalley discovers
first biologically active
polysaccharide from
aloe vera gel (Manapol®
and acemannan). More
than 150 patents are
granted worldwide on
the stabilization and
uses of this discovery.
1984
Hydrogel with polysaccharides
from aloe vera gel (Carrisyn®
HydrogelWound Dressing)
goes on the market.
1990
BioTechnology magazine
publishes article“Capitalizing on
Carbohydrates.”Carbohydrates
are identified as essential for
immune function. Multinational
chemical and pharmaceutical
concerns identify carbohydrates
as forming the next wave
of drug development.
1992
Acemannan is approved
by the USDA for use as
a vaccine adjuvant in
chickens and licensed
to Solvay Animal
Health, Inc., the world’s
largest manufacturer of
veterinary vaccines.
1994
Mannatech negotiates exclusive
distribution rights to Manapol and
launches company with nutrition
industry’s first stabilized aloe
vera gel dietary supplement.
1996
Harper’sBiochemistrylists the eight
sugars found in glycoproteins.
“Like valleys they spread out,
like gardens beside a river, like
aloes planted by the Lord, like
cedars beside the waters.”
Numbers 24:6
Mannatech’s Discovery of Glyconutrients
has Helped Pioneer the Exciting New
Field of Nutritional Glycobiology.
1998
Study by Berger, et al., in
Metabolism showed that
galactose and mannose
were directly incorporated
into human glycoproteins
without first being
converted into glucose.
Authors concluded that
specific dietary sugars
could represent a new
class of nutrients.
2002
(July) ScientificAmerican
article,“Sweet Medicine,”
reports on pharma’s big
new strategy for making
better drugs from sugars.
2002
(October) NewScientist
magazine article,“Sugar
Rush,”emphasizes
glycobiology as the
basis of understanding
immunology, neurology
and developmental
biology.
2012
National Academy of Sciences
publishes“Transforming
Glycoscience,”a roadmap for
the integration of glycoscience
as a significant part of
higher-education curriculae
within the next decade.
2200 B.C.
Aloe, considered
a divine plant
in Nippur
(Mesopotamia),
is used for
intestinal health.
1953
Atomic Energy Commission
scientists (Lushbaugh and
Hale) demonstrate for the
first time the ability of
topical fresh aloe vera gel
to protect
animals’skin.
1988
The term“glycobiology”
appears in the Oxford
English Dictionary to
recognize the merging
of the disciplines of
carbohydrate chemistry
and biochemistry.
1990
JournalofGlycobiology
launched by Oxford
University Press.
Glycobiology is the
study of the structure,
biosynthesis and biology of
saccharides (sugar chains,
or glycans) that are widely
distributed in nature.
1991
Injectable polysaccharide
from aloe vera
gel (Acemannan
Immunostimulant™) is
approved by the USDA
for use in cats and dogs.
1993
Injectable acemannan
rejected by the FDA
as a drug for humans
(no LD50). —Dr. Bill
McAnalley, AStory
ofDiscovery (2010).
1995
Nature magazine article
states cell surface sugars are
necessary for recognition
and immune function.
1995
Dr. McAnalley joins
Mannatech with
focus on new field
of carbohydrate
technologies.
1996
Mannatech files
patents on the world’s
first composition
of glyconutrients
and introduces
Ambrotose® complex.
1998–2002
As dietary sugars
begin to gain
acceptance as a“new
class of nutrients,”
Mannatech is issued
more than 50 patents
worldwide for
technology
related to
Ambrotose
complex.
2001
Scripps Institute
awarded $34
million from NIH to
study glycobiology.
2002–2010
Ambrotose complex approved
claims expand to include
improved memory, cognition
and visual discrimination as well
as positive prebiotic effects.*
2011
Definitive proof! Dr. Azita
Alavi and colleagues publish
study in the European
JournalofClinicalNutrition
showing for the first time
that the oral intake of
Ambrotose powder
can have a
significant
impact on the
glycosylation
status of serum
glycoproteins
with no adverse
effects.
4 The Story 5
The Gift of Provision
Amazing, Disruptive Discoveries
In 1996, Mannatech’s first Chief Science Officer, Bill
McAnalley, PhD, made the discovery of a whole new
category of plant-based nutrients called glyconutrients.
Mannatech formulated the world’s first glyconutrient
product, called Ambrotose® complex.Though this
pioneering discovery was at first questioned, even
ridiculed, by the traditional scientific community,
technology supporting it has since received more than
50 worldwide patents, and it’s now revered as science’s
next frontier. Ambrotose complex, formulated with
the Manapol® aloe vera extract, became Mannatech’s
foundational solution for proper cell-to-cell
communication and immune system support.
Real FoodTechnology® Solutions
Mannatech’s current CEO and Chief Science Officer, Robert Sinnott, MNS, PhD, extended
Mannatech’s proprietary product base through the formulation of PhytoMatrix® caplets, the
industry’s first vitamin and mineral product produced from natural and plant-sourced ingredients
at standardized, nutritionally effective levels.This approach quickly led to the development
of many new, unique products based on Real FoodTechnology solutions. In 2012, Dr. Sinnott
blended Mannatech’s proprietary glyconutrient complex, its proprietary antioxidant composition
and its proprietary real-food vitamin/mineral formulation into a whole-food base.This new
product was named NutriVerus™ powder, and it became a complete Real FoodTechnology
solution for global health.
A Desire to Make a Difference
In 1994, Mannatech founder Sam Caster felt called into
the marketplace to launch a“Company of Provision”that
would impact the lives of people in all the nations of the
world.This company was destined to become a new vehicle
for addressing the growing epidemic of malnourishment
and its impact on the lives of billions of people, including
the world’s most vulnerable children. It would require a
disruptive new discovery in nutritional science combined
with a revolutionary new business strategy in order to create
a sustainable solution.
The Story Behind Mannatech
Sam Caster
FounderofMannatech
EnjoythefullstorybehindthebeginningofMannatech
inthevideo,DestinyUnfolding.
http://bit.ly/18cLCFK
6 Mission and Vision 7
O u r M ission and Vision
Our mission is to fight global malnutrition by
nourishing the world with Real Food Technology®
supplementation while empowering and rewarding
the lives of those who champion our cause.
Our vision is to impact the global epidemic of
childhood malnutrition by linking five million
consumers of Real Food Technology supplementation
with five million children in need.
A World-Changing Approach
As of mid 2013, Mannatech operates in 24 countries around the world. The
company adopted the dynamic business model of social entrepreneurship to
link its international product sales directly to the needs of the world’s most at-risk
children. Through its MISSION 5 MILLIONSM
movement, Mannatech empowers caring
individuals all around the world to join the fight against childhood malnutrition
by simply choosing to nourish themselves with advanced nutrition sourced from
real foods. At the same time, Mannatech offers an unprecedented, purpose-
driven business opportunity for those who choose to champion this cause.
Findouthowyoucanjoininthefightagainstglobalmalnutrition.VisitMannatech.comtoday.
Three to five million children
under the age of 5 die every year
from the devastating effects of
malnutrition.1
That means every
six seconds a child dies from
malnutrition. That’s 14,000 a day.
The facts are heartbreaking.
Staggering. But not unbeatable,
thanks to people like you.
1
”Progress for Children: A Report Card
on Nutrition”UNICEF, May 2006
8 The Changing Face 9The Problem
What Has Gone Wrong?The Changing Face
of Malnutrition
We used to think malnourishment was a problem that
existed on the other side of the world. Now, it’s a problem
that often exists just on the other side of the table.
“Malnutrition is a phenomenon that touches the lives
of 55 million children at any given moment.”
UNICEF
“Up to one-half of all childhood deaths in the world
are linked to malnutrition.”
NewYorkTimes
“Five million children under the age of five die each
year in developing countries from malnutrition.”
UNICEF
“Poor health conditions linked directly to poor
nutrition have become the number one cause of
disability and death in America.”
Center for Science in the Public Interest
“Approximately 215 million Americans now live daily
with diet-related health concerns.”
“Nutrition Policy”Center for Science in the
Public Interest
“Nearly the entire U.S. population fails to eat a diet in line with the Dietary Guidelines for Americans.”
TheJournalofNutrition, 2010
Today, malnourishment has become a global epidemic.
The New York Times calls it the“New Hidden Hunger.”
STRESSEDTOXICSTARVED
l	 Nearly the entire U.S. population fails to eat a diet
	 in line with the dietary guidelines for Americans.1
l	 90% of all the money Americans spend on
	 food is used to buy processed food.2
1
Krebs-Smith, S.M., Guenther, P.M., Subar, A.F., et al. Americans do not meet federal dietary
recommendations. J Nutr 2010; 140(10): 1832-8.
2
Schlosser E. Fast Food Nation: The Dark Side of the All-American Meal. Perennial/
Harper Collins: 2001.
Many of us are not consuming enough
essential nutrients!
l	 Over 75,000 synthetic chemicals introduced since 1980
l	 Numerous pollutants common in our air and water
l	 Artifical sweeteners, colorings and preservatives in our foods
l	 Household cleaners, pesticides and other chemicals
We live in a toxic environment!
We are stressed!
Stress produces free radicals that attack and destroy healthy cells.
l	 Emotional stress
l	 Excessive exercise
l	 Smoking (including second-hand)
l	 Excessive alcohol consumption
l	 Use of pharmaceuticals
l	 Food preservatives
Classic Face
In developing countries, the problem is
consuming too little of the right kind of food.
New Face
In industrialized countries, the problem has become
consuming too much of the wrong kind of food.
10 Industry’s Solution 11
Industry’s“Solution” 1 Industry’s“Solution” 2
Industry saw an opportunity in our problems. Synthetically made“nutritional”alternatives
Industry’s“solution”to the loss of essential nutrients in our
modern diets was the creation of synthetically made alternative
nutrients. It was cheaper and more profitable to synthesize vitamins and
minerals than to extract them in their natural form, from whole foods.
Every so-called“solution”has typically
presented more problems.
And while the“solutions”continue to increase,
our overall health continues to decline.
+	+	=
Genetically Modified Seeds Bigger Livestock Pesticides Big Profits
But instead, industry has radically“changed”
our food over the last 50 years.
Industry set out to“improve”food.
In the mid-1900s, commercial farming found new ways to grow food faster and bigger.
Then, industry focused on reinventing food by combining highly processed food ingredients
with chemically made sweeteners, colorings, flavorings and preservatives. Processed food is so poor in
nutritional value that one expert refers to them as“edible food-like substances.”1
1
Pollan M. In Defense of Food. New York, New York: The Penguin Press, 2008.
•	Synthetic vitamins are chemically produced from
petroleum and coal tar derivatives, not food.
•	It’s estimated that over 95% of all vitamins sold
are synthetically made.1
	 1
www.organicconsumers.org/articles/article_3697.cfm
2
Ensley BD, Elless MP, Blaylock MJ, Huang JW. Hydroponic cultivation of metal-accumulating plants as a source of mineral nutrient supplements. Metal Ions in
Biology and Medicine 2000;531–3.
“Minerals are generally recovered by mining ores
or from chemical processes. Preliminary tests have
shown that minerals contained in [many of] the
most popular brands of multivitamins may not
dissolve (they are not soluble) in the stomach or
small intestine. They may pass through the body
without being absorbed.”2
A Quick Guide for
Evaluating Vitamin and
Mineral Supplements
Synthetically Made
Synthetic vitamins are produced chemically in a
laboratory and may be made from petroleum or
coal tar; they’re not in a food form.
Because they are less expensive, most
minerals used for supplementation are
mined from the ground or manufactured
from chemical processes.
Tests have shown that these minerals do not
dissolve well (they are not soluble) in either the
stomach or small intestine.
Plant-Sourced
Naturally sourced vitamins are extracted from foods or
plants or are cultured in yeast.
Plants use multiple processes to accumulate
minerals from the soil, predigest them and then
bond them into a food matrix. Minerals from
plants are, therefore, more soluble.
Research suggests that naturally sourced
vitamins are easier to absorb and retain than
synthetically made vitamins.
How Real IsYourVitamin?
*These stateme
nts have not been evaluated by the Food and
Drug Adm
inistration.
This
product is not intended to diag
nose, trea
t, cure
or prev
ent any
dise
ase.
Our PhytoMatrix®
caplets deliver real
food-sourced nutrients!
To achieve standardized levels of vitamin and
mineral ingredients, there are only two sources:
Approximately 150 million consumers in North America now take a vitamin/mineral
supplement daily
1
. But most people don’t even know the source, quality or efficacy of the
products they take. Mannatech believes that the best vitamin and mineral supplementation
should include:
•	Naturally sourced vitamins with standardized and properly labeled amounts
•	Plant-sourced minerals at standardized and properly labeled amounts
Do You Know
Where Your
Multivitamin
Comes From?
1Source
Datam
onitor
: Dietar
y Suppl
emen
ts Marke
tTrend
s & Oppo
rtuniti
es 4/29/0
9 (Dieta
ry Suppl
emen
t Marke
t USA)
How Real Is Your Vitamin?
Findoutwiththistearsheetat
http://bit.ly/ZC8v0v
12 Ancient Wisdom 13
Ancient Wisdom
What did they tell us?
“Everything man needs to sustain good health is provided by
God in nature. The job of science is to find it.”
Paracelsus
The Design of Life: “I have given you every seed-bearing plant
throughout the earth and all of the fruit trees for your food.”
Genesis 1:29
Pietro Longhi. TheApothecary—Aloe vera was a
common tool in doctors' offices in the mid 18th century.
Paracelsus and Hippocrates, considered to be the fathers
of pharmacology and medicine, respectively, believed that
having good health was dependent upon proper nutrition.
Overthecenturies,technologieshaveevolvedinbothfoodand
medicine,butthisprincipleremainsastruetodayasitwasthen.
New research is showing us how the human body functions
at the cellular level and how nutrients in their real-food form
support these critical functions. Science is now bringing us full
circle to the very foundations of health and ancient wisdom.
14 Modern Science 15
Modern Science
Mannatech accepted the challenge.
Mannatech used science to pioneer
Real Food Technology® solutions.
Robert A. Sinnott, MNS, PhD
CEO and Chief Science Officer
•	 Oversees the overall development
and R&D management of Mannatech’s
Real Food Technology products
•	 Earned Bachelor’s Degree in Biological
Sciences, a Master of Natural Sciences
Degree and a PhD from 1987–1995,
all from Arizona State University
•	 Focused on plant medicinal chemistry and
plant biotechnology in graduate training
•	 Instrumental in establishing the science
branch of a nonprofit educational institution
for training economically disadvantaged
students in science-based careers
•	 Joined Mannatech in 2005
•	 Instrumental in the creation of Mannatech’s
Real Food Technology approach
Thanks to its dedication to food-based research and development,
Mannatech has become a leader in the Real Food Revolution.
•	Mannatech has invested tens of millions of dollars in research, development and validation.
•	Working from Mannatech’s in-house laboratories, the company’s scientists and
product development specialists actively explore new technologies for sourcing
and formulating real-food solutions for consumer health and nutrition.
•	The company’s Research Group collaborates with major universities and
research firms around the world to conduct clinical trials and
studies on our products and ingredients.
Visit MannatechScience.org for full details.
16 Sweet Language of Life 17The Discovery
Sweet Language of Life The Missing Link
Bill McAnalley's AStoryofDiscovery -
Ambrotose: http://bit.ly/11DgiyU
“Almost without exception, whenever two or more living
cells interact in a specific way, cell-surface carbohydrates
will be involved.”
Hodgson J., Capitalizing on Carbohydrates, 1991.
“Indeed, cell-surface glycosolation (i.e., the process by
which cells create and display their sugar structures) is as
important to understanding life as is the genetic code.”
Committee on Assessing the Importance and Impact of Glycomics and Glycosciences.
Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012.
Nourish
Me
Repair
Me
Destroy
Me
Protect
Me
Regulate
Me
IMMUNE CELL
Cell-surface sugar
structures called
glycoproteins
are necessary for the proper
recognition and functioning of
most of our cells.
Immune cells read the cell-
surface sugar structures on other
cells to determine if they are
healthy, need repair or need to
be destroyed.
Missing Sugars = Altered MessageOur cells need sugars to communicate all their needs.
Missing Sugars Can Spell Trouble
Removing one sugar [from their cell-surface
structures] turns protective antibodies (repair cells)
into attackers. The research shows that the mere
destructive autoimmune functions appear to be
lacking antibodies associated with this (sugar).
Rockefeller University, July 4, 2007
When bad cells go undetected, as in degenerative
type functions, research has shown that sugars are
missing from their glycoprotein structures.
Capitalizing on Carbohydrates, 1991
The Missing Link
Of the 200 that naturally occur in nature, our cells
use eight of these sugars like letters of an alphabet
to create cellular words. The potential information
content of these sugar structures vastly exceeds
that of any class of macromolecules.1
“Every living cell on the planet is covered with a
dense and complex array of sugar molecules. Every
molecule, cell or organism that interacts with a cell
must do so through these cell-surface sugar structures.”1
1
Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future.
The National Academies Press: 2012.
What are Glycans?
Glycans—also known as carbohydrates, saccharides,
or simply as sugars—are molecules made up of
combinations of different sugar units, such as glucose.
These units can link together to form complex, three-
dimensional structures.
18 Glycoscience Validation 19Self-Evidence
Glycoscience: A Road map for the Future
Self-Evident
“Every molecule, cell or organism that interacts with a cell
must do so through these cell-surface sugar structures.”1
In 2012, a report titled Transforming Glycoscience: a Roadmap for the Future conducted by the National
Academy of Sciences offered bold support for the function and importance of glycans (or glyconutrients).
1
Committee on Assessing the Importance and Impact of Glycomics and Glycosciences.
Transforming Glycoscience: A Roadmap for the Future.
The National Academies Press: 2012.
Dr. John Rollins, a former award-winning U.S.Trademark and Patent
Office official, upon his introduction to glyconutrients, said,“In the past
23 years ... our group at the U.S. Patent Office had the opportunity to
review the best technology presented by the world’s best scientists.
There have been many significant discoveries, but one stands head
and shoulders above the rest: the discovery of a new category of vital
nutrients called glyconutrients.”
To review the full report entitled:
Transforming GlycoScience: A Roadmap for the Future
go to www.nap.edu and search“glyco.”
Integrating glycoscience into
relevant disciplines in high school,
undergraduate, and graduate
education, and developing
curricula and standardized
testing for science competency
would increase public as well as
professional awareness.1
1
Committee on Assessing the Importance and Impact of
Glycomics and Glycosciences. Transforming Glycoscience: A
Roadmap for the Future.
The National Academies Press: 2012.
Roadmap Goals:
l	Within five years, integrate glycoscience as a significant part of the science
curriculum, including both lecture materials and hands-on experiments or activities.
l	Within 10 years, integrate and teach glycoscience at every level for which it is
relevant to understanding the scientific content. Competency in glycoscience
could also be included in all standardized testing wherever relevant (for example,
as part of the SAT and GRE Subject Tests, MCAT, and Medical Board Exams).
20 Validation 21Awards & Recognition
Awards & RecognitionGlycoNutrient Validation
March 14, 2006
Mannatech was the 29th fastest-growing public company in the Dallas/Fort Worth
Metroplex, according to the Dallas Business Journal.
January 31, 2007
Mannatech received first- and second-place awards for basic science research indicating
bacteria from the human digestive tract can metabolize the complex carbohydrates in the
company’s glyconutritional supplements.
May 30, 2007
Mannatech was recognized by BusinessWeek as the 12th-best“Hot Growth”small company in
America and as the 4th best in average return on capital over three years.
March 14, 2009
Chief Science Officer and Senior Vice President Robert Sinnott, MNS, PhD, was selected as the
vice chairman of the Senior Scientific Advisory Council (SSAC) for the Council for Responsible
Nutrition (CRN).
November 24, 2009
Mannatech’s educational website, MannatechScience.org, received a Web Health Merit
Award for its accuracy, success in reaching its targeted audience and overall quality.
June 2011
CEO and Chief Science Officer Dr. Rob Sinnott featured in Natural Products Insider magazine
article,“Aloe veritas.”
April 2012
Mannatech presents new study at the 10th Jenner Glycobiology and Medicine Symposium in
the Netherlands.
July 2012
Mannatech presents product research at the 9th Annual International Society of Sports
Nutrition Conference.
April 2013
Dr. Sinnott featured in Nutraceuticals World magazine article,“Open Innovation in
Nutraceuticals & Functional Foods.”
We do all that we can to earn the trust consumers
place in us every time they use a Mannatech product.
We hold more than 50 patents in 30 countries for the technology relating
to our Ambrotose complex glyconutrient formulation. And our patent
positions have been repeatedly reaffirmed in court, most recently in July
2010, when Mannatech won judgments against seven companies found to
be manufacturing and marketing products that infringed on our patented
glyconutrient technology.
Patents
Recent Glyconutrient Studies
October 2012 University of Ghent scientists publish Ambrotose product prebiotic study in the Antoine van Leeuwenhoek Journal
of Microbiology.
February 2012 Review of effects of polysaccharides on brain function is published, Mechanisms that might explain the cognitive
benefits of glyconutrients and other polysaccharides are explored.
September 2011 Study shows Mannatech's Ambrotose complex improves well-being in healthy adults (titled Perceived changes
in well-being following polysaccharide intake in middle-aged adults).
Quality and Standards
Mannatech is committed to meeting customer, regulatory and industry standards by manufacturing
products of the highest quality and value. Our suppliers conduct statistical sampling then follow it with
inspection and testing. No product is ever shipped from Mannatech without the highest level of assurance
that it meets our quality standards.
Current Good Manufacturing Practices
As a global innovator, we adhere to industry-wide current Good Manufacturing
Practices (cGMPs) established by various U.S. and international regulatory
agencies. You can rest assured that our products are safe, effective and
precisely labeled.
NSF Certification—Third-Party Mark of Excellence
A growing number of our health products have been Certified by NSF
International, an independent, third-party organization that helps
ensure that supplements and ingredients are labeled accurately and
contain no adulterants or contaminants.
100% Satisfaction Guarantee
You can trust the science and quality behind our products.
We’re so confident you’ll love our products that we offer a
six-month Satisfaction Guarantee.†
†
Mannatech guarantees your full satisfaction. If not completely satisfied, contact Customer
Care and return the product within 180 days for a full refund. See Mannatech.com for details.
CERTIFIED
PRODUCE
DWITH SOLA
RENERGY
To see the full collection
of studies and
published research, visit
MannatechScience.org.
22 System Support 23The Role of Nutrients
A Common-Sense Appr oach to Optimal Health
The Role of Nutrients
Completing the Circle of Care
Consider for a minute your body as an
automobile. Daily support and maintenance is
required or breakdowns occur.
l	The modern car is designed to run on certain
	 raw materials.
l	It requires routine maintenance.
l	It will usually last about 100,000 miles or so.
The car must have fuel in the tank, oil in the
engine, water in the radiator, air in the tires and,
of course, a driver behind the wheel.
The car also must be maintained by changing the oil and filling the gas tank.
There are numerous things that may improve its performance or looks, but these components are
mandatory for it to start and run. If any of the basic components are missing, or the car isn’t maintained
properly, it’s not going to travel very far without breaking down. And a shiny new paint job or fresh tires
won’t help if the basics are not met.
GAS
OIL
WATER
AIR
DRIVER
The same concept can be applied to
understanding the human body.
l	Our bodies were designed to run on specific raw materials.
l	They require routine maintenance.
l	And they are designed to last about 85 years or so.
Countless things may enhance how we look or feel, but nutrients are essential.
Unless we provide our bodies with these basic essentials and perform the
necessary maintenance, it is very difficult to sustain good health.
Nourish
Me
Repair
Me
Destroy
Me
Protect
Me
Regulate
Me
IMMUNE CELL
It All Starts
with the Cells
A variety of food-based nutrients is
required to support healthy cells.
Healthy cells are necessary to support
healthy glands, organs, tissues, bones,
fluids, blood and skin.
Healthy cells =
Healthy tissue
Healthy tissue =
Healthy organs
Healthy organs =
Healthy systems
Healthy systems =
Healthy bodies
Body
Systems
Organs
Tissue
Cells
For optimal wellness, your body needs
ongoing maintenance in such areas as:
Cellular Support
–– Communication
–– Protection
–– Nourishment
System Support
–– Endocrine
–– Cardiovascular
–– Digestive
Body Fitness
–– Sustainable Fat Loss
–– Performance
–– Recovery
Cellular Communication Ambrotose® Complex
and Advanced Ambrotose®
24 Cellular Communication 25Ambrotose
The Science of Glyconutrients
Research published in the European Journal of Clinical Nutrition
revealed for the first time in the scientific community that:
• The ingestion of a standardized blend of plant poly-
saccharides (Ambrotose powder) can induce significant
changes in blood glycoprotein structures.
• And there were no reported adverse events.1
1
Alavi, A., Fraser O, Tarelli E, et al. An open-label dosing study to evaluate the safety and effects of a
dietary plant-derived polysaccharide supplement on the N-glycosylation profile of serum in healthy
subjects. Eur J Clin Nutr 2008; 65: 648–56
The Old Theory
Scientists once believed that it was not possible to influence the body’s production of
cell-surface sugar structures through dietary intervention.
The New Reality
Thesecomplexsugarsareusuallyreferredtoasglycans.Glycansareoneofthefourmajorclassesof
macromolecules—nucleic acids, proteins, and lipids being the other three—that are essential for
life and are involved in every aspect of biology, medicine, and a number of practical applications.
These other three classes often incorporate or rely on glycans for their activity.
1
Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future.
The National Academies Press: 2012.
Missing Sugars = Altered MessageOur cells need sugars to communicate all their needs.
Glyconutrients
Ambrotose Products
l	Support cellular communication*†
l	Improve cognitive function*†
l	Improve memory, concentration and attentiveness*†
l	Improve mood and decrease irritability*†
l	Support immune system function*†
l	Support digestive system health*†
The first standardized blend of
plant-sourced polysaccharides.
More than 50 patents
issued worldwide for this
breakthrough technology.
†
Benefits vary by product.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
26 Cellular Protection 27Ambrotose AO
Cellular Protection Ambrotose AO®
Capsules
Antioxidantsl	In part, premature aging is the breakdown of the body’s natural ability to regenerate its trillions of cells
and produce new ones. This repair and renewal process goes on every second of every day of your life.
l	It has been postulated that naturally occurring invaders, called“free radicals,”can damage cells,
interfere with their repair and regeneration, and thereby speed up the aging process.
l	Sunlight, physical and emotional stress, and environmental toxins are sources of free radicals that can
damage cells and accelerate the aging process.
l	Cells can protect themselves from these environmental factors, but research suggests that they require
the right nutrients, called antioxidants, to provide proper protection.
l	Certain fat- and water-soluble vitamins, minerals and plant phytochemicals are antioxidants that can
neutralize free radicals and prevent the damage they cause.
l	It has been postulated that premature aging can start to occur when cells don’t get enough
antioxidant support, and the body cannot keep up with the demands of damaged cells.
l	Antioxidant nutrients are abundant in vine-ripened fruits and vegetables.
Free radicals can attack our cells as many as 10,000 times a day.
The right blend of fat- and water-soluble antioxidants may protect our cells from this attack.
Included
inOSP
Packets
Ambrotose AO is a scientifically proven
antioxidant supplement designed to support
optimal health by effectively
enhancing antioxidant protection
in the body.*
l	Research has shown that two Ambrotose AO
capsules can increase overall antioxidant protection
in humans by 37.9%.†
That’s more than two and
a half times the ORAC impact of five servings of
fruits and vegetables (serum ORAC results).
l	Ambrotose AO capsules:
	 -	 Help protect against cell damage caused by
	 physical and oxidative stress (free radicals),
	 toxins, environmental stress, and poor diet, all
	 of which can damage cells, tissues, and DNA.*
	 -	 Provide plant-sourced ingredients for
	 antioxidant and immune support.*
†
Comparison of serum ORAC values obtained in two separate clinical studies funded by Mannatech.
According to a study funded by the USDA,
five daily servings of fruits and vegetables can increase overall antioxidant
protection by 13.9% (serum ORAC
results).1
Ambrotose AO capsules can
increase overall antioxidant protection
in humans by more than two and a half
times that amount. Read the full study
at: http://bit.ly/11otcQf
1
Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human
plasma antioxidant capacity after consumption of controlled diets high in fruit and
vegetables. Am J Clin Nutr 1998;68:1081–7.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
28 Cellular Nourishment 29PhytoMatrix
Cellular Nourishment PhytoMatrix®
Caplets
Vitamins and Minerals
PhytoBurst® Chews
Essential Nutrition
Your Cells Need Nourishment
l	Every cell in your body requires a variety of nutrients to help build and support its proper structure and
function.
l	Your body is building millions of new cells every second.
l	There are more than 26 essential vitamins and minerals, and multiple trace elements, that MUST be
obtained through your diet.
Proprietary Hydroponic Growing Technology
At the heart of our PhytoMatrix product is a patented, hydroponic cultivation technology
that uses the Indian mustard plant nicknamed“nature’s magnet”for its ability to absorb
minerals from the soil. These plants are hydroponically grown in solution, allowing them
to absorb a controlled amount of concentrated minerals, which are then stored in the
plant tissue.
Why is this significant? Because food sources—like Indian mustard—provide minerals
in their most natural form, so they can be readily absorbed and utilized by the body.
The hydroponic process ensures standardized concentrations of essential minerals
that meet minimum requirements with a daily serving of four tablets. Even fresh
fruits and vegetables—which usually have high concentrations of vitamins—may be
low in essential minerals.
Foods are comprised of synergistic blends of
[essential] nutrients bound together into the
food matrix.
It is the food matrix [blend] that best supports human biological processes.
Jacobs DR, Jr., Tapsell LC. Food, not nutrients, is the fundamental unit in nutrition. Nutr Rev 2007;65:439-50.
Included
inOSP
Packets
Mannatech’s PhytoMatrix
multivitamin/mineral supplement
provides the industry’s first standardized
blend of food-sourced vitamins, minerals
and phytonutrients.
PhytoMatrix caplets support:
l	Cell protection with powerful antioxidants*
l	Energy production with a full complement of B vitamins*
l	Heart health with vitamins B6
, B12
, B3
(niacin), C, and B9
(folic acid)*
l	Healthy eyesight with vitamins A, C, E, and niacin, plus the mineral zinc*
l	Immune system function with vitamins A, C, E, B6
, and folic acid, plus minerals zinc,
copper and iron*
PhytoBurst Chews: A Delicious Delivery
Method for Food-Sourced Nutrition
l	Delicious fruit-flavored chews (lemon and mixed berry)
l	Incorporates hydroponic technology found in our PhytoMatrix caplets
l	Great on-the-go bursts of nutrition
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
30 Cellular Health 31NutriVerus
Real Nutrition NutriVerusTM
PowderReal Value
Nutrition the Way Your Body Wants it.
The Ultimate Solution for
Cellular Health
Mannatech’s Core Innovations in
One Product
NutriVerus™ powder delivers the nutrition your body
needs, the way your body wants it. This completely
unique supplement combines natural, food-sourced
vitamins, minerals, glyconutrients and fat- and water-
soluble antioxidants in a nutrient-dense, real-food base
of stabilized rice bran and organic fruits and vegetables.
The result? Energy-boosting, immune system–
supporting nutrition in an environment just right for
nutritional synergies to occur, increasing the potential
interaction of the individual nutrients.*
Highly Valued Benefits at a Value-Conscious Price
Glyconutrients and food-sourced nutrients for just $2 a day!
l	Supports cell-to-cell communication through a blend of specific
plant saccharides including glyconutrients*
l	Offers antioxidant and immune system support*
l	Supports brain health*
l	Helps protect your cardiovascular system*
l	Supports healthy digestion*
l	Helps your body maintain energy levels*
l	Provides a natural, food-sourced vitamin/mineral complex for maximum absorption*
l	Suitable for all ages, including kids age 4 and up
NutriVerus powder features a nutrient-dense, real-food
base of stabilized rice bran, organic fruits and vegetables,
antioxidants and glyco- and phytonutrients.
Stabilized Rice Bran (SRB) is one
of the most nutrient-dense food
ingredients in the world.
l	Unlike other grains, it is gluten-free
l	More than 100 antioxidants, metabolic co-
factors, and trace elements in its food matrix
l	Vitamin E complex with tocopherols and tocotrienols
l	Naturally rich in B vitamins
l	High in inositol
l	Rich in phytosterols
l	Rich in fatty acids
l	Good protein source
l	Good source of potassium, magnesium and phosphorus
Learn more about NutriVerus powder and
the Real Food Revolution.
Watch this video.
http://bit.ly/13FgYV0
Essential
Vitamins
& Minerals
from Real Food
Real-Food Base
from rice bran and organic
fruits and vegetables
Glyconutrients
Fat- & Water-Soluble
Anti-
oxidants
Organic Fruit Blend Organic Vegetable Blend
Strawberry Raspberry Broccoli Broccoli Sprouts
Blueberry Tart Cherry Tomato Carrot
Pomegranate Cranberry Spinach Kale
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
32 Endocrine System Support 33PLUS
Endocrine System PLUS
TM
CapletsSupport
Endocrine System Support
The Endocrine System Is Your Body’s Command Central.
When functioning well, its glands direct operations by producing vital hormones that send signals to
keep you ready for anything and help your body stay balanced.
Because this important control center ultimately influences almost every cell organ and function of your
body, making sure it gets the nutrients it needs is a must. Mannatech’s PLUS™ caplets, can help by keeping
this vital system functioning smoothly in a state of equilibrium.*
Mannatech’s PLUS caplets don’t contain hormones. Instead, they provide specific nutrients, including plant
sterols, to support your glands’natural function.*
And because we don’t always eat right, we can miss out on important nutrients like plant sterols and amino
acids that help keep our systems functioning well. That’s why Mannatech developed PLUS caplets—to
supply the body with a proprietary blend of specific, standardized nutrients, including important plant
sterols and amino acids that we may not always get on a consistent basis from diet alone.
Mannatech’s PLUS caplets include a
proprietary blend of standardized plant
sterols formulated to support a well-
functioning endocrine system.*
PLUS caplets:
l	Furnish raw materials for endocrine support*
l	Supply essential amino acids to support natural hormone production*
l	Support breast, bone and colon health as well as the
immune, nervous and cardiovascular systems*
l	Support prostate health*
Amino acids—the“building blocks”of proteins
Did you know that of the 20 amino acids that we all need to survive,
the human body produces only 10?
We must rely on our diets for the other half, but not all proteins are created equal. Some contain specific
amino acids for hormone production while others do not. And because humans don’t store amino acids in
their bodies, we need a steady supply every day.
Included
inOSP
Packets
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
34 Cardiovascular 35Cardiovascular
Cardiovascular System Omega-3
with Vitamin D3Support
Healthy Heart
CardioBALANCE®
Capsules
Additional Cardiovascular Support
Your body doesn’t produce omega-3.
For centuries, people got enough omega-3s through their diets. Not so anymore. Today’s diet trends result
in too much omega-6 in our bodies. Even farm-raised fish are often grain fed and contribute more omega-6
than omega-3.
Although omega-6 is important, it competes with omega-3 for space in our cells. Our current diets have
created a ratio that ranges as high as 30:1 omega-6 to omega-3. This imbalance has given rise to an
unhealthy inflammatory response, which is a key contributor to many of the health concerns in our diet.
A Fat Your Body Needs
There are good fats and bad, but omega-3 fatty acids are a fat that you
absolutely must have.
l	Help support cardiovascular and heart health*
l	Help support brain health and function*
l	Help maintain a healthy immune system and support a healthy inflammatory response—a key contributor
to good health*
l	Provide support for healthy triglyceride levels already within normal levels*
l	Vitamin D is essential for calcium absorption*
Learn more about how our Omega-3 with
Vitamin D3
is unique. Watch this video.
http://bit.ly/186Q7oi
Mannatech’s Omega-3 with Vitamin D3 is your
best choice with:
l	Over 1,000 mg of highly concentrated EPA and DHA per serving
l	Made from molecularly distilled, high-quality fish oils for
ultra-purity
l	Pleasant lemon flavor in an easy-to-swallow gel capsule
l	830 IU of vitamin D3, a natural and preferred source of
vitamin D
Omega-3
fatty acids
are considered
“essential” because
they are vital to
your health and
your body cannot
produce them.
CardioBALANCE Capsules:
l	Provide nourishment for cardiovascular health through
a unique herbal vitamin and amino acid blend*
l	Help maintain homocysteine levels that are already within normal range*
l	Include folate as well as L-arginine, which is thought to increase nitric
oxide production—essential in maintaining blood vessel health—as well
as CoQ10, which is often depleted by cholesterol-lowering drugs*
Research shows that most people are deficient in omega-3
fatty acids.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
36 Digestive 37Digestive
Digestive System GI-ProBalance®
Support Slimsticks
Approximately 70% of your immune system
which is located in your digestive tract is
dependent on good digestion.
Healthy Digestion
GI-Zyme®
Capsules
Healthy Digestion
l	One of the digestive system’s most important functions is to
process food and absorb all the nutrients our cells can use. It
also serves as the first line of defense against harmful bacteria.
l	Because the digestive system’s organs rely on nutrients from
food, the health of the digestive system depends on the
quality of our diet.
l	To digest food, the intestines maintain an environment that
includes healthy bacteria and enzymes.
l	Probiotics are dietary bacteria that assist in digestion.
Enzymes regulate the speed of metabolism, among other
bodily processes.
l	Probiotic bacteria must be regularly replenished. In the past,
they were found in many common, raw foods. However, preservatives, pasteurization and other processing
have generally eliminated probiotics from today’s foods. This forces the body to dip into and, perhaps,
deplete its own supply.
So when your
gut is healthy,
it helps your
whole body
stay healthy.
tuned to unleash
the power of
Ambrotose®
Performance
Developed after extensive research on the
digestion and beneficial effects of Ambrotose
complex, GI-ProBalance slimsticks were
formulated to enhance the benefits of Ambrotose
products. The specially formulated probiotic
blend breaks down the polysaccharides in the
Ambrotose products, thereby enhancing the
ability of both exceptional products to support
the digestive and immune systems.*
Mannatech’s GI-ProBalance
slimsticks provide the“right”
bacteria to help maintain the
microbial balance in a healthy
intestine.*
This balance can promote a healthy effect among the
various microflora that live in the human intestine,
thereby supporting optimal digestive function.*
Mannatech’s GI-Zyme capsules are
formulated to:
l	Help improve the level of digestion*
l	Assist in breaking down proteins, fats and carbohydrates*
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
38 Fat Loss 39OsoLean®
A New Perspective on Sustainable Fat Loss†
OsoLean®
Powder
Target Fat Loss
Retaining lean muscle when burning fat is important in maintaining
body strength and a healthy metabolism. In a clinical study, the key
ingredient in OsoLean powder promoted fat loss and minimized muscle
loss when combined with a proper diet and exercise.*
More than just a typical whey protein product, OsoLean powder
incorporates a proprietary advanced peptide technology that separates
and concentrates specific parts of whey protein, called peptides, to
ensure your body receives the optimal level of fat-loss peptides.*
The Answer?
SUSTAINABLE weight management from REAL-FOOD SOURCES.
Don’t Make This Common Weight-Management Mistake!
When shedding pounds, don’t overlook your body’s basic nutritional needs. Add
NutriVerus™ powder to your weight-management regimen and give your body the
foundational, whole-food nutrients it craves.
We’re Dieting More Often
The desire to lose weight is not a new one. But it’s one
that’s received unmatched attention in the past thirty years.
Conventional wisdom tells us that too many calories and too
little exercise are the major contributors to weight gain. So
we’ve tried to address those issues in many creative ways. From
exercise programs and eating plans, to metabolism-enhancing
pills, meal replacements and even surgery, we’ve virtually
thrown the kitchen sink at losing weight.
l	75 to 100 million Americans diet each year.1
l	The typical American dieter now makes four weight-loss
attempts per year—the highest number in 15 years.1
1
The weight-loss industry by the numbers, ABC News, May 8, 2012
We’re Spending More Money
l	The U.S. weight-loss market now exceeds $60 billion.
	 U.S. Weight Loss Market Worth $60.9 billion, PRWeb, May 9, 2011
l	If you consider that“only”75 million Americans are trying to
lose weight, that’s $800 per person per year!
We’re Gaining More Weight
Even when we do lose weight, we seem to have even bigger
challenges keeping it off. Many of us lose a few inches today,
only to gain it all back—and even more—tomorrow.
l	Globally, there are more than one billion overweight adults,
and the number is growing.
	 Worldometers.com, Marketdata research 2013
l	According to the American Heart Association, 66% of
Americans are overweight and 34% are obese.
	 Trend spotting 2013, Foodnavigator.com, December 3, 2012
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
40 Performance 41Recovery
Performance Recovery
Perform Better Recover Faster
Mannatech’s advanced Weight and Fitness products are natural and
formulated with food-sourced nutrients to help you go the extra mile,
and look amazing while doing it.
SPORT™ capsules:
l	Help maintain existing normal blood sugar levels and support carbohydrate
utilization*
l	A proprietary blend of herbs and herbal extracts
l	A plant sterol supplement formulated with a combination of Ambrotose complex
and wild yam
AmbroStart®drink mix is a delicious, orange-flavored,
energy-releasing supplement that:
l	Delivers nutrients that provide the body with energy*
l	Includes medium-chain triglycerides that are readily broken down into
short-chain, free-fatty acids that can be used as fuel for muscles*
l	Is a good source of fiber
l	Helps support a healthy immune system*
EM∙PACT®citrus-flavored drink mix:
l	May enhance the body’s ability to use oxygen
during athletic exertion*
l	May improve athletic endurance*
l	Includes medium-chain triglycerides (MCTs) that are readily broken
down into short-chain, free-fatty acids that are used as fuel for muscles*
l	Has been clinically shown†
to enhance cardiorespiratory fitness and
improve endurance*
Our BounceBack®capsules allow you to stay active and mobile.*
When taken daily, over time, BounceBack capsules can:
l	Help reduce muscle pain and stiffness due to overexertion or physical activity*
l	Aid the body’s natural recovery process*
l	Support optimal joint and cartilage health*
l	Provide immune system support*
Mannatech’s ImmunoSTART®tablets prime your immune system.*
If it’s operating well, your immune system will remove toxins and keep you healthy. But,
everyday stresses, not eating properly and irregular sleep habits can take a heavy toll
on your immune system. These factors may accelerate your use of and need for nutrients.
Eventually, your immune system may encounter difficulty keeping up with the demands
placed upon it, so it’s critical that you give it the right nourishment.
l	Helps build, support and nurture immune system health*
l	Engineered with a targeted array of nutrients, including bovine colostrum and
lactoferrin that work to stimulate and support the body’s natural immune response*
l	Increases plasma levels of neutrophil precursors—neutrophils are the most
abundant immune cells and form an integral part of the immune system*
Manna-C™capsules contain natural forms of vitamin C from wild bush
plum and acerola—wild fruits that are considered two of nature’s richest
sources of this vitamin.
l	Includes classic Ambrotose® complex, along with wild bush plum and acerola fruit
extract, both natural sources of vitamin C
l	Herbal blend with a natural plant source of vitamin C for the maintenance of good
health*
Our Manna-C capsules combine Ambrotose complex plant polysaccharides with an herbal
blend that yields natural sources of vitamin C. This specially formulated herbal blend
includes lemon verbena, sage, peppermint and other herbs.
†Mannatech-funded clinical studies
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
42 Protecting the Future 43Children
Protecting Our Future Children
Start a Tradition of Good Nutrition
“This could be the first generation of children in the United States that
lives less than its parents.”
Richard Carmona,
former Surgeon General of the United States, 2009
The pursuit of
wellness is one
that lasts
a lifetime.
Give your child
the healthy
advantages
that come from
good nutrition
early in life.
Many Mannatech products are appropriate for children. Just check the
labels for any possible age and/or directional restrictions. For starters, here
are some products deemed as“favorites”by kids and parents alike.
MannaBears™ Gummies
A tasty alternative to sweets full of refined sugars and other“junk”foods, MannaBears
gummies include a specially formulated glyconutrient blend as well as 11 dehydrated
fruits and vegetables—like broccoli, carrot, cauliflower, tomato, papaya and pineapple—
to help protect cells from free radical damage.*
GI-ProBalance® Probiotic Slimsticks
Since 70% of your child’s immune system is located in the digestive tract, her
body relies on a wide variety of bacteria and other microorganisms to help keep
it running properly, including probiotics and prebiotics. Kids love the taste of
these delicious slimsticks as much as parents love how they’re working.
Recommended for children 4 years of age and older.
NutriVerus™ Powder
NutriVerus brings real-food glyconutrient and vitamin/mineral technologies in a
nutrient-dense food base of stabilized rice bran and organic fruits and vegetables.
Sprinkle it on your child’s food every day to help ensure his meals are more nutritious.
Recommended for children 4 years of age and older.
ImmunoSTART® Tablets
With everything going on in their world, your child’s immune system can become
overloaded quickly. Give them ImmunoSTART tablets every day to help build, support and
nurture immune system health.*
Do not give to children under age 4 without adult supervision.
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.
44 The Science of Beauty 45Skin Care
The Science of Beauty
Healthy Body, Healthy Hair
We’ve Got You Covered
Mannatech products not only help you feel your best, our natural, glyconutrient-
infused skin care products help you look great, too.
FIRM with Ambrotose® Body Cream
Suitable for all skin types, this rich, botanically based body cream is a
proprietary blend utilizing both science and nature. Formulated without
synthetic colors, it’s also paraben-free and contains no mineral oil to clog
pores. It will leave your whole body feeling refreshed, hydrated and soft.
The Age-Defying Mannatech LIFT™ Skin Care System
Glowing, younger-looking skin is achievable at any age. Inspired by French technology
and formulated with over 30 botanical ingredients, the Mannatech LIFT skin care system is
paraben-free and can help turn back the clock to give skin a more natural,
youthful appearance.
With just three easy steps—cleanse, treat and moisturize—plus
our Jeunesse 7™ proprietary blend that is known to moisturize,
hydrate and reduce the appearance of fine lines and wrinkles, you
can say“bonjour”to younger-looking skin in no time.
Aging is natural. Looking your age doesn’t have to be. Look as
healthy as you feel with the Mannatech LIFT Skin Care System.
Emprizone® Gel
Refresh and moisturize dry, itchy skin with hydrating, aloe-based Emprizone gel.
With vitamins A and E, it’s pH-balanced to leave your skin feeling soft and revitalized
after shaving or waxing. It’s also perfect after drying exposure to the sun and
contains no oils or pore-clogging ingredients.
Ageless Beauty Whose Time Has Come
Release your body’s natural ability to support beautiful, healthy skin through a new, patented microsphere
delivery system that nourishes your skin with youth-inducing ingredients in a time-released pattern.This
pattern optimizes the natural production of skin cells at all levels by delivering naturally sourced glycans,
featuring Manapol® powder.
Finally, what we’ve all been looking for: Youth.
Clinical studies of key ingredients in Mannatech Ūth
Crème
have shown to:
l	Help reduce the appearance of wrinkles
l	Help reduce the appearance of lines
l	Increase moisture and hydration
l	Give the skin greater luminosity
l	Even skin’s tone
l	Improve the elasticity of the skin
l	Refine pore size
46 How You Can Help 47Please Join Us!
Change YOUR WORLD Change THE WORLD!
†
Mission 5 MillionSM
donations are generated through monthly automatic product orders.
‡
4Free Member Discount Program credits are based on monthly automatic product orders.
Consume
One Simple Act
SM
Become a CUSTOMER and help nourish a
child in need.†
Share
4Free Discount Program
As a Member, refer a few people,
earn discounts on your orders‡
(up to FREE!) and help nourish
more children.
Champion
Become a Champion
Help us change the world while creating a
life of significance for yourself.
—Our Goal—
Linking five million consumers
with five million children in need.
PLEASE JOIN US!
Find out how people
just like you are playing
a crucial role in the fight
against global malnutrition.
16931.1113
Item Number: 1275101
Mannatech, Incorporated
600 S. Royal Lane, Suite 200
Coppell, TX 75019
Mannatech.com
Advanced Ambrotose, AmbroStart, Ambrotose, Ambrotose AO, BounceBack, CardioBALANCE, EM•PACT, Emprizone, FIRM with Ambrotose, GI-ProBalance, Give for Real and Design, GI-Zyme, ImmunoSTART, Jeunesse 7, Live
for Real, Manapol, MannaBears, Manna-C, Mannatech LIFT, M5M, Mission 5 Million and Design, NutriVerus, One Simple Act, OsoLean, PhytoBlend, PhytoBurst, PhytoMatrix, PLUS, Real Food Technology, SPORT, Stylized M
Design and Mannatech are trademarks of Mannatech, Incorporated.
Be the Change You Want to See.
Helping to nourish many of the world’s most vulnerable
children is as easy as simply nourishing yourself.
Just purchase the daily supplements you need, and
Mannatech, through MannaRelief, helps a child in need.
When you do this, MannaRelief will provide a monthly donation
of PhytoBlend™ powder; a Real Food Technology® solution!
That’s REAL PLANT & FOOD-BASED NUTRITION to help battle
malnutrition in developing countries around the world.
Partner with Mannatech through our MISSION 5
MILLIONSM
movement, and be a part of the change you
want to see in the world! For more information about
this important program, visit www.Mannatech.com.
Hope for the Future.

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Glyconutritionals Through the Ages: Mannatech's Discovery

  • 1. A Company of Destiny MannatechMannatech
  • 2. 2 3Timeline Glyconutritionals Through the Ages *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 340 B.C. Alexander the Great carries aloe vera plants with him for soldiers wounded in war. 1906 Erythropoietin (a glycoprotein hormone that controls the formation of red blood cells) is discovered. Since the beginning of recorded time, history has validated the importance of the amazing aloe vera plant. 1983 Dr. Bill McAnalley discovers first biologically active polysaccharide from aloe vera gel (Manapol® and acemannan). More than 150 patents are granted worldwide on the stabilization and uses of this discovery. 1984 Hydrogel with polysaccharides from aloe vera gel (Carrisyn® HydrogelWound Dressing) goes on the market. 1990 BioTechnology magazine publishes article“Capitalizing on Carbohydrates.”Carbohydrates are identified as essential for immune function. Multinational chemical and pharmaceutical concerns identify carbohydrates as forming the next wave of drug development. 1992 Acemannan is approved by the USDA for use as a vaccine adjuvant in chickens and licensed to Solvay Animal Health, Inc., the world’s largest manufacturer of veterinary vaccines. 1994 Mannatech negotiates exclusive distribution rights to Manapol and launches company with nutrition industry’s first stabilized aloe vera gel dietary supplement. 1996 Harper’sBiochemistrylists the eight sugars found in glycoproteins. “Like valleys they spread out, like gardens beside a river, like aloes planted by the Lord, like cedars beside the waters.” Numbers 24:6 Mannatech’s Discovery of Glyconutrients has Helped Pioneer the Exciting New Field of Nutritional Glycobiology. 1998 Study by Berger, et al., in Metabolism showed that galactose and mannose were directly incorporated into human glycoproteins without first being converted into glucose. Authors concluded that specific dietary sugars could represent a new class of nutrients. 2002 (July) ScientificAmerican article,“Sweet Medicine,” reports on pharma’s big new strategy for making better drugs from sugars. 2002 (October) NewScientist magazine article,“Sugar Rush,”emphasizes glycobiology as the basis of understanding immunology, neurology and developmental biology. 2012 National Academy of Sciences publishes“Transforming Glycoscience,”a roadmap for the integration of glycoscience as a significant part of higher-education curriculae within the next decade. 2200 B.C. Aloe, considered a divine plant in Nippur (Mesopotamia), is used for intestinal health. 1953 Atomic Energy Commission scientists (Lushbaugh and Hale) demonstrate for the first time the ability of topical fresh aloe vera gel to protect animals’skin. 1988 The term“glycobiology” appears in the Oxford English Dictionary to recognize the merging of the disciplines of carbohydrate chemistry and biochemistry. 1990 JournalofGlycobiology launched by Oxford University Press. Glycobiology is the study of the structure, biosynthesis and biology of saccharides (sugar chains, or glycans) that are widely distributed in nature. 1991 Injectable polysaccharide from aloe vera gel (Acemannan Immunostimulant™) is approved by the USDA for use in cats and dogs. 1993 Injectable acemannan rejected by the FDA as a drug for humans (no LD50). —Dr. Bill McAnalley, AStory ofDiscovery (2010). 1995 Nature magazine article states cell surface sugars are necessary for recognition and immune function. 1995 Dr. McAnalley joins Mannatech with focus on new field of carbohydrate technologies. 1996 Mannatech files patents on the world’s first composition of glyconutrients and introduces Ambrotose® complex. 1998–2002 As dietary sugars begin to gain acceptance as a“new class of nutrients,” Mannatech is issued more than 50 patents worldwide for technology related to Ambrotose complex. 2001 Scripps Institute awarded $34 million from NIH to study glycobiology. 2002–2010 Ambrotose complex approved claims expand to include improved memory, cognition and visual discrimination as well as positive prebiotic effects.* 2011 Definitive proof! Dr. Azita Alavi and colleagues publish study in the European JournalofClinicalNutrition showing for the first time that the oral intake of Ambrotose powder can have a significant impact on the glycosylation status of serum glycoproteins with no adverse effects.
  • 3. 4 The Story 5 The Gift of Provision Amazing, Disruptive Discoveries In 1996, Mannatech’s first Chief Science Officer, Bill McAnalley, PhD, made the discovery of a whole new category of plant-based nutrients called glyconutrients. Mannatech formulated the world’s first glyconutrient product, called Ambrotose® complex.Though this pioneering discovery was at first questioned, even ridiculed, by the traditional scientific community, technology supporting it has since received more than 50 worldwide patents, and it’s now revered as science’s next frontier. Ambrotose complex, formulated with the Manapol® aloe vera extract, became Mannatech’s foundational solution for proper cell-to-cell communication and immune system support. Real FoodTechnology® Solutions Mannatech’s current CEO and Chief Science Officer, Robert Sinnott, MNS, PhD, extended Mannatech’s proprietary product base through the formulation of PhytoMatrix® caplets, the industry’s first vitamin and mineral product produced from natural and plant-sourced ingredients at standardized, nutritionally effective levels.This approach quickly led to the development of many new, unique products based on Real FoodTechnology solutions. In 2012, Dr. Sinnott blended Mannatech’s proprietary glyconutrient complex, its proprietary antioxidant composition and its proprietary real-food vitamin/mineral formulation into a whole-food base.This new product was named NutriVerus™ powder, and it became a complete Real FoodTechnology solution for global health. A Desire to Make a Difference In 1994, Mannatech founder Sam Caster felt called into the marketplace to launch a“Company of Provision”that would impact the lives of people in all the nations of the world.This company was destined to become a new vehicle for addressing the growing epidemic of malnourishment and its impact on the lives of billions of people, including the world’s most vulnerable children. It would require a disruptive new discovery in nutritional science combined with a revolutionary new business strategy in order to create a sustainable solution. The Story Behind Mannatech Sam Caster FounderofMannatech EnjoythefullstorybehindthebeginningofMannatech inthevideo,DestinyUnfolding. http://bit.ly/18cLCFK
  • 4. 6 Mission and Vision 7 O u r M ission and Vision Our mission is to fight global malnutrition by nourishing the world with Real Food Technology® supplementation while empowering and rewarding the lives of those who champion our cause. Our vision is to impact the global epidemic of childhood malnutrition by linking five million consumers of Real Food Technology supplementation with five million children in need. A World-Changing Approach As of mid 2013, Mannatech operates in 24 countries around the world. The company adopted the dynamic business model of social entrepreneurship to link its international product sales directly to the needs of the world’s most at-risk children. Through its MISSION 5 MILLIONSM movement, Mannatech empowers caring individuals all around the world to join the fight against childhood malnutrition by simply choosing to nourish themselves with advanced nutrition sourced from real foods. At the same time, Mannatech offers an unprecedented, purpose- driven business opportunity for those who choose to champion this cause. Findouthowyoucanjoininthefightagainstglobalmalnutrition.VisitMannatech.comtoday. Three to five million children under the age of 5 die every year from the devastating effects of malnutrition.1 That means every six seconds a child dies from malnutrition. That’s 14,000 a day. The facts are heartbreaking. Staggering. But not unbeatable, thanks to people like you. 1 ”Progress for Children: A Report Card on Nutrition”UNICEF, May 2006
  • 5. 8 The Changing Face 9The Problem What Has Gone Wrong?The Changing Face of Malnutrition We used to think malnourishment was a problem that existed on the other side of the world. Now, it’s a problem that often exists just on the other side of the table. “Malnutrition is a phenomenon that touches the lives of 55 million children at any given moment.” UNICEF “Up to one-half of all childhood deaths in the world are linked to malnutrition.” NewYorkTimes “Five million children under the age of five die each year in developing countries from malnutrition.” UNICEF “Poor health conditions linked directly to poor nutrition have become the number one cause of disability and death in America.” Center for Science in the Public Interest “Approximately 215 million Americans now live daily with diet-related health concerns.” “Nutrition Policy”Center for Science in the Public Interest “Nearly the entire U.S. population fails to eat a diet in line with the Dietary Guidelines for Americans.” TheJournalofNutrition, 2010 Today, malnourishment has become a global epidemic. The New York Times calls it the“New Hidden Hunger.” STRESSEDTOXICSTARVED l Nearly the entire U.S. population fails to eat a diet in line with the dietary guidelines for Americans.1 l 90% of all the money Americans spend on food is used to buy processed food.2 1 Krebs-Smith, S.M., Guenther, P.M., Subar, A.F., et al. Americans do not meet federal dietary recommendations. J Nutr 2010; 140(10): 1832-8. 2 Schlosser E. Fast Food Nation: The Dark Side of the All-American Meal. Perennial/ Harper Collins: 2001. Many of us are not consuming enough essential nutrients! l Over 75,000 synthetic chemicals introduced since 1980 l Numerous pollutants common in our air and water l Artifical sweeteners, colorings and preservatives in our foods l Household cleaners, pesticides and other chemicals We live in a toxic environment! We are stressed! Stress produces free radicals that attack and destroy healthy cells. l Emotional stress l Excessive exercise l Smoking (including second-hand) l Excessive alcohol consumption l Use of pharmaceuticals l Food preservatives Classic Face In developing countries, the problem is consuming too little of the right kind of food. New Face In industrialized countries, the problem has become consuming too much of the wrong kind of food.
  • 6. 10 Industry’s Solution 11 Industry’s“Solution” 1 Industry’s“Solution” 2 Industry saw an opportunity in our problems. Synthetically made“nutritional”alternatives Industry’s“solution”to the loss of essential nutrients in our modern diets was the creation of synthetically made alternative nutrients. It was cheaper and more profitable to synthesize vitamins and minerals than to extract them in their natural form, from whole foods. Every so-called“solution”has typically presented more problems. And while the“solutions”continue to increase, our overall health continues to decline. + + = Genetically Modified Seeds Bigger Livestock Pesticides Big Profits But instead, industry has radically“changed” our food over the last 50 years. Industry set out to“improve”food. In the mid-1900s, commercial farming found new ways to grow food faster and bigger. Then, industry focused on reinventing food by combining highly processed food ingredients with chemically made sweeteners, colorings, flavorings and preservatives. Processed food is so poor in nutritional value that one expert refers to them as“edible food-like substances.”1 1 Pollan M. In Defense of Food. New York, New York: The Penguin Press, 2008. • Synthetic vitamins are chemically produced from petroleum and coal tar derivatives, not food. • It’s estimated that over 95% of all vitamins sold are synthetically made.1 1 www.organicconsumers.org/articles/article_3697.cfm 2 Ensley BD, Elless MP, Blaylock MJ, Huang JW. Hydroponic cultivation of metal-accumulating plants as a source of mineral nutrient supplements. Metal Ions in Biology and Medicine 2000;531–3. “Minerals are generally recovered by mining ores or from chemical processes. Preliminary tests have shown that minerals contained in [many of] the most popular brands of multivitamins may not dissolve (they are not soluble) in the stomach or small intestine. They may pass through the body without being absorbed.”2 A Quick Guide for Evaluating Vitamin and Mineral Supplements Synthetically Made Synthetic vitamins are produced chemically in a laboratory and may be made from petroleum or coal tar; they’re not in a food form. Because they are less expensive, most minerals used for supplementation are mined from the ground or manufactured from chemical processes. Tests have shown that these minerals do not dissolve well (they are not soluble) in either the stomach or small intestine. Plant-Sourced Naturally sourced vitamins are extracted from foods or plants or are cultured in yeast. Plants use multiple processes to accumulate minerals from the soil, predigest them and then bond them into a food matrix. Minerals from plants are, therefore, more soluble. Research suggests that naturally sourced vitamins are easier to absorb and retain than synthetically made vitamins. How Real IsYourVitamin? *These stateme nts have not been evaluated by the Food and Drug Adm inistration. This product is not intended to diag nose, trea t, cure or prev ent any dise ase. Our PhytoMatrix® caplets deliver real food-sourced nutrients! To achieve standardized levels of vitamin and mineral ingredients, there are only two sources: Approximately 150 million consumers in North America now take a vitamin/mineral supplement daily 1 . But most people don’t even know the source, quality or efficacy of the products they take. Mannatech believes that the best vitamin and mineral supplementation should include: • Naturally sourced vitamins with standardized and properly labeled amounts • Plant-sourced minerals at standardized and properly labeled amounts Do You Know Where Your Multivitamin Comes From? 1Source Datam onitor : Dietar y Suppl emen ts Marke tTrend s & Oppo rtuniti es 4/29/0 9 (Dieta ry Suppl emen t Marke t USA) How Real Is Your Vitamin? Findoutwiththistearsheetat http://bit.ly/ZC8v0v
  • 7. 12 Ancient Wisdom 13 Ancient Wisdom What did they tell us? “Everything man needs to sustain good health is provided by God in nature. The job of science is to find it.” Paracelsus The Design of Life: “I have given you every seed-bearing plant throughout the earth and all of the fruit trees for your food.” Genesis 1:29 Pietro Longhi. TheApothecary—Aloe vera was a common tool in doctors' offices in the mid 18th century. Paracelsus and Hippocrates, considered to be the fathers of pharmacology and medicine, respectively, believed that having good health was dependent upon proper nutrition. Overthecenturies,technologieshaveevolvedinbothfoodand medicine,butthisprincipleremainsastruetodayasitwasthen. New research is showing us how the human body functions at the cellular level and how nutrients in their real-food form support these critical functions. Science is now bringing us full circle to the very foundations of health and ancient wisdom.
  • 8. 14 Modern Science 15 Modern Science Mannatech accepted the challenge. Mannatech used science to pioneer Real Food Technology® solutions. Robert A. Sinnott, MNS, PhD CEO and Chief Science Officer • Oversees the overall development and R&D management of Mannatech’s Real Food Technology products • Earned Bachelor’s Degree in Biological Sciences, a Master of Natural Sciences Degree and a PhD from 1987–1995, all from Arizona State University • Focused on plant medicinal chemistry and plant biotechnology in graduate training • Instrumental in establishing the science branch of a nonprofit educational institution for training economically disadvantaged students in science-based careers • Joined Mannatech in 2005 • Instrumental in the creation of Mannatech’s Real Food Technology approach Thanks to its dedication to food-based research and development, Mannatech has become a leader in the Real Food Revolution. • Mannatech has invested tens of millions of dollars in research, development and validation. • Working from Mannatech’s in-house laboratories, the company’s scientists and product development specialists actively explore new technologies for sourcing and formulating real-food solutions for consumer health and nutrition. • The company’s Research Group collaborates with major universities and research firms around the world to conduct clinical trials and studies on our products and ingredients. Visit MannatechScience.org for full details.
  • 9. 16 Sweet Language of Life 17The Discovery Sweet Language of Life The Missing Link Bill McAnalley's AStoryofDiscovery - Ambrotose: http://bit.ly/11DgiyU “Almost without exception, whenever two or more living cells interact in a specific way, cell-surface carbohydrates will be involved.” Hodgson J., Capitalizing on Carbohydrates, 1991. “Indeed, cell-surface glycosolation (i.e., the process by which cells create and display their sugar structures) is as important to understanding life as is the genetic code.” Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012. Nourish Me Repair Me Destroy Me Protect Me Regulate Me IMMUNE CELL Cell-surface sugar structures called glycoproteins are necessary for the proper recognition and functioning of most of our cells. Immune cells read the cell- surface sugar structures on other cells to determine if they are healthy, need repair or need to be destroyed. Missing Sugars = Altered MessageOur cells need sugars to communicate all their needs. Missing Sugars Can Spell Trouble Removing one sugar [from their cell-surface structures] turns protective antibodies (repair cells) into attackers. The research shows that the mere destructive autoimmune functions appear to be lacking antibodies associated with this (sugar). Rockefeller University, July 4, 2007 When bad cells go undetected, as in degenerative type functions, research has shown that sugars are missing from their glycoprotein structures. Capitalizing on Carbohydrates, 1991 The Missing Link Of the 200 that naturally occur in nature, our cells use eight of these sugars like letters of an alphabet to create cellular words. The potential information content of these sugar structures vastly exceeds that of any class of macromolecules.1 “Every living cell on the planet is covered with a dense and complex array of sugar molecules. Every molecule, cell or organism that interacts with a cell must do so through these cell-surface sugar structures.”1 1 Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012. What are Glycans? Glycans—also known as carbohydrates, saccharides, or simply as sugars—are molecules made up of combinations of different sugar units, such as glucose. These units can link together to form complex, three- dimensional structures.
  • 10. 18 Glycoscience Validation 19Self-Evidence Glycoscience: A Road map for the Future Self-Evident “Every molecule, cell or organism that interacts with a cell must do so through these cell-surface sugar structures.”1 In 2012, a report titled Transforming Glycoscience: a Roadmap for the Future conducted by the National Academy of Sciences offered bold support for the function and importance of glycans (or glyconutrients). 1 Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012. Dr. John Rollins, a former award-winning U.S.Trademark and Patent Office official, upon his introduction to glyconutrients, said,“In the past 23 years ... our group at the U.S. Patent Office had the opportunity to review the best technology presented by the world’s best scientists. There have been many significant discoveries, but one stands head and shoulders above the rest: the discovery of a new category of vital nutrients called glyconutrients.” To review the full report entitled: Transforming GlycoScience: A Roadmap for the Future go to www.nap.edu and search“glyco.” Integrating glycoscience into relevant disciplines in high school, undergraduate, and graduate education, and developing curricula and standardized testing for science competency would increase public as well as professional awareness.1 1 Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012. Roadmap Goals: l Within five years, integrate glycoscience as a significant part of the science curriculum, including both lecture materials and hands-on experiments or activities. l Within 10 years, integrate and teach glycoscience at every level for which it is relevant to understanding the scientific content. Competency in glycoscience could also be included in all standardized testing wherever relevant (for example, as part of the SAT and GRE Subject Tests, MCAT, and Medical Board Exams).
  • 11. 20 Validation 21Awards & Recognition Awards & RecognitionGlycoNutrient Validation March 14, 2006 Mannatech was the 29th fastest-growing public company in the Dallas/Fort Worth Metroplex, according to the Dallas Business Journal. January 31, 2007 Mannatech received first- and second-place awards for basic science research indicating bacteria from the human digestive tract can metabolize the complex carbohydrates in the company’s glyconutritional supplements. May 30, 2007 Mannatech was recognized by BusinessWeek as the 12th-best“Hot Growth”small company in America and as the 4th best in average return on capital over three years. March 14, 2009 Chief Science Officer and Senior Vice President Robert Sinnott, MNS, PhD, was selected as the vice chairman of the Senior Scientific Advisory Council (SSAC) for the Council for Responsible Nutrition (CRN). November 24, 2009 Mannatech’s educational website, MannatechScience.org, received a Web Health Merit Award for its accuracy, success in reaching its targeted audience and overall quality. June 2011 CEO and Chief Science Officer Dr. Rob Sinnott featured in Natural Products Insider magazine article,“Aloe veritas.” April 2012 Mannatech presents new study at the 10th Jenner Glycobiology and Medicine Symposium in the Netherlands. July 2012 Mannatech presents product research at the 9th Annual International Society of Sports Nutrition Conference. April 2013 Dr. Sinnott featured in Nutraceuticals World magazine article,“Open Innovation in Nutraceuticals & Functional Foods.” We do all that we can to earn the trust consumers place in us every time they use a Mannatech product. We hold more than 50 patents in 30 countries for the technology relating to our Ambrotose complex glyconutrient formulation. And our patent positions have been repeatedly reaffirmed in court, most recently in July 2010, when Mannatech won judgments against seven companies found to be manufacturing and marketing products that infringed on our patented glyconutrient technology. Patents Recent Glyconutrient Studies October 2012 University of Ghent scientists publish Ambrotose product prebiotic study in the Antoine van Leeuwenhoek Journal of Microbiology. February 2012 Review of effects of polysaccharides on brain function is published, Mechanisms that might explain the cognitive benefits of glyconutrients and other polysaccharides are explored. September 2011 Study shows Mannatech's Ambrotose complex improves well-being in healthy adults (titled Perceived changes in well-being following polysaccharide intake in middle-aged adults). Quality and Standards Mannatech is committed to meeting customer, regulatory and industry standards by manufacturing products of the highest quality and value. Our suppliers conduct statistical sampling then follow it with inspection and testing. No product is ever shipped from Mannatech without the highest level of assurance that it meets our quality standards. Current Good Manufacturing Practices As a global innovator, we adhere to industry-wide current Good Manufacturing Practices (cGMPs) established by various U.S. and international regulatory agencies. You can rest assured that our products are safe, effective and precisely labeled. NSF Certification—Third-Party Mark of Excellence A growing number of our health products have been Certified by NSF International, an independent, third-party organization that helps ensure that supplements and ingredients are labeled accurately and contain no adulterants or contaminants. 100% Satisfaction Guarantee You can trust the science and quality behind our products. We’re so confident you’ll love our products that we offer a six-month Satisfaction Guarantee.† † Mannatech guarantees your full satisfaction. If not completely satisfied, contact Customer Care and return the product within 180 days for a full refund. See Mannatech.com for details. CERTIFIED PRODUCE DWITH SOLA RENERGY To see the full collection of studies and published research, visit MannatechScience.org.
  • 12. 22 System Support 23The Role of Nutrients A Common-Sense Appr oach to Optimal Health The Role of Nutrients Completing the Circle of Care Consider for a minute your body as an automobile. Daily support and maintenance is required or breakdowns occur. l The modern car is designed to run on certain raw materials. l It requires routine maintenance. l It will usually last about 100,000 miles or so. The car must have fuel in the tank, oil in the engine, water in the radiator, air in the tires and, of course, a driver behind the wheel. The car also must be maintained by changing the oil and filling the gas tank. There are numerous things that may improve its performance or looks, but these components are mandatory for it to start and run. If any of the basic components are missing, or the car isn’t maintained properly, it’s not going to travel very far without breaking down. And a shiny new paint job or fresh tires won’t help if the basics are not met. GAS OIL WATER AIR DRIVER The same concept can be applied to understanding the human body. l Our bodies were designed to run on specific raw materials. l They require routine maintenance. l And they are designed to last about 85 years or so. Countless things may enhance how we look or feel, but nutrients are essential. Unless we provide our bodies with these basic essentials and perform the necessary maintenance, it is very difficult to sustain good health. Nourish Me Repair Me Destroy Me Protect Me Regulate Me IMMUNE CELL It All Starts with the Cells A variety of food-based nutrients is required to support healthy cells. Healthy cells are necessary to support healthy glands, organs, tissues, bones, fluids, blood and skin. Healthy cells = Healthy tissue Healthy tissue = Healthy organs Healthy organs = Healthy systems Healthy systems = Healthy bodies Body Systems Organs Tissue Cells For optimal wellness, your body needs ongoing maintenance in such areas as: Cellular Support –– Communication –– Protection –– Nourishment System Support –– Endocrine –– Cardiovascular –– Digestive Body Fitness –– Sustainable Fat Loss –– Performance –– Recovery
  • 13. Cellular Communication Ambrotose® Complex and Advanced Ambrotose® 24 Cellular Communication 25Ambrotose The Science of Glyconutrients Research published in the European Journal of Clinical Nutrition revealed for the first time in the scientific community that: • The ingestion of a standardized blend of plant poly- saccharides (Ambrotose powder) can induce significant changes in blood glycoprotein structures. • And there were no reported adverse events.1 1 Alavi, A., Fraser O, Tarelli E, et al. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation profile of serum in healthy subjects. Eur J Clin Nutr 2008; 65: 648–56 The Old Theory Scientists once believed that it was not possible to influence the body’s production of cell-surface sugar structures through dietary intervention. The New Reality Thesecomplexsugarsareusuallyreferredtoasglycans.Glycansareoneofthefourmajorclassesof macromolecules—nucleic acids, proteins, and lipids being the other three—that are essential for life and are involved in every aspect of biology, medicine, and a number of practical applications. These other three classes often incorporate or rely on glycans for their activity. 1 Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012. Missing Sugars = Altered MessageOur cells need sugars to communicate all their needs. Glyconutrients Ambrotose Products l Support cellular communication*† l Improve cognitive function*† l Improve memory, concentration and attentiveness*† l Improve mood and decrease irritability*† l Support immune system function*† l Support digestive system health*† The first standardized blend of plant-sourced polysaccharides. More than 50 patents issued worldwide for this breakthrough technology. † Benefits vary by product. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 14. 26 Cellular Protection 27Ambrotose AO Cellular Protection Ambrotose AO® Capsules Antioxidantsl In part, premature aging is the breakdown of the body’s natural ability to regenerate its trillions of cells and produce new ones. This repair and renewal process goes on every second of every day of your life. l It has been postulated that naturally occurring invaders, called“free radicals,”can damage cells, interfere with their repair and regeneration, and thereby speed up the aging process. l Sunlight, physical and emotional stress, and environmental toxins are sources of free radicals that can damage cells and accelerate the aging process. l Cells can protect themselves from these environmental factors, but research suggests that they require the right nutrients, called antioxidants, to provide proper protection. l Certain fat- and water-soluble vitamins, minerals and plant phytochemicals are antioxidants that can neutralize free radicals and prevent the damage they cause. l It has been postulated that premature aging can start to occur when cells don’t get enough antioxidant support, and the body cannot keep up with the demands of damaged cells. l Antioxidant nutrients are abundant in vine-ripened fruits and vegetables. Free radicals can attack our cells as many as 10,000 times a day. The right blend of fat- and water-soluble antioxidants may protect our cells from this attack. Included inOSP Packets Ambrotose AO is a scientifically proven antioxidant supplement designed to support optimal health by effectively enhancing antioxidant protection in the body.* l Research has shown that two Ambrotose AO capsules can increase overall antioxidant protection in humans by 37.9%.† That’s more than two and a half times the ORAC impact of five servings of fruits and vegetables (serum ORAC results). l Ambrotose AO capsules: - Help protect against cell damage caused by physical and oxidative stress (free radicals), toxins, environmental stress, and poor diet, all of which can damage cells, tissues, and DNA.* - Provide plant-sourced ingredients for antioxidant and immune support.* † Comparison of serum ORAC values obtained in two separate clinical studies funded by Mannatech. According to a study funded by the USDA, five daily servings of fruits and vegetables can increase overall antioxidant protection by 13.9% (serum ORAC results).1 Ambrotose AO capsules can increase overall antioxidant protection in humans by more than two and a half times that amount. Read the full study at: http://bit.ly/11otcQf 1 Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr 1998;68:1081–7. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 15. 28 Cellular Nourishment 29PhytoMatrix Cellular Nourishment PhytoMatrix® Caplets Vitamins and Minerals PhytoBurst® Chews Essential Nutrition Your Cells Need Nourishment l Every cell in your body requires a variety of nutrients to help build and support its proper structure and function. l Your body is building millions of new cells every second. l There are more than 26 essential vitamins and minerals, and multiple trace elements, that MUST be obtained through your diet. Proprietary Hydroponic Growing Technology At the heart of our PhytoMatrix product is a patented, hydroponic cultivation technology that uses the Indian mustard plant nicknamed“nature’s magnet”for its ability to absorb minerals from the soil. These plants are hydroponically grown in solution, allowing them to absorb a controlled amount of concentrated minerals, which are then stored in the plant tissue. Why is this significant? Because food sources—like Indian mustard—provide minerals in their most natural form, so they can be readily absorbed and utilized by the body. The hydroponic process ensures standardized concentrations of essential minerals that meet minimum requirements with a daily serving of four tablets. Even fresh fruits and vegetables—which usually have high concentrations of vitamins—may be low in essential minerals. Foods are comprised of synergistic blends of [essential] nutrients bound together into the food matrix. It is the food matrix [blend] that best supports human biological processes. Jacobs DR, Jr., Tapsell LC. Food, not nutrients, is the fundamental unit in nutrition. Nutr Rev 2007;65:439-50. Included inOSP Packets Mannatech’s PhytoMatrix multivitamin/mineral supplement provides the industry’s first standardized blend of food-sourced vitamins, minerals and phytonutrients. PhytoMatrix caplets support: l Cell protection with powerful antioxidants* l Energy production with a full complement of B vitamins* l Heart health with vitamins B6 , B12 , B3 (niacin), C, and B9 (folic acid)* l Healthy eyesight with vitamins A, C, E, and niacin, plus the mineral zinc* l Immune system function with vitamins A, C, E, B6 , and folic acid, plus minerals zinc, copper and iron* PhytoBurst Chews: A Delicious Delivery Method for Food-Sourced Nutrition l Delicious fruit-flavored chews (lemon and mixed berry) l Incorporates hydroponic technology found in our PhytoMatrix caplets l Great on-the-go bursts of nutrition *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 16. 30 Cellular Health 31NutriVerus Real Nutrition NutriVerusTM PowderReal Value Nutrition the Way Your Body Wants it. The Ultimate Solution for Cellular Health Mannatech’s Core Innovations in One Product NutriVerus™ powder delivers the nutrition your body needs, the way your body wants it. This completely unique supplement combines natural, food-sourced vitamins, minerals, glyconutrients and fat- and water- soluble antioxidants in a nutrient-dense, real-food base of stabilized rice bran and organic fruits and vegetables. The result? Energy-boosting, immune system– supporting nutrition in an environment just right for nutritional synergies to occur, increasing the potential interaction of the individual nutrients.* Highly Valued Benefits at a Value-Conscious Price Glyconutrients and food-sourced nutrients for just $2 a day! l Supports cell-to-cell communication through a blend of specific plant saccharides including glyconutrients* l Offers antioxidant and immune system support* l Supports brain health* l Helps protect your cardiovascular system* l Supports healthy digestion* l Helps your body maintain energy levels* l Provides a natural, food-sourced vitamin/mineral complex for maximum absorption* l Suitable for all ages, including kids age 4 and up NutriVerus powder features a nutrient-dense, real-food base of stabilized rice bran, organic fruits and vegetables, antioxidants and glyco- and phytonutrients. Stabilized Rice Bran (SRB) is one of the most nutrient-dense food ingredients in the world. l Unlike other grains, it is gluten-free l More than 100 antioxidants, metabolic co- factors, and trace elements in its food matrix l Vitamin E complex with tocopherols and tocotrienols l Naturally rich in B vitamins l High in inositol l Rich in phytosterols l Rich in fatty acids l Good protein source l Good source of potassium, magnesium and phosphorus Learn more about NutriVerus powder and the Real Food Revolution. Watch this video. http://bit.ly/13FgYV0 Essential Vitamins & Minerals from Real Food Real-Food Base from rice bran and organic fruits and vegetables Glyconutrients Fat- & Water-Soluble Anti- oxidants Organic Fruit Blend Organic Vegetable Blend Strawberry Raspberry Broccoli Broccoli Sprouts Blueberry Tart Cherry Tomato Carrot Pomegranate Cranberry Spinach Kale *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 17. 32 Endocrine System Support 33PLUS Endocrine System PLUS TM CapletsSupport Endocrine System Support The Endocrine System Is Your Body’s Command Central. When functioning well, its glands direct operations by producing vital hormones that send signals to keep you ready for anything and help your body stay balanced. Because this important control center ultimately influences almost every cell organ and function of your body, making sure it gets the nutrients it needs is a must. Mannatech’s PLUS™ caplets, can help by keeping this vital system functioning smoothly in a state of equilibrium.* Mannatech’s PLUS caplets don’t contain hormones. Instead, they provide specific nutrients, including plant sterols, to support your glands’natural function.* And because we don’t always eat right, we can miss out on important nutrients like plant sterols and amino acids that help keep our systems functioning well. That’s why Mannatech developed PLUS caplets—to supply the body with a proprietary blend of specific, standardized nutrients, including important plant sterols and amino acids that we may not always get on a consistent basis from diet alone. Mannatech’s PLUS caplets include a proprietary blend of standardized plant sterols formulated to support a well- functioning endocrine system.* PLUS caplets: l Furnish raw materials for endocrine support* l Supply essential amino acids to support natural hormone production* l Support breast, bone and colon health as well as the immune, nervous and cardiovascular systems* l Support prostate health* Amino acids—the“building blocks”of proteins Did you know that of the 20 amino acids that we all need to survive, the human body produces only 10? We must rely on our diets for the other half, but not all proteins are created equal. Some contain specific amino acids for hormone production while others do not. And because humans don’t store amino acids in their bodies, we need a steady supply every day. Included inOSP Packets *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 18. 34 Cardiovascular 35Cardiovascular Cardiovascular System Omega-3 with Vitamin D3Support Healthy Heart CardioBALANCE® Capsules Additional Cardiovascular Support Your body doesn’t produce omega-3. For centuries, people got enough omega-3s through their diets. Not so anymore. Today’s diet trends result in too much omega-6 in our bodies. Even farm-raised fish are often grain fed and contribute more omega-6 than omega-3. Although omega-6 is important, it competes with omega-3 for space in our cells. Our current diets have created a ratio that ranges as high as 30:1 omega-6 to omega-3. This imbalance has given rise to an unhealthy inflammatory response, which is a key contributor to many of the health concerns in our diet. A Fat Your Body Needs There are good fats and bad, but omega-3 fatty acids are a fat that you absolutely must have. l Help support cardiovascular and heart health* l Help support brain health and function* l Help maintain a healthy immune system and support a healthy inflammatory response—a key contributor to good health* l Provide support for healthy triglyceride levels already within normal levels* l Vitamin D is essential for calcium absorption* Learn more about how our Omega-3 with Vitamin D3 is unique. Watch this video. http://bit.ly/186Q7oi Mannatech’s Omega-3 with Vitamin D3 is your best choice with: l Over 1,000 mg of highly concentrated EPA and DHA per serving l Made from molecularly distilled, high-quality fish oils for ultra-purity l Pleasant lemon flavor in an easy-to-swallow gel capsule l 830 IU of vitamin D3, a natural and preferred source of vitamin D Omega-3 fatty acids are considered “essential” because they are vital to your health and your body cannot produce them. CardioBALANCE Capsules: l Provide nourishment for cardiovascular health through a unique herbal vitamin and amino acid blend* l Help maintain homocysteine levels that are already within normal range* l Include folate as well as L-arginine, which is thought to increase nitric oxide production—essential in maintaining blood vessel health—as well as CoQ10, which is often depleted by cholesterol-lowering drugs* Research shows that most people are deficient in omega-3 fatty acids. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 19. 36 Digestive 37Digestive Digestive System GI-ProBalance® Support Slimsticks Approximately 70% of your immune system which is located in your digestive tract is dependent on good digestion. Healthy Digestion GI-Zyme® Capsules Healthy Digestion l One of the digestive system’s most important functions is to process food and absorb all the nutrients our cells can use. It also serves as the first line of defense against harmful bacteria. l Because the digestive system’s organs rely on nutrients from food, the health of the digestive system depends on the quality of our diet. l To digest food, the intestines maintain an environment that includes healthy bacteria and enzymes. l Probiotics are dietary bacteria that assist in digestion. Enzymes regulate the speed of metabolism, among other bodily processes. l Probiotic bacteria must be regularly replenished. In the past, they were found in many common, raw foods. However, preservatives, pasteurization and other processing have generally eliminated probiotics from today’s foods. This forces the body to dip into and, perhaps, deplete its own supply. So when your gut is healthy, it helps your whole body stay healthy. tuned to unleash the power of Ambrotose® Performance Developed after extensive research on the digestion and beneficial effects of Ambrotose complex, GI-ProBalance slimsticks were formulated to enhance the benefits of Ambrotose products. The specially formulated probiotic blend breaks down the polysaccharides in the Ambrotose products, thereby enhancing the ability of both exceptional products to support the digestive and immune systems.* Mannatech’s GI-ProBalance slimsticks provide the“right” bacteria to help maintain the microbial balance in a healthy intestine.* This balance can promote a healthy effect among the various microflora that live in the human intestine, thereby supporting optimal digestive function.* Mannatech’s GI-Zyme capsules are formulated to: l Help improve the level of digestion* l Assist in breaking down proteins, fats and carbohydrates* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 20. 38 Fat Loss 39OsoLean® A New Perspective on Sustainable Fat Loss† OsoLean® Powder Target Fat Loss Retaining lean muscle when burning fat is important in maintaining body strength and a healthy metabolism. In a clinical study, the key ingredient in OsoLean powder promoted fat loss and minimized muscle loss when combined with a proper diet and exercise.* More than just a typical whey protein product, OsoLean powder incorporates a proprietary advanced peptide technology that separates and concentrates specific parts of whey protein, called peptides, to ensure your body receives the optimal level of fat-loss peptides.* The Answer? SUSTAINABLE weight management from REAL-FOOD SOURCES. Don’t Make This Common Weight-Management Mistake! When shedding pounds, don’t overlook your body’s basic nutritional needs. Add NutriVerus™ powder to your weight-management regimen and give your body the foundational, whole-food nutrients it craves. We’re Dieting More Often The desire to lose weight is not a new one. But it’s one that’s received unmatched attention in the past thirty years. Conventional wisdom tells us that too many calories and too little exercise are the major contributors to weight gain. So we’ve tried to address those issues in many creative ways. From exercise programs and eating plans, to metabolism-enhancing pills, meal replacements and even surgery, we’ve virtually thrown the kitchen sink at losing weight. l 75 to 100 million Americans diet each year.1 l The typical American dieter now makes four weight-loss attempts per year—the highest number in 15 years.1 1 The weight-loss industry by the numbers, ABC News, May 8, 2012 We’re Spending More Money l The U.S. weight-loss market now exceeds $60 billion. U.S. Weight Loss Market Worth $60.9 billion, PRWeb, May 9, 2011 l If you consider that“only”75 million Americans are trying to lose weight, that’s $800 per person per year! We’re Gaining More Weight Even when we do lose weight, we seem to have even bigger challenges keeping it off. Many of us lose a few inches today, only to gain it all back—and even more—tomorrow. l Globally, there are more than one billion overweight adults, and the number is growing. Worldometers.com, Marketdata research 2013 l According to the American Heart Association, 66% of Americans are overweight and 34% are obese. Trend spotting 2013, Foodnavigator.com, December 3, 2012 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 21. 40 Performance 41Recovery Performance Recovery Perform Better Recover Faster Mannatech’s advanced Weight and Fitness products are natural and formulated with food-sourced nutrients to help you go the extra mile, and look amazing while doing it. SPORT™ capsules: l Help maintain existing normal blood sugar levels and support carbohydrate utilization* l A proprietary blend of herbs and herbal extracts l A plant sterol supplement formulated with a combination of Ambrotose complex and wild yam AmbroStart®drink mix is a delicious, orange-flavored, energy-releasing supplement that: l Delivers nutrients that provide the body with energy* l Includes medium-chain triglycerides that are readily broken down into short-chain, free-fatty acids that can be used as fuel for muscles* l Is a good source of fiber l Helps support a healthy immune system* EM∙PACT®citrus-flavored drink mix: l May enhance the body’s ability to use oxygen during athletic exertion* l May improve athletic endurance* l Includes medium-chain triglycerides (MCTs) that are readily broken down into short-chain, free-fatty acids that are used as fuel for muscles* l Has been clinically shown† to enhance cardiorespiratory fitness and improve endurance* Our BounceBack®capsules allow you to stay active and mobile.* When taken daily, over time, BounceBack capsules can: l Help reduce muscle pain and stiffness due to overexertion or physical activity* l Aid the body’s natural recovery process* l Support optimal joint and cartilage health* l Provide immune system support* Mannatech’s ImmunoSTART®tablets prime your immune system.* If it’s operating well, your immune system will remove toxins and keep you healthy. But, everyday stresses, not eating properly and irregular sleep habits can take a heavy toll on your immune system. These factors may accelerate your use of and need for nutrients. Eventually, your immune system may encounter difficulty keeping up with the demands placed upon it, so it’s critical that you give it the right nourishment. l Helps build, support and nurture immune system health* l Engineered with a targeted array of nutrients, including bovine colostrum and lactoferrin that work to stimulate and support the body’s natural immune response* l Increases plasma levels of neutrophil precursors—neutrophils are the most abundant immune cells and form an integral part of the immune system* Manna-C™capsules contain natural forms of vitamin C from wild bush plum and acerola—wild fruits that are considered two of nature’s richest sources of this vitamin. l Includes classic Ambrotose® complex, along with wild bush plum and acerola fruit extract, both natural sources of vitamin C l Herbal blend with a natural plant source of vitamin C for the maintenance of good health* Our Manna-C capsules combine Ambrotose complex plant polysaccharides with an herbal blend that yields natural sources of vitamin C. This specially formulated herbal blend includes lemon verbena, sage, peppermint and other herbs. †Mannatech-funded clinical studies *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 22. 42 Protecting the Future 43Children Protecting Our Future Children Start a Tradition of Good Nutrition “This could be the first generation of children in the United States that lives less than its parents.” Richard Carmona, former Surgeon General of the United States, 2009 The pursuit of wellness is one that lasts a lifetime. Give your child the healthy advantages that come from good nutrition early in life. Many Mannatech products are appropriate for children. Just check the labels for any possible age and/or directional restrictions. For starters, here are some products deemed as“favorites”by kids and parents alike. MannaBears™ Gummies A tasty alternative to sweets full of refined sugars and other“junk”foods, MannaBears gummies include a specially formulated glyconutrient blend as well as 11 dehydrated fruits and vegetables—like broccoli, carrot, cauliflower, tomato, papaya and pineapple— to help protect cells from free radical damage.* GI-ProBalance® Probiotic Slimsticks Since 70% of your child’s immune system is located in the digestive tract, her body relies on a wide variety of bacteria and other microorganisms to help keep it running properly, including probiotics and prebiotics. Kids love the taste of these delicious slimsticks as much as parents love how they’re working. Recommended for children 4 years of age and older. NutriVerus™ Powder NutriVerus brings real-food glyconutrient and vitamin/mineral technologies in a nutrient-dense food base of stabilized rice bran and organic fruits and vegetables. Sprinkle it on your child’s food every day to help ensure his meals are more nutritious. Recommended for children 4 years of age and older. ImmunoSTART® Tablets With everything going on in their world, your child’s immune system can become overloaded quickly. Give them ImmunoSTART tablets every day to help build, support and nurture immune system health.* Do not give to children under age 4 without adult supervision. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
  • 23. 44 The Science of Beauty 45Skin Care The Science of Beauty Healthy Body, Healthy Hair We’ve Got You Covered Mannatech products not only help you feel your best, our natural, glyconutrient- infused skin care products help you look great, too. FIRM with Ambrotose® Body Cream Suitable for all skin types, this rich, botanically based body cream is a proprietary blend utilizing both science and nature. Formulated without synthetic colors, it’s also paraben-free and contains no mineral oil to clog pores. It will leave your whole body feeling refreshed, hydrated and soft. The Age-Defying Mannatech LIFT™ Skin Care System Glowing, younger-looking skin is achievable at any age. Inspired by French technology and formulated with over 30 botanical ingredients, the Mannatech LIFT skin care system is paraben-free and can help turn back the clock to give skin a more natural, youthful appearance. With just three easy steps—cleanse, treat and moisturize—plus our Jeunesse 7™ proprietary blend that is known to moisturize, hydrate and reduce the appearance of fine lines and wrinkles, you can say“bonjour”to younger-looking skin in no time. Aging is natural. Looking your age doesn’t have to be. Look as healthy as you feel with the Mannatech LIFT Skin Care System. Emprizone® Gel Refresh and moisturize dry, itchy skin with hydrating, aloe-based Emprizone gel. With vitamins A and E, it’s pH-balanced to leave your skin feeling soft and revitalized after shaving or waxing. It’s also perfect after drying exposure to the sun and contains no oils or pore-clogging ingredients. Ageless Beauty Whose Time Has Come Release your body’s natural ability to support beautiful, healthy skin through a new, patented microsphere delivery system that nourishes your skin with youth-inducing ingredients in a time-released pattern.This pattern optimizes the natural production of skin cells at all levels by delivering naturally sourced glycans, featuring Manapol® powder. Finally, what we’ve all been looking for: Youth. Clinical studies of key ingredients in Mannatech Ūth Crème have shown to: l Help reduce the appearance of wrinkles l Help reduce the appearance of lines l Increase moisture and hydration l Give the skin greater luminosity l Even skin’s tone l Improve the elasticity of the skin l Refine pore size
  • 24. 46 How You Can Help 47Please Join Us! Change YOUR WORLD Change THE WORLD! † Mission 5 MillionSM donations are generated through monthly automatic product orders. ‡ 4Free Member Discount Program credits are based on monthly automatic product orders. Consume One Simple Act SM Become a CUSTOMER and help nourish a child in need.† Share 4Free Discount Program As a Member, refer a few people, earn discounts on your orders‡ (up to FREE!) and help nourish more children. Champion Become a Champion Help us change the world while creating a life of significance for yourself. —Our Goal— Linking five million consumers with five million children in need. PLEASE JOIN US! Find out how people just like you are playing a crucial role in the fight against global malnutrition.
  • 25. 16931.1113 Item Number: 1275101 Mannatech, Incorporated 600 S. Royal Lane, Suite 200 Coppell, TX 75019 Mannatech.com Advanced Ambrotose, AmbroStart, Ambrotose, Ambrotose AO, BounceBack, CardioBALANCE, EM•PACT, Emprizone, FIRM with Ambrotose, GI-ProBalance, Give for Real and Design, GI-Zyme, ImmunoSTART, Jeunesse 7, Live for Real, Manapol, MannaBears, Manna-C, Mannatech LIFT, M5M, Mission 5 Million and Design, NutriVerus, One Simple Act, OsoLean, PhytoBlend, PhytoBurst, PhytoMatrix, PLUS, Real Food Technology, SPORT, Stylized M Design and Mannatech are trademarks of Mannatech, Incorporated. Be the Change You Want to See. Helping to nourish many of the world’s most vulnerable children is as easy as simply nourishing yourself. Just purchase the daily supplements you need, and Mannatech, through MannaRelief, helps a child in need. When you do this, MannaRelief will provide a monthly donation of PhytoBlend™ powder; a Real Food Technology® solution! That’s REAL PLANT & FOOD-BASED NUTRITION to help battle malnutrition in developing countries around the world. Partner with Mannatech through our MISSION 5 MILLIONSM movement, and be a part of the change you want to see in the world! For more information about this important program, visit www.Mannatech.com. Hope for the Future.