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Progressive Spastic Paraparesis AskTheNeurologist.Com Author Anon
R.A ,[object Object],[object Object]
History I ,[object Object],[object Object],[object Object],[object Object]
History 2 ,[object Object],[object Object],[object Object],[object Object],[object Object]
History 3 ,[object Object],[object Object],[object Object],[object Object],[object Object]
History 4 ,[object Object],[object Object],[object Object],[object Object]
History 5 ,[object Object],[object Object]
Family History ,[object Object],[object Object],[object Object],[object Object],[object Object]
Family History II ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Examination ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Examination II
Investigations I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Investigations II
[object Object],[object Object],[object Object],[object Object],Investigations III
[object Object],[object Object],[object Object],Investigations IV
DD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
Stained with Luxol fast blue – stains myelinated axons
A  L A  L
Usually lose ability to walk by age 60-70 Usually ambulant until death from other cause More prominent weakness, sensory loss and urinary symptoms Weakness, Sensory loss and urinary symptoms less marked More rapidly evolving course Slower course Onset after 35 years Onset before 35 years TYPE II TYPE I
 
 
 
 
 
 
HSP caused by impaired development of the   corticospinal tract
 
PLP mutation ,[object Object],[object Object]
 
Paraplegin ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Paraplegin II
[object Object],[object Object],Paraplegin III
[object Object],[object Object],[object Object],[object Object],Paraplegin II
 
Treatment options ,[object Object],[object Object],[object Object],[object Object]
Follow-Up ,[object Object]

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Progressive Spastic Paraparesis

  • 1. Progressive Spastic Paraparesis AskTheNeurologist.Com Author Anon
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  • 23. Stained with Luxol fast blue – stains myelinated axons
  • 24. A L A L
  • 25. Usually lose ability to walk by age 60-70 Usually ambulant until death from other cause More prominent weakness, sensory loss and urinary symptoms Weakness, Sensory loss and urinary symptoms less marked More rapidly evolving course Slower course Onset after 35 years Onset before 35 years TYPE II TYPE I
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  • 32. HSP caused by impaired development of the corticospinal tract
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