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  THE ROLE OF NGOs IN TOBACCO CONTROL  Prof. Dr Lekhraj Rampal  MBBS, MPH, DRPH, FRSH, FAMM Deputy Chairman Malaysian Health Promotian Board  Chairman, Action on Smoking and Health Committee, MMA 1993, 1996 -2009  Chairman, International Quit smoking and Win – MALAYSIA 1998, 2000, 2002, 2004,2006 Chairman, National Organizing Committee-  World No Tobacco Day – Malaysia1993, 2002, 2004,2006 9th August 2009 RAMPAL
CONTENTS ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
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THE GLOBAL  IMPACT OF SMOKING ON HEALTH ,[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
The 5 million deaths per year from tobacco smoking are not the result of liberty and free choice by adult and responsible consumers (60 to 80% want to stop). 9th August 2009 RAMPAL
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Gender-Specific Smoking Prevalence Across the World 1. Mackay J, et al.  The Tobacco Atlas . Second Ed. American Cancer Society Myriad Editions Limited, Atlanta, Georgia, 2006. Also available online at: http://www.myriadeditions.com/statmap/. US 24% 19% Men Women Australia 19% 16% Belarus 53% 7% Brazil 22% 14% Canada 22% 17% Chile 48% 37% China 67% 2% Egypt 45% 12% France 30% 21% Iceland 25% 20% Mexico 13% 5% Iran 22%  2% Kenya 21% 1% Sweden 17% 18% Philippines 41% 8% Portugal 33% 10% South Africa 23% 8% India 47% 17% Russian Fed 60% 16% Italy 33% 17% Spain 39% 25% Germany 37% 28%
Four Stages of the Tobacco Epidemic: Mortality Is Increasing in Many Countries 1 % female deaths 0 ,[object Object],If current smoking patterns continue, deaths from smoking in Asia—home to a third of the world’s population—are expected to increase by 2020 to 4.9 million annually. 2 Percentage  of smokers  among adults Percentage  of deaths caused by smoking ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],STAGE 1 STAGE 2 STAGE 3 STAGE 4 70 60 50 40 30 20 10 0 70 60 50 40 30 20 10 0 80 90 100 40 30 20 10 % male deaths % male smokers % female smokers Years 1. Lopez AD, et al.  Tobacco Control . 1994;3:242-247. 2. Shafey O, et al (eds). Tobacco Control Country Profiles 2003, American Cancer Society; 2003; Atlanta, Georgia. Available at: http://www.who.int/tobacco/global_data/country_profiles/en/. Accessed June 2006.
Developing Countries ,[object Object],[object Object],9th August 2009 RAMPAL
Every day , THOUSANDS of young people around the world are trying their first cigarette and 80,000 – 100,000 are becoming regular smokers often precipitating a lifetime of addiction and untimely death. 9th August 2009 RAMPAL
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Annual Deaths Attributable to Tobacco: Worldwide Estimates Canada >25% Australia 20%-24% UK >25%   Germany  >25% China & Taiwan 10%-14% Brazil  15%-19% % of Total Deaths Attributable to Tobacco* *Regional estimates in 2000 in men aged >35 years. 1. Mackay J, Eriksen M.  The Tobacco Atlas.  Second Ed.   World Health Organization; 2006. US  >25% Mexico  15%-19% Argentina  15%-19% Spain >25% Russian Federation >25% Sweden  >25% Turkey >25% 9th August 2009 RAMPAL
Fig 13:“Youth should be inculcated in a  “ Calture without Tobacco”- Chairman ASH IQSW 2000 9th August 2009 RAMPAL
Tobacco must be seen as a drug, not as a more agricultural product. Tobacco is a dangerous product and hazardous to health and it is lethal. 9th August 2009 RAMPAL
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World No Tobacco Day  Geneva, 30 May 2006  ,[object Object],9th August 2009 RAMPAL
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WORLD HEALTH DAY 2007 ,[object Object],9th August 2009 RAMPAL
[object Object],[object Object],WHO Director-General Dr Margaret Chan.  9th August 2009 RAMPAL
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ECONOMIC  LOSS ,[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
RM 4.5 billion per year (US$1.3 BILLION/PER YEAR)  1 st  JUNE  2007 9th August 2009 RAMPAL
Estimated Annual Costs Attributable to Tobacco Canada $12.9 Australia $14.2 France $16.4 Germany $24.4 China $4.3 US  $184.5 Estimated Costs to the Economy Attributable to Tobacco (US $ Billions) UK $2.3 Norway $1.62 1. Mackay J, et al.  The Tobacco Atlas.  Second Ed. American Cancer Society Myriad Editions Limited. Atlanta, Georgia, 2006. Also available online at: http://www.myriadeditions.com/statmap/. Venezuela  $.284 Total Costs Direct Healthcare Costs 9th August 2009 RAMPAL
What’s in a Cigarette? ,[object Object],[object Object],[object Object],1. National Toxicology Program. 11th Report on Carcinogens; 2005. Available at: http://ntp-server.niehs.nih.gov. 2. Mackay J, Eriksen M.  The Tobacco Atlas . World Health Organization; 2006. 3.  Harvard Health Letter . May 2005. 4. Surgeon General’s Report.  The Health Consequences of Smoking ; 2004.  Chemical in Tobacco Smoke 2 Also Found In…  Acetone Paint stripper Butane Lighter fluid Arsenic Ant poison Cadmium Car batteries Carbon monoxide Car exhaust fumes Toluene Industrial solvent
Chemicals 9th August 2009 RAMPAL
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Tobacco is the only freely available product which, when used as intended by the manufacturer, kills half of its dedicated users. 9th August 2009 RAMPAL
Mechanisms of Action:  How Smoking Causes Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1. Surgeon General’s Report.  The Health Consequences of Smoking ; 2004.
Smoking: Leading Preventable Cause of Disease and Death 1 Top 3 Smoking-Attributable Causes of Death in US #1 Lung cancer  #2 Ischemic heart disease #3 COPD Cancer Lung (#1)*  Leukemia (AML, ALL, CLL) 2-4 Oral cavity/pharynx  Laryngeal Esophageal  Stomach Pancreatic  Kidney Bladder  Cervical Cardiovascular Ischemic heart disease (#2)* Stroke – Vascular dementia 5   Peripheral vascular disease 6 Abdominal aortic aneurysm Respiratory COPD (#3)* Pneumonia Poor asthma control Reproductive Low-birth weight Pregnancy complications Reduced fertility Sudden Infant Death Syndrome Other Adverse surgical outcomes/wound healing Hip fractures Low-bone density Cataract Peptic ulcer disease † *Top 3 smoking-attributable causes of death.  † In patients who are  Helicobacter pylori  positive. AML = Acute myeloid leukemia; ALL =  acute lymphocytic leukemia; CLL = chronic lymphocytic leukemia; COPD = chronic obstructive pulmonary disease; SIDS = sudden infant death syndrome. 1. Surgeon General’s Report.  The Health Consequences of Smoking ; 2004. 2. Sandler DP, et al.  J Natl Cancer Inst . 1993;85(24):1994-2003. 3. Crane MM, et al.  Cancer Epidemiol Biomarkers Prev . 1996;5(8):639-644. 4. Miligi L, et al.  Am J Ind Med . 1999;36(1):60-69. 5. Roman GC.  Cerebrovasc Dis . 2005;20(Suppl 2):91-100. 6. Willigendael EM, et al.  J Vasc Surg . 2004;40:1158-1165. 9th August 2009 RAMPAL
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There are more than 25 tobacco related diseases known today including  : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
Merokok menyebabakan 90% daripada kematian akibat kanser  paru-paru, 9th August 2009 RAMPAL
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Common cancer among Tobacco chewing are     -Oral cavity carcinoma   -Oral Sub mucous  fibrosis 9th August 2009 RAMPAL
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Carcinoma of buccal mucosa Carcinoma of Maxilla  9th August 2009 RAMPAL
RESPIRATORY DISEASES ,[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
CARDIOVASCULAR  DISEASES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
Cardiovascular diseases are now responsible for 30% of all deaths worldwide.  Smoking is a well-established risk factor for cardiovascular disease.  9th August 2009 RAMPAL
38 YEARS SMOKER WHO DIED DUE TO WITH CEREBRAL STROKE 9th August 2009 RAMPAL
PAEDIATRIC  DISEASES ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
Smoking During Pregnancy  Harms Infants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],*1990s. 1. Fagerström K.  Drugs . 2002;62(Suppl 2):1–9. 2. Le Souef PN.  Thorax . 2000;55:1063–1067.  3. Mackay J, et al.  The Tobacco Atlas.  World Health Organization; 2002. 4. Hellstrom-Lindahl E,  et al.  Respiration.  2002;69:289-293. 9th August 2009 RAMPAL
For every person who dies from tobacco use, another 20 suffer with at least one serious tobacco-related illness.  Half of all long-term smokers die prematurely from smoking-related causes. Until recently this epidemic of chronic disease and premature deaths mainly affected the rich countries. It is now rapidly shifting to the developing world.  9th August 2009 RAMPAL
IMPACT OF SMOKING ON MALE SEXUAL HEALTH ,[object Object],[object Object],9th August 2009 RAMPAL
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What Does Secondhand Smoke Do? ,[object Object],[object Object],[object Object],[object Object],1. News release, June 27, 2006; US Department of Health & Human Services. Available at: http://www.hhs.gov/news/press/2006pres/20060627.html. 2. Mackay J, et al.  The Tobacco Atlas.  World Health Organization; 2002. 3. Teo KK, et al.  Lancet.  2006;368:647-658.  9th August 2009 RAMPAL
PREVALEVE OF SMOKING  IN MALAYSIA 9th August 2009 RAMPAL
Prevalence of Smoking among Malaysians   Estimated: ~ 3 million smokers in Malaysia (2006) 9th August 2009 RAMPAL 1996 2004 2006 NHMS2 UPM NHMS3 ( > 18 yrs) ( > 18 yrs) ( > 18 yrs) Overall 24.8% 23.2% 21.5% Male 49.2% 47.2 46.4% Female 3.5% 2.7% 1.6% Malay 27.9% 28.9   % 24% Chinese 19.2% 18.7% 16.2% Indian 16.2% 16.8% 13.7% Others 32.4% 22.5% 23.8%
Table III: Prevalence of ever and current smokers by sex and ethnicity 2004   9th August 2009 RAMPAL Ethnicity Sex Prevalence of Ever Smokers % (SE %) Prevalence of Current Smokers % (SE %)  All Races Male Female Both 59.3 (0.7) 4.8 (0.3) 32.0 (0.5 ) 47.2 (0.7) 2.7 (0.2) 24.9 (0.4) Malay Male Female Both 69.8 (0.8) 4.6 (0.3) 37.0 (0.6) 55.6 (0.9) 2.6 (0.2) 28.9 (0.6 ) Chinese Male Female Both 45.2 (1.6) 5.0 (0.6) 25.3 (1.0) 34.1 (1.5) 3.0 (0.4) 18.7 (0.9) Indian Male Female Both 41.1 (2.2) 1.1 (0.3) 21.1 (1.3 ) 33.4 (2.1) 0.5 (0.2) 16.8 (1.2) Others Male Female Both 55.4 (10.4) 5.1 (2.0) 27.5 (4.7 ) 46.1 (9.4) 3.5 (1.6) 22.5 (4.4) Bumiputra Sarawak Male Female Both 61.2 (3.6) 10.7 (1.9) 35.8 (2.3 ) 50.9 (3.2) 5.2 (1.4) 27.9 (2.0) Bumiputra Sabah Male Female Both 57.5 (2.4) 5.5 (1.0) 32.0 (1.6 ) 50.2 (2.2) 2.6 (0.6) 26.8 (1.6)
NHMS3 - Adult Smoking Prevalence   9th August 2009 RAMPAL Ever Smoker Current Smoker Ex-Smoker Overall 27.0% 21.5% (2.73M) 5.4% Male 57.6% 46.4% (2.61M) 11.0% Female 2.5% 1.6% (0.12M) 0.9% Urban 24.1% 18.9% (1.56 M) 5.0% Rural 32.3% 26.2% (1.17 M) 6.0%
NHMS3 - Adolescent Smoking Prevalence ( 13 to <18 years)   9th August 2009 RAMPAL Overall Boys Girls Ever smokers - Young people who have ever smoked a cigarette (even 1puff) 14.7% (180,328) 26.2% (162,438) 3.0% (17,891) Current smokers - Young people who smoke on at least one day in the last 30 days preceding the survey 8.7% (107,154) 16.6% (103,240) 0.7% (3,914) Frequent/ established smokers  Young people who have smoked on at least 20 of the 30days preceding survey 3.3% (40,172) 6.4% (39,083) 0.18% (1,089) Experimental smokers - Young people who have smoked < 20days for the past 30 days & not smoked for last 7 days 1.1% 1.9% 0.2% Triers - Young people who ever tried to smoke but stopped after only one (1) cigarette or after a few puffs 5.2% 8.3% 2%
10 Principal Causes of Deaths  in MOH Hospitals, 2006   9th August 2009 RAMPAL Septicaemia 16.87% Heart Diseases & Diseases of Pulmonary Circulation  15.70% Malignant Neoplasm 10.59% Cerebrovascular Diseases 8.49% Pneumonia 5.81% Accidents 5.59% Diseases of the Digestive Systems 4.47% Certain Conditions Originating in the Perinatal Period 4.20% Nephritis, Nephrotic Syndrome & Nephrosis 3.83% Ill-defined conditions 3.03%
Total Treatment Cost for 3 Smoking Related Diseases/ Year (RM - million ) Syed Aljunid, 2005 9th August 2009 RAMPAL Mean Min Max Patient 949.8 682.3 1730.6 Provider 1975.0 925.0 3257.7 Total 2924.8 1607.3 4988.3 % of GDP 0.74 0.41 1.27 % of NHE 16.49 9.06 28.12 % MOH budget 26.14 12.24 43.11
Factors Influencing Tobacco Use 9th August 2009 RAMPAL
1. Tobacco industry marketing and  advertising 2.  Profit margin/  Sales are legal even though it kills half of its user  3. Nicotine Addiction 4. Low Tobacco Tax 5. Peer smoking status and influence 6. Parental smoking status 7. Smoking environment in Workplace and house 8. Greed and Corruption 9. Smuggling of tobacco products 9th August 2009 RAMPAL
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TOBACCO INDUSTRY TARGETTED YOUNG PEOPLE (  DYER C. BMJ 1998;316:1923 ,[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
ON THE SIDE OF A SHOP TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
RESTAURANT TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
2. NICOTINE ADDICTION 9th August 2009 RAMPAL
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Section 2:  Tobacco Dependence Mechanisms  ,[object Object],[object Object],[object Object],[object Object]
Mechanism of Action of Nicotine in the Central Nervous System ,[object Object],[object Object], 4  2  2  2  4  4  2 Nicotinic Receptor
Nicotine Stimulates Dopamine Release  ,[object Object],D Ventral Tegmental Area Nucleus Accumbens Adapted from Picciotto MR, et al.  Nicotine and Tob Res . 1999: Suppl 2:S121-S125. D  4  2 Nicotinic Receptor  Nicotine  Dopamine Reward D D D Axon
Nicotine May Cause Up-Regulation and Desensitization of Receptors Resulting in Tolerance ,[object Object],[object Object],[object Object],[object Object],[object Object],1. Schroeder SA.  JAMA.  2005;294:482-487.  2. Jarvis MJ. BMJ. 2004; 328:277-279.
The Cycle of Nicotine Addiction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1. Jarvis MJ. BMJ. 2004; 328:277-279. 2. Picciotto MR, et al.  Nicotine and Tob Res . 1999: Suppl 2:S121-S125. Dopamine Nicotine
Tobacco Industry ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
SMOKING IN UTERO INCREASES RISK OF LATER ADDICTION ARNOLD MANN   NIDA, 2004: 19 (4) 9th August 2009 RAMPAL
Patrick Zickler NIDA 2004; 19 (2) SMOKING MAY BE MORE ADDICTIVE  IF IT IS INITIATED DURING ADOLESCENCE, AND EARLY EXPOSURE MAY  HEIGHTEN RESPONSE TO OTHER ADDICTIVE DRUGS. MALES AND FEMALES MAY DIFFER IN THEIR SUSCEPTIBILITY TO THESE EFFECTS 9th August 2009 RAMPAL
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REAL PRICE OF TOBACCO  TO CONSUMER – PRICE WAR 9th August 2009 RAMPAL
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TOBACCO PRICE WAR - Decline in tobacco price ???Answer: Increase Taxes to such an extent that tobacco companies don’t think of reducing their price again. Use the money for Tobacco control activities and for Victims of Tobacco Use  9th August 2009 RAMPAL
PEERS  SMOKING 9th August 2009 RAMPAL
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PARENTAL SMOKING 9th August 2009 RAMPAL
9th August 2009 RAMPAL Risk factors Crude Odds Ratio P  value Adjusted Odds Ratio P  value Highest education achieved University/ College Secondary Primary No formal Education 1.00 1.61 (1.40, 1.86) 1.41 (1.2, 1.65) 0.98 (0.81, 1.19) <0.001 <0.001 0.846 1.00 2.22 (1.87, 2.64) 2.68 (2.18, 3.30) 6.61 (4.91, 8.89) <0.001 <0.001 <0.001 Friends who smoke No Yes 1.00 17.95 (15.25, 21.13) <0.001 1.00 4.9 (4.03, 5.96) <0.001 Family who smoke No Yes 1.00 1.58 (1.44, 1.74) <0.0001 1.00 2.20 (1.97, 4.47) <0.001 Self Esteem High Moderate Low 1.00 0.97 (0.88, 1.07) 1.29 (1.16, 1.45) 0.565 <0.001 1.00 0.92 (0.81, 1.04) 1.31 (1.13, 1.51) 0.185 <0.001
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GREED AND CORRUPTION 9th August 2009 RAMPAL
A letter from James F. Ripslinger to Sylvester Stallone dated June 14 1983 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
It is sad that very few  is calling for its BAN 9th August 2009 RAMPAL
Quitting at Any Age May Increase Life Expectancy 1. Doll R, et al.  BMJ . 2004;328:1519–1527. ,[object Object],Survival At Each Age  Point (%) 40 35-44 Stopped Age  Results From a Study of Male Physician Smokers in the United Kingdom Nonsmokers  Cigarette Smokers  Age (Years)
Risk of Cardiovascular Disease (CVD) Reduced By Quitting Smoking  ,[object Object],[object Object],[object Object],*Defined as self-reported smokers who were cotinine negative. 1. Critchley JA, Capewell S.  JAMA . 2003;290:86-97. 2. Twardella D et al.  Eur Heart J . 2004;25:2101–2108. 0.71 0.64 0.44 1.00 0.00 0.20 0.40 0.60 0.80 1.00 1.20 Currently Smokes Recently Quit* Formerly Smoked Never Smoked Odds Ratio
COMBATTING THE PROBLEM 9th August 2009 RAMPAL
1.  CORE DEMAND REDUCTION 2.  CORE SUPPLY REDUCTION 9th August 2009 RAMPAL
NGOs  Role in tobacco control efforts should be focused on several fronts: ,[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
WHO classifies interventions into two major groups, those aimed at reducing the demand for tobacco:  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
and those aimed at reducing the supply of tobacco: ,[object Object],9th August 2009 RAMPAL
ROLE OF NGOs IN TOBACCO CONTROL  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
MALAYSIAN EXPERIENCE ,[object Object],[object Object],9th August 2009 RAMPAL
[object Object],[object Object],[object Object],9th August 2009 RAMPAL
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
MMA SUBMITS MEMORENDAM TO GOVERNMENT TO BAN SMOKING IN PUBLIC PLACES 9th August 2009 RAMPAL
IMPACT: CABINET RULING  BANS SMOKING IN GOVERNMENT MEETINGS AND PLACES  9th August 2009 RAMPAL
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LEAD ROLE :CATALYST  ASH,MMA ORGANISES WORKSHOP ON SMOKING OR HEALTH 1983 9th August 2009 RAMPAL
SLIDE  SHOWING WORKSHOP AND EXHIBITION “ON SMOKING OR HEALTH  9.10.1983 Dr  RAMPAL 9th August 2009 RAMPAL
NATIONAL NO SMOKING DAY 6 TH  NOV 1986 ORGANISED BY ASH, MMA WITH COLLABORATION WITH MOH AND OTHER NGO’S 9th August 2009 RAMPAL
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ROLE: EDUCATIONAL ASH, MMA  HIGHLIGHTS HAZARDS OF PASSIVE SMOKING 9th August 2009 RAMPAL
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ROLE : EDUCATIONAL ASH, MMA HIGHLIGHTS  ROLE OF HEALTH PROFESSIONALS IN TOBACCO CONTROL 9th August 2009 RAMPAL
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WORLD NO TOBACCO DAY 1993 9th August 2009 RAMPAL
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ROLE :ADVOCATIVE ASH MMA WRITES TO MALAYSIAN AIRLINES TO BAN SMOKING ON LOCAL FLIGHTS 9th August 2009 RAMPAL
Impact Of Health Promotion And Advocacy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
Impact Of Health Promotion And Advocacy ,[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
ASH, MMA SUBMITS MEMORENDAM TO GOVERNMENT TO BAN SMOKING IN PUBLIC PLACES 9th August 2009 RAMPAL
IMPACT ,[object Object],9th August 2009 RAMPAL
IMPACT ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
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ROLES: LEAD AND CATALYST 9th August 2009 RAMPAL
INTERNATIONAL QUIT SMOKING AND WIN CAMPAIGN – MALAYSIA  1998, 2000, 2002 , 2004  9th August 2009 RAMPAL
Rules and Regulations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PRIZES 9th August 2009 RAMPAL
PANEL OF JUDGES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
The International Quit Smoking and Win  is an Global Joint event involving 75 countries and we expect  500,000 to one million participants to give up smoking for at least one month it also helps to  inform the general public about harmful effects on health by tobacco consumption. 9th August 2009 RAMPAL
Assisted by: ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
The IQSW  application forms were published in the English, Malay, Chinese and Tamil Language Newspapers which had Nation-wide circulation. 9th August 2009 RAMPAL
IQSW 1998 POSTER 9th August 2009 RAMPAL
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Fig 10: International Quit Smoking And  Win Campaign 1998-Malaysia 9th August 2009 RAMPAL
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  ROLE  - ADVOCATIVE Tobacco Advertisment Issue brought up by Dr Lekhraj Rampal, Chairman, ASH ,MMA’ and Minister Agrees to bring up the Issue of  Tobacco Advertisment to Cabinet 9th August 2009 RAMPAL
ROLE : ADVOCATIVE ,[object Object],9th August 2009 RAMPAL
IMPACT Malaysia enacted the control of Tobacco Product Regulations 1993 under the Food Act 1983 to discourage smoking in the country. A number of provisions are made in the Regulations to curb smoking. This includes areas such as cigarette accessibility to children, health warning messages and cigarette advertising.  One of the programs intended to discourage smoking is the anti-tobacco media campaign. 9th August 2009 RAMPAL
Fig 14: President Malaysian Medical Association and Chairman ASH Slam Tobacco Firms Over Warning Labels  9th August 2009 RAMPAL
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DR RAMPAL 9th August 2009 RAMPAL
Launched by Deputy Minister of Health, Malaysia 9th August 2009 RAMPAL
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ROLE :ADVOCATIVE ASH MMA WRITES TO THE GOVERNMENT  TO INCREASE TAX ON TOBACCO AND HAVE A SPECIAL FUND FOR TOBACCO CONTROL ACTIVITIES  9th August 2009 RAMPAL
Message form Prof Dr Lekhraj Rampal Chairman, ASH, MMA on World No Tobacco Day 31 st  May 2007 Major TV stations and Newspapers and again on 2 July 2007 TV 2 ,[object Object],[object Object],9th August 2009 RAMPAL
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WE CAN QUIT SMOKING Fig 11: Bank Staff  Quit As A Group During IQSW 1998 9th August 2009 RAMPAL
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DEPUTY MINISTER OF HEALTH   QUITS SMOKING  9th August 2009 RAMPAL
Fig. 5: Launching of the No Smoking Week 1987 .  Deputy Minister of Health. Kicks The Habit Himself (30 Years As a Smoker) 9th August 2009 RAMPAL
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GETTING THE HEALTH PROFESSIONALS IN THE ARMED FORCES INVOLVED 9th August 2009 RAMPAL
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NGOs Roles include:   ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
As Scientist   ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
As a Leader  ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
Opinion-builder ,[object Object],9th August 2009 RAMPAL
Alliance-builder ,[object Object],9th August 2009 RAMPAL
Watch out for tobacco industry activities ,[object Object],[object Object],9th August 2009 RAMPAL
BARRIERS TO NGOs INVOLVEMENT IN TOBACCO CONTROL   ,[object Object],[object Object],[object Object],9th August 2009 RAMPAL
ROLE:TRAINING  HEALTH PROFESSIONALS IN SMOKING CESSATION TECHNIQUES 9th August 2009 RAMPAL
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PARTICIPATION  IN  LOCAL  AND INTERNATIONAL CONFERENCES AND FORUMS 9th August 2009 RAMPAL
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DR PETO AT WORLD CONFERENCE IN FINLAND 9th August 2009 RAMPAL
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Dr Judith Mackay at APACT Conference in Taiwan 9th August 2009 RAMPAL
MALAYSIAN HEALTH PROMOTION BOARD 9th August 2009 RAMPAL
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YOUTH INVOLVEMENT 9th August 2009 RAMPAL
DEPUTY MINISTER OF YOUTH AND SPORTS  LAUCHES TOBACCO CONTROL ACTIVITIES  AMONGST THE YOUTH USING INTERACT AND  ROTERACT  CLUBS 9th August 2009 RAMPAL
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TOBACCO FREE SPORTS   NATIONAL ART POSTER  & SLOGAN COMPETITION INTERNATIONAL QUIT SMOKING AND WIN 2002 THEME: TOBACCO FREE SPORTS 9th August 2009 RAMPAL
Organized by  MMA AND COMMONWEALTH MEDICAL ASSOCIATION 9th August 2009 RAMPAL
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9th August 2009 RAMPAL
IMPACT ON THE MEMORENDUM  GIVEN BY ASH, MMA TO THE GOVERNMENT TO INCREASE TAXES AND USE THE MONEY FOR TOBACCO CONTROL ACTIVITIES-  SIN TAX 9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
2005 WORLD NO TOBACCO DAY Launched by  MINISTER OF WILAYAH PERSEKTUAN   31.5.2005 AT UNIVRSITY MALAYA 9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
WINNERS OF COMPETITION BEING GIVEN PRIZES 9th August 2009 RAMPAL
USING ART AND CULTURE IN TOBACCO CONTROL 9th August 2009 RAMPAL
NATIONAL ART COMPETITION 2005   ASH, MMA THEME:  HARMFUL EFFECTS OF TOBACCO AND TOBACCO PRODUCTS –  START A HEALTHY LIFESTYLE WITHOUT TOBACCO ORGANIZED BY MMA WITH THE ASSISTANCE OF MINISTRY OF EDUCATION, HEALTH AND PRIVATE SECTOR 9th August 2009 RAMPAL
NATIONAL ART POSTER COMPETITION  - 2005 ORGANIZED BY ASH, MMA ,[object Object],9th August 2009 RAMPAL
9th August 2009 RAMPAL
JUDGES SELECTING THE WINNERS MR VICTOR CHIN (PROFESSIONAL ARTIST ) 9th August 2009 RAMPAL
9th August 2009 RAMPAL
PROF DR KRISHNA GOPAL TRUSTEE NATIONAL ART MUSEUM 9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
CHAIRMAN ASH,MMA DR RAMPAL WITH THE WINNERS 9th August 2009 RAMPAL
9th August 2009 RAMPAL
9th August 2009 RAMPAL
PLEASE  ADVOCATE TO  EXTEND THE EXISTING BAN TO INCLUDE  9th August 2009 RAMPAL
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
IN CONCLUSION: YOU AND YOUR NGOs CAN PLAY THE FOLLOWING ROLES IN TOBACCO CONTROL  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],9th August 2009 RAMPAL
IN CONCLUSION: Malaysia has taken several steps forward in tobacco control.   We need to work together locally and globally to achieve  – “  A Tobacco Free World”. 9th August 2009 RAMPAL
9th August 2009 RAMPAL

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Role Of Ng Os In Tobacco Control

  • 1. THE ROLE OF NGOs IN TOBACCO CONTROL Prof. Dr Lekhraj Rampal MBBS, MPH, DRPH, FRSH, FAMM Deputy Chairman Malaysian Health Promotian Board Chairman, Action on Smoking and Health Committee, MMA 1993, 1996 -2009 Chairman, International Quit smoking and Win – MALAYSIA 1998, 2000, 2002, 2004,2006 Chairman, National Organizing Committee- World No Tobacco Day – Malaysia1993, 2002, 2004,2006 9th August 2009 RAMPAL
  • 2.
  • 3.
  • 4.
  • 5. The 5 million deaths per year from tobacco smoking are not the result of liberty and free choice by adult and responsible consumers (60 to 80% want to stop). 9th August 2009 RAMPAL
  • 6.
  • 7. Gender-Specific Smoking Prevalence Across the World 1. Mackay J, et al. The Tobacco Atlas . Second Ed. American Cancer Society Myriad Editions Limited, Atlanta, Georgia, 2006. Also available online at: http://www.myriadeditions.com/statmap/. US 24% 19% Men Women Australia 19% 16% Belarus 53% 7% Brazil 22% 14% Canada 22% 17% Chile 48% 37% China 67% 2% Egypt 45% 12% France 30% 21% Iceland 25% 20% Mexico 13% 5% Iran 22% 2% Kenya 21% 1% Sweden 17% 18% Philippines 41% 8% Portugal 33% 10% South Africa 23% 8% India 47% 17% Russian Fed 60% 16% Italy 33% 17% Spain 39% 25% Germany 37% 28%
  • 8.
  • 9.
  • 10. Every day , THOUSANDS of young people around the world are trying their first cigarette and 80,000 – 100,000 are becoming regular smokers often precipitating a lifetime of addiction and untimely death. 9th August 2009 RAMPAL
  • 11. 9th August 2009 RAMPAL
  • 12. Annual Deaths Attributable to Tobacco: Worldwide Estimates Canada >25% Australia 20%-24% UK >25% Germany >25% China & Taiwan 10%-14% Brazil 15%-19% % of Total Deaths Attributable to Tobacco* *Regional estimates in 2000 in men aged >35 years. 1. Mackay J, Eriksen M. The Tobacco Atlas. Second Ed. World Health Organization; 2006. US >25% Mexico 15%-19% Argentina 15%-19% Spain >25% Russian Federation >25% Sweden >25% Turkey >25% 9th August 2009 RAMPAL
  • 13. Fig 13:“Youth should be inculcated in a “ Calture without Tobacco”- Chairman ASH IQSW 2000 9th August 2009 RAMPAL
  • 14. Tobacco must be seen as a drug, not as a more agricultural product. Tobacco is a dangerous product and hazardous to health and it is lethal. 9th August 2009 RAMPAL
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22. RM 4.5 billion per year (US$1.3 BILLION/PER YEAR) 1 st JUNE 2007 9th August 2009 RAMPAL
  • 23. Estimated Annual Costs Attributable to Tobacco Canada $12.9 Australia $14.2 France $16.4 Germany $24.4 China $4.3 US $184.5 Estimated Costs to the Economy Attributable to Tobacco (US $ Billions) UK $2.3 Norway $1.62 1. Mackay J, et al. The Tobacco Atlas. Second Ed. American Cancer Society Myriad Editions Limited. Atlanta, Georgia, 2006. Also available online at: http://www.myriadeditions.com/statmap/. Venezuela $.284 Total Costs Direct Healthcare Costs 9th August 2009 RAMPAL
  • 24.
  • 25. Chemicals 9th August 2009 RAMPAL
  • 26.
  • 27. Tobacco is the only freely available product which, when used as intended by the manufacturer, kills half of its dedicated users. 9th August 2009 RAMPAL
  • 28.
  • 29. Smoking: Leading Preventable Cause of Disease and Death 1 Top 3 Smoking-Attributable Causes of Death in US #1 Lung cancer #2 Ischemic heart disease #3 COPD Cancer Lung (#1)* Leukemia (AML, ALL, CLL) 2-4 Oral cavity/pharynx Laryngeal Esophageal Stomach Pancreatic Kidney Bladder Cervical Cardiovascular Ischemic heart disease (#2)* Stroke – Vascular dementia 5 Peripheral vascular disease 6 Abdominal aortic aneurysm Respiratory COPD (#3)* Pneumonia Poor asthma control Reproductive Low-birth weight Pregnancy complications Reduced fertility Sudden Infant Death Syndrome Other Adverse surgical outcomes/wound healing Hip fractures Low-bone density Cataract Peptic ulcer disease † *Top 3 smoking-attributable causes of death. † In patients who are Helicobacter pylori positive. AML = Acute myeloid leukemia; ALL = acute lymphocytic leukemia; CLL = chronic lymphocytic leukemia; COPD = chronic obstructive pulmonary disease; SIDS = sudden infant death syndrome. 1. Surgeon General’s Report. The Health Consequences of Smoking ; 2004. 2. Sandler DP, et al. J Natl Cancer Inst . 1993;85(24):1994-2003. 3. Crane MM, et al. Cancer Epidemiol Biomarkers Prev . 1996;5(8):639-644. 4. Miligi L, et al. Am J Ind Med . 1999;36(1):60-69. 5. Roman GC. Cerebrovasc Dis . 2005;20(Suppl 2):91-100. 6. Willigendael EM, et al. J Vasc Surg . 2004;40:1158-1165. 9th August 2009 RAMPAL
  • 30. 9th August 2009 RAMPAL
  • 31.
  • 32. Merokok menyebabakan 90% daripada kematian akibat kanser paru-paru, 9th August 2009 RAMPAL
  • 33.
  • 34. Common cancer among Tobacco chewing are -Oral cavity carcinoma -Oral Sub mucous fibrosis 9th August 2009 RAMPAL
  • 35.
  • 36. Carcinoma of buccal mucosa Carcinoma of Maxilla 9th August 2009 RAMPAL
  • 37.
  • 38.
  • 39. Cardiovascular diseases are now responsible for 30% of all deaths worldwide. Smoking is a well-established risk factor for cardiovascular disease. 9th August 2009 RAMPAL
  • 40. 38 YEARS SMOKER WHO DIED DUE TO WITH CEREBRAL STROKE 9th August 2009 RAMPAL
  • 41.
  • 42.
  • 43. For every person who dies from tobacco use, another 20 suffer with at least one serious tobacco-related illness. Half of all long-term smokers die prematurely from smoking-related causes. Until recently this epidemic of chronic disease and premature deaths mainly affected the rich countries. It is now rapidly shifting to the developing world. 9th August 2009 RAMPAL
  • 44.
  • 45. 9th August 2009 RAMPAL
  • 46.
  • 47. PREVALEVE OF SMOKING IN MALAYSIA 9th August 2009 RAMPAL
  • 48. Prevalence of Smoking among Malaysians Estimated: ~ 3 million smokers in Malaysia (2006) 9th August 2009 RAMPAL 1996 2004 2006 NHMS2 UPM NHMS3 ( > 18 yrs) ( > 18 yrs) ( > 18 yrs) Overall 24.8% 23.2% 21.5% Male 49.2% 47.2 46.4% Female 3.5% 2.7% 1.6% Malay 27.9% 28.9 % 24% Chinese 19.2% 18.7% 16.2% Indian 16.2% 16.8% 13.7% Others 32.4% 22.5% 23.8%
  • 49. Table III: Prevalence of ever and current smokers by sex and ethnicity 2004 9th August 2009 RAMPAL Ethnicity Sex Prevalence of Ever Smokers % (SE %) Prevalence of Current Smokers % (SE %) All Races Male Female Both 59.3 (0.7) 4.8 (0.3) 32.0 (0.5 ) 47.2 (0.7) 2.7 (0.2) 24.9 (0.4) Malay Male Female Both 69.8 (0.8) 4.6 (0.3) 37.0 (0.6) 55.6 (0.9) 2.6 (0.2) 28.9 (0.6 ) Chinese Male Female Both 45.2 (1.6) 5.0 (0.6) 25.3 (1.0) 34.1 (1.5) 3.0 (0.4) 18.7 (0.9) Indian Male Female Both 41.1 (2.2) 1.1 (0.3) 21.1 (1.3 ) 33.4 (2.1) 0.5 (0.2) 16.8 (1.2) Others Male Female Both 55.4 (10.4) 5.1 (2.0) 27.5 (4.7 ) 46.1 (9.4) 3.5 (1.6) 22.5 (4.4) Bumiputra Sarawak Male Female Both 61.2 (3.6) 10.7 (1.9) 35.8 (2.3 ) 50.9 (3.2) 5.2 (1.4) 27.9 (2.0) Bumiputra Sabah Male Female Both 57.5 (2.4) 5.5 (1.0) 32.0 (1.6 ) 50.2 (2.2) 2.6 (0.6) 26.8 (1.6)
  • 50. NHMS3 - Adult Smoking Prevalence 9th August 2009 RAMPAL Ever Smoker Current Smoker Ex-Smoker Overall 27.0% 21.5% (2.73M) 5.4% Male 57.6% 46.4% (2.61M) 11.0% Female 2.5% 1.6% (0.12M) 0.9% Urban 24.1% 18.9% (1.56 M) 5.0% Rural 32.3% 26.2% (1.17 M) 6.0%
  • 51. NHMS3 - Adolescent Smoking Prevalence ( 13 to <18 years) 9th August 2009 RAMPAL Overall Boys Girls Ever smokers - Young people who have ever smoked a cigarette (even 1puff) 14.7% (180,328) 26.2% (162,438) 3.0% (17,891) Current smokers - Young people who smoke on at least one day in the last 30 days preceding the survey 8.7% (107,154) 16.6% (103,240) 0.7% (3,914) Frequent/ established smokers Young people who have smoked on at least 20 of the 30days preceding survey 3.3% (40,172) 6.4% (39,083) 0.18% (1,089) Experimental smokers - Young people who have smoked < 20days for the past 30 days & not smoked for last 7 days 1.1% 1.9% 0.2% Triers - Young people who ever tried to smoke but stopped after only one (1) cigarette or after a few puffs 5.2% 8.3% 2%
  • 52. 10 Principal Causes of Deaths in MOH Hospitals, 2006 9th August 2009 RAMPAL Septicaemia 16.87% Heart Diseases & Diseases of Pulmonary Circulation 15.70% Malignant Neoplasm 10.59% Cerebrovascular Diseases 8.49% Pneumonia 5.81% Accidents 5.59% Diseases of the Digestive Systems 4.47% Certain Conditions Originating in the Perinatal Period 4.20% Nephritis, Nephrotic Syndrome & Nephrosis 3.83% Ill-defined conditions 3.03%
  • 53. Total Treatment Cost for 3 Smoking Related Diseases/ Year (RM - million ) Syed Aljunid, 2005 9th August 2009 RAMPAL Mean Min Max Patient 949.8 682.3 1730.6 Provider 1975.0 925.0 3257.7 Total 2924.8 1607.3 4988.3 % of GDP 0.74 0.41 1.27 % of NHE 16.49 9.06 28.12 % MOH budget 26.14 12.24 43.11
  • 54. Factors Influencing Tobacco Use 9th August 2009 RAMPAL
  • 55. 1. Tobacco industry marketing and advertising 2. Profit margin/ Sales are legal even though it kills half of its user 3. Nicotine Addiction 4. Low Tobacco Tax 5. Peer smoking status and influence 6. Parental smoking status 7. Smoking environment in Workplace and house 8. Greed and Corruption 9. Smuggling of tobacco products 9th August 2009 RAMPAL
  • 56.
  • 57.
  • 58. TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
  • 59. ON THE SIDE OF A SHOP TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
  • 60. RESTAURANT TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
  • 61. TOBACCO INDUSTRY – ADVERTISMENT?? 9th August 2009 RAMPAL
  • 62. 2. NICOTINE ADDICTION 9th August 2009 RAMPAL
  • 63. 9th August 2009 RAMPAL
  • 64.
  • 65.
  • 66.
  • 67.
  • 68.
  • 69.
  • 70. SMOKING IN UTERO INCREASES RISK OF LATER ADDICTION ARNOLD MANN NIDA, 2004: 19 (4) 9th August 2009 RAMPAL
  • 71. Patrick Zickler NIDA 2004; 19 (2) SMOKING MAY BE MORE ADDICTIVE IF IT IS INITIATED DURING ADOLESCENCE, AND EARLY EXPOSURE MAY HEIGHTEN RESPONSE TO OTHER ADDICTIVE DRUGS. MALES AND FEMALES MAY DIFFER IN THEIR SUSCEPTIBILITY TO THESE EFFECTS 9th August 2009 RAMPAL
  • 72. 9th August 2009 RAMPAL
  • 73. 9th August 2009 RAMPAL
  • 74. REAL PRICE OF TOBACCO TO CONSUMER – PRICE WAR 9th August 2009 RAMPAL
  • 75. 9th August 2009 RAMPAL
  • 76. 9th August 2009 RAMPAL
  • 77. 9th August 2009 RAMPAL
  • 78. TOBACCO PRICE WAR - Decline in tobacco price ???Answer: Increase Taxes to such an extent that tobacco companies don’t think of reducing their price again. Use the money for Tobacco control activities and for Victims of Tobacco Use 9th August 2009 RAMPAL
  • 79. PEERS SMOKING 9th August 2009 RAMPAL
  • 80. 9th August 2009 RAMPAL
  • 81. PARENTAL SMOKING 9th August 2009 RAMPAL
  • 82. 9th August 2009 RAMPAL Risk factors Crude Odds Ratio P value Adjusted Odds Ratio P value Highest education achieved University/ College Secondary Primary No formal Education 1.00 1.61 (1.40, 1.86) 1.41 (1.2, 1.65) 0.98 (0.81, 1.19) <0.001 <0.001 0.846 1.00 2.22 (1.87, 2.64) 2.68 (2.18, 3.30) 6.61 (4.91, 8.89) <0.001 <0.001 <0.001 Friends who smoke No Yes 1.00 17.95 (15.25, 21.13) <0.001 1.00 4.9 (4.03, 5.96) <0.001 Family who smoke No Yes 1.00 1.58 (1.44, 1.74) <0.0001 1.00 2.20 (1.97, 4.47) <0.001 Self Esteem High Moderate Low 1.00 0.97 (0.88, 1.07) 1.29 (1.16, 1.45) 0.565 <0.001 1.00 0.92 (0.81, 1.04) 1.31 (1.13, 1.51) 0.185 <0.001
  • 83.
  • 84. GREED AND CORRUPTION 9th August 2009 RAMPAL
  • 85.
  • 86. It is sad that very few is calling for its BAN 9th August 2009 RAMPAL
  • 87.
  • 88.
  • 89. COMBATTING THE PROBLEM 9th August 2009 RAMPAL
  • 90. 1. CORE DEMAND REDUCTION 2. CORE SUPPLY REDUCTION 9th August 2009 RAMPAL
  • 91.
  • 92.
  • 93.
  • 94.
  • 95.
  • 96.
  • 97.
  • 98. 9th August 2009 RAMPAL
  • 99. 9th August 2009 RAMPAL
  • 100.
  • 101. MMA SUBMITS MEMORENDAM TO GOVERNMENT TO BAN SMOKING IN PUBLIC PLACES 9th August 2009 RAMPAL
  • 102. IMPACT: CABINET RULING BANS SMOKING IN GOVERNMENT MEETINGS AND PLACES 9th August 2009 RAMPAL
  • 103. 9th August 2009 RAMPAL
  • 104. 9th August 2009 RAMPAL
  • 105. LEAD ROLE :CATALYST ASH,MMA ORGANISES WORKSHOP ON SMOKING OR HEALTH 1983 9th August 2009 RAMPAL
  • 106. SLIDE SHOWING WORKSHOP AND EXHIBITION “ON SMOKING OR HEALTH 9.10.1983 Dr RAMPAL 9th August 2009 RAMPAL
  • 107. NATIONAL NO SMOKING DAY 6 TH NOV 1986 ORGANISED BY ASH, MMA WITH COLLABORATION WITH MOH AND OTHER NGO’S 9th August 2009 RAMPAL
  • 108. 9th August 2009 RAMPAL
  • 109. 9th August 2009 RAMPAL
  • 110. 9th August 2009 RAMPAL
  • 111. 9th August 2009 RAMPAL
  • 112. 9th August 2009 RAMPAL
  • 113. 9th August 2009 RAMPAL
  • 114. 9th August 2009 RAMPAL
  • 115. ROLE: EDUCATIONAL ASH, MMA HIGHLIGHTS HAZARDS OF PASSIVE SMOKING 9th August 2009 RAMPAL
  • 116. 9th August 2009 RAMPAL
  • 117. 9th August 2009 RAMPAL
  • 118. ROLE : EDUCATIONAL ASH, MMA HIGHLIGHTS ROLE OF HEALTH PROFESSIONALS IN TOBACCO CONTROL 9th August 2009 RAMPAL
  • 119. 9th August 2009 RAMPAL
  • 120. WORLD NO TOBACCO DAY 1993 9th August 2009 RAMPAL
  • 121. 9th August 2009 RAMPAL
  • 122. 9th August 2009 RAMPAL
  • 123. ROLE :ADVOCATIVE ASH MMA WRITES TO MALAYSIAN AIRLINES TO BAN SMOKING ON LOCAL FLIGHTS 9th August 2009 RAMPAL
  • 124.
  • 125.
  • 126. ASH, MMA SUBMITS MEMORENDAM TO GOVERNMENT TO BAN SMOKING IN PUBLIC PLACES 9th August 2009 RAMPAL
  • 127.
  • 128.
  • 129. 9th August 2009 RAMPAL
  • 130. 9th August 2009 RAMPAL
  • 131. 9th August 2009 RAMPAL
  • 132. ROLES: LEAD AND CATALYST 9th August 2009 RAMPAL
  • 133. INTERNATIONAL QUIT SMOKING AND WIN CAMPAIGN – MALAYSIA 1998, 2000, 2002 , 2004 9th August 2009 RAMPAL
  • 134.
  • 135.
  • 136.
  • 137.
  • 138. The International Quit Smoking and Win is an Global Joint event involving 75 countries and we expect 500,000 to one million participants to give up smoking for at least one month it also helps to inform the general public about harmful effects on health by tobacco consumption. 9th August 2009 RAMPAL
  • 139.
  • 140. The IQSW application forms were published in the English, Malay, Chinese and Tamil Language Newspapers which had Nation-wide circulation. 9th August 2009 RAMPAL
  • 141. IQSW 1998 POSTER 9th August 2009 RAMPAL
  • 142.
  • 143. 9th August 2009 RAMPAL
  • 144. Fig 10: International Quit Smoking And Win Campaign 1998-Malaysia 9th August 2009 RAMPAL
  • 145. 9th August 2009 RAMPAL
  • 146. ROLE - ADVOCATIVE Tobacco Advertisment Issue brought up by Dr Lekhraj Rampal, Chairman, ASH ,MMA’ and Minister Agrees to bring up the Issue of Tobacco Advertisment to Cabinet 9th August 2009 RAMPAL
  • 147.
  • 148. IMPACT Malaysia enacted the control of Tobacco Product Regulations 1993 under the Food Act 1983 to discourage smoking in the country. A number of provisions are made in the Regulations to curb smoking. This includes areas such as cigarette accessibility to children, health warning messages and cigarette advertising. One of the programs intended to discourage smoking is the anti-tobacco media campaign. 9th August 2009 RAMPAL
  • 149. Fig 14: President Malaysian Medical Association and Chairman ASH Slam Tobacco Firms Over Warning Labels 9th August 2009 RAMPAL
  • 150. 9th August 2009 RAMPAL
  • 151. DR RAMPAL 9th August 2009 RAMPAL
  • 152. Launched by Deputy Minister of Health, Malaysia 9th August 2009 RAMPAL
  • 153. 9th August 2009 RAMPAL
  • 154. 9th August 2009 RAMPAL
  • 155. ROLE :ADVOCATIVE ASH MMA WRITES TO THE GOVERNMENT TO INCREASE TAX ON TOBACCO AND HAVE A SPECIAL FUND FOR TOBACCO CONTROL ACTIVITIES 9th August 2009 RAMPAL
  • 156.
  • 157. 9th August 2009 RAMPAL
  • 158. 9th August 2009 RAMPAL
  • 159. 9th August 2009 RAMPAL
  • 160. 9th August 2009 RAMPAL
  • 161. 9th August 2009 RAMPAL
  • 162. 9th August 2009 RAMPAL
  • 163. 9th August 2009 RAMPAL
  • 164. 9th August 2009 RAMPAL
  • 165. 9th August 2009 RAMPAL
  • 166. 9th August 2009 RAMPAL
  • 167. 9th August 2009 RAMPAL
  • 168. 9th August 2009 RAMPAL
  • 169. WE CAN QUIT SMOKING Fig 11: Bank Staff Quit As A Group During IQSW 1998 9th August 2009 RAMPAL
  • 170. 9th August 2009 RAMPAL
  • 171. 9th August 2009 RAMPAL
  • 172. 9th August 2009 RAMPAL
  • 173. DEPUTY MINISTER OF HEALTH QUITS SMOKING 9th August 2009 RAMPAL
  • 174. Fig. 5: Launching of the No Smoking Week 1987 . Deputy Minister of Health. Kicks The Habit Himself (30 Years As a Smoker) 9th August 2009 RAMPAL
  • 175. 9th August 2009 RAMPAL
  • 176. GETTING THE HEALTH PROFESSIONALS IN THE ARMED FORCES INVOLVED 9th August 2009 RAMPAL
  • 177. 9th August 2009 RAMPAL
  • 178. 9th August 2009 RAMPAL
  • 179.
  • 180.
  • 181.
  • 182.
  • 183.
  • 184.
  • 185.
  • 186.
  • 187. ROLE:TRAINING HEALTH PROFESSIONALS IN SMOKING CESSATION TECHNIQUES 9th August 2009 RAMPAL
  • 188. 9th August 2009 RAMPAL
  • 189. 9th August 2009 RAMPAL
  • 190. 9th August 2009 RAMPAL
  • 191. PARTICIPATION IN LOCAL AND INTERNATIONAL CONFERENCES AND FORUMS 9th August 2009 RAMPAL
  • 192. 9th August 2009 RAMPAL
  • 193. DR PETO AT WORLD CONFERENCE IN FINLAND 9th August 2009 RAMPAL
  • 194. 9th August 2009 RAMPAL
  • 195. Dr Judith Mackay at APACT Conference in Taiwan 9th August 2009 RAMPAL
  • 196. MALAYSIAN HEALTH PROMOTION BOARD 9th August 2009 RAMPAL
  • 197. 9th August 2009 RAMPAL
  • 198. YOUTH INVOLVEMENT 9th August 2009 RAMPAL
  • 199. DEPUTY MINISTER OF YOUTH AND SPORTS LAUCHES TOBACCO CONTROL ACTIVITIES AMONGST THE YOUTH USING INTERACT AND ROTERACT CLUBS 9th August 2009 RAMPAL
  • 200. 9th August 2009 RAMPAL
  • 201. TOBACCO FREE SPORTS   NATIONAL ART POSTER & SLOGAN COMPETITION INTERNATIONAL QUIT SMOKING AND WIN 2002 THEME: TOBACCO FREE SPORTS 9th August 2009 RAMPAL
  • 202. Organized by MMA AND COMMONWEALTH MEDICAL ASSOCIATION 9th August 2009 RAMPAL
  • 203. 9th August 2009 RAMPAL
  • 204. 9th August 2009 RAMPAL
  • 205. IMPACT ON THE MEMORENDUM GIVEN BY ASH, MMA TO THE GOVERNMENT TO INCREASE TAXES AND USE THE MONEY FOR TOBACCO CONTROL ACTIVITIES- SIN TAX 9th August 2009 RAMPAL
  • 206. 9th August 2009 RAMPAL
  • 207. 9th August 2009 RAMPAL
  • 208. 9th August 2009 RAMPAL
  • 209. 9th August 2009 RAMPAL
  • 210. 9th August 2009 RAMPAL
  • 211. 2005 WORLD NO TOBACCO DAY Launched by MINISTER OF WILAYAH PERSEKTUAN 31.5.2005 AT UNIVRSITY MALAYA 9th August 2009 RAMPAL
  • 212. 9th August 2009 RAMPAL
  • 213. 9th August 2009 RAMPAL
  • 214. 9th August 2009 RAMPAL
  • 215. 9th August 2009 RAMPAL
  • 216. WINNERS OF COMPETITION BEING GIVEN PRIZES 9th August 2009 RAMPAL
  • 217. USING ART AND CULTURE IN TOBACCO CONTROL 9th August 2009 RAMPAL
  • 218. NATIONAL ART COMPETITION 2005 ASH, MMA THEME: HARMFUL EFFECTS OF TOBACCO AND TOBACCO PRODUCTS – START A HEALTHY LIFESTYLE WITHOUT TOBACCO ORGANIZED BY MMA WITH THE ASSISTANCE OF MINISTRY OF EDUCATION, HEALTH AND PRIVATE SECTOR 9th August 2009 RAMPAL
  • 219.
  • 220. 9th August 2009 RAMPAL
  • 221. JUDGES SELECTING THE WINNERS MR VICTOR CHIN (PROFESSIONAL ARTIST ) 9th August 2009 RAMPAL
  • 222. 9th August 2009 RAMPAL
  • 223. PROF DR KRISHNA GOPAL TRUSTEE NATIONAL ART MUSEUM 9th August 2009 RAMPAL
  • 224. 9th August 2009 RAMPAL
  • 225. 9th August 2009 RAMPAL
  • 226. 9th August 2009 RAMPAL
  • 227. CHAIRMAN ASH,MMA DR RAMPAL WITH THE WINNERS 9th August 2009 RAMPAL
  • 228. 9th August 2009 RAMPAL
  • 229. 9th August 2009 RAMPAL
  • 230. PLEASE ADVOCATE TO EXTEND THE EXISTING BAN TO INCLUDE 9th August 2009 RAMPAL
  • 231.
  • 232.
  • 233. IN CONCLUSION: Malaysia has taken several steps forward in tobacco control.   We need to work together locally and globally to achieve – “ A Tobacco Free World”. 9th August 2009 RAMPAL
  • 234. 9th August 2009 RAMPAL

Notas del editor

  1. Key Point Gender-specific smoking prevalence varies across the world. Background Worldwide, there are marked differences in smoking prevalence rates between men and women from country to country. For example, in South Africa, the Philippines, China, Iran, and Portugal, smoking prevalence is much lower in women than in men. In contrast, in the United States, Canada, Australia, and Iceland, the prevalence of smoking in men is only slightly higher than that in women. 1 Overall, the prevalence of smoking in men is declining. However, although smoking prevalence in women is declining in some countries, such as the United States, the United Kingdom, Australia, and Canada, in several southern, central, and eastern European countries, the rate of smoking in women is not in decline or is still increasing. 1 Reference 1. Mackay J, Eriksen M, Shafey O. The Tobacco Atlas. Second Ed. American Cancer Society Myriad Editions Limited. Atlanta, Georgia, 2006. Also available online at: http://www.myriadeditions.com/statmap/. 1/Mackay/pp. 98-104, Table A 1/Mackay/pp. 98-104, Table A 1/Mackay/ pp 98-105
  2. Key Point Smoking prevalence rates in some countries are declining. However, mortality associated with smoking is increasing since smoking-related mortality is more closely associated with previous tobacco use rather than with current tobacco use. Background Using data from countries with the longest history of prevalent smoking, Lopez and colleagues constructed a 4-stage model of trends in smoking and subsequent smoking-related mortality. As the model illustrates, peaks in smoking prevalence in the population do not correspond to peaks in smoking-associated mortality, because current mortality rates are more closely related to previous smoking levels. Therefore, although in some regions, such as Western Europe and North America, smoking prevalence in men and women is on the decline, smoking-related mortality is increasing. Similarly, in areas like Asia, Central and South America, and North Africa, where smoking prevalence rates are increasing, the true impact in terms of smoking-related deaths will not be apparent for several decades. 1 In Asia, where one third of the world’s population lives, smoking-related mortality is expected to rise to 4.9 million people annually by 2020 if current smoking trends continue. 2 References 1. Lopez AD, Collishaw NE, Piha T. A descriptive model of the cigarette epidemic in developed countries. Tob Control . 1994;3:242–247. 2. Shafey O, Dolwick S, Guindon GE (eds). Tobacco Control Country Profiles 2003, American Cancer Society; 2003; Atlanta, Georgia. Available at: http://www.who.int/tobacco/global_data/country_profiles/en/. Accessed June 2006. Lopez/p 246/figure A 1/Lopez/p 242/abstract; p 245/col 2/ ¶3; p 246/col 2/ ¶1; figure 2/Shafey/ p 7/col 2/ ¶1
  3. Key Point In some countries, deaths attributable to tobacco account for &gt;25% of total deaths in men aged &gt; 35 years. Background The World Health Organization estimates that in the year 2000, 25% of total deaths in men aged &gt;35 years in most countries in the Northern Hemisphere (including the United States, Canada, Cuba, Israel, Russia and all European nations) were tobacco related. In these countries, &gt;25% of all men died from tobacco-related disorders. Twenty to 25% of women over the age of 35 died from tobacco-related disorders in the United States, Canada, and Cuba. Reference 1. Mackay J, Eriksen M. The Tobacco Atlas . Second Ed. Geneva, Switzerland: World Health Organization; 2006. 2/Mackay/ pp 42, 43. 1/Mackay/ p 36/Figure at bottom; p.37/Figure; p. 40-41/Globe figure 2/Mackay/ pp 42, 43. 1/Mackay/ p 36/Figure at bottom; p.37/Figure; p. 40-41/ Globe figure 2/Mackay/ pp 98-105
  4. Key Point Tobacco puts a considerable burden on estimated annual costs to the economy worldwide. Background The estimated annual costs to the economy attributable to tobacco amounts to billions of US dollars. Examples of these costs range from a high of $184.5 billion in the US (total costs) to $284 million in Venezuela (direct healthcare costs only). Reference 1. Mackay J, Eriksen M, Shafey O. The Tobacco Atlas. Second Ed. American Cancer Society Myriad Editions Limited. Atlanta, Georgia, 2006. Also available online at: http://www.myriadeditions.com/statmap/. 1/Mackay/ 2006, pp 42, 43. 1/Mackay/2006/ pp 42,43 1/Mackay/ pp 98-105
  5. Key Point Tobacco smoke exposes the body to  250 toxic or carcinogenic chemicals. Background Tobacco and tobacco smoke are known to be carcinogenic in humans.Tobacco smoke contains at least 4000 chemicals, at least 250 of which are toxic or carcinogenic. 1 For example, tobacco smoke contains irritants, such as acetone, ammonia, and toluene, found in paint stripper, cleaners, and solvents respectively; toxic heavy metals, such as cadmium, used in car batteries, and arsenic, used in poisons; and carbon monoxide, which is a hazardous component of exhaust fumes. 2 Although it is addictive, the nicotine found in tobacco is not a known carcinogen. 3 All cigarettes are toxic: the US Surgeon General’s report noted that smoking cigarettes with lower yields of tar and nicotine provides no health benefit. 4 References 1. National Toxicology Program. 11th Report on Carcinogens; 2005. Available at: www.cdc.gov/tobacco/ets. 2. Mackay J, Eriksen M. The Tobacco Atlas . Second Ed. Geneva, Switzerland: World Health Organization; 2006. 3. Harvard Health Letter . May 2005. 4. US Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General. Atlanta, Georgia: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004. 4/SGR/p. 25/col2/¶2 1/NTP/p. 1/col2/¶4,5 2/Mackay/p34/”Deadly Chemicals” 3/Harvard/p.2/¶3/figure 1/NTP/p. 1/col 2/¶4,5; p. 3/col 1/¶3; p. 4/col 2/¶2; p. 5/col 2/¶4 2/Mackay/ p. 34/ “Deadly Chemicals” 4/SGR /p. 25/ col2/¶2 3/Harvard/ p.2/¶3/ figure
  6. The Tobacco Atlas, 2002 Map 7: Health Inset: Deadly chemicals 100?
  7. Key Point Smoking leads to diminished health status either by contributing to specific disease pathogenesis or by other nonspecific mechanisms. Background The pathological mechanisms of smoking include those specifically linked to the pathogenesis of diseases and those that are less specific. For example, smoking directly exposes lung cells to the potent mutagens and carcinogens which cause genetic changes in lung cells associated with lung cancer development. Smoking causes or contributes to endothelial injury and dysfunction, prothrombotic/fibrinolytic effects, inflammation, and adverse lipid profiles, which lead to cardiovascular disease. Finally, biological processes resulting in airway and alveolar injury and the accelerated decline in respiratory function caused by smoking contribute to the development of COPD. Reference 1. US Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General. Atlanta, Georgia: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004. Surgeon General: Lung/p 47/col 2/¶3; IHD/p 365/col1/¶2; p 366/col1/¶3; p367/col 1/¶2; p 368/col 1/¶3, Col 2, ¶4; COPD/p 463/col 2/¶2; p 464/Table 4.13 Surgeon General: p.615/col1/¶1; Lung/ p. 25/col 1/¶2; p 47/col 2/¶3; IHD/ p365/col1/ ¶2; p366/col1/ ¶3; p367/col 1/ ¶2; p 368/col 1/ ¶3, col. 2, ¶4; p. 371/ col 2/¶1 p. 626/col 1/¶2, COPD/ p. 27/col 2/#7; p 463/col 2/¶2; p 464/Table 4.13
  8. Key Point Smoking is causally linked to a host of cardiovascular, respiratory, reproductive, and other conditions, as well as many types of cancer. The top 3 smoking attributable causes of death in the United States are lung cancer, ischemic heart disease, and chronic obstructive pulmonary disease (COPD). Background In 2004, the US Surgeon General published a report on the health effects of active smoking, focusing specifically on the evidence for a causal relationship between smoking and disease and death. According to the research summarized in the report, many serious conditions are caused by smoking, including cardiovascular, respiratory, reproductive, and other conditions, as well as cancer affecting diverse areas and organs of the body. In addition to the widely-known consequences of lung cancer and respiratory disease, smoking has been causally linked to such diverse morbidities as low-bone density, nuclear cataract, bladder cancer, and reduced fertility. 1 Other studies have linked smoking to vascular dementia 2 and peripheral arterial disease. 3 These conditions can affect young and middle-aged smokers and, in general, as a smoker’s age increases, the frequency of smoking-caused diseases rises. 1 References 1. US Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General. Atlanta, Ga: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004. 2. Roman GC. Vascular dementia prevention: a risk factor analysis. Cerebrovasc Dis . 2005;20(Suppl 2):91–100. 3. Willigendael EM, Teijink JA, Bartelink ML, et al. Influence of smoking on incidence and prevalence of peripheral arterial disease. J Vasc Surg . 2004;40:1158–1165. 4. Ezzati M, Lopez AD. Regional, disease specific patterns of smoking-attributable mortality in 2000. Tobacco Control . 2004;13:388–395. 1/SGR/p 4-8/Table 1.1; p 860/Table 7.3 2/Roman pg 91 abstract 3/Willigendael pg 1158 abstract 1/SGR/p. iii/¶3,4,5,6; p. 4-8/ Table 1.1 1/SGR/ p. 860/ Table 7.3 2/Roman pg 91 abstract 3/Willigendael pg 1158 abstract 4/Ezzati/ p. 388/ Abstract
  9. Key Point Tobacco smoke exposure in women during pregnancy is associated with serious consequences for infants and children. Background Exposure to tobacco smoke during pregnancy is associated with serious consequences for infants and children. Environmental smoke is associated with a 4-fold increased risk of low-birth weight and an increased risk of miscarriage, stillbirth, and sudden infant death syndrome (SIDS). 1,2 Annually in the United States during the 1990s, 9700–18,600 cases of low-birth weight infants were related to secondhand smoke. 3 In addition, lung function may be impaired, 2 and a possible association with cognitive and developmental syndromes may exist. 1,4 References 1. Fagerström K. The epidemiology of smoking: health consequences and benefits of cessation. Drugs . 2002;62(Suppl 2):1–9. 2. Le Souef PN. Pediatric origins of adult lung diseases. 4. Tobacco related lung diseases begin in childhood. Thorax . 2000;55:1063–1067. 3. Mackay J, Eriksen M. The Tobacco Atlas . Geneva, Switzerland: World Health Organization; 2002. 4. Hellstrom-Lindahl E, Nordberg A. Smoking during pregnancy: a way to transfer the addiction to the next generation? Respiration . 2002;69:289–293. 1/Fagerstrom/p. 5/col 1/¶3. 2.Le Souef/p. 2/¶1-3. 3/Mackay/p 34. 4/Hellstrom/p289/abs 1/ Fagerstrom /p. 5/col 1/¶3. 2.Le Souef/p. 2/¶1-3. 3/Mackay/ p. 34. 1/ Fagerstrom /p. 5/col 1/¶3. 2.Le Souef/p. 2/¶1-3. 4/Hellstrom/p289/abs
  10. Key Point Exposure to secondhand smoke is a serious health hazard; it increases lung cancer risk and worsens pre-existing respiratory diseases, including asthma, COPD, and emphysema. Background Secondhand smoke is a serious health hazard. According to the US Surgeon General’s 2006 report, there is no risk-free level of exposure to secondhand smoke. 1 This recent report, as well as data from the World Health Organization, estimate exposure to secondhand smoke in nonsmokers increases lung cancer risk by 20%–30%. 1,2 In adults, secondhand smoke exposure may also worsen existing lung disease, such as asthma, COPD, and emphysema. 2 Environmental smoking can induce and exacerbate asthma in children and can cause middle ear disease and otitis media. 2 A study in 52 countries showed that secondhand smoke increases risks of nonfatal acute myocardial infarction. The risk was increased in a graded manner, and the effect was most marked in subjects who never smoked and former smokers. The overall attributable risk was 15.4% in subjects who never smoked but are exposed for ≥1 hour per week to secondhand smoke compared with those who never smoked and never were exposed. 3 The 2006 US Surgeon General’s report notes that secondhand smoke exposure increases the risk of heart disease by 25%–30% in nonsmokers. 1 References 1. US Department of Health &amp; Human Services. News release, June 27, 2006; Available at: http://www.hhs.gov/news/press/2006pres/20060627.html. Accessed July 10, 2006. 2. Mackay J, Eriksen M. The Tobacco Atlas . Second Ed. Geneva, Switzerland: World Health Organization; 2006. 3. Teo KK, Ounpuu S, Hawken S, et al. Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study. Lancet . 2006;368:647–658. 1/USDDHS/p 1/¶1 2/Mackay/p 35 3/Teo/p 1/abstract 1/USDDHS/p 1/¶1 2/Mackay/p 35/figure; p 36/col 1 /¶2; p 37/lower figure 3/Teo/p 1/abstract
  11. Key Point Nicotine stimulates dopamine release in areas of the brain which is believed to result in the reward and satisfaction effect associated with smoking. Background After inhalation, nicotine preferentially binds to nicotinic acetylcholinergic (nACh) receptors located in the mesolimbic-dopamine system of the brain within a matter of seconds. Nicotine specifically activates  4 β 2 nicotinic receptors in the Ventral Tegmental Area (VTA) causing an immediate dopamine release at the Nucleus Accumbens (nAcc). 1 The dopamine release is believed to be a key component of the reward circuitry associated with cigarette smoking. 1 Reference 1. Picciotto MR, Zoli M, Changeux J. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine Tob Res . 1999; Suppl 2:S121-125. 1/Picciotto, p. S121, para 1 1/Picciotto, p. S121, para 1
  12. Key Point Nicotine stimulates dopamine release in areas of the brain which is believed to result in the reward and satisfaction effect associated with smoking. Background Nicotine activates  4  2 nicotinic receptors that are localized to the neuronal bodies and terminal axons of the cells in the ventral tegmental area. This activation thereafter causes dopamine release at the nucleus accumbens, which is believed to result in the short-term reward/satisfaction effect associated with cigarette smoking. Reference Picciotto MR, Zoli M, Changeux J. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine Tob Res. 1999; Suppl 2:S121-S125. 1/Picciotto, p. S121, para 1 1/Picciotto, p. S121, para 1
  13. Key Point Nicotine may cause up-regulation and desensitization of nicotinic receptors resulting in tolerance. Drops in nicotine levels in combination with up-regualtion and desentization can result in withdrawal and craving. Background Tolerance typically develops after longer-term nicotine use. Tolerance is related to both the up-regulation (increased number) and the desensitization of nicotinic receptors in the VTA that occurs as a result of long-term exposure to nicotine. A drop in nicotine level, in combination with the up-regulation and decreased sensitivity of the nicotinic receptor, can result in withdrawal symptoms and cravings. Smokers have the ability to self regulate nicotine intake by the frequency of cigarette consumption and the intensity of inhalation. In order to maintain a steady nicotine level, smokers generally titrate their smoking to achieve maximal stimulation and avoid symptoms of withdrawal and craving. References 1. Schroeder SA. What to do with a patient who smokes. JAMA. 2005;294:482-487. 2. Jarvis MJ. Why people smoke. BMJ . 2004;328:277-279. 2/Jarvis/ p 277, para 1 1/Schroeder/ p 483, col 2 para 1 1/Schroeder/ p 483, col 2 para 2 2/Jarvis/ p 277, para 1 1/Schroeder/ p 483, col 2 para 1 1/Schroeder/ p 483, col 2 para 2
  14. Key Point Nicotine addiction is a cycle which begins with nicotine binding to receptors in the brain causing the release of dopamine which in turn results in feelings of pleasure and calmness. Background The distribution of nicotine is very rapid. It can reach the brain within 10 to 20 seconds after inhaling cigarette smoke. 1 The binding of nicotine to its relevant receptors results in the release of multiple neurotransmitters, most critically dopamine. The release of dopamine in the nucleus accumbens neurons is thought to play a critical role in the addictive nature of nicotine. This release of dopamine requires binding of nicotine to  4  2 receptors. 1,2 Absorption of cigarette smoke from the lungs is rapid and complete, producing with each inhalation a high concentration of arterial nicotine that reaches the brain within 10 to 16 seconds. Nicotine has a terminal half-life in blood of 2 hours. Smokers therefore experience a pattern of repetitive and transient high blood nicotine concentrations from each cigarette. Nicotine’s activation of acetylcholinergic receptors induces the release of dopamine in the nucleus accumbens. This is similar to the effect produced by other drugs of misuse, such as amphetamines and cocaine. The symptoms of nicotine withdrawal are a major barrier to smoking cessation. Smokers start to experience impairment of mood and performance within hours of their last cigarette. These effects are completely alleviated by smoking a cigarette. Withdrawal symptoms include irritability, restlessness, feeling miserable, impaired concentration, and increased appetite, as well as craving for cigarettes. Cravings, sometimes intense, can persist for many months. References Jarvis MJ. Why people smoke. BMJ . 2004;328:277-279. Picciotto MR, Zoli M, Changeux J. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine Tob Res. 1999; Suppl 2:S121-S125. 1/Jarvis/ p 278, para 1 1/Jarvis/ p 278, para 1 1/Jarvis/ p 278, para 1 1/Jarvis/ p 278, para 2 1/Jarvis/ p 277, para 5 1/Jarvis/ p 278, para 1, 2, 3 1/Jarvis/ p 277, para 5 2/Picciotto, p. S121, para 1 2/Picciotto, p. S121, para 1
  15. Key Point Quitting smoking reduces the risk of cardiovascular events. Background Quitting smoking substantially reduces the risk of all-cause mortality in individuals with CHD. A 2003 review of 9 electronic databases containing data from 1966 to 2003 for prospective cohort studies of patients with CHD, found that those who quit smoking had a 36% reduction in odds of all-cause mortality. 1 A reduction in risk of cardiac events is evident even among those who recently quit. In a German study of 967 patients aged 30–70 years who already had experienced an acute coronary event, Twardella et al found that the odds ratio (OR) for subsequent cardiovascular events decreased according to smoking status. Based on serum cotinine levels, patients were classified as never smokers, former smokers, and current smokers. Patients who said they smoked but who were negative for cotinine were classified as recent quitters. Assigning an OR of 1.00 for current smokers, the OR for recent quitters was 0.71, 0.64 for former smokers, and 0.44 for those who never smoked. 2 References 1. Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review. JAMA . 2003;290:86–97. 2. Twardella D, Kupper-Nybelen J, Rothenbacher D, Hahmann H, Wusten B, Brenner H. Short-term benefit of smoking cessation in patients with coronary heart disease: estimates based on self-reported smoking data and serum cotinine measurements. Eur Heart J . 2004;25:2101–2108. 1/Critchley/ p 86/abstract 2/Twardella/ p. 2106/ Table 4; p 2107/col 2/¶2 2/Twardella/ p. 2101/ abstract; p. 2102/ col 1/¶5; p. 2106/ Table 4 1/Critchley/ p 86/ abstract/p87 methods