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Life After the Golden Age of Antibacterials

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I was invited by Adamson University Biology Society to give a talk about antimicrobial resistance during their Biocon 2018: Insights on the Latest Trends on Applied Biological Sciences in Ozanam AVR, Adamson University last February 22, 2018

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Life After the Golden Age of Antibacterials

  1. 1. Life After the Golden Age of Antibacterials OURLAD ALZEUS G. TANTENGCO MD-PhD Molecular Medicine Candidate College of Medicine, UP Manila Biocon 2018: Insights on the Latest Trends on Applied Biological Sciences. Ozanam AVR, Adamson University. February 22, 2018
  2. 2. Infection after surgery in 1921 was a major risk
  3. 3. Fresh Air treatment for TB sufferers in London 1936
  4. 4. Giving birth was far more dangerous before antibiotics
  5. 5. Start of the Golden Era of Antibiotics
  6. 6. Sensors 2011, 11(10), 9450-9466; doi:10.3390/s111009450
  7. 7. But bacteria, evolve and develop defense against these compounds.
  8. 8. Nature 499: 394-396 (2013)
  9. 9. Antibiotic resistance crisis An increase in resistant organisms + A limited number of new antimicrobial drugs = a problematic scenario “The pharmaceutical industry has largely turned away from antibiotic research due to the low likelihood of getting a return on investment. Any new class of antibiotics would need to be used sparingly to conserve their effectiveness, meaning sales would be slow.” - WSJ
  10. 10. Post-antibiotic era Currently: - 80% of gonorrhoeal infections are now resistant to antibiotics. - 440,000 new cases of drug-resistant tuberculosis annually. Sally Davies (Britain’s Chief Medical Officer) “Antibiotic resistance should be added to the list of national emergencies”. In the future: - Strep throat to a scraped knee could kill you. - A simple hip replacement would result in 1 and 6 deaths. - The cost to treat drug-resistant cases is estimated to be at least double.
  11. 11. Top 10 Leading Causes of Morbidity in the Philippines (2013)
  12. 12. Top 10 Leading Causes of Mortality in the Philippines (2013)
  13. 13. “What is the use of treating people, only to send them back to conditions that gave rise to their illness in the first place?” Commission on the Social Determinants of Health, 2008
  14. 14.
  15. 15. The Davos Declaration “International pharmaceutical, diagnostics and biotechnology companies, as well as key industry bodies, have come together to work in parallel in taking comprehensive action against drug-resistant infections “. 1. Reducing the development of drug resistance. 2. Increasing investment in R&D that meets global public health needs. 3. Improve access to high-quality antibiotics for all.
  16. 16. Discovering Antibiotics in New Ways Teixobactin: A new class of antibiotics Binds to lipids that build the cell wall. In the Nature study, teixobactin was shown to kill Staphylococcus aureus and Mycobacterium tuberculosis without the bacteria developing a resistance to the antibiotic. iChip
  17. 17. 'One Health' is an approach to designing and implementing programmes, policies, legislation and research in which multiple sectors communicate and work together to achieve better public health outcomes.
  18. 18. We can all take a tiny step to address an overwhelming problem of antibiotic resistance