Lefteris Thireos talks about big data and evidence-based medicine in Greece. Workshop title: Datathons in Evidence-Based Medicine: Applying Open Science Principles to Support Cross-Disciplinary Education and Research Workshop abstract: In this interactive workshop, we explore how open science enables “datathons”, events that bring together teams of researchers to work together on unanswered clinical questions. We begin by outlining the datathon model and describe our experiences in holding these events internationally. We then offer an opportunity to participate in an interactice exercise, working together to analyse highly detailed information collected from patients admitted to critical care units at a large tertiary care hospital. Participants will learn about open science in clinical research and gain an overview of MIMIC-III, a freely-available critical care dataset collected from over >50,000 hospital stays. DAY 2 - PARALLEL SESSION 3 http://opensciencefair.eu/training/parallel-day-2-1/datathons-in-evidence-based-medicine-applying-open-science-principles-to-support-cross-disciplinary-education-and-research

1. Lefteris Thireos MD, MSc in Public Health
General Practitioner/Family Physician
Member of the National E-Health Board of Greece
Secretary General, Athens Medical Society
Big data and evidence-based medicine
in Greece
DATATHONS IN EVIDENCE-BASED MEDICINE: APPLYING OPEN SCIENCE
PRINCIPLES TO SUPPORT CROSS-DISCIPLINARY EDUCATION AND RESEARCH

9. the clinician’s
cumulated
experience,
education and
clinical skills
patient’s
personal
preferences and
unique
concerns,
expectations
and values

11. Clinical effectivenessCost effectiveness

12.  As Therapeutic Protocols defined by the set of
instructions diagnosis and treatment of a disease,
based on the findings and the clinical application of
medical science.
(Ν. 3697/2008, άρθρο 35)
 A Therapeutic Prescription Protocol is a structured,
comprehensive, coherent and scientifically
documented description of the pharmaceutical
treatment of a specific disease or condition.

13. Key objectives for the development of Therapeutic
Prescription Protocols (TPP) are to be used:
 by all physicians as an aid in prescription,
 to set out a framework of “good medical practice” at
all levels of care, as a result of fully adapted
guidelines, based on the up-to-day clinical
evidence.
 to improve the quality of health services,
 both in paper and electronic form.

14. The development of the web-based application for the TPP has the
following objectives and benefits:
 Common form and common coding and nomenclature for all
protocols
 Usable and easily accessible and searchable
 Information-rich content combining ICD-10 codes for diagnoses
and standard EOF ATC4/ATC5 coding for Medicines
 Fast and easy use by all users (doctors) in devices such as PCs,
tablets, etc.
 Interconnection with other application (DRGs/KEN, ePrescription/
e-syntagografisis, etc) through standardized Application
Programming Interfaces – API (phase II of the project)
Digital imaging and documentation of TPP

15. 1. Initial development of
Medicines Prescription
Protocols by EOF Working
Groups / Medical Societies as
unstructured test (PDF Files)
2. Filtering of initial text and
transcription into tabular structured
text, suitable for digital display and
processing (EXCEL template)
3. Import of EXCEL Template data
into the MPPA Application Database
4. Prescription Protocol is available on-line
through World-Wide-Web. Easy access and
display of the Protocols by all prescribing
physicians through the web-based MPPA
application. The Application also allows
access to the full PDF documentation of the
protocol if needed.
Maintenance and update of Protocols in the MPPA
Database is assigned to specialized Working
Groups / Medical Societies. The whole process is
under the auspices of the Athens Medical Society
(AMS) & the National Organization for Medicines
(EOF). AMS IT experts Group undertake the
contractual technical support of the application.
5. Prescribing physician have
fast and easy access to the
MPPA application to assist him
on prescription. Cost-efficient
prescription may gradually
become mandatory.
6. Statutory Insurance Funds can
control Medicines Reimbursement by
paying only cost-efficient prescriptions
according to the (mandatory)
Prescribing Protocols Schemes.

17. From TPP…

18. … to risk assessment

19. … in forming an excel_template

29. Patient
registration
Specialist
centers
Patient code, Therapeutic
Plan and information for
the GP
Web
registration
Follow-up
Adverse drug
reaction
General
Practitioners
End of
treatment
NHS Common Components
Central registries
(MPIs, HCP, Nomenclatures,
etc)
1...n)
Data Location Registries
(1...n)
Central Data Repositories
(1...n)
Security Components - eID
Hospital Information
System
(1...n)
Cloud Based HIS
(IDIKA)
(1...n)
Regional Healthcare
Information System
(1...7)
NHS Primary Care System
Doctor Information
Systems
(1...n)
Laboratory
Information Systems
(1...n)
Hospital Information
System
(1...n)
Doctor Information
Systems
(1...n)
Laboratory
Information
Systems
(1...n)
User 1 User 2 User n
...
User 1 User 2 User n
...
ePrescription System
(IDIKA)
User 1
User 2
User n
...
Reinbursement &
Insured Records
(EOPYY)

31. Thank you for your attention