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Saponin at ABIC 2008 Cork, Ireland

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Saponin at ABIC 2008 Cork, Ireland

  1. 1. SAPONIN Inc. - The Prairie Carnation™ Company - Pink(s) to the Prairies! Dr. Michael M. Oelck, PAg, Co-founder and CEO 1
  2. 2. Pink(s) to the Prairies! ABIC 2008, Cork Ireland, 2
  3. 3. Two Parts Part I - The SAPONIN business case. Part II - Why did the investors invest? 3
  4. 4. Part I • Company Intro 4
  5. 5. Mission SAPONIN is the leading supplier of industrial bio- products from Prairie Carnation™ (Saponaria vaccaria) . We produce and sell • the finest native starch from any plant for cosmetics, • saponins for vaccine adjuvants and • cyclopeptides for medical applications! 5
  6. 6. The Crop • Prairie CarnationTM • Saponaria vaccaria L. • syn. Vaccaria pyramidata 6
  7. 7. Brand New Crop! - A Patent Attorney‘s Dream - 7
  8. 8. Agronomy that Works! 8
  9. 9. The Seed Useable Content in % Starch 60 Protein 13 Lipids 5 Saponins 3 Cyclopeptides 0.3 Phenolics 05 Soluble fibre 5 84 % 9
  10. 10. Genetics • 18 chromosomes • Self compatible fertilisation > 80% • Microsospore derived embyro regeneration • Double haploid breeding lines • Hybrids for variety protection • Si system required or molecular male sterility • Transformation system in progress • Molecular pharming potential 7/5/2011 10
  11. 11. The Products 11
  12. 12. The Biorefinery Starch Concept Phenolics Soluble fibre 12 O 28 16 O OH HOOC HO O O 4 O H3C FUC RO O CHO OH 23 R3O O OH O O HO GAL ARA HO O HO OR2 O RHA O CH3 R1O OH OH Seed Extract H3C O HO OH Saponins OH cyclo (gly-val-pro-val-trp-ala) O O N H Protein HN O HN N NH H O NH N SEGETALIN A O O MW 609.3274 Cyclic peptides Oil 12
  13. 13. Micro-Starch cash flow early • Novel! • Granule size of 1 micron - smallest starch known in nature • Remarkable texture and performance properties • Proprietary production method • Premium pricing • Cosmetic and specialty foods ingredient • New industrial applications 25 μm 1 μm 13 Wheat starch 20-100um Prairie Carnation starch 1um
  14. 14. Saponins Membrane active because of detergent structure 12 O 28 16 O OH HOOC HO O O 4 O H3C FUC RO O CHO OH 23 R3O O OH O O HO GAL ARA HO O HO OR2 O RHA O CH3 R1O OH OH O OH H3C HO OH • Mode of action of saponins as cholesterol analogue • Free cholesterol in the blood stream binds saponins • Membrane effects against fungi and bacteria • Cholesterol in cell membrane binds cholesterol • Cell membranes permeable for seconds • Removal with cholesterol by the liver • Catalytic effect to help big molecules into cells 14
  15. 15. Saponin Market: Vaccine Adjuvants • Cholesterol binding • Immune stimulant • Less hemolytic than any other saponins • Antigen developed QS-21Saponin • GSK has QS-21 for first Malaria vaccine to come 15
  16. 16. Saponin Market: Cancer 16
  17. 17. Cyclopeptides Part of Natural Defense System of Plants cyclo (gly-val-pro-val-trp-ala) O O N H HN HN O N NH H O NH N SEGETALIN A O O MW 609.3274 Effects: • Antimicrobial effect against protozoa, bacteria Markets: • Veterinary feed supplement • Natural Fungicides for Organic Production • Cardiovascular Therapy 17
  18. 18. Ingredient Market Marketing Starch Cosmetics license for customer products, supply raw product, customer does regulatory Saponins Cosmetics Adstringend , anti-wrinkle, sell to formulators and cosmetics Saponins Adjuvant Develop proof of concept, then license To vet first, pharma second Saponins Pharmaceutical Develop proof of concept, then license (e.g. mouse models in cancer) Segetalins Pharmaceutical Develop proof of concept, (cyclic peptides) then license (e.g. mouse models ) 18
  19. 19. Conclusion of Intro (Part I) • SAPONIN is a new bio-pharmaceutical company • Agriculture and seed production accomplished! • Regulatory expertise needed at the beginning. • Creative fractionation easy for more than one product. • Natural Actives in large scale production! • Markets are cosmetics, agriculture , vet. and pharma 19
  20. 20. Part II Why did the Investors Invest? Less Risk, more Rewards! 20
  21. 21. Investors Need a Convincing Team - enriched by their own "experts", just in case… SAPONIN was founded in 2003. Clarity Capital Corporation invested $2.2 Million into SAPONIN Inc. in 2006 and $1 Million in 2008. The company is looking for another investment of $5Million at present. ABIC 2008, Cork, Ireland 21
  22. 22. Own the Value Chain! Germplasm Contract production Processing Product Quality Control 22
  23. 23. Intellectual Property Position METHOD FOR PRODUCTION OF SAPONARIA FROM MICROSPORES , PCT/CA2006/000725 EXCLUSIVE LICENCE OF SCOTT LANDLINE FROM AAFC, Closed loop production system with contract farmers PROCESSING OF SAPONARIA VACCARIA SEED, United States Patent 3622389 EXCLUSIVE PRODUCT ACCESS AS USP 23
  24. 24. Early to Market Cash Flow: Starch Low regulatory hurdles for cosmetic applications Features Benefits Extremely small, uniform, smooth For improved skin feel Large inner surface area High carrying load for ingredients White free flowing powder Easy formulation Amylose content ~13% Physical-chemical properties for potentially superior gels Large scale seed production Domestic production and security of supply for cosmetic needs Exclusive partnerships Marketing by product segment and by geography Unique Novelty Product Branding exclusivity, A must for the cosmetic industry 24
  25. 25. $10/kg Wild type seed Prairie Carnation Value Chain $100/kg Identity preserved double haploid seed $1kg Contract produced farmer seed $250kg Seed extract,:60% saponin, phenolics, cyclic peptides $20kg Seed flower – finest starch, proteins, fibre, oil $10kg Vaccine adjuvants vet + human $1000kg Therapeutic saponins Licence Downpayment$10Mill Cell Proliferation Joint Venture $50Mill Cardiovascular Royalties $10Mill Example with theoretical values Royalties $100Mill 25
  26. 26. $10/kg $25/kg Where is the home run? Focus! Wild type seed Double haploid seed $50/kg Identity preserved certified seed 500 to $1/kg Contract produced farmer seed 50 to $100/kg Seed extract saponins, antioxidants, soluble fibre 400 to $20/kg Seed flower particle starch, conformations 50 to $2/kg Seed Protein protein for food, feed, 15 to $10/kg Seed Oil seed oil for food 30 kg $30/kg Saponin adjuvant vet. adjuvants 30 kg $10/kg Saponin adjuvants vaccines 30 kg $200/kg Therapeutic saponins Outlicence $1Mill Seed Peptides Library Downpayment$1Mill Cell Proliferation Potential Value per 100 ha: Joint Venture $50Mill Blood Pressure Royalties $10Mill Drugs Royalties $100Mill Example with theoretical values 26
  27. 27. Added Value: Cyclopeptide Pharma Doesn’t this sound like a home run? • Known multiple pharmacological properties • Not easy to produce – creates barrier • Identified application for cardiovascular disease • Compound library for numerous new drug candidates • Proprietary production methods in-place • Patent in preparation 27
  28. 28. Productive Agriculture Taken for Granted 28
  29. 29. Broad Markets are a Backup toothpaste Mouth rinse shampoo ore separation Commercial saponin uses root beer fire extinguishers photographic degreasing and beer emulsions cleaning products 29
  30. 30. The Upscale Potential! Prairie Carnation ( sales value per bushel) Saponin – crude $ 250 or Saponin – animal adjuvant (100µL/dose) $7,500 or Saponin – human adjuvant (100µL/dose) $3.75 MM or Saponin – cancer drug (100 mg/dose) $4.5 MM and Cyclopeptides – cardiovascular drug (100 mg) $75,000 30
  31. 31. The Business Concept the six pillar company! Question: Why would anybody grow a brand new crop? Answer: Control of the crop from the seed all the way to end user products! • Create a strong intellectual property position, • Multi faceted (six) uses of all seed contents, • Multiple pharmaceutical compounds with proof of concept product in pre-clinics • Identity preserved germplasm control Fazit: Proprietary Technology Platform offering FTO, Genetics, Extraction for six significant commercial uses , 31
  32. 32. The Six Pillars 1. Starch for cosmetic application 2. Saponins for vaccine adjuvants, dermatology, 3. Biological fungicide, nematicide, SAR 4. Cyclic peptides for blood pressure application etc. 5. Antioxidant for food supplement 6. Edible Protein for food and feed 32
  33. 33. Investor Speak ABIC 2008, Cork, Ireland 33
  34. 34. Concept for Success 34
  35. 35. Contact Info Michael M. Oelck, Manotick (Ottawa) Ontario Canada K4M 1A6 (613) 692-2382 IM Skype: Moelck Michael M. Oelck, Ph.D., PAg. (Seed Business, Genetics, Regulatory) Elke Steinmann-Oelck, Ph.D. (Agronomy, Plant Pathology) 35
  36. 36. Prairie Carnation 36